Umbelliferone attenuates glycerol‐induced myoglobinuric acute kidney injury through peroxisome proliferator‐activated receptor‐γ agonism in rats

Rhabdomyolysis is a clinical syndrome caused by damage to skeletal muscle, which consequently releases breakdown products into circulation and causes acute kidney injury (AKI) in humans. Intramuscular injection of glycerol mimics rhabdomyolysis and associated AKI. In this study, we explored the role of umbelliferone against glycerol‐induced AKI in rats. Kidney function was assessed by measuring serum creatinine, urea, electrolytes, and microproteinuria. Renal oxidative stress was quantified using thiobarbituric acid reactive substances, superoxide anion generation, and reduced glutathione assay. Renal histological changes were determined using periodic acid Schiff and hematoxylin‐eosin staining, and immunohistology of apoptotic markers (Bax, Bcl‐2) was done. Serum creatine kinase was quantified to assess glycerol‐induced muscle damage. Umbelliferone attenuated glycerol‐induced change in biochemical parameters, oxidative stress, histological alterations, and renal apoptosis. Pretreatment with bisphenol A diglycidyl ether, a peroxisome proliferator‐activated receptor‐γ (PPAR‐γ) antagonist, attenuated umbelliferone‐mediated protection. It is concluded that umbelliferone attenuates glycerol‐induced AKI possibly through PPAR‐γ agonism in rats.

• Publication year

  2021

• Venue

  Journal of biochemical and molecular toxicology

• Publication date

  2021-08-19

• Fields of study

  Medicine

• Identifiers
  DOI 10.1002/jbt.22892PMID 34409680
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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