Pharmacological and molecular docking studies reveal that glibenclamide competitively inhibits diazoxide-induced mitochondrial ATP-sensitive potassium channel activation and pharmacological preconditioning.

No abstract is available for this paper.

• Publication year

  2021

• Venue

  European Journal of Pharmacology

• Publication date

  2021-07-26

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.ejphar.2021.174379PMID 34324857
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Global knockout of ROMK potassium channel worsens cardiac ischemia-reperfusion injury but cardiomyocyte-specific knockout does not: Implications for the identity of mitoKATP.

  2020cited by this paper
• The mitochondrial K-ATP channel opener diazoxide upregulates STIM1 and Orai1 via ROS and the MAPK pathway in adult rat cardiomyocytes

  2020cited by this paper
• Identification of an ATP-sensitive potassium channel in mitochondria

  2019cited by this paper
• Mechanistic Role of Kinases in the Regulation of Mitochondrial Fitness.

  2017cited by this paper
• Diazoxide prevents reactive oxygen species and mitochondrial damage, leading to anti-hypertrophic effects.

  2017cited by this paper
• Mitochondrial ATP-sensitive Potassium Channel Opening Inhibits Isoproterenol-induced Cardiac Hypertrophy by Preventing Oxidative Damage

  2015cited by this paper
• A Novel Pharmacologic Inhibitor of the NLRP3 Inflammasome Limits Myocardial Injury After Ischemia–Reperfusion in the Mouse

  2014cited by this paper
• Disruption of ATP-binding cassette B8 in mice leads to cardiomyopathy through a decrease in mitochondrial iron export

  2012cited by this paper
• Mitochondrial ROMK Channel Is a Molecular Component of MitoKATP

  2012cited by this paper
• Mitochondrial ATP-sensitive K+ channels are redox-sensitive pathways that control reactive oxygen species production.

  2007cited by this paper
• Ischemic preconditioning requires increases in reactive oxygen release independent of mitochondrial K+ channel activity.

  2006cited by this paper
• Antidiabetic sulphonylureas activate mitochondrial permeability transition in rat skeletal muscle

  2005cited by this paper
• A Highly Active ATP-Insensitive K+ Import Pathway in Plant Mitochondria

  2004cited by this paper
• Functional Distinctions between the Mitochondrial ATP-dependent K+ Channel (mitoKATP) and Its Inward Rectifier Subunit (mitoKIR)*

  2004cited by this paper
• UCSF Chimera—A visualization system for exploratory research and analysis

  2004cited by this paper
• Bioenergetic consequences of opening the ATP-sensitive K(+) channel of heart mitochondria.

  2001cited by this paper
• Identification and characterization of a mammalian mitochondrial ATP-binding cassette membrane protein.

  1999cited by this paper
• Cardioprotective effect of diazoxide and its interaction with mitochondrial ATP-sensitive K+ channels. Possible mechanism of cardioprotection.

  1997cited by this paper
• The mitochondrial sulfonylurea receptor: identification and characterization.

  1997cited by this paper
• Oral sulfonylurea hypoglycemic agents prevent ischemic preconditioning in human myocardium. Two paradoxes revisited.

  1997cited by this paper
• The Mitochondrial K Channel as a Receptor for Potassium Channel Openers (*)

  1996cited by this paper
• The fiftieth anniversary of hypoglycaemic sulphonamides. How did the mother compound work?

  1992cited by this paper
• ATP-sensitive K+ channel in the mitochondrial inner membrane

  1991cited by this paper
• On the nature of ion leaks in energy-transducing membranes.

  1989cited by this paper

• Pharmacological Preconditioning with Diazoxide Upregulates HCN4 Channels in the Sinoatrial Node of Adult Rat Cardiomyocytes

  2025cites this paper
• Pharmacologic ROMK Inhibition Protects Against Myocardial Ischemia Reperfusion Injury

  2025cites this paper
• A Glibenclamide Analog Lacking the Cyclohexylurea Portion Fails to Block Ischemic Preconditioning-Induced Mitochondrial and Cardiac Protection Against Ischemia/Reperfusion Injury.

  2025cites this paper
• Mitochondrial Electron Transport Chain Disruption and Oxidative Stress in Lipopolysaccharide-Induced Cardiac Dysfunction in rats and mice

  2025influential citation
• Advancing systemic toxicity risk assessment: Evaluation of a NAM-based toolbox approach

  2024cites this paper
• Carbon Paste-Glibanclamide-Graphene Oxide Modified Electrode Analysis for Dopamine

  2024cites this paper
• The acute combined effect of Pinacidil and Glimepiride on ischemia and reperfusion induced arrhythmia, “The Role of ATP- Dependent Potassium Channel”

  2024cites this paper
• Tocolytic Effect of White Pepper (Piper nigrum Linn.) on Isolated Rat Uterine Contraction in vitro

  2023cites this paper
• Competitive interaction between ATP and GTP regulates mitochondrial ATP-sensitive potassium channels

  2023cites this paper
• Pharmacological Characterization of a Recombinant Mitochondrial ROMK2 Potassium Channel Expressed in Bacteria and Reconstituted in Planar Lipid Bilayers

  2023cites this paper
• A dual-emission ratiometric fluorescent biosensor for ultrasensitive detection of glibenclamide using S-CDs/CdS quantum dots.

  2023cites this paper
• Targeted Mitochondrial Drugs for Treatment of Ischemia-Reperfusion Injury.

  2022cites this paper
• Functional Regulation of KATP Channels and Mutant Insight Into Clinical Therapeutic Strategies in Cardiovascular Diseases

  2022cites this paper
• Insulinotropic Potential of Moxifloxacin and Gemifloxacin: An In Vivo Rabbits Model Study Followed by Randomized Phase I Clinical Trial

  2022cites this paper
• The role of sulfonylureas in the treatment of type 2 diabetes

  2021cites this paper