Pathogenic CD4+ T cells recognizing an unstable peptide of insulin are directly recruited into islets bypassing local lymph nodes

A diabetogenic, insulin-reactive TCR transgenic mouse shows that CD4+ T cells that escape negative selection are directly recruited to islets, bypassing initial priming in pancreatic LNs, and also induce antiinsulin antibodies.

• Publication year

  2013

• Venue

  Journal of Experimental Medicine

• Publication date

  2013-10-21

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1084/jem.20130582PMID 24127484PMCID 3804950
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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