Camptothecin analogs with enhanced activity against human breast cancer cells. II. Impact of the tumor pH gradient

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Cancer Chemotherapy and Pharmacology

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1007/s00280-005-0008-5PMID 16001167
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Determinants of drug response in camptothecin-11-resistant glioma cell lines

  2005cited by this paper
• Hypoxia-inducible factor 1 alpha in high-risk breast cancer: an independent prognostic parameter?

  2004cited by this paper
• Camptothecins in clinical development

  2004cited by this paper
• Levels of hypoxia‐inducible factor‐1α independently predict prognosis in patients with lymph node negative breast carcinoma

  2003cited by this paper
• The activity of camptothecin analogues is enhanced in histocultures of human tumors and human tumor xenografts by modulation of extracellular pH

  2003cited by this paper
• Tumor acidity, ion trapping and chemotherapeutics. I. Acid pH affects the distribution of chemotherapeutic agents in vitro.

  2003cited by this paper
• Tumor acidity, ion trapping and chemotherapeutics. II. pH-dependent partition coefficients predict importance of ion trapping on pharmacokinetics of weakly basic chemotherapeutic agents.

  2003cited by this paper
• Understanding the tumor metabolic phenotype in the genomic era.

  2003cited by this paper
• Overexpression of hypoxia-inducible factor 1alpha is associated with an unfavorable prognosis in lymph node-positive breast cancer.

  2002cited by this paper
• Hypoxia as a target for combined modality treatments.

  2002cited by this paper
• An integrated database of chemosensitivity to 55 anticancer drugs and gene expression profiles of 39 human cancer cell lines.

  2002cited by this paper
• Regulation of intracellular pH in human melanoma: potential therapeutic implications.

  2002cited by this paper
• Transcriptional response to hypoxia in human tumors.

  2001cited by this paper
• Tumor cell death induced by topoisomerase-targeting drugs.

  2001cited by this paper
• Dual role of glutathione in modulating camptothecin activity: depletion potentiates activity, but conjugation enhances the stability of the topoisomerase I-DNA cleavage complex.

  2001cited by this paper
• Modulation of camptothecin analogs in the treatment of cancer: a review

  2001cited by this paper
• Hypoxia and oxidative stress in breast cancer: Tumour hypoxia – therapeutic considerations

  2001cited by this paper
• Intracellular pH regulation in a nonmalignant and a derived malignant human breast cell line

  2000cited by this paper
• The relationship between intracellular and extracellular pH in spontaneous canine tumors.

  2000cited by this paper
• The novel silatecan 7-tert-butyldimethylsilyl-10-hydroxycamptothecin displays high lipophilicity, improved human blood stability, and potent anticancer activity.

  2000cited by this paper
• New highly lipophilic camptothecin BNP1350 is an effective drug in experimental human cancer

  2000cited by this paper
• 7- and 10-substituted camptothecins: dependence of topoisomerase I-DNA cleavable complex formation and stability on the 7- and 10-substituents.

  2000cited by this paper
• Camptothecin analogues with enhanced antitumor activity at acidic pH

  2000cited by this paper
• Characterisation of a synergistic interaction between a thymidylate synthase inhibitor, ZD1694, and a novel lipophilic topoisomerase I inhibitor karenitecin, BNP1100: mechanisms and clinical implications.

  1999cited by this paper
• The hypoxic cell: a target for selective cancer therapy--eighteenth Bruce F. Cain Memorial Award lecture.

  1999cited by this paper
• Mechanism of action of eukaryotic DNA topoisomerase I and drugs targeted to the enzyme.

  1998cited by this paper
• Tumor oxygenation correlates with molecular growth determinants in breast cancer

  1998cited by this paper
• Mammalian cells adapted to growth at pH 6.7 have elevated HSP27 levels and are resistant to cisplatin.

  1997cited by this paper
• The interaction of buthionine sulphoximide (BSO) and the topoisomerase I inhibitor CPT-11.

  1996cited by this paper
• Cellular pH gradient in tumor versus normal tissue: potential exploitation for the treatment of cancer.

  1996cited by this paper
• Elevation of topoisomerase I messenger RNA, protein, and catalytic activity in human tumors: demonstration of tumor-type specificity and implications for cancer chemotherapy.

  1994cited by this paper
• Oxygenation of mammary tumors as evaluated by ultrasound-guided computerized-pO2-histography.

  1994cited by this paper
• Mechanism of cross-resistance to a camptothecin analogue (CPT-11) in a human ovarian cancer cell line selected by cisplatin.

  1992cited by this paper
• Oxygenation of human tumors: evaluation of tissue oxygen distribution in breast cancers by computerized O2 tension measurements.

  1991cited by this paper
• P-glycoprotein expression and DNA topoisomerase I and II activity in benign tumors of the ovary and in malignant tumors of the ovary, before and after platinum/cyclophosphamide chemotherapy.

  1991cited by this paper
• DNA topoisomerase I--targeted chemotherapy of human colon cancer in xenografts.

  1989cited by this paper
• Structure-activity study of the actions of camptothecin derivatives on mammalian topoisomerase I: evidence for a specific receptor site and a relation to antitumor activity.

  1989cited by this paper
• Acid pH in tumors and its potential for therapeutic exploitation.

  1989cited by this paper
• The relevance of tumour pH to the treatment of malignant disease.

  1984cited by this paper
• ©1999 Cancer Research Campaign Article no. bjoc.1998.0455 Enhancement of chemotherapy by manipulation of tumour pH

  year unknowncited by this paper

• Protein kinase inhibitors in the management of cancer: therapeutic opportunities from natural compounds

  2024cites this paper
• PTSA-induced synthesis, in silico and nano study of novel ethylquinolin-thiazolo-triazole in cervical cancer.

  2024cites this paper
• A network-based drug prioritization and combination analysis for the MEK5/ERK5 pathway in breast cancer

  2024cites this paper
• Radioimmunotherapy Targeting B7-H3 in situ glioma models enhanced antitumor efficacy by Reconstructing the tumor microenvironment

  2023cites this paper
• Rhabdomyosarcoma: Current Therapy, Challenges, and Future Approaches to Treatment Strategies

  2023cites this paper
• Deep Learning Promotes the Screening of Natural Products with Potential Microtubule Inhibition Activity

  2022cites this paper
• Fungal Endophytes: an Accessible Source of Bioactive Compounds with Potential Anticancer Activity

  2022cites this paper
• A Review on Mechanistic Insight of Plant Derived Anticancer Bioactive Phytocompounds and Their Structure Activity Relationship

  2022cites this paper
• Enyne Amides to Fused Pyridones: Scope and Limitations.

  2021cites this paper
• DFT studies of camptothecins cytotoxicity I. Active and inactive forms of camptothecin

  2021cites this paper
• Dual responsive PMEEECL-PAE block copolymers

  2020cites this paper
• Photocatalytic redox-neutral hydroxyalkylation of N-heteroaromatics with aldehydes†

  2020cites this paper
• Signatures of co-deregulated genes and their transcriptional regulators in colorectal cancer

  2020cites this paper
• Dual responsive PMEEECL–PAE block copolymers: a computational self-assembly and doxorubicin uptake study

  2020cites this paper
• Cellular acidosis triggers human MondoA transcriptional activity by driving mitochondrial ATP production

  2019cites this paper
• Natural products as important tyrosine kinase inhibitors.

  2019cites this paper
• Light-Responsive Prodrug-Based Supramolecular Nanosystems for Site-Specific Combination Therapy of Cancer

  2019cites this paper
• Anticancer Activity of Natural Compounds from Plant and Marine Environment

  2018cites this paper
• Cellular acidosis triggers MondoA transcriptional activity by driving mitochondrial ATP production

  2018cites this paper
• TQ-B3203, a potent proliferation inhibitor derived from camptothecin

  2017cites this paper
• A novel anti-mitotic activity on human cells by Pulchelloid A, a compound isolated from the prairie plant Gaillardia aristata

  2017cites this paper
• DNA topoisomerase-targeting chemotherapeutics: what’s new?

  2017cites this paper
• Depletion of carbonic anhydrase IX abrogates hypoxia-induced overexpression of stanniocalcin-1 in triple negative breast cancer cells

  2017cites this paper
• Low level phosphorylation of histone H2AX on serine 139 (γH2AX) is not associated with DNA double-strand breaks

  2016cites this paper
• GSH-responsive biotinylated poly(vinyl alcohol)-grafted GO as a nanocarrier for targeted delivery of camptothecin

  2016cites this paper
• Compatibility studies between an amphiphilic pH-sensitive polymer and hydrophobic drug using multiscale simulations

  2016cites this paper
• Mesoscale Simulations and Experimental Studies of pH-Sensitive Micelles for Controlled Drug Delivery.

  2015cites this paper
• Cascade cyclization of 1-(2-yl-3-phenylprop-2-enyl)-6-oxo-1,6-dihydropyridine-2-carbonitrile radical: Mechanistic insights from DFT study

  2014cites this paper
• Enantioselective desymmetrization of diesters.

  2014cites this paper
• Total Aglycones from Marsdenia tenacissima Increases Antitumor Efficacy of Paclitaxel in Nude Mice

  2014cites this paper
• Transdermal delivery of 10,11-methylenedioxycamptothecin by hyaluronic acid based nanoemulsion for inhibition of keloid fibroblast.

  2014cites this paper
• CAMPTOTHECIN AND ITS ANALOGS ANTITUMOR ACTIVITY BY POISONING TOPOISOMERASE I, THEIRSTRUCTUREACTIVITYRELATIONSHIPANDCLINICALDEVELOPMENT PERSPECTIVEOFANALOGS

  2014cites this paper
• Supercritical Fluid Extraction of Camptothecin from Nothapodytes Foetida

  2014cites this paper
• Testing the relationship between checkpoint adaptation and micronuclei in human fibroblastic glioma and normal lung cells

  2014influential citation
• Acidic pH of Tumor Microenvironment Enhances Cytotoxicity of the Disulfiram/Cu2+ Complex to Breast and Colon Cancer Cells

  2013cites this paper
• Camptothecin resistance in cancer: insights into the molecular mechanisms of a DNA-damaging drug.

  2013cites this paper
• Therapeutic Efficacy of Genistein-Topotecan Combination Compared to Vitamin D3-Topotecan Combination in LNCaP Prostate Cancer Cells

  2013cites this paper
• Role of river-derived algae on bioaccumulation in fixed bed reactors; a low-cost safe drinking water plant

  2012cites this paper
• Biotechnologically produced secondary plant metabolites for cancer treatment and prevention.

  2012cites this paper
• The Valley of Death in anticancer drug development: a reassessment.

  2012cites this paper
• Anticancer activities of genistein-topotecan combination in prostate cancer cells

  2012cites this paper
• pH-sensitive drug loading/releasing in amphiphilic copolymer PAE-PEG: integrating molecular dynamics and dissipative particle dynamics simulations.

  2012cites this paper
• Enhancing Photodynamyc Therapy Efficacy by Combination Therapy: Dated, Current and Oncoming Strategies

  2011cites this paper
• Biomimetic Synthesis of Alkaloids with a Modified Indole Nucleus

  2011cites this paper
• BACPTDP: a water-soluble camptothecin pro-drug with enhanced activity in hypoxic/acidic tumors

  2011cites this paper
• Tumor physiology and charge dynamics of anticancer drugs: implications for camptothecin-based drug development.

  2011cites this paper
• Lactic Acidosis Triggers Starvation Response with Paradoxical Induction of TXNIP through MondoA

  2010cites this paper
• Evaluation of the anticancer potential of plants used as traditional medicines by Aboriginal people

  2010cites this paper
• Cell Membranes, Cytosolic pH and Drug Transport in Cancer and MDR: Physics, Biochemistry and Molecular Biology

  2009cites this paper
• Proton transport inhibitors as potentially selective anticancer drugs.

  2009cites this paper
• The Genomic Analysis of Lactic Acidosis and Acidosis Response in Human Cancers

  2008cites this paper
• Characterization of 111In and 177Lu‐labeled antibodies binding to CD44v6 using a novel automated radioimmunoassay

  2008cites this paper
• Effect of pH and human serum albumin on the cytotoxicity of a glucuronide prodrug of 9-aminocamptothecin

  2007cites this paper
• Irinotecan–cisplatin interactions assessed in cell-based screening assays: cytotoxicity, drug accumulation and DNA adduct formation in an NSCLC cell line

  2007cites this paper
• Photoinduced transformation of camptothecin in the presence of iron(III) ions

  2007cites this paper
• Relevance of extracellular and intracellular interactions of camptothecins as determinants of antitumor activity.

  2007cites this paper
• Automated, high-resolution cellular retention and uptake studies in vitro.

  2006cites this paper
• Overcoming Physiologic Barriers to Cancer Treatment by Molecularly Targeting the Tumor Microenvironment

  2006cites this paper
• Effect of a Novel Vacuolar-H+-ATPase Inhibitor on Cell and Tumor Response to Camptothecins

  2006cites this paper
• Ectopic Localization of Mitochondrial ATP Synthase: A Target for Anti-Angiogenesis Intervention?

  2005cites this paper