Efficacy of temporally intensified exposure for anxiety disorders: A multicenter randomized clinical trial

The need to optimize exposure treatments for anxiety disorders may be addressed by temporally intensified exposure sessions. Effects on symptom reduction and public health benefits should be examined across different anxiety disorders with comorbid conditions.

• Publication year

  2021

• Venue

  Depression and Anxiety

• Publication date

  2021-07-22

• Fields of study

  Medicine, Psychology

• Identifiers
  DOI 10.1002/da.23204PMID 34293223
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Long-term stability

  2020cited by this paper
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  2018cited by this paper
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  2018cited by this paper
• Equivalence Testing for Psychological Research: A Tutorial

  2018cited by this paper
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  2018cited by this paper
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  2017cited by this paper
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  2017cited by this paper
• Bridging the Gaps Between Basic Science and Cognitive-Behavioral Treatments for Anxiety Disorders in Routine Care: Current Status and Future Demands

  2017cited by this paper
• The key role of extinction learning in anxiety disorders: behavioral strategies to enhance exposure-based treatments

  2016cited by this paper
• Response rates for CBT for anxiety disorders: Need for standardized criteria.

  2015cited by this paper
• Efficacy of treatments for anxiety disorders: a meta-analysis

  2015cited by this paper
• Maximizing exposure therapy: an inhibitory learning approach.

  2014cited by this paper
• Diagnostic and Statistical Manual of Mental Disorders

  2013cited by this paper
• Long-term stability of cognitive behavioral therapy effects for panic disorder with agoraphobia: a two-year follow-up study.

  2013cited by this paper
• Maximizing the efficacy of interoceptive exposure by optimizing inhibitory learning: a randomized controlled trial.

  2013cited by this paper
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  2013cited by this paper
• Depression Does Not Affect the Treatment Outcome of CBT for Panic and Agoraphobia: Results from a Multicenter Randomized Trial

  2012cited by this paper
• Psychological treatment for panic disorder with agoraphobia: a randomized controlled trial to examine the role of therapist-guided exposure in situ in CBT.

  2011cited by this paper
• Equivalence Testing

  2011cited by this paper
• Brief Symptom Inventory

  2011cited by this paper
• Measuring health and disability : manual for WHO Disability Assessment Schedule : WHODAS 2.0

  2010influential reference
• Identifying HAM‐A cutoffs for mild, moderate, and severe generalized anxiety disorder

  2010cited by this paper
• Relapse of Successfully Treated Anxiety and Fear: Theoretical Issues and Recommendations for Clinical Practice

  2009cited by this paper
• Cognitive-behavioral therapy for adult anxiety disorders: a meta-analysis of randomized placebo-controlled trials.

  2008cited by this paper
• Optimizing inhibitory learning during exposure therapy.

  2008cited by this paper
• DISORDERS : A META-ANALYSIS OF RANDOMIZED PLACEBO-CONTROLLED TRIALS

  2008cited by this paper
• Cognitive-Behavioral Therapy.

  2008cited by this paper
• A Meta-Analytic Review of Adult Cognitive-Behavioral Treatment Outcome Across the Anxiety Disorders

  2007cited by this paper
• Modelling Survival Data in Medical Research

  2004cited by this paper
• Context and behavioral processes in extinction.

  2004cited by this paper
• 한국어판 Composite International Diagnostic Interview의 타당도

  2003influential reference
• Context, ambiguity, and unlearning: sources of relapse after behavioral extinction.

  2002cited by this paper
• Reliability and validity of a structured interview guide for the Hamilton Anxiety Rating Scale (SIGH‐A)

  2001cited by this paper
• EQ-SD: a measure of health status from the EuroQol Group

  2001cited by this paper
• Timing of treatment and return of fear: Effects of massed, uniform-, and expanding-spaced exposure schedules

  2000cited by this paper
• To what degree does the Composite International Diagnostic Interview (CIDI) correctly identify DSM‐IV disorders? Testing validity issues in a clinical sample

  1998cited by this paper
• Effects of an expanding-spaced vs massed exposure schedule on fear reduction and return of fear.

  1998cited by this paper
• THE COMPOSITE INTERNATIONAL DIAGNOSTIC INTERVIEW (CIDI)

  1994cited by this paper
• Reliability and validity studies of the WHO--Composite International Diagnostic Interview (CIDI): a critical review.

  1994cited by this paper
• Psychological Treatment of Panic

  1989cited by this paper
• The Composite International Diagnostic Interview. An epidemiologic Instrument suitable for use in conjunction with different diagnostic systems and in different cultures.

  1988cited by this paper
• A comparison of the Two One-Sided Tests Procedure and the Power Approach for assessing the equivalence of average bioavailability

  1987cited by this paper
• Emotional processing of fear: exposure to corrective information.

  1986cited by this paper
• The Brief Symptom Inventory: an introductory report

  1983cited by this paper
• The statistical analysis of failure time data

  1981cited by this paper
• Fear-reduction research and clinical phobias.

  1978cited by this paper
• A theory of Pavlovian conditioning : Variations in the effectiveness of reinforcement and nonreinforcement

  1972cited by this paper

• Waiting for translation: A review of translational research in psychological treatment.

  2026cites this paper
• Instructed increase in fear activation during exposure exercises does not enhance treatment effects of cognitive behavioral therapy for panic disorder and agoraphobia.

  2026cites this paper
• Joy beyond fear: Positive emotions after exposure in patients with anxiety disorders and their link to threat expectancy and treatment outcome.

  2025cites this paper
• Same same but different: Threat expectancy change and fear reduction as readouts of exposure rationales are only weakly associated and contribute differentially to treatment outcome in anxiety disorders.

  2025cites this paper
• Overcoming Automatic Behavioral Tendencies in Approach‐Avoidance Conflict Decisions

  2025cites this paper
• Advancing CBT for panic disorder and agoraphobia by integrating a digital intervention into treatment: a pilot randomized controlled trial.

  2025cites this paper
• Induced awareness of stimulus differences impedes the generalization of extinction learning with various, highly similar stimuli.

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• Epigenetic markers of disease risk and psychotherapy response in anxiety disorders – a longitudinal analysis of the DNA methylome

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• The bergen 4-day treatment for panic disorder: a longer-term follow-up

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• Perceptions and Use of Extended-Duration Exposure Therapy Amongst Psychologists.

  2025cites this paper
• The Bergen 4-Day Treatment for panic disorder patients in a rural clinical setting: a long-term follow-up study

  2025cites this paper
• The impact of temporal distribution on fear extinction learning

  2025cites this paper
• Sustainability of treatment success five years after exposure-based cognitive-behavioral therapy for anxiety disorders.

  2025cites this paper
• Intensive treatments for children and adolescents with anxiety or obsessive-compulsive disorders: A systematic review and meta-analysis.

  2024cites this paper
• Latent-state and model-based learning in PTSD.

  2024cites this paper
• The Bergen 4-day treatment for social anxiety disorder: a pilot study

  2024influential citation
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  2024cites this paper
• Lack of evidence for predictive utility from resting state fMRI data for individual exposure-based cognitive behavioral therapy outcomes: A machine learning study in two large multi-site samples in anxiety disorders

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• Mechanisms of Change in Exposure Therapy for Anxiety and Related Disorders: A Research Agenda

  2024cites this paper
• Elevated accuracy in recognition of subliminal happy facial expressions in patients with panic disorder after psychotherapy

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• Arbeitsunfähigkeit bei psychischen Störungen – ökonomische, individuelle und behandlungsspezifische Aspekte

  2024cites this paper
• Effect of Psychotherapy on Intolerance of Uncertainty: A Systematic Review and Meta-Analysis.

  2024cites this paper
• Multifaceted, Brief Intensive Home-Based Exposure Treatment in Patients with Obsessive-Compulsive Disorder Who are Nonresponsive to Regular Cognitive Behavior Therapy: An Uncontrolled Pilot Study

  2024cites this paper
• Resting-state functional connectivity in anxiety disorders: a multicenter fMRI study

  2024cites this paper
• Augmentation of cognitive-behavioural therapy for obsessive-compulsive and anxiety disorders: a protocol for a systematic review and meta-analysis

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• Decoding threat neurocircuitry representations during traumatic memory recall in PTSD

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• Intermittent theta burst stimulation to the left prefrontal cortex enhances extinction learning but not extinction recall.

  2024cites this paper
• Advancing the personalized advantage index (PAI): a systematic review and application in two large multi-site samples in anxiety disorders

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• Fear and Safety Learning in Anxiety- and Stress-Related Disorders: An Updated Meta-Analysis.

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  2023cites this paper
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  2023influential citation
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  2023cites this paper
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  2023cites this paper
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  2023cites this paper
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  2023cites this paper
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  2022cites this paper
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  2022cites this paper
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  2022influential citation
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  2022cites this paper
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  2022cites this paper
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