Inhibiting cadherin function by dominant mutant E-cadherin expression increases the extent of tight junction assembly.

No abstract is available for this paper.

• Publication year

  2000

• Venue

  Journal of Cell Science

• Publication date

  2000-03-15

• Fields of study

  Biology, Medicine

• Identifiers
  PMID 10683147
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Direct Binding of Three Tight Junction-Associated Maguks, Zo-1, Zo-2, and Zo-3, with the Cooh Termini of Claudins

  1999cited by this paper
• Mechanism of extracellular domain-deleted dominant negative cadherins.

  1999cited by this paper
• Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands.

  1999cited by this paper
• New perspectives on mechanisms involved in generating epithelial cell polarity.

  1999cited by this paper
• Paracellin-1, a renal tight junction protein required for paracellular Mg2+ resorption.

  1999cited by this paper
• Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands

  1999cited by this paper
• Desmosomes: intercellular adhesive junctions specialized for attachment of intermediate filaments.

  1999cited by this paper
• Cadherin function in junctional complex rearrangement and posttranslational control of cadherin expression.

  1999cited by this paper
• beta-catenin signalling modulates proliferative potential of human epidermal keratinocytes independently of intercellular adhesion.

  1999cited by this paper
• Role of tight junctions in establishing and maintaining cell polarity.

  1998cited by this paper
• A Single Gene Product, Claudin-1 or -2, Reconstitutes Tight Junction Strands and Recruits Occludin in Fibroblasts

  1998cited by this paper
• Molecular architecture of tight junctions.

  1998cited by this paper
• Claudin-1 and -2: Novel Integral Membrane Proteins Localizing at Tight Junctions with No Sequence Similarity to Occludin

  1998cited by this paper
• Effects of Regulated Expression of Mutant RhoA and Rac1 Small GTPases on the Development of Epithelial (MDCK) Cell Polarity

  1998cited by this paper
• Structural and Functional Regulation of Tight Junctions by RhoA and Rac1 Small GTPases

  1998cited by this paper
• Mechanisms of Epithelial Cell–Cell Adhesion and Cell Compaction Revealed by High-resolution Tracking of E-Cadherin– Green Fluorescent Protein

  1998cited by this paper
• Regulation of the movement of solutes across tight junctions.

  1998cited by this paper
• The Tight Junction Protein ZO-1 Establishes a Link between the Transmembrane Protein Occludin and the Actin Cytoskeleton*

  1998cited by this paper
• Rho GTPase signaling regulates tight junction assembly and protects tight junctions during ATP depletion.

  1998cited by this paper
• A causal role for E-cadherin in the transition from adenoma to carcinoma

  1998cited by this paper
• Modulation of cell-cell adherens junctions by surface clustering of the N-cadherin cytoplasmic tail.

  1998cited by this paper
• Rho GTPase signaling regulates tight junction assembly and protects tight junctions during ATP depletion.

  1998cited by this paper
• Regulation of Cell–Cell Adhesion by Rac and Rho Small G Proteins in MDCK Cells

  1997cited by this paper
• Involvement of ZO-1 in Cadherin-based Cell Adhesion through Its Direct Binding to α Catenin and Actin Filaments

  1997cited by this paper
• A Synthetic Peptide Corresponding to the Extracellular Domain of Occludin Perturbs the Tight Junction Permeability Barrier

  1997cited by this paper
• Possible Involvement of Phosphorylation of Occludin in Tight Junction Formation

  1997cited by this paper
• Dynamics of β-Catenin Interactions with APC Protein Regulate Epithelial Tubulogenesis

  1997cited by this paper
• NH2-terminal Deletion of β-Catenin Results in Stable Colocalization of Mutant β-Catenin with Adenomatous Polyposis Coli Protein and Altered MDCK Cell Adhesion

  1997cited by this paper
• COOH Terminus of Occludin Is Required for Tight Junction Barrier Function in Early Xenopus Embryos

  1997cited by this paper
• Molecular and functional analysis of cadherin-based adherens junctions.

  1997cited by this paper
• Expression of a dominant negative cadherin mutant inhibits proliferation and stimulates terminal differentiation of human epidermal keratinocytes.

  1996cited by this paper
• Cadherins regulate aggregation of pancreatic beta-cells in vivo.

  1996cited by this paper
• Functional dissociation of paracellular permeability and transepithelial electrical resistance and disruption of the apical- basolateral intramembrane diffusion barrier by expression of a mutant tight junction membrane protein

  1996cited by this paper
• Quantitative analysis of cadherin-catenin-actin reorganization during development of cell-cell adhesion

  1996cited by this paper
• Occludin is a functional component of the tight junction.

  1996cited by this paper
• Delayed assembly of desmosomes in keratinocytes with disrupted classic-cadherin-mediated cell adhesion by a dominant negative mutant.

  1995cited by this paper
• Inflammatory Bowel Disease and Adenomas in Mice Expressing a Dominant Negative N-Cadherin

  1995cited by this paper
• Rho protein regulates tight junctions and perijunctional actin organization in polarized epithelia.

  1995cited by this paper
• In vivo analysis of cadherin function in the mouse intestinal epithelium: essential roles in adhesion, maintenance of differentiation, and regulation of programmed cell death

  1995cited by this paper
• Induction of polarized cell-cell association and retardation of growth by activation of the E-cadherin-catenin adhesion system in a dispersed carcinoma line

  1994influential reference
• Direct association of occludin with ZO-1 and its possible involvement in the localization of occludin at tight junctions

  1994cited by this paper
• Wnt-1 modulates cell-cell adhesion in mammalian cells by stabilizing beta-catenin binding to the cell adhesion protein cadherin

  1994cited by this paper
• Differential perturbations in the morphogenesis of anterior structures induced by overexpression of truncated XB- and N-cadherins in Xenopus embryos

  1994cited by this paper
• Occludin: a novel integral membrane protein localizing at tight junctions

  1993cited by this paper
• Spatial and temporal dissection of immediate and early events following cadherin-mediated epithelial cell adhesion

  1993cited by this paper
• Assembly of the tight junction: the role of diacylglycerol

  1993cited by this paper
• Disruption of epithelial cell-cell adhesion by exogenous expression of a mutated nonfunctional N-cadherin.

  1993cited by this paper
• Transmembrane control of cadherin-mediated cell-cell adhesion.

  1993cited by this paper
• Distinguishing roles of the membrane-cytoskeleton and cadherin mediated cell-cell adhesion in generating different Na+,K(+)-ATPase distributions in polarized epithelia

  1993cited by this paper
• Regulation of embryonic cell adhesion by the cadherin cytoplasmic domain.

  1992cited by this paper
• Tight control of gene expression in mammalian cells by tetracycline-responsive promoters.

  1992cited by this paper
• Specific proto-oncogenic tyrosine kinases of src family are enriched in cell-to-cell adherens junctions where the level of tyrosine phosphorylation is elevated

  1991cited by this paper
• The role of the cell adhesion molecule uvomorulin in the formation and maintenance of the epithelial junctional complex

  1988cited by this paper
• Localization of the tight junction protein, ZO-1, is modulated by extracellular calcium and cell-cell contact in Madin-Darby canine kidney epithelial cells

  1988cited by this paper
• Kinetics of desmosome assembly in Madin-Darby canine kidney epithelial cells: temporal and spatial regulation of desmoplakin organization and stabilization upon cell-cell contact. I. Biochemical analysis

  1988cited by this paper
• Kinetics of desmosome assembly in Madin-Darby canine kidney epithelial cells: temporal and spatial regulation of desmoplakin organization and stabilization upon cell-cell contact. II. Morphological analysis

  1988cited by this paper
• Calcium-dependent cell-cell adhesion molecules (cadherins): subclass specificities and possible involvement of actin bundles

  1987cited by this paper
• A functional assay for proteins involved in establishing an epithelial occluding barrier: identification of a uvomorulin-like polypeptide

  1986cited by this paper
• Identification of ZO-1: a high molecular weight polypeptide associated with the tight junction (zonula occludens) in a variety of epithelia

  1986cited by this paper
• Identification of a putative cell adhesion domain of uvomorulin.

  1985cited by this paper
• Occluding junction structure-function relationships in a cultured epithelial monolayer

  1985cited by this paper
• Interactions between actin filaments and between actin filaments and membranes in quick-frozen and deeply etched hair cells of the chick ear

  1982cited by this paper
• Occluding junctions in cultured epithelial monolayers.

  1981cited by this paper
• Cytoplasmic regulation of tight-junction permeability: effect of plant cytokinins.

  1980cited by this paper
• Morphological Analysis

  1973cited by this paper

• E-cadherin mechanotransduction activates EGFR-ERK signaling in epithelial monolayers by inducing ADAM-mediated ligand shedding.

  2025cites this paper
• Cyclic stretch regulates epithelial cell migration in a frequency dependent manner via intercellular vinculin recruitment

  2024cites this paper
• Cholesterol-rich domain formation mediated by ZO proteins is essential for tight junction formation

  2023cites this paper
• Cyclic stretch regulates epithelial cell migration in a frequency dependent manner via vinculin recruitment to cell-cell contacts

  2023influential citation
• The nature of cell division forces in epithelial monolayers

  2021influential citation
• An asymmetric junctional mechanoresponse coordinates mitotic rounding with epithelial integrity

  2021cites this paper
• The nature of mitotic forces in epithelial monolayers

  2020cites this paper
• Palmitic Acid Affects Intestinal Epithelial Barrier Integrity and Permeability In Vitro

  2020cites this paper
• The soluble extracellular domain of E‐cadherin interferes with EPEC adherence via interaction with the Tir:intimin complex

  2018cites this paper
• Metformin attenuates the effect of Staphylococcus aureus on airway tight junctions by increasing PKCζ‐mediated phosphorylation of occludin

  2018cites this paper
• Exogenous 3-Deoxyglucosone-Induced Carbonyl and Oxidative Stress Causes β-Cells Dysfunction by Impairing Gut Permeability in Rats

  2018cites this paper
• Shear-induced damped oscillations in an epithelium depend on actomyosin contraction and E-cadherin cell adhesion

  2018cites this paper
• E-cadherin and LGN align epithelial cell divisions with tissue tension independently of cell shape

  2017influential citation
• Cell division orientation is coupled to cell–cell adhesion by the E-cadherin/LGN complex

  2017cites this paper
• Epithelial self-healing is recapitulated by a 3D biomimetic E-cadherin junction

  2016cites this paper
• Differential protection by cell wall components of Lactobacillus amylovorus DSM 16698Tagainst alterations of membrane barrier and NF-kB activation induced by enterotoxigenic F4+Escherichia coli on intestinal cells

  2016cites this paper
• Mechanical strain induces E-cadherin–dependent Yap1 and β-catenin activation to drive cell cycle entry

  2015cites this paper
• Pathological implications of cadherin zonation in mouse liver

  2015cites this paper
• Epithelial adhesion molecules and the regulation of intestinal homeostasis during neutrophil transepithelial migration

  2015cites this paper
• Cadherin Cytoplasmic Domains Inhibit the Cell Surface Localization of Endogenous E-Cadherin, Blocking Desmosome and Tight Junction Formation and Inducing Cell Dissociation

  2014cites this paper
• Genetic control of the seasonal reproductive cycle in micromammals

  2014cites this paper
• Vocal fold epithelial barrier in health and injury: a research review.

  2014cites this paper
• Regulation of endometrial regeneration; mechanisms contributing to repair and restoration of tissue integrity following menses

  2014cites this paper
• Intestinal Epithelial CD98 Directly Modulates the Innate Host Response to Enteric Bacterial Pathogens

  2013cites this paper
• Valores normales de la enzima β-Glucosidasa Citosolica en lactantes menores de dos meses.Utilidad como biomarcador en tiempo real de diagnóstico de enterocolitis necrotizante del lactante: valores predictivos, sensibilidad y especificidad

  2013cites this paper
• Hepatocyte polarity.

  2013cites this paper
• Lactobacillus amylophilus D14 protects tight junction from enteropathogenic bacteria damage in Caco-2 cells.

  2012cites this paper
• E-cadherin is required for intestinal morphogenesis in the mouse.

  2012cites this paper
• Regulatory Function of Trefoil peptides (TFF) on Intestinal Cell Junctional Complexes

  2012cites this paper
• Soluble E-cadherin promotes cell survival by activating epidermal growth factor receptor.

  2011cites this paper
• An EMT–Driven Alternative Splicing Program Occurs in Human Breast Cancer and Modulates Cellular Phenotype

  2011cites this paper
• Cadherins and Pak1 Control Contact Inhibition of Proliferation by Pak1- (cid:1) PIX-GIT Complex-Dependent Regulation of Cell-Matrix Signaling (cid:1)

  2010cites this paper
• Cadherins and Pak1 Control Contact Inhibition of Proliferation by Pak1-βPIX-GIT Complex-Dependent Regulation of Cell-Matrix Signaling

  2010cites this paper
• E-cadherin and claudin-4 expression has circadian rhythm in adult rat kidney.

  2009cites this paper
• Intracellular uptake and intraspheroidal distribution of hypericin and hydrophilic analogues using E-cadherin transfected T-24 human bladder cancer cells

  2008cites this paper
• Cell polarity development and protein trafficking in hepatocytes lacking E-cadherin/beta-catenin-based adherens junctions.

  2007cites this paper
• Par1b promotes hepatic-type lumen polarity in Madin Darby canine kidney cells via myosin II- and E-cadherin-dependent signaling.

  2007cites this paper
• University of Groningen Cell polarity development and protein trafficking in hepatocytes lacking E-cadherin/beta- catenin-based adherens junctions Theard,

  2007cites this paper
• Proteomic and bioinformatic analysis of epithelial tight junction reveals an unexpected cluster of synaptic molecules

  2006cites this paper
• Kip 1 in cell-cell adhesion and cell polarity

  2006cites this paper
• Multiple functions of Na,K-ATPase in epithelial cells.

  2005cites this paper
• Cadherin-10 is a novel blood-brain barrier adhesion molecule in human and mouse.

  2005cites this paper
• Chapter 24 – Role of Epithelium in Mucosal Immunity

  2005cites this paper
• The transcription factor Snail downregulates the tight junction components independently of E-cadherin downregulation

  2004cites this paper
• Regulation of cadherin stability and turnover by p120ctn: implications in disease and cancer.

  2004cites this paper
• Cell adhesion, polarity, and epithelia in the dawn of metazoans.

  2004cites this paper
• Metazoans Cell Adhesion , Polarity , and Epithelia in the Dawn of

  2004cites this paper
• Sertoli Cell Tight Junction Dynamics: Their Regulation During Spermatogenesis1

  2003cites this paper
• Proceedings of the Eighth International Workshop on Developmental Nephrology: Genes, Morphogenesis, and Function. The Sessions

  2003cites this paper
• Regulation of adherens junctions and epithelial paracellular permeability: a novel function for polyamines.

  2003cites this paper
• Pulses of Cell Ca2+ and the Dynamics of Tight Junction Opening and Closing

  2003cites this paper
• NZO-3 Expression Causes Global Changes to the Actin Cytoskeleton in MDCK Cells : Linking a Tight Junction Protein to Rho GTPases

  2003cites this paper
• Assembly and functional analysis of tight junction in a colon adenocarcinoma cell line: effect of glucose depletion.

  2003cites this paper
• NZO-3 expression causes global changes to actin cytoskeleton in Madin-Darby canine kidney cells: linking a tight junction protein to Rho GTPases.

  2003cites this paper
• Rac1, but not RhoA, signaling protects epithelial adherens junction assembly during ATP depletion.

  2002cites this paper
• Protein phosphatase 2A associates with and regulates atypical PKC and the epithelial tight junction complex

  2002cites this paper
• The small GTPase Rab13 regulates assembly of functional tight junctions in epithelial cells.

  2002cites this paper
• Cell junction dynamics in the testis: Sertoli-germ cell interactions and male contraceptive development.

  2002influential citation
• Clinicopathologic implications of E‐cadherin reactivity in patients with lobular carcinoma in situ of the breast

  2001cites this paper
• Assessment of the Activation of Rho Family GTP-Binding Proteins in Breast Cancer Cells and Specimens

  2001cites this paper
• E-cadherin reactivity of 95 noninvasive ductal and lobular lesions of the breast. Implications for the interpretation of problematic lesions.

  2001cites this paper
• Biogenesis of Epithelial Polarity and Tight Junctions

  2001cites this paper
• Ischemia-induced tight junction dysfunction in the kidney

  2001cites this paper
• Evidence that increased tyrosine phosphorylation causes disassembly of adherens junctions but does not perturb paracellular permeability in Caco-2 cells.

  2001cites this paper
• Exogenous expression of E-cadherin in gallbladder carcinoma cell line G-415 restores its cellular polarity and differentiation.

  2001cites this paper
• Na,K-ATPase activity is required for formation of tight junctions, desmosomes, and induction of polarity in epithelial cells.

  2001cites this paper
• Mutant cadherin affects epithelial morphogenesis and invasion, but not transformation.

  2001cites this paper
• Structural organization of gap junctions as revealed by freeze-fracture and SDS fracture-labeling.

  2000cites this paper
• Molecular physiology and pathophysiology of tight junctions. I. Biogenesis of tight junctions and epithelial polarity.

  2000cites this paper
• Exogenous Expression of the Amino-Terminal Half of the Tight Junction Protein Zo-3 Perturbs Junctional Complex Assembly

  2000influential citation