Morphine alters the selective association between mu-opioid receptors and specific RGS proteins in mouse periaqueductal gray matter.

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Neuropharmacology

• Publication date

  2005-05-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/J.NEUROPHARM.2005.01.004PMID 15829256
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• RGS-Rz and RGS9-2 proteins control mu-opioid receptor desensitisation in CNS: the role of activated Galphaz subunits.

  2005cited by this paper
• RGS2 Binds Directly and Selectively to the M1 Muscarinic Acetylcholine Receptor Third Intracellular Loop to Modulate Gq/11α Signaling*

  2004cited by this paper
• RGSZ1 and GAIP Regulate μ- but Not δ-Opioid Receptors in Mouse CNS: Role in Tachyphylaxis and Acute Tolerance

  2004cited by this paper
• RGS17/RGSZ2, a Novel Regulator of Gi/o, Gz, and Gq Signaling*

  2004cited by this paper
• A role for heterodimerization of mu and delta opiate receptors in enhancing morphine analgesia.

  2004cited by this paper
• Differential Contribution of GTPase Activation and Effector Antagonism to the Inhibitory Effect of RGS Proteins on Gq-mediated Signaling in Vivo*

  2004cited by this paper
• A role for heterodimerization of μ and δ opiate receptors in enhancing morphine analgesia

  2004cited by this paper
• Estrogen treatment increases the levels of regulator of G protein signaling-Z1 in the hypothalamic paraventricular nucleus: possible role in desensitization of 5-hydroxytryptamine1A receptors.

  2004cited by this paper
• RGSZ1 and GAIP regulate mu- but not delta-opioid receptors in mouse CNS: role in tachyphylaxis and acute tolerance.

  2004cited by this paper
• Regulation of delta-opioid receptor trafficking via mu-opioid receptor stimulation: evidence from mu-opioid receptor knock-out mice.

  2003cited by this paper
• A Novel Endocytic Recycling Signal That Distinguishes the Membrane Trafficking of Naturally Occurring Opioid Receptors*

  2003cited by this paper
• Regulation of δ-Opioid Receptor Trafficking via μ-Opioid Receptor Stimulation: Evidence from μ-Opioid Receptor Knock-Out Mice

  2003cited by this paper
• Recruitment of RGS2 and RGS4 to the plasma membrane by G proteins and receptors reflects functional interactions.

  2003cited by this paper
• Essential role for RGS9 in opiate action

  2003cited by this paper
• The GBeta5 subunit that associates with the R7 subfamily of RGS proteins regulates mu-opioid effects.

  2003cited by this paper
• The R7 Subfamily of RGS Proteins Assists Tachyphylaxis and Acute Tolerance at μ-Opioid Receptors

  2003cited by this paper
• Heterodimerization of Substance P and μ-Opioid Receptors Regulates Receptor Trafficking and Resensitization*

  2003cited by this paper
• Promotion of Gαi3 subunit down-regulation by GIPN, a putative E3 ubiquitin ligase that interacts with RGS-GAIP

  2003cited by this paper
• Glycosylated phosducin-like protein long regulates opioid receptor function in mouse brain.

  2002cited by this paper
• Dimerization: an emerging concept for G protein-coupled receptor ontogeny and function.

  2002cited by this paper
• Receptor-selective Effects of Endogenous RGS3 and RGS5 to Regulate Mitogen-activated Protein Kinase Activation in Rat Vascular Smooth Muscle Cells*

  2002cited by this paper
• Genetic Dissociation of Opiate Tolerance and Physical Dependence in δ-Opioid Receptor-1 and Preproenkephalin Knock-Out Mice

  2002cited by this paper
• Cellular Regulation of RGS Proteins: Modulators and Integrators of G Protein Signaling

  2002cited by this paper
• Alternative splicing of RGS8 gene determines inhibitory function of receptor type-specific Gq signaling

  2002cited by this paper
• Structural models for dimerization of G-protein coupled receptors: the opioid receptor homodimers.

  2002cited by this paper
• RGS9 proteins facilitate acute tolerance to mu‐opioid effects

  2001cited by this paper
• Homo- and Heterodimerization of Somatostatin Receptor Subtypes

  2001cited by this paper
• Mechanisms Governing Subcellular Localization and Function of Human RGS2*

  2001cited by this paper
• GIPC and GAIP form a complex with TrkA: a putative link between G protein and receptor tyrosine kinase pathways.

  2001cited by this paper
• Prolonged Morphine Treatment Targets δ Opioid Receptors to Neuronal Plasma Membranes and Enhances δ-Mediated Antinociception

  2001cited by this paper
• Prolonged morphine treatment targets delta opioid receptors to neuronal plasma membranes and enhances delta-mediated antinociception.

  2001cited by this paper
• RGS2 regulates signal transduction in olfactory neurons by attenuating activation of adenylyl cyclase III

  2001cited by this paper
• Generation of the mu opioid receptor (MOR-1) protein by three new splice variants of the Oprm gene

  2001cited by this paper
• Proteasome Involvement in Agonist-induced Down-regulation of μ and δ Opioid Receptors*

  2001cited by this paper
• Mu-opioid receptor desensitization by beta-arrestin-2 determines morphine tolerance but not dependence.

  2000cited by this paper
• Chronic Heroin Self-Administration Desensitizes μ Opioid Receptor-Activated G-Proteins in Specific Regions of Rat Brain

  2000cited by this paper
• Association of a lower molecular weight protein to the mu-opioid receptor demonstrated by (125)I-beta-endorphin cross-linking studies.

  2000cited by this paper
• μ-Opioid receptor desensitization by β-arrestin-2 determines morphine tolerance but not dependence

  2000cited by this paper
• GTPase-activating proteins for heterotrimeric G proteins: regulators of G protein signaling (RGS) and RGS-like proteins.

  2000cited by this paper
• RGS7 Is Palmitoylated and Exists as Biochemically Distinct Forms

  2000cited by this paper
• Differential distribution in rat brain of mu opioid receptor carboxy terminal splice variants MOR‐1C‐like and MOR‐1‐like immunoreactivity: Evidence for region‐specific processing

  2000cited by this paper
• Immunoprecipitation of high-affinity, guanine nucleotide-sensitive, solubilized mu-opioid receptors from rat brain: coimmunoprecipitation of the G proteins G(alpha o), G(alpha i1), and G(alpha i3).

  2000cited by this paper
• Hypertolerance to morphine in G(z alpha)-deficient mice.

  2000cited by this paper
• In vivo modulation of G proteins and opioid receptor function by antisense oligodeoxynucleotides.

  2000cited by this paper
• Immunoprecipitation of High‐Affinity, Guanine Nucleotide‐Sensitive, Solubilized μ‐Opioid Receptors from Rat Brain

  2000cited by this paper
• Association of a Lower Molecular Weight Protein to the μ‐Opioid Receptor Demonstrated by 125I‐β‐Endorphin Cross‐Linking Studies

  2000cited by this paper
• Hypertolerance to morphine in Gzα-deficient mice

  2000cited by this paper
• RGS3 Inhibits G Protein-Mediated Signaling via Translocation to the Membrane and Binding to Gα11

  1999cited by this paper
• Selective Regulation of Gαq/11 by an RGS Domain in the G Protein-coupled Receptor Kinase, GRK2*

  1999cited by this paper
• RGS Proteins Determine Signaling Specificity of Gq-coupled Receptors*

  1999cited by this paper
• PURIFICATION OF COMPLEXES WITH Gb5 AND ASSESSMENT OF THEIR EFFECTS ON G PROTEIN- MEDIATED SIGNALING PATHWAYS*

  1999cited by this paper
• Regulators of G Protein Signaling 6 and 7

  1999cited by this paper
• Region-Specific Regulation of RGS4 (Regulator of G-Protein–Signaling Protein Type 4) in Brain by Stress and Glucocorticoids: In Vivo and In VitroStudies

  1999cited by this paper
• Emerging roles for RGS proteins in cell signalling.

  1999cited by this paper
• RGSZ1, a Gz-selective Regulator of G Protein Signaling Whose Action Is Sensitive to the Phosphorylation State of Gzα*

  1998cited by this paper
• delta Opioid receptor subtypes activate inositol-signaling pathways in the production of antinociception.

  1998cited by this paper
• RGSZ1, a G(z)-selective rgs protein in brain: Structure, membrane association, regulation by Gα(z) phosphorylation, and relationship to a G(z) gtpase-activating protein subfamily

  1998cited by this paper
• RGSZ1, a Gz-selective RGS Protein in Brain

  1998cited by this paper
• Expression of GTPase-deficient Giα2 Results in Translocation of Cytoplasmic RGS4 to the Plasma Membrane*

  1998cited by this paper
• RGS4 and GAIP are GTPase-activating proteins for Gq alpha and block activation of phospholipase C beta by gamma-thio-GTP-Gq alpha.

  1997cited by this paper
• A new family of G-protein regulators - the RGS proteins.

  1997cited by this paper
• A Truncated Form of RGS3 Negatively Regulates G Protein-coupled Receptor Stimulation of Adenylyl Cyclase and Phosphoinositide Phospholipase C*

  1997cited by this paper
• A GTPase-activating protein for the G protein Galphaz. Identification, purification, and mechanism of action.

  1997cited by this paper
• Immunolocalization of two mu-opioid receptor isoforms (MOR1 and MOR1B) in the rat central nervous system.

  1997cited by this paper
• GX/Z Is Regulated by μ But Not δ Opioid Receptors in the Stimulation of the Low Km GTPase Activity in Mouse Periaqueductal Grey Matter

  1997cited by this paper
• Antisense oligodeoxynucleotides to opioid mu and delta receptors reduced morphine dependence in mice: role of delta-2 opioid receptors.

  1997cited by this paper
• Gx/z is regulated by mu but not delta opioid receptors in the stimulation of the low Km GTPase activity in mouse periaqueductal grey matter.

  1997cited by this paper
• GAIP and RGS4 Are GTPase-Activating Proteins for the Gi Subfamily of G Protein α Subunits

  1996cited by this paper
• Metabotropic Glutamate Receptor 5 Is a Disulfide-linked Dimer*

  1996cited by this paper
• Agonist-selective endocytosis of mu opioid receptor by neurons in vivo.

  1996cited by this paper
• GAIP and RGS4 are GTPase-activating proteins for the Gi subfamily of G protein alpha subunits.

  1996cited by this paper
• Antibodies to the cloned mu-opioid receptor detect various molecular weight forms in areas of mouse brain.

  1995cited by this paper
• Immunoprecipitation of opioid receptor-Go-protein complexes using specific GTP-binding-protein antisera.

  1995cited by this paper
• In vivo injection of antisense oligodeoxynucleotides to G alpha subunits and supraspinal analgesia evoked by mu and delta opioid agonists.

  1995cited by this paper
• Characterization of Irreversible Binding of -Funaltrexamine to the Cloned Rat Opioid Receptor (*)

  1995cited by this paper
• A molecular weight study of the rat brain delta opioid receptor.

  1995cited by this paper
• Gz, a guanine nucleotide-binding protein with unique biochemical properties.

  1990cited by this paper
• Cross-linking of human [125I]beta-endorphin to opioid receptors in rat striatal membranes: biochemical evidence for the existence of a mu/delta opioid receptor complex.

  1990cited by this paper
• Evaluation of delta receptor mediation of supraspinal opioid analgesia by in vivo protection against the beta-funaltrexamine antagonist effect.

  1989cited by this paper
• Evaluation of δ receptor mediation of supraspinal opioid analgesia by in vivo protection against the β-funaltrexamine antagonist effect

  1989cited by this paper
• Affinity crosslinking of 125I-labeled human ß-endorphin to cell lines possessing either μ- or δ-type opioid binding sites

  1988cited by this paper
• Affinity crosslinking of 125I-labeled human beta-endorphin to cell lines possessing either mu- or delta-type opioid binding sites.

  1988cited by this paper
• Identification of endogenous opioid receptor components in rat brain using a monoclonal antibody.

  1988cited by this paper
• The opiate receptor: a single 110 kDa recognition molecule appears to be conserved in Tetrahymena, leech, and rat.

  1988cited by this paper
• Morphine tolerance increases mu-noncompetitive delta binding sites.

  1986cited by this paper
• Morphine tolerance increases -noncompetative d binding sites?

  1986cited by this paper
• Covalent labeling of opioid receptors with radioiodinated human beta-endorphin. Identification of binding site subunit.

  1985cited by this paper
• "Western blotting": electrophoretic transfer of proteins from sodium dodecyl sulfate--polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A.

  1981cited by this paper
• Single-dose tolerance to antinociception, and physical dependence on beta-endorphin in mice.

  1978cited by this paper
• Single-dose tolerance to antinociception, and physical dependence oin β-endorphin in mice

  1978cited by this paper
• Systematic examination in the rat of brain sites sensitive to the direct application of morphine: Observation of differential effects within the periaqueductal gray

  1976cited by this paper
• Human erythrocyte membrane glycoprotein: a re-evaluation of the molecular weight as determined by SDS polyacrylamide gel electrophoresis.

  1971cited by this paper

• αN-Acetyl β-Endorphin Is an Endogenous Ligand of σ1Rs That Regulates Mu-Opioid Receptor Signaling by Exchanging G Proteins for σ2Rs in σ1R Oligomers

  2022cites this paper
• Cellular and circuit diversity determines the impact of endogenous opioids in the descending pain modulatory pathway

  2022cites this paper
• Synthesis of the Mechanisms of Opioid Tolerance: Do We Still Say NO?

  2021cites this paper
• The σ1 Receptor and the HINT1 Protein Control α2δ1 Binding to Glutamate NMDA Receptors: Implications in Neuropathic Pain

  2021cites this paper
• Magnesium and Morphine in the Treatment of Chronic Neuropathic Pain–A Biomedical Mechanism of Action

  2021cites this paper
• Phosphorylation of unique C‐terminal sites of the mu‐opioid receptor variants 1B2 and 1C1 influences their Gs association following chronic morphine

  2020cites this paper
• Calmodulin Supports TRPA1 Channel Association with Opioid Receptors and Glutamate NMDA Receptors in the Nervous Tissue

  2020cites this paper
• Regulators of G Protein Signaling in Analgesia and Addiction

  2020cites this paper
• Differences in antinociceptive signalling mechanisms following morphine and fentanyl microinjections into the rat periaqueductal gray

  2019cites this paper
• Regulators of G-Protein Signaling (RGS) Proteins Promote Receptor Coupling to G-Protein-Coupled Inwardly Rectifying Potassium (GIRK) Channels

  2018influential citation
• Schizophrenia and depression, two poles of endocannabinoid system deregulation

  2017cites this paper
• RGS9-2 Modulates Responses to Oxycodone in Pain-Free and Chronic Pain States

  2017influential citation
• Homo-oligomerization of the Gbeta5-RGS7 complex and its regulation by R7BP and G protein activation

  2016cites this paper
• Evidence for MOR on cell membrane, sarcoplasmatic reticulum and mitochondria in left ventricular myocardium in rats

  2015cites this paper
• The ON:OFF switch, σ1R-HINT1 protein, controls GPCR-NMDA receptor cross-regulation: Implications in neurological disorders

  2015cites this paper
• Regulators of G-protein-signaling proteins: negative modulators of G-protein-coupled receptor signaling.

  2015influential citation
• Development and characterisation of novel fentanyl-delta opioid receptor antagonist based bivalent ligands.

  2015cites this paper
• Dopamine D3 receptor dysfunction prevents anti-nociceptive effects of morphine in the spinal cord

  2014influential citation
• Opioid receptor interacting proteins and the control of opioid signaling.

  2014cites this paper
• Analysis of candidate genes for morphine preference quantitative trait locus Mop2.

  2014cites this paper
• GPCRs Promote the Release of Zinc Ions Mediated by nNOS/NO and the Redox Transducer RGSZ2 Protein

  2012cites this paper
• The Mu-Opioid Receptor and the NMDA Receptor Associate in PAG Neurons: Implications in Pain Control

  2012cites this paper
• The other side of opioid receptor signalling: regulation by protein-protein interaction.

  2012cites this paper
• Direct association of Mu-opioid and NMDA glutamate receptors supports their cross-regulation: molecular implications for opioid tolerance.

  2012cites this paper
• Differential regulation of RGS proteins in the prefrontal cortex of short- and long-term human opiate abusers.

  2012influential citation
• RGS proteins in experimental Parkinsonism and L-DOPA-induced dyskinesia

  2012cites this paper
• The histidine triad nucleotide-binding protein 1 supports mu-opioid receptor–glutamate NMDA receptor cross-regulation

  2011cites this paper
• Opioid Receptor Signal Transduction Mechanisms

  2011cites this paper
• Optimisation and mechanistic insights of dyskinesia in rodent models of Parkinson’s disease

  2011cites this paper
• SUMO-SIM Interactions Regulate the Activity of RGSZ2 Proteins

  2011cites this paper
• Mu-Opioid Receptors Transiently Activate the Akt-nNOS Pathway to Produce Sustained Potentiation of PKC-Mediated NMDAR-CaMKII Signaling

  2010cites this paper
• Identification of μ‐ and κ‐opioid receptors as potential targets to regulate parasympathetic, sympathetic, and sensory neurons within rat intracardiac ganglia

  2010cites this paper
• Plant Gα Structure and Properties

  2010cites this paper
• Gz mediates the long-lasting desensitization of brain CB1 receptors and is essential for cross-tolerance with morphine

  2009cites this paper
• Membrane signalling complexes: implications for development of functionally selective ligands modulating heptahelical receptor signalling.

  2009cites this paper
• Functional Selectivity at Opioid Receptors

  2009cites this paper
• Src Phosphorylation of μ-Receptor Is Responsible for the Receptor Switching from an Inhibitory to a Stimulatory Signal*

  2009cites this paper
• Evidence for a Direct and Functional Interaction between the Regulators of G Protein Signaling-2 and Phosphorylated C Terminus of Cholecystokinin-2 Receptor

  2009cites this paper
• Biology and functions of the RGS9 isoforms.

  2009cites this paper
• Brain-specific Galphaz interacts with Src tyrosine kinase to regulate Mu-opioid receptor-NMDAR signaling pathway.

  2009cites this paper
• Fine Mapping of a Major QTL Influencing Morphine Preference in C57BL/6 and DBA/2 Mice Using Congenic Strains

  2008cites this paper
• Plasticity of Adenylyl Cyclase-Related Signaling Sequelae after Long-Term Morphine Treatment

  2008cites this paper
• Do pharmacological approaches that prevent opioid tolerance target different elements in the same regulatory machinery?

  2008influential citation
• Calcium/calmodulin-dependent protein kinase II supports morphine antinociceptive tolerance by phosphorylation of glycosylated phosducin-like protein.

  2008cites this paper
• Lack of receptor-selective effects of either RGS2, RGS3 or RGS4 on muscarinic M3- and gonadotropin-releasing hormone receptor-mediated signalling through G alpha q/11.

  2008cites this paper
• Lack of receptor selective effects of either RGS 2 , RGS 3 or RGS 4 on muscarinic M 3-and gonadotropin-releasing hormone-receptor-mediated signalling through Gα

  2008cites this paper
• NMDAR-nNOS generated zinc recruits PKCgamma to the HINT1-RGS17 complex bound to the C terminus of Mu-opioid receptors.

  2008cites this paper
• Plasticity of adenylyl cyclase–related signaling sequelae following long-term morphine treatment

  2007cites this paper
• RGS14 prevents morphine from internalizing Mu-opioid receptors in periaqueductal gray neurons.

  2007cites this paper
• Association of the RGS2 gene with extrapyramidal symptoms induced by treatment with antipsychotic medication

  2007cites this paper
• Phosphorylation of Gs α influences its association with the mu-opioid receptor and is modulated by chronic morphine

  2007cites this paper
• RGSZ1 interacts with protein kinase C interacting protein PKCI-1 and modulates mu opioid receptor signaling.

  2007cites this paper
• Ligand-specific receptor states: implications for opiate receptor signalling and regulation.

  2007cites this paper
• The Biochemical Analysis of Methadone Modulation on Morphine-Induced Tolerance and Dependence in the Rat Brain

  2007cites this paper
• Sumoylated RGS-Rz Proteins Act as Scaffolds for Mu-Opioid Receptors and G-Protein Complexes in Mouse Brain

  2007influential citation
• Morphine induces endocytosis of neuronal μ-opioid receptors through the sustained transfer of Gα subunits to RGSZ2 proteins

  2007cites this paper
• Differential coupling of RGS3s and RGS4 to GPCR-GIRK channel signaling complexes

  2006cites this paper
• RGS Proteins and Opioid Signaling

  2006cites this paper
• Bacterial artificial chromosome transgenic analysis of dynamic expression patterns of regulator of G-protein signaling 4 during development. II. Subcortical regions.

  2006cites this paper
• RGS17/RGSZ2 and the RZ/A family of regulators of G-protein signaling.

  2006cites this paper
• Opioid-induced regulation of gene expression in PC12 cells stably transfected with mu-opioid receptor.

  2006cites this paper
• Cellular mechanisms that determine selective RGS protein regulation of G protein-coupled receptor signaling.

  2006cites this paper
• Mammalian RGS proteins: multifunctional regulators of cellular signalling.

  2006cites this paper
• Subcellular Targeting of RGS9-2 Is Controlled by Multiple Molecular Determinants on Its Membrane Anchor, R7BP*

  2006cites this paper
• Bacterial artificial chromosome transgenic analysis of dynamic expression patterns of regulator of G-protein signaling 4 during development. I. Cerebral cortex.

  2006cites this paper
• RGS3 and RGS4 Differentially Associate with G Protein-coupled Receptor-Kir3 Channel Signaling Complexes Revealing Two Modes of RGS Modulation

  2006cites this paper
• How important is protein kinase C in mu-opioid receptor desensitization and morphine tolerance?

  2006cites this paper
• Endogenous opiates and behavior: 2005.

  2006cites this paper
• Ischemia-induced increase in RGS7 mRNA expression in gerbil hippocampus.

  2006cites this paper
• RGS proteins have a signalling complex: interactions between RGS proteins and GPCRs, effectors, and auxiliary proteins.

  2006cites this paper
• N-terminally truncated variant of the mouse GAIP/RGS19 lacks selectivity of full-length GAIP/RGS19 protein in regulating ORL1 receptor signaling.

  2005cites this paper
• Effector antagonism by the regulators of G protein signalling (RGS) proteins causes desensitization of mu-opioid receptors in the CNS

  2005influential citation