Oncometabolites: A New Paradigm for Oncology, Metabolism, and the Clinical Laboratory.

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Clinical Chemistry

• Publication date

  2017-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1373/clinchem.2016.267666PMID 29038145
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Pan-mutant IDH1 inhibitor BAY 1436032 for effective treatment of IDH1 mutant astrocytoma in vivo

  2017cited by this paper
• AG-221, a First-in-Class Therapy Targeting Acute Myeloid Leukemia Harboring Oncogenic IDH2 Mutations.

  2017cited by this paper
• Oncometabolite succinate promotes angiogenesis by upregulating VEGF expression through GPR91-mediated STAT3 and ERK activation

  2017cited by this paper
• Succinate in the cancer-immune cycle.

  2017cited by this paper
• Urine 2-Hydroxyglutarate in Glioma

  2016cited by this paper
• Loss of Fumarate Hydratase and Aberrant Protein Succination Detected With S-(2-Succino)-Cysteine Staining to Identify Patients With Multiple Cutaneous and Uterine Leiomyomatosis and Hereditary Leiomyomatosis and Renal Cell Cancer Syndrome

  2016cited by this paper
• Enantioseparation of d,l-2-hydroxyglutaric acid by capillary electrophoresis with tandem mass spectrometry-Fast and efficient tool for d- and l-2-hydroxyglutaracidurias diagnosis.

  2016cited by this paper
• Oncometabolite D-2-Hydroxyglurate Directly Induces Epithelial-Mesenchymal Transition and is Associated with Distant Metastasis in Colorectal Cancer

  2016cited by this paper
• Chiral separation of 2-hydroxyglutaric acid on cinchonan carbamate based weak chiral anion exchangers by high-performance liquid chromatography.

  2016cited by this paper
• The importance of plasma D‐2HG measurement in screening for IDH mutations in acute myeloid leukaemia

  2016cited by this paper
• Pretreatment d-2-hydroxyglutarate serum levels negatively impact on outcome in IDH1-mutated acute myeloid leukemia

  2016cited by this paper
• Oncometabolites: Unconventional triggers of oncogenic signalling cascades

  2016cited by this paper
• Oncometabolites: tailoring our genes

  2015cited by this paper
• Decreasing GSH and increasing ROS in chemosensitivity gliomas with IDH1 mutation

  2015cited by this paper
• Radioprotection of IDH1-Mutated Cancer Cells by the IDH1-Mutant Inhibitor AGI-5198.

  2015cited by this paper
• Diagnostic value of plasma and urinary 2-hydroxyglutarate to identify patients with isocitrate dehydrogenase-mutated glioma.

  2015cited by this paper
• Glutamate dehydrogenase 1 signals through antioxidant glutathione peroxidase 1 to regulate redox homeostasis and tumor growth.

  2015cited by this paper
• Sensitive Determination of Onco-metabolites of D- and L-2-hydroxyglutarate Enantiomers by Chiral Derivatization Combined with Liquid Chromatography/Mass Spectrometry Analysis

  2015cited by this paper
• Fumarate induces redox-dependent senescence by modifying glutathione metabolism

  2015cited by this paper
• Succinate dehydrogenase-deficient renal cell carcinoma: detailed characterization of 11 tumors defining a unique subtype of renal cell carcinoma

  2015cited by this paper
• Direct comparison of quantitative digital PCR and 2-hydroxyglutarate enantiomeric ratio for IDH mutant allele frequency assessment in myeloid malignancy

  2015cited by this paper
• Protein-mediated assembly of succinate dehydrogenase and its cofactors

  2015cited by this paper
• Circulating Oncometabolite 2-Hydroxyglutarate Is a Potential Surrogate Biomarker in Patients with Isocitrate Dehydrogenase-Mutant Intrahepatic Cholangiocarcinoma

  2014cited by this paper
• Human Phosphoglycerate Dehydrogenase Produces the Oncometabolite d-2-Hydroxyglutarate

  2014cited by this paper
• MYC-driven accumulation of 2-hydroxyglutarate is associated with breast cancer prognosis.

  2014cited by this paper
• Serum 2-hydroxyglutarate production in IDH1- and IDH2-mutated de novo acute myeloid leukemia: a study by the Acute Leukemia French Association group.

  2014cited by this paper
• Isocitrate dehydrogenase 1 (IDH1) mutation in breast adenocarcinoma is associated with elevated levels of serum and urine 2-hydroxyglutarate.

  2014cited by this paper
• Germline mutations in FH confer predisposition to malignant pheochromocytomas and paragangliomas.

  2014cited by this paper
• The role of mutation of metabolism-related genes in genomic hypermethylation.

  2014cited by this paper
• Hereditary Leiomyomatosis and Renal Cell Carcinoma Syndrome–associated Renal Cancer: Recognition of the Syndrome by Pathologic Features and the Utility of Detecting Aberrant Succination by Immunohistochemistry

  2014cited by this paper
• Oncometabolites‐driven tumorigenesis: From genetics to targeted therapy

  2014cited by this paper
• Krebs cycle metabolite profiling for identification and stratification of pheochromocytomas/paragangliomas due to succinate dehydrogenase deficiency.

  2014cited by this paper
• The Oncometabolite Fumarate Promotes Pseudohypoxia Through Noncanonical Activation of NF-κB Signaling*

  2014cited by this paper
• The Succinated Proteome of FH-Mutant Tumours

  2014cited by this paper
• 2-Hydroxyglutarate is not a metabolite; d-2-hydroxyglutarate and l-2-hydroxyglutarate are!

  2013cited by this paper
• Reversed argininosuccinate lyase activity in fumarate hydratase-deficient cancer cells

  2013cited by this paper
• The proto-oncometabolite fumarate binds glutathione to amplify ROS-dependent signaling.

  2013cited by this paper
• Oncometabolites: linking altered metabolism with cancer.

  2013cited by this paper
• Deficiency in SLC25A1, encoding the mitochondrial citrate carrier, causes combined D-2- and L-2-hydroxyglutaric aciduria.

  2013cited by this paper
• Prognostic significance of 2-hydroxyglutarate levels in acute myeloid leukemia in China

  2013cited by this paper
• Identification of a novel recurrent 1q42.2‐1qter deletion in high risk MYCN single copy 11q deleted neuroblastomas

  2012cited by this paper
• Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors.

  2012cited by this paper
• Progress in understanding 2-hydroxyglutaric acidurias

  2012cited by this paper
• Serum 2-hydroxyglutarate levels predict isocitrate dehydrogenase mutations and clinical outcome in acute myeloid leukemia.

  2012cited by this paper
• Detection of 2-Hydroxyglutarate in IDH-Mutated Glioma Patients by In Vivo Spectral-Editing and 2D Correlation Magnetic Resonance Spectroscopy

  2012cited by this paper
• Magnetic Resonance of 2-Hydroxyglutarate in IDH1-Mutated Low-Grade Gliomas

  2012cited by this paper
• Identification of lysine succinylation as a new post-translational modification.

  2011cited by this paper
• 2-hydroxyglutarate detection by magnetic resonance spectroscopy in IDH-mutated glioma patients

  2011cited by this paper
• Succination of Keap1 and activation of Nrf2-dependent antioxidant pathways in FH-deficient papillary renal cell carcinoma type 2.

  2011cited by this paper
• SDH mutations in cancer.

  2011cited by this paper
• Papillary thyroid carcinoma shows elevated levels of 2-hydroxyglutarate

  2011cited by this paper
• Hallmarks of cancer: the next generation.

  2011cited by this paper
• Aberrant succination of proteins in fumarate hydratase‐deficient mice and HLRCC patients is a robust biomarker of mutation status

  2011cited by this paper
• Isocitrate dehydrogenase 1/2 mutational analyses and 2‐hydroxyglutarate measurements in Wilms tumors

  2011cited by this paper
• IDH1 and IDH2 mutations are frequent events in central chondrosarcoma and central and periosteal chondromas but not in other mesenchymal tumours

  2011cited by this paper
• The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate.

  2010cited by this paper
• Urine organic acid analysis for inherited metabolic disease using gas chromatography-mass spectrometry.

  2010cited by this paper
• IDH2 Mutations in Patients with d-2-Hydroxyglutaric Aciduria

  2010cited by this paper
• Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

  2010cited by this paper
• Wilms Tumor in a Child with L-2-hydroxyglutaric Aciduria

  2010cited by this paper
• SDH5, a Gene Required for Flavination of Succinate Dehydrogenase, Is Mutated in Paraganglioma

  2009cited by this paper
• Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

  2009cited by this paper
• Hydroxyglutaric aciduria and malignant brain tumor: a case report and literature review

  2008cited by this paper
• The biology of cancer: metabolic reprogramming fuels cell growth and proliferation.

  2008cited by this paper
• l-2-Hydroxyglutaric aciduria, a defect of metabolite repair

  2007cited by this paper
• Genetics of carney triad: recurrent losses at chromosome 1 but lack of germline mutations in genes associated with paragangliomas and gastrointestinal stromal tumors.

  2007cited by this paper
• A Recurrent Stop-Codon Mutation in Succinate Dehydrogenase Subunit B Gene in Normal Peripheral Blood and Childhood T-Cell Acute Leukemia

  2007cited by this paper
• Mutations in the D-2-hydroxyglutarate dehydrogenase gene cause D-2-hydroxyglutaric aciduria.

  2005cited by this paper
• Development of β-Lapachone Prodrugs for Therapy Against Human Cancer Cells with Elevated NAD(P)H:Quinone Oxidoreductase 1 Levels

  2005cited by this paper
• Measurement of urinary D- and L-2-hydroxyglutarate enantiomers by stable-isotope-dilution liquid chromatography-tandem mass spectrometry after derivatization with diacetyl-L-tartaric anhydride.

  2004cited by this paper
• A gene encoding a putative FAD-dependent L-2-hydroxyglutarate dehydrogenase is mutated in L-2-hydroxyglutaric aciduria.

  2004cited by this paper
• Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer

  2002cited by this paper
• Gene mutations in the succinate dehydrogenase subunit SDHB cause susceptibility to familial pheochromocytoma and to familial paraganglioma.

  2001cited by this paper
• Mutations in SDHD, a mitochondrial complex II gene, in hereditary paraganglioma.

  2000cited by this paper
• Chiral liquid chromatography tandem mass spectrometry in the determination of the configuration of 2-hydroxyglutaric acid in urine.

  2000cited by this paper
• Mutations in SDHC cause autosomal dominant paraganglioma, type 3

  2000cited by this paper
• Stable-Isotope Dilution Analysis of D- and L-2-Hydroxyglutaric Acid: Application to the Detection and Prenatal Diagnosis of D- and L-2-Hydroxyglutaric Acidemias

  1993cited by this paper
• Fumarase deficiency is an autosomal recessive encephalopathy affecting both the mitochondrial and the cytosolic enzymes

  1990cited by this paper
• [Origin of cancer cells].

  1956cited by this paper
• On the origin of cancer cells.

  1956cited by this paper

• The Use of Mass Spectrometry in Preclinical and Clinical Studies in Oncology: a Mini Review

  2026cites this paper
• Multifunctional nanozymes based on MoS₂ for synergistic catalytic activity and cancer photothermal therapy.

  2025cites this paper
• Mitochondrial, metabolic and bioenergetic adaptations drive plasticity of colorectal cancer cells and shape their chemosensitivity

  2025cites this paper
• Tumour-resident oncolytic bacteria trigger potent anticancer effects through selective intratumoural thrombosis and necrosis

  2025cites this paper
• Tricarboxylic Acid Cycle Relationships with Non-Metabolic Processes: A Short Story with DNA Repair and Its Consequences on Cancer Therapy Resistance

  2024cites this paper
• Malate dehydrogenase (MDH) in cancer: a promiscuous enzyme, a redox regulator, and a metabolic co-conspirator.

  2024cites this paper
• Elevated Plasma Concentration of 4-Pyridone-3-carboxamide-1-β-D-ribonucleoside (4PYR) Highlights Malignancy of Renal Cell Carcinoma

  2024cites this paper
• The prowess of metabolomics in cancer research: current trends, challenges and future perspectives

  2024cites this paper
• Emerging Biomarkers in Metabolomics: Advancements in Precision Health and Disease Diagnosis

  2024cites this paper
• Ecosystemic Approach to Understanding Gut Microbiome–Mediated Prevention of Colorectal Cancer

  2024cites this paper
• Obesity-Associated Colorectal Cancer

  2024cites this paper
• A critical appraisal of the relative contribution of tissue architecture, genetics, epigenetics and cell metabolism to carcinogenesis.

  2023cites this paper
• DNA damage-induced senescence is associated with metabolomic reprogramming in breast cancer cells.

  2023cites this paper
• Detection, mechanisms, and therapeutic implications of oncometabolites.

  2023cites this paper
• Tolerable treatment of glioblastoma with redox-cycling ‘mitocans': a comparative study in vivo

  2023cites this paper
• Redox-Cycling “Mitocans” as Effective New Developments in Anticancer Therapy

  2023cites this paper
• Drp1 Regulated Mitochondrial Hypofission Promotes the Invasion and Proliferation of Growth Hormone-Secreting Pituitary Adenomas via Activating STAT3

  2022cites this paper
• Aberrant L-Fucose accumulation and increased core fucosylation are metabolic liabilities in mesenchymal glioblastoma.

  2022cites this paper
• Epigenetic Reprogramming of the Glucose Metabolic Pathways by the Chromatin Effectors During Cancer.

  2022cites this paper
• Warburg-like metabolic transformation underlies neuronal degeneration in sporadic Alzheimer’s disease

  2022cites this paper
• The role of glycolysis and lactate in the induction of tumor-associated macrophages immunosuppressive phenotype.

  2022cites this paper
• Turning around Cycles: An Approach Based on Selected Problems/Cases to Stimulate Collaborative Learning about Krebs and His Four Metabolic Cycles

  2022cites this paper
• Subchronic Graphene Exposure Reshapes Skin Cell Metabolism

  2022cites this paper
• 4-Pyridone-3-carboxamide-1-β-D-ribonucleoside (4PYR)—A Novel Oncometabolite Modulating Cancer-Endothelial Interactions in Breast Cancer Metastasis

  2022cites this paper
• Clinical and biochemical footprints of inherited metabolic diseases. VIII. Neoplasias.

  2022cites this paper
• Role of NMR Metabolomics and MR Imaging in Colon Cancer

  2021cites this paper
• Metabolic Strategies for Inhibiting Cancer Development.

  2021cites this paper
• Stem Cell Impairment at the Host-Microbiota Interface in Colorectal Cancer

  2021cites this paper
• GlcNAc is a mast-cell chromatin-remodeling oncometabolite that promotes systemic mastocytosis aggressiveness.

  2021cites this paper
• Metabolic Rewiring and the Characterization of Oncometabolites

  2021cites this paper
• A Phase I Dose-Escalation and Expansion Study of Telaglenastat in Patients with Advanced or Metastatic Solid Tumors

  2021cites this paper
• Resectable Colorectal Cancer: Current Perceptions on the Correlation of Recurrence Risk, Microbiota and Detection of Genetic Mutations in Liquid Biopsies

  2021cites this paper
• Chromatographic methods coupled to mass spectrometry for the determination of oncometabolites in biological samples-A review.

  2021cites this paper
• Subclinical cardiac damage in cancer patients before chemotherapy

  2021cites this paper
• New Insights into Metabolic Regulation from Hyperpolarized 13C MRS/MRI Studies

  2021cites this paper
• Metabolic control of cancer progression as novel targets for therapy.

  2021cites this paper
• Signals from the Circle: Tricarboxylic Acid Cycle Intermediates as Myometabokines

  2021cites this paper
• D-2-Hydroxyglutarate in Glioma Biology

  2021cites this paper
• Integrative Analysis of Metabolomics and Transcriptomics Data Identifies Prognostic Biomarkers Associated With Oral Squamous Cell Carcinoma

  2021cites this paper
• Tripterygium hypoglaucum (Lévl.) Hutch and Its Main Bioactive Components: Recent Advances in Pharmacological Activity, Pharmacokinetics and Potential Toxicity

  2021cites this paper
• Unraveling Autocrine Signaling Pathways through Metabolic Fingerprinting in Serous Ovarian Cancer Cells

  2021cites this paper
• Association of fetuin-A with the pathogenesis of metabolic diseases

  2020cites this paper
• Targeting Tumor Metabolism to Overcome Radioresistance

  2020cites this paper
• Regulation of succinate dehydrogenase and role of succinate in cancer.

  2020cites this paper
• Metabolic regulation of prostate cancer heterogeneity and plasticity.

  2020cites this paper
• TNFAIP8 drives metabolic reprogramming to promote prostate cancer cell proliferation.

  2020cites this paper
• Closed fumarase C active‐site structures reveal SS Loop residue contribution in catalysis

  2020cites this paper
• Selective Targeting of Cancerous Mitochondria and Suppression of Tumor Growth Using Redox-Active Treatment Adjuvant

  2020cites this paper
• A general 11C-labeling approach enabled by fluoride-mediated desilylation of organosilanes

  2020cites this paper
• Metabolite Sensing GPCRs: Promising Therapeutic Targets for Cancer Treatment?

  2020cites this paper
• Rare Tumor-Normal Matched Whole Exome Sequencing Identifies Novel Genomic Pathogenic Germline and Somatic Aberrations

  2020cites this paper
• Crucial Functions of the JMJD1/KDM3 Epigenetic Regulators in Cancer

  2020cites this paper
• Human Prostate Cancer Is Characterized by an Increase in Urea Cycle Metabolites

  2020cites this paper
• Immunometabolism in Arthropod Vectors: Redefining Interspecies Relationships.

  2020cites this paper
• Targeting the Mitochondrial Metabolic Network: A Promising Strategy in Cancer Treatment

  2020cites this paper
• Quantitative analysis of 2-hydroxyglutarate as a controversial oncometabolite in malignant gliomas.

  2020influential citation
• Metabolic Reprogramming is a Hallmark of Metabolism Itself

  2020cites this paper
• Human 2-oxoglutarate-dependent oxygenases: nutrient sensors, stress responders, and disease mediators

  2020cites this paper
• Menadione/Ascorbate Induces Overproduction of Mitochondrial Superoxide and Impairs Mitochondrial Function in Cancer: Comparative Study on Cancer and Normal Cells of the Same Origin

  2020cites this paper
• Microbiome in Colorectal Cancer: How to Get from Meta-omics to Mechanism?

  2020cites this paper
• Ovarian Cancer Biomarkers: Moving Forward in Early Detection.

  2020cites this paper
• Bioenergetics and translational metabolism: implications for genetics, physiology and precision medicine

  2019cites this paper
• Metabolic Dysregulations and Epigenetics: A Bidirectional Interplay that Drives Tumor Progression

  2019cites this paper
• Untangling the Metabolic Reprogramming in Brain Cancer: Discovering Key Molecular Players Using Mass Spectrometry.

  2019cites this paper
• HSP90 Molecular Chaperones, Metabolic Rewiring, and Epigenetics: Impact on Tumor Progression and Perspective for Anticancer Therapy

  2019cites this paper
• The small members of the JMJD protein family: Enzymatic jewels or jinxes?

  2019cites this paper
• Oncometabolites in cancer aggressiveness and tumour repopulation

  2019cites this paper
• Energy Metabolism and Metabolic Targeting of Neuroblastoma

  2019cites this paper
• Challenges and Opportunities in Cancer Metabolomics

  2019cites this paper
• Bioorthogonal oncometabolite ligation.

  2019cites this paper
• Oncometabolites as biomarkers in thyroid cancer: a systematic review

  2019cites this paper
• Novel methods in adrenal research: a metabolomics approach

  2019cites this paper
• Targeting the insulin-like growth factor-1 receptor in MTAP-deficient renal cell carcinoma

  2019cites this paper
• mTORC1 as a Regulator of Mitochondrial Functions and a Therapeutic Target in Cancer

  2019cites this paper
• Adapt and conquer: Metabolic flexibility in cancer growth, invasion and evasion

  2019cites this paper
• Oncometabolites in renal cancer

  2019cites this paper
• 1H NMR-Based Metabolomics Reveals the Antitumor Mechanisms of Triptolide in BALB/c Mice Bearing CT26 Tumors

  2019cites this paper
• Drugging cancer metabolism: Expectations vs. reality.

  2019cites this paper
• Interconnexion du métabolisme cellulaire et de la voie de glucuronidation

  2018cites this paper
• Differential effects of graphene materials on the metabolism and function of human skin cells.

  2018cites this paper
• Inborn-like errors of metabolism are determinants of breast cancer risk, clinical response and survival: a study of human biochemical individuality

  2018cites this paper
• Deciphering the role of human arylamine N-acetyltransferase 1 (NAT1) in breast cancer cell metabolism using a systems biology approach.

  2018cites this paper
• Serum metabolomic profiles associated with postmenopausal hormone use

  2018cites this paper