Glutathione conjugation of 4-hydroxy-trans-2,3-nonenal in the rat in vivo, the isolated perfused liver and erythrocytes.

No abstract is available for this paper.

• Publication year

  1999

• Venue

  Toxicology and Applied Pharmacology

• Publication date

  1999-09-15

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1006/TAAP.1999.8742PMID 10486308
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Identification of novel urinary metabolites of the lipid peroxidation product 4-hydroxy-2-nonenal in rats.

  1998influential reference
• Immunological evidence for increased oxidative stress in diabetic rats

  1998cited by this paper
• Metabolism of the Lipid Peroxidation Product, 4-Hydroxy-trans-2-nonenal, in Isolated Perfused Rat Heart*

  1998cited by this paper
• 4‐Hydroxynonenal‐Derived Advanced Lipid Peroxidation End Products Are Increased in Alzheimer's Disease

  1997cited by this paper
• Increased lipid peroxidation in children with autoimmune diseases

  1997cited by this paper
• Metabolic fate of 4-hydroxynonenal in hepatocytes: 1,4-dihydroxynonene is not the main product.

  1997cited by this paper
• Lipid peroxidation as a potential endogenous source for the formation of exocyclic DNA adducts.

  1996cited by this paper
• Disposition in rat of [2-3H]-trans-4-hydroxy-2,3-nonenal, a product of lipid peroxidation.

  1996cited by this paper
• The hepatocellular metabolism of 4-hydroxynonenal by alcohol dehydrogenase, aldehyde dehydrogenase, and glutathione S-transferase.

  1995cited by this paper
• The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance.

  1995influential reference
• Mercapturic acid conjugates as urinary end metabolites of the lipid peroxidation product 4-hydroxy-2-nonenal in the rat.

  1995influential reference
• 4-hydroxynonenal is degraded to mercapturic acid conjugate in rat kidney.

  1995cited by this paper
• Synthesis of 4-hydroxy[4-3h]-2(e)-nonen-1-al-diethylacetal

  1995cited by this paper
• Improved Synthesis of Various Isotope Labeled 4-Hydroxyalkenals and Peroxidation Intermediates

  1995cited by this paper
• Toxic aldehydes formed by lipid peroxidation. I. Sensitive, gas chromatography-based stereoanalysis of 4-hydroxyalkenals, toxic products of lipid peroxidation.

  1994cited by this paper
• Glutathione S-transferases: structure and mechanism of an archetypical detoxication enzyme.

  1994cited by this paper
• SYNTHESIS OF DEUTERATED 4-HYDROXYALKENALS

  1993cited by this paper
• 023 Qualitative and quantitative determination of metabolites of the lipid peroxidation product 4-hydroxynonenal from hepatocytes, enterocytes and tumor cells

  1992cited by this paper
• Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes.

  1991cited by this paper
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  1991cited by this paper
• Conjugation Reactions in Drug Metabolism: Mulder, G.J. (Ed.), X+413 pp., London, New York, Philadelphia: Taylor and Francis (1990)

  1991cited by this paper
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  1990cited by this paper
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  1989cited by this paper
• Liquid chromatographic determination of diastereomeric glutathione conjugates and further derivatives of alpha-bromoisovalerylurea in rat bile and urine by electrochemically generated bromine.

  1988cited by this paper
• Pro-hemolytic effect of aldehydic products of lipid peroxidation.

  1987cited by this paper
• Fumaraldehyde monodimethyl acetal: An easily accessible and versatile intermediate.

  1987cited by this paper
• Comparison of electrochemical detection methods in liquid chromatography for the determination of N-acetylcysteine in plasma.

  1986cited by this paper
• 4‐Hydroxyalk‐2‐enals are substrates for glutathione transferase

  1985cited by this paper
• Metabolism of the lipid peroxidation product 4-hydroxynonenal by isolated hepatocytes and by liver cytosolic fractions.

  1985cited by this paper
• Amberlyst-15, A Superior Acid Catalyst for the Cleavage of Acetals

  1984cited by this paper
• Collection of metabolites in bile and urine from the rat.

  1981cited by this paper
• [11] Isolated perfused rat liver technique

  1981cited by this paper
• Isolated perfused rat liver technique.

  1981cited by this paper
• Oxidation of long-chain and related alcohols to carbonyls by dimethyl sulfoxide "activated" by oxalyl chloride

  1978cited by this paper
• Reaction of Glutathione with Conjugated Carbonyls

  1975cited by this paper

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