Age and sex‐related variability in the presentation of generalized anxiety and depression symptoms

Generalized anxiety and depression are extremely prevalent and debilitating. There is evidence for age and sex variability in symptoms of depression, but despite comorbidity it is unclear whether this extends to anxiety symptomatology. Studies using questionnaire sum scores typically fail to address this phenotypic complexity.

• Publication year

  2021

• Venue

  Depression and Anxiety

• Publication date

  2021-09-08

• Fields of study

  Medicine, Psychology

• Identifiers
  DOI 10.1002/da.23213PMID 34496112
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Using Major Depression Polygenic Risk Scores to Explore the Depressive Symptom Continuum

  2020influential reference
• The Genetic Links to Anxiety and Depression (GLAD) Study: Online recruitment into the largest recontactable study of depression and anxiety

  2019cited by this paper
• Depression: A cognitive perspective.

  2019cited by this paper
• Age and Sex Differences in Self-Stigma and Public Stigma Concerning Depression and Suicide in Men

  2019cited by this paper
• The symptom‐specific efficacy of antidepressant medication vs. cognitive behavioral therapy in the treatment of depression: results from an individual patient data meta‐analysis

  2019cited by this paper
• Investigating Genetic Heterogeneity in Major Depression Through Item-level Genetic Analyses of the PHQ-9

  2019cited by this paper
• Chronic diseases and social risk factors in relation to specific symptoms of depression: Evidence from the U.S. national health and nutrition examination surveys.

  2019influential reference
• Structure and Connectivity of Depressive Symptom Networks Corresponding to Early Treatment Response

  2019cited by this paper
• Racial and ethnic differences in depression: current perspectives

  2019cited by this paper
• Prevalence of Depression in the Community from 30 Countries between 1994 and 2014

  2018cited by this paper
• Severity, course trajectory, and within‐person variability of individual symptoms in patients with major depressive disorder

  2018cited by this paper
• For the Patient.

  2018cited by this paper
• Parsing the heterogeneity of depression: An exploratory factor analysis across commonly used depression rating scales.

  2018cited by this paper
• Somatic symptoms vary in major depressive disorder in China.

  2018cited by this paper
• Adverse life outcomes associated with adolescent psychotic experiences and depressive symptoms

  2018cited by this paper
• Anxiety and Depression as Bidirectional Risk Factors for One Another: A Meta-Analysis of Longitudinal Studies

  2017cited by this paper
• psych: Procedures for Personality and Psychological Research

  2017cited by this paper
• Gender Differences in Anxiety Trajectories from Middle to Late Adolescence

  2016cited by this paper
• Risk factors for sleep disturbances in older adults: Evidence from prospective studies.

  2016cited by this paper
• Perceived anxiety control is associated with sleep disturbance in young and older adults

  2016cited by this paper
• Age-related variability in the presentation of symptoms of major depressive disorder

  2016influential reference
• Clinical Significance of Individual GAD Symptoms in Later Life

  2016cited by this paper
• Depression sum-scores don’t add up: why analyzing specific depression symptoms is essential

  2015cited by this paper
• Why is depression more prevalent in women?

  2015cited by this paper
• Recovery and reliable change rates for patients scoring severe on depression, anxiety or impaired functioning in a psychological therapies service: IAPT

  2015cited by this paper
• Depression is not a consistent syndrome: An investigation of unique symptom patterns in the STAR*D study.

  2015cited by this paper
• Beyond generalized anxiety disorder: psychometric properties of the GAD-7 in a heterogeneous psychiatric sample.

  2014cited by this paper
• Who worries most? Worry prevalence and patterns across the lifespan

  2013cited by this paper
• Diagnostic and Statistical Manual of Mental Disorders

  2013cited by this paper
• Depression is more than the sum score of its parts: individual DSM symptoms have different risk factors

  2013cited by this paper
• Estimating Ordinal Reliability for Likert-Type and Ordinal Item Response Data: A Conceptual, Empirical, and Practical Guide.

  2012cited by this paper
• Validity of the Generalized Anxiety Disorder-7 scale in an acute psychiatric sample.

  2012cited by this paper
• Phenomenology of depression in older compared with younger adults: meta-analysis.

  2012cited by this paper
• Ordinary Least Squares Estimation of Parameters in Exploratory Factor Analysis With Ordinal Data

  2012cited by this paper
• lavaan: An R Package for Structural Equation Modeling

  2012cited by this paper
• Implementing NICE guidelines for the psychological treatment of depression and anxiety disorders: The IAPT experience

  2011cited by this paper
• The Patient Health Questionnaire Somatic, Anxiety, and Depressive Symptom Scales: a systematic review.

  2010influential reference
• Factor Analysis with Ordinal Indicators: A Monte Carlo Study Comparing DWLS and ULS Estimation

  2009cited by this paper
• The prevalence of anxiety in older adults: methodological issues and a review of the literature.

  2008cited by this paper
• Lifetime prevalence and age of onset distributions of mental disorders in the World Mental Health Survey Initiative.

  2008cited by this paper
• Validation and Standardization of the Generalized Anxiety Disorder Screener (GAD-7) in the General Population

  2008cited by this paper
• Gender differences in generalized anxiety disorder: results from the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC).

  2008cited by this paper
• Age-Related Differences in Worry and Related Processes

  2008cited by this paper
• Polychoric versus Pearson correlations in exploratory and confirmatory factor analysis of ordinal variables

  2008influential reference
• Book Review: Exploratory and Confirmatory Factor Analysis: Understanding Concepts and Applications

  2007influential reference
• Anxiety Disorders in Primary Care: Prevalence, Impairment, Comorbidity, and Detection

  2007cited by this paper
• Depression and generalized anxiety disorder: cumulative and sequential comorbidity in a birth cohort followed prospectively to age 32 years.

  2007cited by this paper
• Sleep in Normal Aging.

  2006cited by this paper
• A brief measure for assessing generalized anxiety disorder: the GAD-7.

  2006influential reference
• Reporting Structural Equation Modeling and Confirmatory Factor Analysis Results: A Review

  2006influential reference
• Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication.

  2005cited by this paper
• Somatic Symptoms in Late-Life Anxiety: Treatment Issues

  2005cited by this paper
• Sleep disturbances and chronic disease in older adults: results of the 2003 National Sleep Foundation Sleep in America Survey.

  2004cited by this paper
• Exploratory and Confirmatory Factor Analysis: Understanding Concepts and Applications

  2004influential reference
• Current and lifetime comorbidity of the DSM-IV anxiety and mood disorders in a large clinical sample.

  2001cited by this paper
• The PHQ-9

  2001influential reference
• The PHQ-9: validity of a brief depression severity measure.

  2001cited by this paper
• Cutoff criteria for fit indexes in covariance structure analysis : Conventional criteria versus new alternatives

  1999influential reference
• Depression and generalized anxiety

  1998cited by this paper
• Controlling the false discovery rate: a practical and powerful approach to multiple testing

  1995cited by this paper
• Tripartite model of anxiety and depression: psychometric evidence and taxonomic implications.

  1991cited by this paper
• Very Simple Structure: An Alternative Procedure For Estimating The Optimal Number Of Interpretable Factors.

  1979cited by this paper
• Determining the number of components from the matrix of partial correlations

  1976cited by this paper
• An index of factorial simplicity

  1974cited by this paper
• A rationale and test for the number of factors in factor analysis

  1965cited by this paper
• TESTS OF SIGNIFICANCE IN FACTOR ANALYSIS

  1950cited by this paper
• Sleep in Normal Aging

  year unknowncited by this paper

• A Case-Control Study of the Association Between Hypocholesterolemia and Depressive Symptoms in a Mexican Population from Los Altos Sur, Jalisco

  2026cites this paper
• Interleukin-6 moderates the relationship between social support, strain, and future depressive symptoms

  2025cites this paper
• From Monoamines to Systems Psychiatry: Rewiring Depression Science and Care (1960s–2025)

  2025cites this paper
• Perfil emocional del paciente en hemodiálisis. Estudio multicéntrico

  2025cites this paper
• Clustering and drivers of symptoms observed at week six after antidepressant treatment in depressed outpatients

  2025cites this paper
• Disparities in anxiety and related factors among Chinese older adults across different aged-care models: a comparison of two cross-sectional studies

  2025cites this paper
• Increased Depressive and Anxiety Symptoms Predict Increased Severity of Functional Impairment After Five Years: A Nationally Representative Retrospective Cohort Study.

  2025cites this paper
• Body Image and Negative Emotions in Chinese Deaf and Hard-of-Hearing College Students: The Mediating Role of Core Self-Evaluation and the Moderating Role of Self-Compassion

  2025cites this paper
• Effects of the Soothe Vision well-being tool on university students’ mood: a pilot study

  2025cites this paper
• Heritability of generalized anxiety stability: a longitudinal twin study among young adults

  2025cites this paper
• Genetic overlap between functional impairment and depression and anxiety symptom severity: evidence from the GLAD Study

  2025cites this paper
• Depressive and Anxious Symptoms in Spanish Adolescents: Normative Data for the PHQ-9 and GAD-7

  2024cites this paper
• Association of social support with depression and anxiety among the migrant population of Henan, China: Based on a large cross-sectional study.

  2024cites this paper
• Risk factors for anxiety in patients with epilepsy: A meta-analysis.

  2024cites this paper
• Screening for anxiety in adolescents: Validation of the Generalized Anxiety Disorder Assessment-7 in a representative sample of adolescents.

  2024cites this paper
• The causal relationship between anxiety and tinnitus severity: a Mendelian randomization study

  2024cites this paper
• Chronic unpredictable stress induces depression/anxiety-related behaviors and alterations of hippocampal monoamine receptor mRNA expression in female mice at different ages

  2023cites this paper
• Validating repurposed GAD‐7 anchored in COVID‐19 pandemic experiences: A factor‐ and person‐centered approach

  2023cites this paper
• Low and mismatched socioeconomic status between newlyweds increased their risk of depressive symptoms: A multi-center study

  2023cites this paper
• Evaluating sex-differences in the prevalence and associated factors of mood disorders in Canada.

  2023cites this paper
• Symptom clustering of major depression in a national telehealth sample.

  2023cites this paper
• Association of Generalized Anxiety Disorder With Autonomic Hypersensitivity and Blunted Ventromedial Prefrontal Cortex Activity During Peripheral Adrenergic Stimulation

  2022cites this paper
• Association Between Cardiorespiratory Fitness and Incident Purchase of Hypnotic Drugs in Adults: The HUNT Study.

  2022cites this paper
• Greater variability in daily sleep efficiency predicts depression and anxiety in young adults: Estimation of depression severity using the two-week sleep quality records of wearable devices

  2022cites this paper
• Genetic overlap between functional impairment and depression Genetic overlap between functional impairment and depression and anxiety symptom severity: Evidence from the GLAD Study and anxiety symptom severity: Evidence from the GLAD Study

  year unknowncites this paper
• Clínica y Salud

  year unknowncites this paper