Type‐I IFN drives the differentiation of short‐lived effector CD8+ T cells in vivo

No abstract is available for this paper.

• Publication year

  2012

• Venue

  European Journal of Immunology

• Publication date

  2012-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/eji.201142091PMID 22102057
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Signal 3 requirement for memory CD8+ T‐cell activation is determined by the infectious pathogen

  2011cited by this paper
• Regulation of effector and memory T‐cell functions by type I interferon

  2011cited by this paper
• Type I IFN Substitutes for T Cell Help during Viral Infections

  2011cited by this paper
• Cutting Edge: The Transcription Factor Eomesodermin Enables CD8+ T Cells To Compete for the Memory Cell Niche

  2010cited by this paper
• Th Cells Act Via Two Synergistic Pathways To Promote Antiviral CD8+ T Cell Responses

  2010cited by this paper
• Prolonged interleukin-2Ralpha expression on virus-specific CD8+ T cells favors terminal-effector differentiation in vivo.

  2010cited by this paper
• γc deficiency precludes CD8+ T cell memory despite formation of potent T cell effectors

  2010cited by this paper
• Early Signals during CD8+ T Cell Priming Regulate the Generation of Central Memory Cells

  2010cited by this paper
• The mTOR kinase determines effector versus memory CD8+ T cell fate by regulating the expression of transcription factors T-bet and Eomesodermin.

  2010cited by this paper
• Once a killer, always a killer: from cytotoxic T cell to memory cell

  2010cited by this paper
• Interleukin-2 and inflammation induce distinct transcriptional programs that promote the differentiation of effector cytolytic T cells.

  2010cited by this paper
• T-bet-mediated differentiation of the activated CD8+ T cell

  2010cited by this paper
• Generating diversity: transcriptional regulation of effector and memory CD8+ T‐cell differentiation

  2010cited by this paper
• Runx3 and T-box proteins cooperate to establish the transcriptional program of effector CTLs

  2009cited by this paper
• Diversity in CD8(+) T cell differentiation.

  2009cited by this paper
• Gene Regulation and Chromatin Remodeling by IL-12 and Type I IFN in Programming for CD8 T Cell Effector Function and Memory1

  2009cited by this paper
• Programming for CD8 T Cell Memory Development Requires IL-12 or Type I IFN1

  2009cited by this paper
• CD4+ T cell regulation of CD25 expression controls development of short-lived effector CD8+ T cells in primary and secondary responses

  2009cited by this paper
• IFN-α Enhances Peptide Vaccine-Induced CD8+ T Cell Numbers, Effector Function, and Antitumor Activity1

  2009cited by this paper
• Effector T‐cell differentiation during viral and bacterial infections: Role of direct IL‐12 signals for cell fate decision of CD8+ T cells

  2009cited by this paper
• IL-12 Signaling Drives CD8+ T Cell IFN-γ Production and Differentiation of KLRG1+ Effector Subpopulations during Toxoplasma gondii Infection1

  2008cited by this paper
• Generation of CD8 T Cell Memory Is Regulated by IL-121

  2007cited by this paper
• Inflammation directs memory precursor and short-lived effector CD8(+) T cell fates via the graded expression of T-bet transcription factor.

  2007cited by this paper
• Cutting Edge: CD8 T Cells Specific for Lymphocytic Choriomeningitis Virus Require Type I IFN Receptor for Clonal Expansion1

  2006cited by this paper
• Innate Inflammatory Signals Induced by Various Pathogens Differentially Dictate the IFN-I Dependence of CD8 T Cells for Clonal Expansion and Memory Formation1

  2006cited by this paper
• Cutting Edge: IL-12 Inversely Regulates T-bet and Eomesodermin Expression during Pathogen-Induced CD8+ T Cell Differentiation1

  2006cited by this paper
• Type I interferons act directly on CD8 T cells to allow clonal expansion and memory formation in response to viral infection

  2005cited by this paper
• Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin

  2005cited by this paper
• Cutting Edge: Type I IFNs Provide a Third Signal to CD8 T Cells to Stimulate Clonal Expansion and Differentiation1

  2005cited by this paper
• Signal 3 Determines Tolerance versus Full Activation of Naive CD8 T Cells

  2003cited by this paper
• Cross-priming of CD8+ T cells stimulated by virus-induced type I interferon

  2003cited by this paper
• Control of Effector CD8+ T Cell Function by the Transcription Factor Eomesodermin

  2003cited by this paper
• Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells

  2003cited by this paper
• CD8 T Cell Clonal Expansion and Development of Effector Function Require Prolonged Exposure to Antigen, Costimulation, and Signal 3 Cytokine 1

  2003cited by this paper
• Interferon (cid:2) / (cid:3) and Interleukin 12 Responses to Viral Infections: Pathways Regulating Dendritic Cell Cytokine Expression In Vivo

  2002cited by this paper
• Peptide Antigen Priming of Naive, But Not Memory, CD8 T Cells Requires a Third Signal That Can Be Provided by IL-121

  2002cited by this paper
• Two subsets of memory T lymphocytes with distinct homing potentials and effector functions

  1999cited by this paper
• Inflammatory cytokines provide a third signal for activation of naive CD4+ and CD8+ T cells.

  1999cited by this paper
• Two subsets of memory T lymphocytes with distinct homing potentials and effector functions

  1999cited by this paper
• Two Roads Diverged: Interferon α/β– and Interleukin 12–mediated Pathways in Promoting T Cell Interferon γ Responses during Viral Infection

  1999cited by this paper
• Virus‐specific major MHC class II‐restricted TCR‐transgenic mice: effects on humoral and cellular immune responses after viral infection

  1998cited by this paper
• Calmodulin regulates L-selectin adhesion molecule expression and function through a protease-dependent mechanism.

  1998cited by this paper
• Viral escape by selection of cytotoxic T cell-resistant virus variants in vivo

  1990cited by this paper
• Edinburgh Research Explorer Effects of Signal 3 during CD8 T cell priming

  year unknowncited by this paper

• Cell-Intrinsic Type I Interferon Signaling as a Pleiotropic Orchestrator of CD4 T Cell Immunity

  2026cites this paper
• T-bet overexpression enhances CAR T cell effector functions and antigen sensitivity

  2025cites this paper
• Severe malaria enforces short-lived effector cell differentiation but does not prevent effective secondary responses by memory CD8 T cells

  2025cites this paper
• Architects of immunity: How dendritic cells shape CD8+ T cell fate in cancer.

  2025cites this paper
• IFN-λ uniquely promotes CD8 T cell immunity against SARS-CoV-2 relative to type I IFN

  2024cites this paper
• mRNA Vaccine Nanoplatforms and Innate Immunity

  2024cites this paper
• The dawn of a new Era: mRNA vaccines in colorectal cancer immunotherapy.

  2024cites this paper
• Immunogenic clearance combined with PD-1 blockade elicits antitumor effect by promoting the recruitment and expansion of the effector memory-like CD8+T cell

  2024cites this paper
• The interaction of innate immune and adaptive immune system

  2024cites this paper
• The significance of T-BET-positive CD8 T-cells with diminished CD5 expression in Kikuchi-Fujimoto disease

  2024cites this paper
• The alarmin interleukin-33 promotes the expansion and preserves the stemness of Tcf-1+ CD8+ T cells in chronic viral infection.

  2023cites this paper
• IFN‐γ–STAT1‐mediated NK2R expression is involved in the induction of antitumor effector CD8 + T cells in vivo

  2023cites this paper
• Med1 Controls Effector CD8+ T Cell Differentiation and Survival through C/EBPβ-Mediated Transcriptional Control of T-bet

  2022cites this paper
• Regulation of effector and memory CD8 + T cell differentiation: a focus on orphan nuclear receptor NR4A family, transcription factor, and metabolism

  2022cites this paper
• Morphologic and Molecular Patterns of Polymyositis With Mitochondrial Pathology and Inclusion Body Myositis

  2022cites this paper
• Alum-anchored intratumoral retention improves the tolerability and antitumor efficacy of type I interferon therapies

  2022cites this paper
• LCMV induced downregulation of HVEM on antiviral T cells is critical for an efficient effector response

  2022cites this paper
• The Potential of T Cell Factor 1 in Sustaining CD8+ T Lymphocyte-Directed Anti-Tumor Immunity

  2021cites this paper
• IFNβ Is a Potent Adjuvant for Cancer Vaccination Strategies

  2021cites this paper
• Fine-Tuning the Tumour Microenvironment: Current Perspectives on the Mechanisms of Tumour Immunosuppression

  2021cites this paper
• Tcf1+ cells are required to maintain the inflationary T cell pool upon MCMV infection

  2020cites this paper
• The Opposing Effect of Type I IFN on the T Cell Response by Non-modified mRNA-Lipoplex Vaccines Is Determined by the Route of Administration

  2020cites this paper
• ROR agonist hampers the proliferation and survival of postactivated CD8+ T cells through the downregulation of cholesterol synthesis‐related genes

  2020cites this paper
• TCR Signal Strength and Antigen Affinity Regulate CD8+ Memory T Cells

  2020cites this paper
• Chronic virus infection drives CD8 T cell-mediated thymic destruction and impaired negative selection

  2020cites this paper
• Priming of HIV-1-specific CD8+ T cells with strong functional properties from naïve T cells

  2019cites this paper
• The evolving role of T-bet in resistance to infection

  2019cites this paper
• Fuel and brake of memory T cell inflation

  2019cites this paper
• Coincident airway exposure to low-potency allergen and cytomegalovirus sensitizes for allergic airway disease by viral activation of migratory dendritic cells

  2019cites this paper
• Regulators of T‐cell fate: Integration of cell migration, differentiation and function

  2019cites this paper
• Poly(I:C) Potentiates T Cell Immunity to a Dendritic Cell Targeted HIV-Multiepitope Vaccine

  2019cites this paper
• The long noncoding RNA Morrbid regulates CD8 T cells in response to viral infection

  2019cites this paper
• Enlisting the mRNA Vaccine Platform to Combat Parasitic Infections

  2019cites this paper
• Transcriptional and Epigenetic Regulation of Effector and Memory CD8 T Cell Differentiation

  2018cites this paper
• Genealogy, Dendritic Cell Priming, and Differentiation of Tissue-Resident Memory CD8+ T Cells

  2018cites this paper
• The PDL1-inducible GTPase Arl4d controls T effector function by limiting IL-2 production

  2018cites this paper
• The Vast Universe of T Cell Diversity: Subsets of Memory Cells and Their Differentiation.

  2017cites this paper
• Cyclophosphamide treatment regulates the balance of functional/exhausted tumor-specific CD8+ T cells

  2017cites this paper
• Type I Interferons Modulate CD8+ T Cell Immunity to mRNA Vaccines.

  2017cites this paper
• Transcription Factor T-bet Orchestrates Lineage Development and Function in the Immune System.

  2017cites this paper
• IRF9 Prevents CD8+ T Cell Exhaustion in an Extrinsic Manner during Acute Lymphocytic Choriomeningitis Virus Infection

  2017cites this paper
• Type I Interferon in Chronic Virus Infection and Cancer.

  2017cites this paper
• Investigating the Role of Lipopolysaccharide and Polyinosinic:Polycytidylic Acid in Boosting CD4 T cell Responses

  2017cites this paper
• Type I Interferons Regulate the Magnitude and Functionality of Mouse Polyomavirus-Specific CD8 T Cells in a Virus Strain-Dependent Manner

  2016cites this paper
• Leucocyte subset-specific type 1 interferon signatures in SLE and other immune-mediated diseases

  2016cites this paper
• Type I IFN Signaling Is Dispensable during Secondary Viral Infection

  2016cites this paper
• Rôles de deux corécepteurs impliqués dans le maintien des cellules T mémoires CD8+ et la maturation des cellules dendritiques

  2016cites this paper
• mRNA-based vaccines to elicit CD8⁺ T cell immunity

  2016cites this paper
• Regulatory T cell memory

  2015cites this paper
• The viral context instructs the redundancy of costimulatory pathways in driving CD8+ T cell expansion

  2015cites this paper
• NK cells and interferons.

  2015cites this paper
• CD70 and IFN‐1 selectively induce eomesodermin or T‐bet and synergize to promote CD8+ T‐cell responses

  2015cites this paper
• Regulation of antiviral T cell responses by type I interferons

  2015cites this paper
• Moving to the suburbs: T‐cell positioning within lymph nodes during activation and memory

  2015cites this paper
• The Role of Signal 3 Cytokine Timing in CD8 T Cell Activation: A Dissertation

  2015influential citation
• Out-of-Sequence Signal 3 as a Mechanism for Virus-Induced Immune Suppression of CD8 T Cell Responses

  2014influential citation
• Development of anti-viral CD8+ T cell memory in the respiratory environment

  2014cites this paper
• Listeria Monocytogenes Protection from Mediated - T Cell + Enhances CD8 Nanoparticle Adjuvant Sensing by TLR7

  2014cites this paper
• The role of type I interferon signaling on T cells during acute viral infections

  2014cites this paper
• The activation of the adaptive immune system: cross-talk between antigen-presenting cells, T cells and B cells.

  2014cites this paper
• T‐cell help dependence of memory CD8+ T‐cell expansion upon vaccinia virus challenge relies on CD40 signaling

  2014cites this paper
• Asymptomatic memory CD8+ T cells

  2014cites this paper
• Gammaherpesvirus Latency Differentially Impacts the Generation of Primary versus Secondary Memory CD8+ T Cells during Subsequent Infection

  2014cites this paper
• The protein tyrosine phosphatase PTPN22 controls forkhead box protein 3 T regulatory cell induction but is dispensable for T helper type 1 cell polarization

  2014cites this paper
• Type I interferons protect T cells against NK cell attack mediated by the activating receptor NCR1.

  2014cites this paper
• Therapeutic Activity of High-Dose Intratumoral IFN-β Requires Direct Effect on the Tumor Vasculature

  2014cites this paper
• Interferon regulatory factor 3 in adaptive immune responses

  2014cites this paper
• A central role for Notch in effector CD8+ T cell differentiation

  2014cites this paper
• Comparative Analysis of the Magnitude, Quality, Phenotype, and Protective Capacity of Simian Immunodeficiency Virus Gag-Specific CD8+ T Cells following Human-, Simian-, and Chimpanzee-Derived Recombinant Adenoviral Vector Immunization

  2013cites this paper
• Critical Role for All-trans Retinoic Acid for Optimal Effector and Effector Memory CD8 T Cell Differentiation

  2013cites this paper
• TRANSCRIPTIONAL REGULATION OF CD8 + T CELL DIFFERENTIATION

  2013cites this paper
• Macrophage and T Cell Produced IL-10 Promotes Viral Chronicity

  2013cites this paper
• In vitro generation and programming of human CD8+ memory T cells

  2013influential citation
• Die Funktion des Chemokinrezeptors CXCR6 in der T-Zellantwort der Maus gegen Listeria monocytogenes

  2013cites this paper
• This information is current as Infection Listeria Monocytogenes Protection from Mediated − T Cell + Enhances CD 8 Nanoparticle Adjuvant Sensing by TLR 7

  2013cites this paper
• CD8+ T-cell responses in a Th2-polarized inflammatory setting

  2013cites this paper
• Anti-viral CD8 T cells and the cytokines that they love.

  2013cites this paper
• Diversification and senescence of Foxp3+ regulatory T cells during experimental autoimmune encephalomyelitis

  2013cites this paper
• Signal 3 Cytokines as Modulators of Primary Immune Responses during Infections: The Interplay of Type I IFN and IL-12 in CD8 T Cell Responses

  2012cites this paper
• Transcriptional control of effector and memory CD8+ T cell differentiation

  2012cites this paper
• Toll-like receptor 7 is required for effective adaptive immune responses that prevent persistent virus infection.

  2012cites this paper
• Primary and Secondary Immune Responses During Sequential West Nile Virus and Japanese Encephalitis Virus Infections: A Dissertation

  2012cites this paper
• Intranasal Administration of dsRNA Analog Poly(I:C) Induces Interferon-α Receptor-Dependent Accumulation of Antigen Experienced T Cells in the Airways

  2012cites this paper
• Modulation of T‐cell function by type I interferon

  2012cites this paper
• Activated iNKT Cells Promote Memory CD8+ T Cell Differentiation during Viral Infection

  2012cites this paper
• Immunization Recombinant Adenoviral Vector Human-, Simian-, and Chimpanzee-derived T Cells following + Gag-specific Cd8 of Simian Immunodeficiency Virus Quality, Phenotype, and Protective Capacity Comparative Analysis of the Magnitude

  year unknowncites this paper
• On the Tumor Vasculature Requires Direct Effect Β Intratumoral Ifn- Therapeutic Activity of High-dose

  year unknowncites this paper
• On the Tumor Vasculature Requires Direct Effect Β Intratumoral Ifn- Therapeutic Activity of High-dose

  year unknowncites this paper
• T Cell Differentiation Optimal Effector and Effector Memory Cd8 Retinoic Acid for Trans Critical Role for All

  year unknowncites this paper