The Cancer Genome Atlas Predicts the Prognosis of Lung Carcinoma Based on Genes Associated with m6A Methylation

Lung cancer has become a predominant cause of death in relation with carcinoma worldwide. N6-methylladenosine (m6A) is a common mRNA that is internally modified, which has a pivotal role in mRNA splicing, outputting, localizing, and translating and in identifying stable features. This study evaluated the expression pattern and prognostic value of m6A-related genes in lung cancer. Expression data of lung cancer samples with related clinical information were obtained from The Cancer Genome Atlas (TCGA). Then, R software was used in combination with several corresponding software packages to identify the regulatory factors of m6A RNA methylation with differential expression. Three genes (METTL3, YTHDF1, and FTO) were overexpressed in lung cancer. METTL3 had a low survival rate (P < 0.05). Significant differences in survival rate were observed among the subgroups, which possessed differently expressed m6A levels. Two latent predicting factors (METTL3 and KIAA1429) that met the independent predictive values were selected. M6A RNA methylation modulators may be involved with the malignant progression of lung cancer, and the two selected risk characteristics of m6A RNA methylation regulators may be a potential prognostic biological marker for guiding customized therapies in patients with lung carcinoma.

• Publication year

  2021

• Venue

  Unknown venue

• Publication date

  2021-07-10

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.21203/RS.3.RS-688141/V1
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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