Retinal pigment epithelial cells play a central role in the conservation of docosahexaenoic acid by photoreceptor cells after shedding and phagocytosis.

No abstract is available for this paper.

• Publication year

  1992

• Venue

  Current Eye Research

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.3109/02713689209069169PMID 1532774
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Rapid and selective uptake, metabolism, and cellular distribution of docosahexaenoic acid among rod and cone photoreceptor cells in the frog retina

  1991cited by this paper
• Quantitative analysis of fatty acids in phospholipids, diacylglycerols, free fatty acids, and other lipids.

  1990cited by this paper
• Preferential uptake and metabolism of docosahexaenoic acid in membrane phospholipids from rod and cone photoreceptor cells of human and monkey retinas

  1990cited by this paper
• Docosahexaenoic acid utilization during rod photoreceptor cell renewal

  1990cited by this paper
• Membrane docosahexaenoate is supplied to the developing brain and retina by the liver.

  1989cited by this paper
• Fatty acid composition of bovine rod outer segment plasma membrane.

  1989cited by this paper
• Biochemical and functional effects of prenatal and postnatal omega 3 fatty acid deficiency on retina and brain in rhesus monkeys.

  1986cited by this paper
• DIETARY OMEGA‐3 FATTY ACID DEFICIENCY AND VISUAL LOSS IN INFANT RHESUS MONKEYS

  1985cited by this paper
• Retinal photoreceptor-pigment epithelium interactions. Friedenwald lecture.

  1985cited by this paper
• Endogenous fatty acids are covalently and noncovalently bound to interphotoreceptor retinoid-binding protein in the monkey retina.

  1985cited by this paper
• Dietary omega-3 fatty acid deficiency and visual loss in infant rhesus monkeys.

  1984cited by this paper
• Chemistry and metabolism of lipids in the vertebrate retina.

  1983cited by this paper
• Molecular species of phosphatidylcholine, -ethanolamine, -serine, and -inositol in microsomal and photoreceptor membranes of bovine retina.

  1983cited by this paper
• Dietary requirements and functions of alpha-linolenic acid in animals.

  1982cited by this paper
• Dietary requirements and functions of α-linolenic acid in animals

  1982cited by this paper
• Composition and biosynthesis of molecular species of retina phosphoglycerides.

  1980cited by this paper
• A possible essential role for dietary linolenic acid in the development of the young rat.

  1976cited by this paper
• Visual membranes: specificity of fatty acid precursors for the electrical response to illumination.

  1975cited by this paper
• RENEWAL OF FATTY ACIDS IN THE MEMBRANES OF VISUAL CELL OUTER SEGMENTS

  1974cited by this paper
• Phospholipids and acyl groups of synaptosomal and myelin membranes isolated from the cerebral cortex of squirrel monkey (Saimiri sciureus).

  1972cited by this paper
• Effect of essential fatty acid deficiency on the fatty acid composition, morphology, and electroretinographic response of the retina.

  1971cited by this paper
• Two dimensional then layer chromatographic separation of polar lipids and determination of phospholipids by phosphorus analysis of spots.

  1970cited by this paper
• Lipid composition of synaptic plasma membranes isolated from rat brain by zonal centrifugation.

  1969cited by this paper

• Probing Deposit-Driven Age-Related Macular Degeneration Via Thicknesses of Outer Retinal Bands and Choroid: ALSTAR2 Baseline

  2024cites this paper
• Restoring retinal polyunsaturated fatty acid balance and retina function by targeting ceramide in AdipoR1-deficient mice

  2024cites this paper
• Screening and evaluation of antioxidants for retinal pigment epithelial cell protection: L-ergothioneine as a novel therapeutic candidate through NRF2 activation.

  2024cites this paper
• Rod-specific downregulation of omega-3 very-long-chain polyunsaturated fatty acid pathway in age-related macular degeneration.

  2023cites this paper
• The resolution of phagosomes

  2023cites this paper
• Long chain acyl‐CoA synthetase 6 facilitates the local distribution of di‐docosahexaenoic acid‐ and ultra‐long‐chain‐PUFA‐containing phospholipids in the retina to support normal visual function in mice

  2023cites this paper
• New Retinal Pigment Epithelial Cell Model to Unravel Neuroprotection Sensors of Neurodegeneration in Retinal Disease

  2022cites this paper
• Malondialdehyde-Modified Photoreceptor Outer Segments Promote Choroidal Neovascularization in Mice

  2022cites this paper
• Dysfunctional peroxisomal lipid metabolisms and their ocular manifestations

  2022cites this paper
• Dynamic lipid turnover in photoreceptors and retinal pigment epithelium throughout life.

  2021cites this paper
• Genetic interaction between Mfrp and Adipor1 mutations affect retinal disease phenotypes.

  2021cites this paper
• Overview of how N32 and N34 elovanoids sustain sight by protecting retinal pigment epithelial cells and photoreceptors

  2021cites this paper
• Fatty acid oxidation and photoreceptor metabolic needs Thematic Review Series: Seeing 2020: Lipids and Lipid-Soluble Molecules in the Eye

  2021cites this paper
• Metabolism in Retinopathy of Prematurity

  2021cites this paper
• Genetic Interaction between Mfrp and Adipor1 Mutations Affect Retinal Disease Phenotypes

  2021cites this paper
• Phagocytosis by the Retinal Pigment Epithelium: Recognition, Resolution, Recycling

  2020cites this paper
• Overview of how N32 and N34 elovanoids sustain sight by protecting retinal pigment epithelial cells and photoreceptors.

  2020cites this paper
• MTOR‐initiated metabolic switch and degeneration in the retinal pigment epithelium

  2020cites this paper
• Fatty acid oxidation and photoreceptor metabolic needs

  2020cites this paper
• Therapeutic Benefits from Nanoparticles: The Potential Significance of Nanoscience in Retinal Degenerative Diseases.

  2019cites this paper
• Repeat exposure to polyinosinic:polycytidylic acid induces TLR3 expression via JAK-STAT signaling and synergistically potentiates NFκB-RelA signaling in ARPE-19 cells.

  2019cites this paper
• Docosanoids and elovanoids from omega-3 fatty acids are pro-homeostatic modulators of inflammatory responses, cell damage and neuroprotection.

  2018cites this paper
• Regulated efflux of photoreceptor outer segment‐derived cholesterol by human RPE cells

  2017cites this paper
• Phagocytosis-dependent ketogenesis in retinal pigment epithelium

  2017cites this paper
• Pericellular interphotoreceptor matrix dictates outer retina critical surface tension

  2017cites this paper
• Laminin modification subretinal bio-scaffold remodels retinal pigment epithelium-driven microenvironment in vitro and in vivo

  2016cites this paper
• Adiponectin receptor 1 conserves docosahexaenoic acid and promotes photoreceptor cell survival

  2015cites this paper
• Sirtuin 1 regulates lipid metabolism associated with optic nerve regeneration.

  2015cites this paper
• Corrigendum: Adiponectin receptor 1 conserves docosahexaenoic acid and promotes photoreceptor cell survival

  2015cites this paper
• Primary cilia and dendritic spines: Different but similar signaling compartments

  2013cites this paper
• Dietary &ohgr;-3 Deficiency and IOP Insult Are Additive Risk Factors for Ganglion Cell Dysfunction

  2013cites this paper
• Mediator Lipidomics in Ophthalmology: Targets for Modulation in Inflammation, Neuroprotection and Nerve Regeneration

  2013cites this paper
• Dietary docosahexaenoic acid supplementation prevents age-related functional losses and A2E accumulation in the retina.

  2012cites this paper
• Screening for MicroRNA Regulators of an Orphan Cytochrome P450 4V2 (CYP4V2)

  2012cites this paper
• Screening for MicroRNA Regulators of an Orphan Cytochrome P 450 4 V 2 ( CYP 4 V 2 )

  2012cites this paper
• RPE barrier breakdown in diabetic retinopathy: seeing is believing

  2011cites this paper
• Significance of outer blood-retina barrier breakdown in diabetes and ischemia.

  2011cites this paper
• Docosahexaenoic acid signalolipidomics in nutrition: significance in aging, neuroinflammation, macular degeneration, Alzheimer's, and other neurodegenerative diseases.

  2011influential citation
• Long-chain and very long-chain polyunsaturated fatty acids in ocular aging and age-related macular degeneration

  2010cites this paper
• A Hapten Generated from an Oxidation Fragment of Docosahexaenoic Acid Is Sufficient to Initiate Age-Related Macular Degeneration

  2010cites this paper
• Reticular pseudodrusen are subretinal drusenoid deposits.

  2010cites this paper
• Omega-3 fatty acid docosahexaenoic acid is the precursor of neuroprotectin D1 in the nervous system.

  2009cites this paper
• Photoreceptor—RPE Interactions

  2008cites this paper
• Peroxidized docosahexaenoic acid causes RPE dysfunction: implications for retinal ageing and AMD

  2008cites this paper
• Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.

  2007influential citation
• The Onset of Brain Injury and Neurodegeneration Triggers the Synthesis of Docosanoid Neuroprotective Signaling

  2006cites this paper
• Survival signaling in retinal pigment epithelial cells in response to oxidative stress: significance in retinal degenerations.

  2006cites this paper
• Docosahexaenoic acid and neurologic development in animals.

  2006cites this paper
• Abnormal plasma lipids of patients withRetinitis pigmentosa

  2006cites this paper
• Timely Topics in Nutrition

  2006influential citation
• Brain Response to Injury and Neurodegeneration

  2005cites this paper
• Brain response to injury and neurodegeneration: endogenous neuroprotective signaling.

  2005cites this paper
• Lipid signaling in neural plasticity, brain repair, and neuroprotection

  2005cites this paper
• Enrichment of canine gestation and lactation diets with n-3 polyunsaturated fatty acids to support neurologic development

  2005influential citation
• The retinal pigment epithelium in visual function.

  2005cites this paper
• Neuroprotectin D1 (NPD1): A DHA‐Derived Mediator that Protects Brain and Retina Against Cell Injury‐Induced Oxidative Stress

  2005cites this paper
• Neuroprotectin D1: a docosahexaenoic acid-derived docosatriene protects human retinal pigment epithelial cells from oxidative stress.

  2004cites this paper
• Synaptic lipid signaling Published, JLR Papers in Press, September 16, 2003. DOI 10.1194/jlr.R300013-JLR200

  2003cites this paper
• Retinal docosahexaenoic acid, age-related diseases, and glaucoma

  2003cites this paper
• Retinal pigment epithelial acid lipase activity and lipoprotein receptors: effects of dietary omega-3 fatty acids.

  2002cites this paper
• Ca2+-channels in the RPE.

  2002cites this paper
• Brain astrocyte synthesis of docosahexaenoic acid from n-3 fatty acids is limited at the elongation of docosapentaenoic acid DOI 10.1194/jlr.M200120-JLR200

  2002cites this paper
• Recent Advances in the Supply of Docosahexaenoic Acid to the Nervous System

  2001cites this paper
• The essentiality of long chain n-3 fatty acids in relation to development and function of the brain and retina.

  2001cites this paper
• Phospholipid incorporation and metabolic conversion of n‐3 polyunsaturated fatty acids in the Y79 retinoblastoma cell line

  2000cites this paper
• Uptake and Incorporation of Docosahexaenoic Acid (DHA) into Neuronal Cell Body and Neurite/Nerve Growth Cone Lipids: Evidence of Compartmental DHA Metabolism in Nerve Growth Factor-Differentiated PC12 Cells

  2000cites this paper
• Strong Association of Unesterified [3H]Docosahexaenoic Acid and [3H-Docosahexaenoyl]Phosphatidate to Rhodopsin During In Vivo Labeling of Frog Retinal Rod Outer Segments

  2000cites this paper
• Selective retinal pigment epithelial cell lipid metabolism and remodeling conserves photoreceptor docosahexaenoic acid following phagocytosis

  1999cites this paper
• Automated quantification of keratocyte density by using confocal microscopy in vivo.

  1999cites this paper
• Synthesis and release of docosahexaenoic acid by the RPE cells of prcd-affected dogs.

  1999cites this paper
• Effects of dietary n-3 fatty acid deficiency and repletion in the guinea pig retina.

  1999cites this paper
• The Royal College of Surgeons Rat: An Animal Model for Inherited Retinal Degeneration with a Still Unknown Genetic Defect

  1998cites this paper
• Effect of diet on the fatty acid and molecular species composition of dog retina phospholipids

  1998cites this paper
• Nutrition supplements and the eye

  1998cites this paper
• Expression of hematopoietic cell markers by retinal pigment epithelial cells.

  1997cites this paper
• Diets enriched in docosahexaenoic acid fail to correct progressive rod-cone degeneration (prcd) phenotype.

  1997cites this paper
• Lipocalin-Type Prostaglandin D Synthase (β-Trace) Is Located in Pigment Epithelial Cells of Rat Retina and Accumulates within Interphotoreceptor Matrix

  1996cites this paper
• Effect of dietary fat and environmental lighting on the phospholipid molecular species of rat photoreceptor membranes.

  1995cites this paper
• Differential transport of docosahexaenoate and palmitate through the blood-retina and blood-brain barrier of the rat.

  1994cites this paper
• Diurnal change and prolonged dark effect on myeloid bodies in the retinal pigment epithelium of the leopard frog.

  1994cites this paper
• Evaluation of oxidative processes in human pigment epithelial cells associated with retinal outer segment phagocytosis.

  1994cites this paper
• Effect of dietary N-3 fatty acids upon the phospholipid molecular species of the monkey retina.

  1994cites this paper
• Review: Pharmacological Manipulation of Docosahexaenoic-Phospholipid Biosynthesis in Photoreceptor Cells: Implications in Retinal Degeneration

  1994cites this paper
• Pathways for the uptake and conservation of docosahexaenoic acid in photoreceptors and synapses: biochemical and autoradiographic studies.

  1993cites this paper
• Systemic Alterations in Docosahexaenoic Acid Metabolism in Inherited Retinal Degenerations

  1993cites this paper
• Effect of photoreceptor outer segment disk shedding on myeloid body formation in the retinal pigment epithelium of the leopard frog.

  1993cites this paper
• Differential incorporation of docosahexaenoic and arachidonic acids in frog retinal pigment epithelium.

  1993cites this paper
• Synthesis of docosahexaenoic acid by retina and retinal pigment epithelium.

  1993cites this paper
• Metabolism in frog retinal pigment epithelium of docosahexaenoic and arachidonic acids derived from rod outer segment membranes.

  1993cites this paper
• Comparison of uptake and incorporation of docosahexaenoic and arachidonic acids by frog retinas.

  1993cites this paper
• Visualization of [3H]docosahexaenoic acid trafficking through photoreceptors and retinal pigment epithelium by electron microscopic autoradiography.

  1993cites this paper
• Neurobiology of Essential Fatty Acids

  1992cites this paper
• Docosahexaenoic acid uptake and metabolism in photoreceptors: retinal conservation by an efficient retinal pigment epithelial cell-mediated recycling process.

  1992cites this paper
• Autofluorescence of the macula

  year unknowncites this paper
• 12 New Insights into AMD Pathogenesis

  year unknowncites this paper