Stereochemical characterisation of the non-canonical α-humulene synthase from Acremonium strictum.

The non-canonical fungal α-humulene synthase was investigated through isotopic labelling experiments for its stereochemical course regarding inversion or retention at C-1, the face selectivity at C-11, and the stereoselectivity of the final deprotonation. A new and convenient desymmetrisation strategy was developed to enable a full stereochemical analysis of the catalysed steps to the achiral α-humulene product from stereoselectively labelled farnesyl diphosphate.

• Publication year

  2021

• Venue

  Organic and biomolecular chemistry

• Publication date

  2021-09-17

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1039/d1ob01769aPMID 34533184
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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