İnterlökin-33 Düzeylerinin Erken veya Acil Safra Drenajı Gerektiren Akut Kolanjitli Hastalarda Tanısal Kullanımı

Objective: Treatment of cholangitis is life-saving in patients with severe acute cholangitis (AC). We aimed to investigate usefulness of interleukin-33 (IL-33) to discriminate need of early or urgent biliary drainage in patients with acute cholangitis according to Tokyo Guidelines 2018 (TG18) grading system. Material and Methods: The study population consisted of a total of 79 subjects (48 AC and 31 healthy controls). Patients with AC were categorized based on TG18, and the IL-33 levels and laboratory markers were measured. Results: IL-33 level was significantly higher in the AC group (p <0.0001). ROC curve analysis was performed to distinguish patients with AC from normal healthy patients and to determine a cutoff value for IL-33. As a result of this analysis, the cut-off value for serum IL-33 was 0.59 pg / mL (sensitivity: 83.3% (95% CI: 69.8-92.5), specificity: 90.3% (95% CI: 74.2-98.0)) and the area under the ROC curve (AUC) was found to be 0.902 (p <0.0001; 95% CI: 0.814-0.957). The median IL-33 level was significantly higher in patients who needed early/emergency biliary drainage (moderate or severe AC) compared to patients with mild AC (0.79 vs 0.60, p = 0.01). Conclusion: This study showed that IL-33 increased significantly in patients with moderate/severe AC who need immediate biliary drainage.

• Publication year

  2021

• Venue

  Akdeniz Medical Journal

• Publication date

  2021-07-12

• Fields of study

  Not labeled

• Identifiers
  DOI 10.53394/AKD.959931
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• [Research progress on the role of IL-33/ST2 axis in pathogenesis of allergic rhinitis].

  2019cited by this paper
• Tokyo Guidelines 2018: diagnostic criteria and severity grading of acute cholangitis (with videos)

  2018influential reference
• Early biliary drainage is associated with favourable outcomes in critically-ill patients with acute cholangitis

  2018influential reference
• Tokyo Guidelines 2018: updated Tokyo Guidelines for the management of acute cholangitis/acute cholecystitis

  2018influential reference
• Tokyo Guidelines 2018: initial management of acute biliary infection and flowchart for acute cholangitis

  2018cited by this paper
• Endoscopic management of acute cholangitis according to the TG13

  2017cited by this paper
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  2017cited by this paper
• Role of the IL-33-ST2 axis in sepsis

  2017cited by this paper
• The immunoprotective activity of interleukin-33 in mouse model of cecal ligation and puncture-induced sepsis.

  2016cited by this paper
• Role of Presepsin for the Assessment of Acute Cholangitis Severity.

  2016cited by this paper
• Diagnostic Value of Upar, IL-33, and ST2 Levels in Childhood Sepsis.

  2016influential reference
• Delayed endoscopic retrograde cholangiopancreatography is associated with persistent organ failure in hospitalised patients with acute cholangitis

  2015influential reference
• Soluble ST2 Has a Prognostic Role in Patients With Suspected Sepsis

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  2015influential reference
• Procalcitonin as a useful biomarker for determining the need to perform emergency biliary drainage in cases of acute cholangitis

  2014influential reference
• TG13: Updated Tokyo Guidelines for the management of acute cholangitis and cholecystitis

  2013cited by this paper
• Soluble ST2 plasma concentrations predict mortality in severe sepsis

  2010cited by this paper
• Disease-associated functions of IL-33: the new kid in the IL-1 family

  2010influential reference
• Interleukin-33 attenuates sepsis by enhancing neutrophil influx to the site of infection

  2010cited by this paper
• Interleukin-33 - cytokine of dual function or novel alarmin?

  2009influential reference
• The IL-1-like cytokine IL-33 is inactivated after maturation by caspase-1

  2009influential reference
• Background: Tokyo Guidelines for the management of acute cholangitis and cholecystitis

  2007influential reference
• IL-1 receptor accessory protein is essential for IL-33-induced activation of T lymphocytes and mast cells

  2007influential reference
• IL-1 Receptor Accessory Protein and ST2 Comprise the IL-33 Receptor Complex

  2007influential reference
• Predictors for emergency biliary decompression in acute cholangitis.

  2006cited by this paper
• IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines.

  2005influential reference
• Endoscopic Biliary Drainage by Nasobiliary Drain or by Stent Placement in Patients with Acute Cholangitis

  2005cited by this paper
• Increased levels of soluble ST2 protein and IgG1 production in patients with sepsis and trauma

  2004cited by this paper
• Endoscopic drainage aborts endotoxaemia in acute cholangitis

  1996influential reference

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