Experimental model of traumatic ulcer in the cheek mucosa of rats.

PURPOSE To establish an experimental model of traumatic ulcer in rat cheek mucosa for utilization in future alternative therapy studies. METHODS A total of 60 adult male rats (250 - 300g) were used. Ulceration of the left cheek mucosa was provoked by abrasion using a nº 15 scalpel blade. The animals were observed for 10 days, during which they were weighed and their ulcers were measured. The histological characteristics were analyzed and scored according to the ulcer phase. In the statistical analysis, a value of p<0.01 was considered a statistically significant response in all cases. RESULTS During the five first days, the animals lost weight (Student t test, p<0.01). The ulcerated area receded linearly over time and was almost completely cicatrized after 10 days (ANOVA, Tendency posttest, p<0.0001). Groups on days 1, 2 and 3 days displayed similar results, but a decrease in scores were observed after the 4th day. CONCLUSION The proposed cheek mucosa ulcer model in rats can be considered an efficient, low-cost, reliable, and reproducible method.

• Publication year

  2011

• Venue

  Acta Cirurgica Brasileira

• Publication date

  2011-05-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1590/S0102-86502011000300012PMID 21537526
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Long-standing oral ulcers: proposal for a new 'S-C-D classification system'.

  2010influential reference
• Long-standing oral ulcers: proposal for a new 'S-C-D classification system'.

  2008cited by this paper
• Avaliação clínica e aspectos histopatológicos de feridas cutâneas de cães tratadas com curativo temporário de pele

  2008cited by this paper
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  2006cited by this paper
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  2006cited by this paper
• [Topic use of aqueous extract of Orbignya phalerata (babassu) in rats: analysis of its healing effect].

  2006cited by this paper
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  2005cited by this paper
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  2005cited by this paper
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  2005cited by this paper
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  2002cited by this paper
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  2001cited by this paper
• Recurrent aphthous ulcers: a review of diagnosis and treatment.

  1996cited by this paper
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  1995cited by this paper
• Tongue ulcerated by trauma: report of case.

  1992cited by this paper

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