Biliverdin reductase-A protein levels are reduced in type 2 diabetes and are associated with poor glycometabolic control.

No abstract is available for this paper.

• Publication year

  2021

• Venue

  Life Science

• Publication date

  2021-08-25

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/j.lfs.2021.119913PMID 34453944
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Insulin resistance, oxidative stress and mitochondrial defects in Ts65dn mice brain: a harmful synergistic path in Down syndrome.

  2021cited by this paper
• Heme Oxygenase-1 Signaling and Redox Homeostasis in Physiopathological Conditions

  2021cited by this paper
• Bilirubin remodels murine white adipose tissue by reshaping mitochondrial activity and the coregulator profile of peroxisome proliferator–activated receptor α

  2020cited by this paper
• Bilirubin as a Metabolic Hormone: The Physiological Relevance of Low Levels.

  2020cited by this paper
• Reduced Biliverdin Reductase-A Expression in Visceral Adipose Tissue is Associated with Adipocyte Dysfunction and NAFLD in Human Obesity

  2020cited by this paper
• Rats Genetically Selected for High Aerobic Exercise Capacity Have Elevated Plasma Bilirubin by Upregulation of Hepatic Biliverdin Reductase-A (BVRA) and Suppression of UGT1A1

  2020cited by this paper
• Biliverdin Reductase A (BVRA) Knockout in Adipocytes Induces Hypertrophy and Reduces Mitochondria in White Fat of Obese Mice

  2020cited by this paper
• Relationship between Serum Indirect Bilirubin Level and Insulin Sensitivity: Results from Two Independent Cohorts of Obese Patients with Impaired Glucose Regulation and Type 2 Diabetes Mellitus in China

  2020cited by this paper
• Adipose tissue remodelling in obese subjects is a determinant of presence and severity of fatty liver disease

  2020cited by this paper
• HO-1 overexpression and underexpression: Clinical implications.

  2019cited by this paper
• Reduced biliverdin reductase-A levels are associated with early alterations of insulin signaling in obesity.

  2019cited by this paper
• Loss of biliverdin reductase-A favors Tau hyper-phosphorylation in Alzheimer's disease.

  2019cited by this paper
• CRISPR Cas9-mediated deletion of biliverdin reductase A (BVRA) in mouse liver cells induces oxidative stress and lipid accumulation.

  2019cited by this paper
• Association between serum total bilirubin levels and the risk of type 2 diabetes mellitus.

  2019cited by this paper
• Type 2 diabetes: a multifaceted disease

  2019cited by this paper
• Biliverdin reductase-A impairment links brain insulin resistance with increased Aβ production in an animal model of aging: Implications for Alzheimer disease.

  2018cited by this paper
• Biliverdin Reductase-A Mediates the Beneficial Effects of Intranasal Insulin in Alzheimer Disease

  2018cited by this paper
• Correlation between heat shock proteins, adiponectin, and T lymphocyte cytokine expression in type 2 diabetics

  2018cited by this paper
• Tumor Necrosis Factor‐Alpha: Role in Development of Insulin Resistance and Pathogenesis of Type 2 Diabetes Mellitus

  2018cited by this paper
• Biliverdin reductase-A attenuated GMH-induced inflammatory response in the spleen by inhibiting toll-like receptor-4 through eNOS/NO pathway

  2018cited by this paper
• A review on heme oxygenase-1 induction: is it a necessary evil

  2018cited by this paper
• Translational Significance of Heme Oxygenase in Obesity and Metabolic Syndrome.

  2016cited by this paper
• Impairment of biliverdin reductase-A promotes brain insulin resistance in Alzheimer disease: A new paradigm.

  2016cited by this paper
• Nanoparticle Delivered Human Biliverdin Reductase-Based Peptide Increases Glucose Uptake by Activating IRK/Akt/GSK3 Axis: The Peptide Is Effective in the Cell and Wild-Type and Diabetic Ob/Ob Mice

  2016cited by this paper
• Interaction of human biliverdin reductase with Akt/protein kinase B and phosphatidylinositol‐dependent kinase 1 regulates glycogen synthase kinase 3 activity: a novel mechanism of Akt activation

  2016cited by this paper
• Biliverdin Reductase A Attenuates Hepatic Steatosis by Inhibition of Glycogen Synthase Kinase (GSK) 3β Phosphorylation of Serine 73 of Peroxisome Proliferator-activated Receptor (PPAR) α*

  2016cited by this paper
• Biliverdin reductase isozymes in metabolism.

  2015cited by this paper
• Tat-biliverdin reductase A inhibits inflammatory response by regulation of MAPK and NF-κB pathways in Raw 264.7 cells and edema mouse model.

  2015cited by this paper
• Increased Mammalian Target of Rapamycin Signaling Contributes to the Accumulation of Protein Oxidative Damage in a Mouse Model of Down's Syndrome

  2015cited by this paper
• Heme oxygenase-1 drives metaflammation and insulin resistance in mouse and man.

  2014cited by this paper
• The Janus face of the heme oxygenase/biliverdin reductase system in Alzheimer disease: it's time for reconciliation.

  2014cited by this paper
• Human biliverdin reductase‐based peptides activate and inhibit glucose uptake through direct interaction with the kinase domain of insulin receptor

  2014cited by this paper
• The Heme Oxygenase System Suppresses Perirenal Visceral Adiposity, Abates Renal Inflammation and Ameliorates Diabetic Nephropathy in Zucker Diabetic Fatty Rats

  2014cited by this paper
• Inactivation of brain Cofilin-1 by age, Alzheimer's disease and γ-secretase.

  2014cited by this paper
• The Heme Oxygenase System Rescues Hepatic Deterioration in the Condition of Obesity Co-Morbid with Type-2 Diabetes

  2013cited by this paper
• Increased HO-1 Levels Ameliorate Fatty Liver Development Through a Reduction of Heme and Recruitment of FGF21

  2013cited by this paper
• Potential Therapeutic Effects of Natural Heme Oxygenase-1 Inducers in Cardiovascular Diseases

  2013cited by this paper
• Heme oxygenase-2/adiponectin protein-protein interaction in metabolic syndrome.

  2013cited by this paper
• Heme oxygenase, a novel target for the treatment of hypertension and obesity?

  2012cited by this paper
• Go Green: The Anti-Inflammatory Effects of Biliverdin Reductase

  2012cited by this paper
• HO-1/BVR-A System Analysis in Plasma from Probable Alzheimer's Disease and Mild Cognitive Impairment Subjects: A Potential Biochemical Marker for the Prediction of the Disease

  2012cited by this paper
• High‐Fat Diet Exacerbates Renal Dysfunction in SHR: Reversal by Induction of HO‐1–Adiponectin Axis

  2012cited by this paper
• Curcumin and Alzheimer Disease: This Marriage Is Not to Be Performed

  2011cited by this paper
• Chronic HO-1 Induction with Cobalt Protoporphyrin (CoPP) Treatment Increases Oxygen Consumption, Activity, Heat Production and Lowers Body Weight in Obese Melanocortin-4 Receptor Deficient Mice

  2011cited by this paper
• Investigations of cellular glucose transport and its regulation under the influence of insulin in human peripheral blood lymphocytes.

  2010cited by this paper
• Adipocyte Heme Oxygenase-1 Induction Attenuates Metabolic Syndrome in Both Male and Female Obese Mice

  2010cited by this paper
• Plasma Heme Oxygenase-1 Concentration Is Elevated in Individuals with Type 2 Diabetes Mellitus

  2010cited by this paper
• Role of Heme Oxygenase in Inflammation, Insulin-Signalling, Diabetes and Obesity

  2010cited by this paper
• Characterization of the human biliverdin reductase gene structure and regulatory elements: promoter activity is enhanced by hypoxia and suppressed by TNF‐α‐activated NF‐κB

  2010cited by this paper
• The L-4F mimetic peptide prevents insulin resistance through increased levels of HO-1, pAMPK, and pAKT in obese mice

  2009cited by this paper
• Up-regulating the hemeoxygenase system enhances insulin sensitivity and improves glucose metabolism in insulin-resistant diabetes in Goto-Kakizaki rats.

  2009cited by this paper
• Studies of insulin resistance in patients with clinical and subclinical hypothyroidism.

  2009cited by this paper
• Heme Oxygenase-1 Induction Remodels Adipose Tissue and Improves Insulin Sensitivity in Obesity-Induced Diabetic Rats

  2009cited by this paper
• Pleiotropic functions of biliverdin reductase: cellular signaling and generation of cytoprotective and cytotoxic bilirubin.

  2009cited by this paper
• Cellular glucose transport and glucotransporter 4 expression as a therapeutic target: clinical and experimental studies

  2009cited by this paper
• American Association of Clinical Endocrinologists and American Diabetes Association Consensus Statement on Inpatient Glycemic Control

  2009cited by this paper
• Downregulation of genes involved in NFκB activation in peripheral blood mononuclear cells after weight loss is associated with the improvement of insulin sensitivity in individuals with the metabolic syndrome: the GENOBIN study

  2008cited by this paper
• Effect of weight loss on cytokine messenger RNA expression in peripheral blood mononuclear cells of obese subjects with the metabolic syndrome.

  2008cited by this paper
• Heme Oxygenase-Mediated Increases in Adiponectin Decrease Fat Content and Inflammatory Cytokines Tumor Necrosis Factor-α and Interleukin-6 in Zucker Rats and Reduce Adipogenesis in Human Mesenchymal Stem Cells

  2008cited by this paper
• The protective role of carotenoids against 7-keto-cholesterol formation in solution

  2008cited by this paper
• Glucose transporter expression on the plasma membrane of resting and activated white blood cells

  2007cited by this paper
• Differential gene expression of NADPH oxidase (p22phox) and hemoxygenase‐1 in patients with Type 2 diabetes and microangiopathy

  2006cited by this paper
• Up-Regulation of Heme Oxygenase Provides Vascular Protection in an Animal Model of Diabetes through Its Antioxidant and Antiapoptotic Effects

  2006cited by this paper
• Human biliverdin reductase: a member of the insulin receptor substrate family with serine/threonine/tyrosine kinase activity.

  2005cited by this paper
• Small Interference RNA-mediated Gene Silencing of Human Biliverdin Reductase, but Not That of Heme Oxygenase-1, Attenuates Arsenite-mediated Induction of the Oxygenase and Increases Apoptosis in 293A Kidney Cells*

  2005cited by this paper
• Epidemiology of the Metabolic Syndrome

  2005cited by this paper
• Evaluation of glucose transport and its regulation by insulin in human monocytes using flow cytometry

  2005cited by this paper
• Circulating Mononuclear Cells in the Obese Are in a Proinflammatory State

  2004cited by this paper
• Intramuscular heat shock protein 72 and heme oxygenase-1 mRNA are reduced in patients with type 2 diabetes: evidence that insulin resistance is associated with a disturbed antioxidant defense mechanism.

  2003cited by this paper
• Human Biliverdin Reductase Is a Leucine Zipper-like DNA-binding Protein and Functions in Transcriptional Activation of Heme Oxygenase-1 by Oxidative Stress*

  2002cited by this paper
• Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance.

  2001cited by this paper

• Bilirubin Hepatic and Intestinal Transport and Catabolism: Physiology, Pathophysiology, and Benefits

  2025cites this paper
• Biliverdin reductase-A is a key modulator in insulin signaling and metabolism.

  2025cites this paper
• Predictive value of biliverdin reductase‐A and homeostasis model assessment of insulin resistance on mild cognitive impairment in patients with type 2 diabetes

  2025cites this paper
• Biliverdin Reductase-A integrates insulin signaling with mitochondrial metabolism through phosphorylation of GSK3β

  2024cites this paper
• Physiologically Relevant Levels of Biliverdin Do Not Significantly Oppose Oxidative Damage in Plasma In Vitro

  2023cites this paper
• Suppressing Hepatic UGT1A1 Increases Plasma Bilirubin, Lowers Plasma Urobilin, Reorganizes Kinase Signaling Pathways and Lipid Species and Improves Fatty Liver Disease

  2023cites this paper
• Blood chemistry and biliverdin differ according to reproduction and tourism in a free-living lizard

  2023cites this paper
• Dynamic Changes of BVRA Protein Levels Occur in Response to Insulin: A Pilot Study in Humans

  2023cites this paper
• Insulin Resistance in Peripheral Tissues and the Brain: A Tale of Two Sites

  2022cites this paper
• Role of Biliverdin Reductase A in the Regulation of Insulin Signaling in Metabolic and Neurodegenerative Diseases: An Update

  2022cites this paper
• Heme Oxygenase-1: An Anti-Inflammatory Effector in Cardiovascular, Lung, and Related Metabolic Disorders

  2022cites this paper
• The interplay among oxidative stress, brain insulin resistance and AMPK dysfunction contribute to neurodegeneration in type 2 diabetes and Alzheimer disease.

  2021cites this paper