Mitochondrial dysfunction and Parkinson’s disease genes: insights from Drosophila

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Disease Models & Mechanisms

• Publication date

  2009-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1242/dmm.003178PMID 19553694
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The PINK1-Parkin pathway is involved in the regulation of mitochondrial remodeling process.

  2009cited by this paper
• Identification of a Novel Zn2+-binding Domain in the Autosomal Recessive Juvenile Parkinson-related E3 Ligase Parkin*

  2009cited by this paper
• Drosophila HtrA2 is dispensable for apoptosis but acts downstream of PINK1 independently from Parkin

  2009cited by this paper
• Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery

  2008cited by this paper
• The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila

  2008influential reference
• Mitochondrial association of alpha-synuclein causes oxidative stress

  2008cited by this paper
• Mitochondrial Import and Accumulation of α-Synuclein Impair Complex I in Human Dopaminergic Neuronal Cultures and Parkinson Disease Brain*

  2008cited by this paper
• A Drosophila model for LRRK2-linked parkinsonism

  2008cited by this paper
• PINK1 Is Necessary for Long Term Survival and Mitochondrial Function in Human Dopaminergic Neurons

  2008cited by this paper
• Loss-of-Function Analysis Suggests That Omi/HtrA2 Is Not an Essential Component of the pink1/parkin Pathway In Vivo

  2008cited by this paper
• The PINK1/Parkin pathway regulates mitochondrial morphology

  2008cited by this paper
• PINK1 controls mitochondrial localization of Parkin through direct phosphorylation.

  2008cited by this paper
• Drosophila DJ-1 mutants are sensitive to oxidative stress and show reduced lifespan and motor deficits.

  2007cited by this paper
• Loss of LRRK2/PARK8 induces degeneration of dopaminergic neurons in Drosophila.

  2007cited by this paper
• Loss-of-Function of Human PINK1 Results in Mitochondrial Pathology and Can Be Rescued by Parkin

  2007cited by this paper
• Mono- and double-mutant mouse models of Parkinson's disease display severe mitochondrial damage.

  2007cited by this paper
• Normal mitochondrial dynamics requires rhomboid-7 and affects Drosophila lifespan and neuronal function.

  2006cited by this paper
• Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin

  2006cited by this paper
• Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase

  2006cited by this paper
• Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin

  2006cited by this paper
• Parkinson's disease alpha-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death.

  2006cited by this paper
• Mitochondrial fusion and fission in mammals.

  2006cited by this paper
• Parkinson's Disease α-Synuclein Transgenic Mice Develop Neuronal Mitochondrial Degeneration and Cell Death

  2006cited by this paper
• Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin.

  2006influential reference
• Parkin negatively regulates JNK pathway in the dopaminergic neurons of Drosophila.

  2005cited by this paper
• Drosophila DJ-1 mutants are selectively sensitive to environmental toxins associated with Parkinson's disease.

  2005cited by this paper
• Molecular pathophysiology of Parkinson's disease.

  2005cited by this paper
• Synaptic mitochondria are critical for mobilization of reserve pool vesicles at Drosophila neuromuscular junctions.

  2005cited by this paper
• Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling.

  2005cited by this paper
• Roles of Drosophila DJ-1 in survival of dopaminergic neurons and oxidative stress.

  2005cited by this paper
• Drosophila DJ-1 mutants show oxidative stress-sensitive locomotive dysfunction.

  2005cited by this paper
• Enhanced substantia nigra mitochondrial pathology in human alpha-synuclein transgenic mice after treatment with MPTP.

  2004cited by this paper
• The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization

  2004cited by this paper
• Aggresomes formed by alpha-synuclein and synphilin-1 are cytoprotective.

  2004cited by this paper
• Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease.

  2004cited by this paper
• Aggresomes Formed by α-Synuclein and Synphilin-1 Are Cytoprotective*

  2004cited by this paper
• Enhanced substantia nigra mitochondrial pathology in human α-synuclein transgenic mice after treatment with MPTP111-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

  2004cited by this paper
• Drosophila parkin mutants have decreased mass and cell size and increased sensitivity to oxygen radical stress

  2004cited by this paper
• Hereditary Early-Onset Parkinson's Disease Caused by Mutations in PINK1

  2004cited by this paper
• Aggresomes protect cells by enhancing the degradation of toxic polyglutamine-containing protein.

  2003cited by this paper
• Targeted gene expression in Drosophila dopaminergic cells using regulatory sequences from tyrosine hydroxylase.

  2003cited by this paper
• The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress.

  2003influential reference
• Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants

  2003cited by this paper
• Mutations in the DJ-1 Gene Associated with Autosomal Recessive Early-Onset Parkinsonism

  2002cited by this paper
• Impairment of the ubiquitin-proteasome system by protein aggregation.

  2001cited by this paper
• A Drosophila model of Parkinson's disease

  2000cited by this paper
• Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

  1998cited by this paper
• Parkinson's disease. First of two parts.

  1998cited by this paper
• Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease

  1997cited by this paper
• Mutation in the alpha-synuclein gene identified in families with Parkinson's disease.

  1997cited by this paper
• Rhomboid-7 and HtrA 2 / Omi act in a common pathway with the Parkinson ’ s disease factors Pink 1 and Parkin

  year unknowncited by this paper

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  2022cites this paper
• A Comprehensive Study of miRNAs in Parkinson's Disease: Diagnostics and Therapeutic Approaches.

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• Age-related tolerance to paraquat-induced parkinsonism in Drosophila melanogaster.

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• Invertebrate Models Untangle the Mechanism of Neurodegeneration in Parkinson’s Disease

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• Drosophila melanogaster (Meigen, 1830): A Potential Model for Human Diseases

  2021cites this paper
• Genes critical for development and differentiation of dopaminergic neurons are downregulated in Parkinson’s disease

  2020cites this paper
• Gene Prioritization in Parkinson's Disease Using Human Protein-Protein Interaction Network

  2020cites this paper
• Elevating bioavailable iron levels in mitochondria suppresses the defective phenotypes caused by PINK1 loss-of-function in Drosophila melanogaster.

  2020cites this paper
• CaV1.3 L-Type Calcium Channels Increase the Vulnerability of Substantia Nigra Dopaminergic Neurons in MPTP Mouse Model of Parkinson’s Disease

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  2019cites this paper
• Oxidative Stress in Parkinson's Disease

  2018cites this paper
• Interplay between mitochondrial dysfunction and epigenetic alterations in environmental linked Parkinson's Disease

  2018cites this paper
• Activating Autophagy as a Therapeutic Strategy for Parkinson’s Disease

  2018cites this paper
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  2017cites this paper
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  2016cites this paper
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  2013cites this paper
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  2012influential citation
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