EGFR-RAS-MAPK signaling is confined to the plasma membrane and associated endorecycling protrusions

Ras GTPases are key membrane-associated elements of the EGFR-MAPK signaling pathway. Surve et al. demonstrate that endogenous KRAS and NRAS are predominantly localized to the plasma membrane and its tubular shaped protrusions and show that a small pool of surface EGFRs sustain signaling along the RAS-MAPK pathway, whereas internalized EGFRs do not significantly contribute to MAPK activity.

• Publication year

  2021

• Venue

  Journal of Cell Biology

• Publication date

  2021-09-13

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1083/jcb.202107103PMID 34515735PMCID 8563293
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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