Flexible microtubule anchoring modulates the bi-directional motility of the kinesin-5 Cin8

No abstract is available for this paper.

• Publication year

  2021

• Venue

  Cellular and Molecular Life Sciences

• Publication date

  2021-07-17

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s00018-021-03891-xPMID 34274977PMCID PMC11072411
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Characterization of the motility of monomeric kinesin-5/Cin8.

  2021cited by this paper
• The kinesin-5 tail domain directly modulates the mechanochemical cycle of the motor domain for anti-parallel microtubule sliding

  2020cited by this paper
• Drag-induced directionality switching of kinesin-5 Cin8 revealed by cluster-motility analysis

  2020cited by this paper
• Kinesin-5 Regulation and Function in Mitosis.

  2019cited by this paper
• Polyglutamylation of tubulin's C-terminal tail controls pausing and motility of kinesin-3 family member KIF1A

  2019cited by this paper
• Synthetic-Evolution Reveals Narrow Paths to Regulation of the Saccharomyces cerevisiae Mitotic Kinesin-5 Cin8

  2019cited by this paper
• Characterization of Proteins by Size-Exclusion Chromatography Coupled to Multi-Angle Light Scattering (SEC-MALS).

  2019cited by this paper
• Successive Kinesin-5 Microtubule Crosslinking and Sliding Promote Fast, Irreversible Formation of a Stereotyped Bipolar Spindle.

  2019cited by this paper
• BeStSel: a web server for accurate protein secondary structure prediction and fold recognition from the circular dichroism spectra

  2018cited by this paper
• Bidirectional motility of kinesin-5 motor proteins: structural determinants, cumulative functions and physiological roles

  2018cited by this paper
• Ensembles of Bidirectional Kinesin Cin8 Produce Additive Forces in Both Directions of Movement

  2017influential reference
• A potential physiological role for bi-directional motility and motor clustering of mitotic kinesin-5 Cin8 in yeast mitosis

  2017cited by this paper
• Physical determinants of bipolar mitotic spindle assembly and stability in fission yeast

  2017cited by this paper
• Three Cdk1 sites in the kinesin-5 Cin8 catalytic domain coordinate motor localization and activity during anaphase

  2017cited by this paper
• The yeast kinesin-5 Cin8 interacts with the microtubule in a noncanonical manner

  2017influential reference
• TrackMate: An open and extensible platform for single-particle tracking.

  2017cited by this paper
• Motile properties of the bi-directional kinesin-5 Cin8 are affected by phosphorylation in its motor domain

  2016cited by this paper
• Molecular properties of the N-terminal extension of the fission yeast kinesin-5, Cut7.

  2016cited by this paper
• The mitotic kinesin-14 KlpA contains a context-dependent directionality switch

  2016cited by this paper
• A Force-Induced Directional Switch of a Molecular Motor Enables Parallel Microtubule Bundle Formation.

  2016cited by this paper
• Schizosaccharomyces pombe kinesin-5 switches direction using a steric blocking mechanism

  2016influential reference
• Regulation and Possible Physiological Role of BI-Directional Motility of the Kinesin-5 Cin8

  2016cited by this paper
• Kinesin-5 is a microtubule polymerase

  2015cited by this paper
• The structural kinetics of switch-1 and the neck linker explain the functions of kinesin-1 and Eg5

  2015cited by this paper
• Kinesin Motor Enzymology: Chemistry, Structure, and Physics of Nanoscale Molecular Machines

  2015cited by this paper
• Control of cytoplasmic dynein force production and processivity by its C-terminal domain

  2015cited by this paper
• Deletion of the Tail Domain of the Kinesin-5 Cin8 Affects Its Directionality*

  2015cited by this paper
• DISOPRED3: precise disordered region predictions with annotated protein-binding activity

  2014cited by this paper
• Structural basis for the assembly of the mitotic motor Kinesin-5 into bipolar tetramers

  2014cited by this paper
• Bidirectional motility of the fission yeast kinesin-5, Cut7.

  2014cited by this paper
• Advanced methods of microscope control using μManager software.

  2014cited by this paper
• New insights into the mechanism of force generation by kinesin-5 molecular motors.

  2013cited by this paper
• CAPITO - a web server-based analysis and plotting tool for circular dichroism data

  2013cited by this paper
• A Second Tubulin Binding Site on the Kinesin-13 Motor Head Domain Is Important during Mitosis

  2013cited by this paper
• Kinesin-5 Kip1 is a bi-directional motor that stabilizes microtubules and tracks their plus-ends in vivo

  2013cited by this paper
• Fiji: an open-source platform for biological-image analysis

  2012cited by this paper
• Directional Switching of the Kinesin Cin8 Through Motor Coupling

  2011cited by this paper
• A universal pathway for kinesin stepping

  2011cited by this paper
• Phospho-regulation of kinesin-5 during anaphase spindle elongation

  2011cited by this paper
• Directionality of individual kinesin‐5 Cin8 motors is modulated by loop 8, ionic strength and microtubule geometry

  2011cited by this paper
• The diffusive interaction of microtubule binding proteins.

  2009cited by this paper
• Midzone organization restricts interpolar microtubule plus‐end dynamics during spindle elongation

  2009cited by this paper
• Slk19-dependent mid-anaphase pause in kinesin-5-mutated cells

  2008cited by this paper
• Microtubule cross-linking triggers the directional motility of kinesin-5

  2008cited by this paper
• Mid-anaphase arrest in S. cerevisiae cells eliminated for the function of Cin8 and dynein

  2008cited by this paper
• Kinesin motor mechanics: binding, stepping, tracking, gating, and limping.

  2007cited by this paper
• Using circular dichroism spectra to estimate protein secondary structure

  2007cited by this paper
• PrDOS: prediction of disordered protein regions from amino acid sequence

  2007cited by this paper
• [Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen].

  2007cited by this paper
• Oligomeric states of proteins determined by size-exclusion chromatography coupled with light scattering, absorbance, and refractive index detectors.

  2006cited by this paper
• The bipolar mitotic kinesin Eg5 moves on both microtubules that it crosslinks

  2005cited by this paper
• MUSCLE: a multiple sequence alignment method with reduced time and space complexity

  2004cited by this paper
• The Kinesin Family Member BimC Contains a Second Microtubule Binding Region Attached to the N terminus of the Motor Domain*

  2003cited by this paper
• Mechanism of the single-headed processivity: diffusional anchoring between the K-loop of kinesin and the C terminus of tubulin.

  2000cited by this paper
• The Bipolar Kinesin, KLP61F, Cross-links Microtubules within Interpolar Microtubule Bundles of Drosophila Embryonic Mitotic Spindles

  1999cited by this paper
• Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen.

  1999cited by this paper
• A processive single-headed motor: kinesin superfamily protein KIF1A.

  1999cited by this paper
• Time-Lapse Microscopy Reveals Unique Roles for Kinesins during Anaphase in Budding Yeast

  1998cited by this paper
• A bipolar kinesin

  1996cited by this paper
• Purification and Characterization of Intact and Truncated Forms of the Escherichia coli Biotin Carboxyl Carrier Subunit of Acetyl-CoA Carboxylase (*)

  1996cited by this paper
• Phosphorylation by p34cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivo.

  1995cited by this paper
• Microtubule movement by a biotinated kinesin bound to streptavidin-coated surface.

  1994cited by this paper
• A continuous spectrophotometric assay for inorganic phosphate and for measuring phosphate release kinetics in biological systems.

  1992influential reference
• Two Saccharomyces cerevisiae kinesin-related gene products required for mitotic spindle assembly

  1992cited by this paper
• Kinesin-related proteins required for structural integrity of the mitotic spindle.

  1992cited by this paper
• Kinesin-related proteins required for assembly of the mitotic spindle

  1992cited by this paper
• The gene encoding the biotin carboxylase subunit of Escherichia coli acetyl-CoA carboxylase.

  1992cited by this paper

• Dimeric Cin8 motors have an inherent plus-end bias and weak inter-head coordination

  2025influential citation
• Noncanonical interaction with microtubules via the N-terminal nonmotor domain is critical for the functions of a bidirectional kinesin

  2024influential citation
• The kinesin-5 tail and bipolar minifilament domains are the origin of its microtubule crosslinking and sliding activity

  2023influential citation