Proteolysis of calcineurin is increased in human hippocampus during mild cognitive impairment and is stimulated by oligomeric Abeta in primary cell culture

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Aging Cell

• Publication date

  2011-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/j.1474-9726.2010.00645.xPMID 20969723PMCID PMC3021581
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Calpain.

  2020cited by this paper
• Early neuronal dysfunction by amyloid β oligomers depends on activation of NR2B-containing NMDA receptors.

  2011cited by this paper
• Inhibition of calpain prevents NMDA‐induced cell death and β‐amyloid‐induced synaptic dysfunction in hippocampal slice cultures

  2010cited by this paper
• Disparate effects of serum on basal and evoked NFAT activity in primary astrocyte cultures.

  2010cited by this paper
• NFATs and Alzheimer's Disease.

  2010cited by this paper
• Neurodegeneration in an Aβ‐induced model of Alzheimer’s disease: the role of Cdk5

  2010cited by this paper
• Amyloid beta induces the morphological neurodegenerative triad of spine loss, dendritic simplification, and neuritic dystrophies through calcineurin activation.

  2010influential reference
• Hippocampal 'zipper' slice studies reveal a necessary role for calcineurin in the increased activity of L-type Ca(2+) channels with aging.

  2010cited by this paper
• Mechanisms of retinal ganglion cell injury and defense in glaucoma.

  2010cited by this paper
• Memantine Preferentially Blocks Extrasynaptic over Synaptic NMDA Receptor Currents in Hippocampal Autapses

  2010influential reference
• Calpain activation in experimental glaucoma.

  2010cited by this paper
• Subregional hippocampal atrophy predicts Alzheimer's dementia in the cognitively normal.

  2010cited by this paper
• Intermediate- and long-term recognition memory deficits in Tg2576 mice are reversed with acute calcineurin inhibition.

  2009cited by this paper
• Dysregulation of Calcium Homeostasis in Alzheimer’s Disease

  2009influential reference
• Inhibition of Calcineurin-mediated Endocytosis and α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors Prevents Amyloid β Oligomer-induced Synaptic Disruption

  2009cited by this paper
• Faculty Opinions recommendation of Soluble oligomers of amyloid Beta protein facilitate hippocampal long-term depression by disrupting neuronal glutamate uptake.

  2009cited by this paper
• Faculty Opinions recommendation of Divergent pathways mediate spine alterations and cell death induced by amyloid-beta, wild-type tau, and R406W tau.

  2009cited by this paper
• Extrasynaptic NMDA Receptors Couple Preferentially to Excitotoxicity via Calpain-Mediated Cleavage of STEP

  2009cited by this paper
• Soluble oligomers of amyloid Beta protein facilitate hippocampal long-term depression by disrupting neuronal glutamate uptake.

  2009cited by this paper
• Microglial activation and amyloid deposition in mild cognitive impairment

  2009influential reference
• Cognitive Decline in Alzheimer's Disease Is Associated with Selective Changes in Calcineurin/NFAT Signaling

  2009cited by this paper
• Divergent Pathways Mediate Spine Alterations and Cell Death Induced by Amyloid-β, Wild-Type Tau, and R406W Tau

  2009cited by this paper
• Marked Calpastatin (CAST) Depletion in Alzheimer's Disease Accelerates Cytoskeleton Disruption and Neurodegeneration: Neuroprotection by CAST Overexpression

  2008cited by this paper
• Deafferentation-Induced Activation of NFAT (Nuclear Factor of Activated T-Cells) in Cochlear Nucleus Neurons during a Developmental Critical Period: A Role for NFATc4-Dependent Apoptosis in the CNS

  2008cited by this paper
• Abeta plaques lead to aberrant regulation of calcium homeostasis in vivo resulting in structural and functional disruption of neuronal networks.

  2008cited by this paper
• Linking Calcium to A and Alzheimer's Disease

  2008cited by this paper
• Calpain-Mediated Signaling Mechanisms in Neuronal Injury and Neurodegeneration

  2008cited by this paper
• Overactivation of calcineurin induced by amyloid-beta and prion proteins.

  2008cited by this paper
• Postsynaptic Density-95 (PSD-95) and Calcineurin Control the Sensitivity of N-Methyl-d-aspartate Receptors to Calpain Cleavage in Cortical Neurons

  2008influential reference
• Selective induction of calcineurin activity and signaling by oligomeric amyloid beta

  2008influential reference
• Inhibition of calpains improves memory and synaptic transmission in a mouse model of Alzheimer disease.

  2008cited by this paper
• Interleukin-1β-dependent Signaling between Astrocytes and Neurons Depends Critically on Astrocytic Calcineurin/NFAT Activity*

  2008cited by this paper
• Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease.

  2008cited by this paper
• Role of calpain and caspase in beta-amyloid-induced cell death in rat primary septal cultured neurons.

  2008cited by this paper
• Activation of caspase-6 in aging and mild cognitive impairment.

  2007cited by this paper
• Calpains and human disease.

  2007cited by this paper
• Clinicopathologic Correlations in a Large Alzheimer Disease Center Autopsy Cohort: Neuritic Plaques and Neurofibrillary Tangles "Do Count" When Staging Disease Severity

  2007cited by this paper
• Constitutively active calcineurin mediates delayed neuronal death through Fas‐ligand expression via activation of NFAT and FKHR transcriptional activities in mouse brain ischemia

  2007cited by this paper
• Memantine: a NMDA receptor antagonist that improves memory by restoration of homeostasis in the glutamatergic system--too little activation is bad, too much is even worse.

  2007cited by this paper
• Expansion of the calcium hypothesis of brain aging and Alzheimer's disease: minding the store

  2007cited by this paper
• Calpastatin levels affect calpain activation and calpain proteolytic activity in APP transgenic mouse model of Alzheimer's disease.

  2007cited by this paper
• Acute inhibition of calcineurin restores associative learning and memory in Tg2576 APP transgenic mice.

  2007cited by this paper
• Natural Oligomers of the Alzheimer Amyloid-β Protein Induce Reversible Synapse Loss by Modulating an NMDA-Type Glutamate Receptor-Dependent Signaling Pathway

  2007influential reference
• Synaptic alterations in CA1 in mild Alzheimer disease and mild cognitive impairment

  2007cited by this paper
• Calpain-calcineurin signaling in the pathogenesis of calcium-dependent disorder.

  2007cited by this paper
• Abeta solubility and deposition during AD progression and in APPxPS-1 knock-in mice.

  2007influential reference
• The importance of being subtle: small changes in calcium homeostasis control cognitive decline in normal aging

  2007cited by this paper
• Aβ solubility and deposition during AD progression and in APP × PS-1 knock-in mice

  2007cited by this paper
• Hippocampal synaptic loss in early Alzheimer's disease and mild cognitive impairment.

  2006cited by this paper
• Generation of constitutively active calcineurin by calpain contributes to delayed neuronal death following mouse brain ischemia

  2006cited by this paper
• Truncation and Activation of Calcineurin A by Calpain I in Alzheimer Disease Brain*

  2005influential reference
• Protection against amyloid beta-peptide (1-42)-induced loss of phospholipid asymmetry in synaptosomal membranes by tricyclodecan-9-xanthogenate (D609) and ferulic acid ethyl ester: implications for Alzheimer's disease.

  2005cited by this paper
• The role of calcineurin in amyloid-β-peptides-mediated cell death

  2005cited by this paper
• The Role of Caspase Cleavage of Tau in Alzheimer Disease Neuropathology

  2005cited by this paper
• Regulation of NMDA receptor trafficking by amyloid-beta.

  2005cited by this paper
• Oxidation of thiol-proteases in the hippocampus of Alzheimer's disease.

  2005cited by this paper
• Calcium in Alzheimer's disease pathogenesis: Too much, too little or in the wrong place?

  2005cited by this paper
• The role of calcineurin in amyloid-beta-peptides-mediated cell death.

  2005cited by this paper
• Calcineurin Triggers Reactive/Inflammatory Processes in Astrocytes and Is Upregulated in Aging and Alzheimer's Models

  2005cited by this paper
• Calcineurin/NFAT Coupling Participates in Pathological, but not Physiological, Cardiac Hypertrophy

  2004cited by this paper
• Critical Role of Calpain-mediated Cleavage of Calcineurin in Excitotoxic Neurodegeneration*

  2004influential reference
• Ca2+ regulation and gene expression in normal brain aging.

  2004cited by this paper
• Calpain mediates calcium-induced activation of the erk1,2 MAPK pathway and cytoskeletal phosphorylation in neurons: relevance to Alzheimer's disease.

  2004cited by this paper
• Selective Activation Induced Cleavage of the NR2B Subunit by Calpain

  2003cited by this paper
• The calpains in aging and aging-related diseases.

  2003cited by this paper
• Calcineurin regulation of neuronal plasticity.

  2003cited by this paper
• The calpain system.

  2003cited by this paper
• Activation of calpain in cultured neurons overexpressing Alzheimer amyloid precursor protein.

  2002influential reference
• Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways

  2002cited by this paper
• Alzheimer Amyloid β-Peptide Inhibits the Late Phase of Long-Term Potentiation through Calcineurin-Dependent Mechanisms in the Hippocampal Dentate Gyrus

  2002cited by this paper
• Caspase-mediated calcineurin activation contributes to IL-2 release during T cell activation.

  2001cited by this paper
• Oxidative Stress Induces Neuronal Death by Recruiting a Protease and Phosphatase-gated Mechanism*

  2001cited by this paper
• Selective changes of calcineurin (protein phosphatase 2B) activity in Alzheimer's disease cerebral cortex.

  2001cited by this paper
• Specific proteolysis of the NR2 subunit at multiple sites by calpain

  2001cited by this paper
• Caspase-mediated proteolytic activation of calcineurin in thapsigargin-mediated apoptosis in SH-SY5Y neuroblastoma cells.

  2000cited by this paper
• Inducible and reversible gene expression with the rtTA system for the study of memory.

  1998cited by this paper
• Genetic and pharmacological evidence for a novel, intermediate phase of long-term potentiation suppressed by calcineurin.

  1998cited by this paper
• Role of calpain- and interleukin-1 beta converting enzyme-like proteases in the beta-amyloid-induced death of rat hippocampal neurons in culture.

  1997cited by this paper
• Role of Calpain‐ and Interleukin‐1β Converting Enzyme‐Like Proteases in the β‐Amyloid‐Induced Death of Rat Hippocampal Neurons in Culture

  1997cited by this paper
• Reduction of Calcineurin Enzymatic Activity in Alzheimer's Disease: Correlation with Neuropathologic Changes

  1996cited by this paper
• Calcineurin immunoreactivity in Alzheimer's disease.

  1994cited by this paper
• Specificity of calcium-activated neutral proteinase (CANP) inhibitors for human μCANP and mCANP

  1993cited by this paper
• Widespread activation of calcium-activated neutral proteinase (calpain) in the brain in Alzheimer disease: a potential molecular basis for neuronal degeneration.

  1993cited by this paper
• Distinct cellular expression of calcineurin A alpha and A beta in rat brain.

  1992cited by this paper
• Distinct Cellular Expression of Calcineurin Aα and Aβ in Rat Brain

  1992cited by this paper
• Characterization of the fragmented forms of calcineurin produced by calpain I.

  1989cited by this paper
• Activation of a calmodulin-dependent phosphatase by a Ca2+-dependent protease.

  1988cited by this paper
• Calcium and the aging nervous system.

  1987cited by this paper
• Prolonged Ca2+-dependent afterhyperpolarizations in hippocampal neurons of aged rats.

  1984cited by this paper

• Tacrolimus mitigates pathological patterns in mouse models of Alzheimer's disease.

  2025cites this paper
• Calcineurin inhibition may prevent Alzheimer disease in people with Down syndrome

  2025cites this paper
• Cyclosporine A Modulates Neuroinflammation-Related Gene Expression Associated with Alzheimer's Disease in SH-SY5Y Neuronal Cell Line: Is Cyclosporine A Beneficial/Detrimental?

  2025cites this paper
• Inhibition of astrocyte signaling leads to sex-specific changes in microglia phenotypes in a diet-based model of small cerebral vessel disease

  2025cites this paper
• Inhibition of astrocyte signaling leads to sex-specific changes in microglia phenotypes in a diet-based model of cerebral small vessel disease

  2025cites this paper
• How calcineurin inhibitors affect cognition

  2024cites this paper
• The Ca^2+-Regulated Enzymes Calpain and Calcineurin in Neurodegenerative Processes and Prospects for Neuroprotective Pharmacotherapy

  2024cites this paper
• Age-Related Brain Atrophy and the Positive Effects of Behavioral Enrichment in Middle-Aged Beagles

  2024cites this paper
• Changes in Astroglial Water Flow in the Pre-amyloid Phase of the STZ Model of AD Dementia

  2024cites this paper
• Is It Time to Repurpose Calcineurin Inhibitors for the Treatment of Cognitive Impairment and Dementia?

  2023cites this paper
• [Ca2+-regulated enzymes calpain and calcineurin in neurodegenerative processes and prospects for neuroprotective pharmacotherapy].

  2023cites this paper
• Inhibiting 5-hydroxytryptamine receptor 3 alleviates pathological changes of a mouse model of Alzheimer’s disease

  2023cites this paper
• Targeting Astrocyte Signaling Alleviates Cerebrovascular and Synaptic Function Deficits in a Diet-Based Mouse Model of Small Cerebral Vessel Disease

  2023cites this paper
• Targeting CaN/NFAT in Alzheimer’s brain degeneration

  2023cites this paper
• Reduced Prevalence of Dementia in Patients Prescribed Tacrolimus, Sirolimus, or Cyclosporine

  2023cites this paper
• Development of a Monoclonal Antibody Specific for a Calpain-Generated ∆48kDa Calcineurin Fragment, a Marker of Distressed Astrocytes.

  2023cites this paper
• Calcineurin Signalling in Astrocytes: From Pathology to Physiology and Control of Neuronal Functions

  2022cites this paper
• Targeting Astrocytes Ameliorates Neurologic Changes in a Mouse Targeting Astrocytes Ameliorates Neurologic Changes in a Mouse Model of Alzheimer's Disease Model of Alzheimer's Disease

  2022cites this paper
• Activity‐Dependent Induction of Younger Biological Phenotypes

  2022cites this paper
• Calpain-Mediated Alterations in Astrocytes Before and During Amyloid Chaos in Alzheimer’s Disease

  2021cites this paper
• The Role of Neuroglial Metabotropic Glutamate Receptors in Alzheimer’s Disease

  2021cites this paper
• Reactive astrocytes: The nexus of pathological and clinical hallmarks of Alzheimer’s disease

  2021cites this paper
• Tacrolimus Protects against Age-Associated Microstructural Changes in the Beagle Brain

  2021cites this paper
• A Review of Oxidative Stress Products and Related Genes in Early Alzheimer’s Disease

  2021cites this paper
• Neurogranin stimulates Ca2+/calmodulin-dependent kinase II by suppressing calcineurin activity at specific calcium spike frequencies

  2020cites this paper
• Onset of Insulin Resistance in Hippocampal Synapses After Traumatic Brain Injury : Relevance to Alzheimer ’ s disease and Therapeutic Implications

  2019cites this paper
• Calcineurin-Mediated Hippocampal Inflammatory Alterations in Streptozotocin-Induced Model of Dementia

  2019cites this paper
• Neurogranin Stimulates Ca2+/calmodulin-dependent Kinase II by Inhibiting Calcineurin at Specific Calcium Spike Frequencies

  2019cites this paper
• Calcineurin: directing the damage in Alzheimer disease

  2018influential citation
• AD-Related N-Terminal Truncated Tau Is Sufficient to Recapitulate In Vivo the Early Perturbations of Human Neuropathology: Implications for Immunotherapy

  2018cites this paper
• Neuronal calcineurin transcriptional targets parallel changes observed in Alzheimer disease brain

  2018cites this paper
• The Tyrosine Phosphatase STEP Is Involved in Age-Related Memory Decline.

  2018cites this paper
• Ca2+, Astrocyte Activation and Calcineurin/NFAT Signaling in Age-Related Neurodegenerative Diseases

  2018influential citation
• Calcineurin/NFAT Signaling in Activated Astrocytes Drives Network Hyperexcitability in Aβ-Bearing Mice

  2017cites this paper
• Dysregulation of neuronal calcium homeostasis in Alzheimer's disease - A therapeutic opportunity?

  2017cites this paper
• Title The participation of insulin-like growth factor-binding protein 3 released by astrocytes in the pathology of Alzheimer ' s disease

  2016cites this paper
• Calpain-Mediated Cleavage of Calcineurin in Puromycin Aminonucleoside-Induced Podocyte Injury

  2016cites this paper
• Pycnogenol protects CA3-CA1 synaptic function in a rat model of traumatic brain injury.

  2016cites this paper
• From Pathology to Physiology of Calcineurin Signalling in Astrocytes

  2016cites this paper
• Upregulation of calpain activity precedes tau phosphorylation and loss of synaptic proteins in Alzheimer’s disease brain

  2016cites this paper
• Blockade of Astrocytic Calcineurin/NFAT Signaling Helps to Normalize Hippocampal Synaptic Function and Plasticity in a Rat Model of Traumatic Brain Injury

  2016cites this paper
• Calcineurin proteolysis in astrocytes: Implications for impaired synaptic function.

  2016cites this paper
• Tau accumulation induces synaptic impairment and memory deficit by calcineurin-mediated inactivation of nuclear CaMKIV/CREB signaling

  2016cites this paper
• The Role of Astrocytic Calcineurin Activation and Downstream Signaling in Neurodegenerative Diseases

  2016cites this paper
• The participation of insulin-like growth factor-binding protein 3 released by astrocytes in the pathology of Alzheimer’s disease

  2015cites this paper
• CALCINEURIN-MEDIATED SIGNALING IN ISCHEMIC PRECONDITIONING AND NEURONAL CELL DEATH

  2014cites this paper
• Calpain Interactions with the Protein Phosphatase Calcineurin in Neurodegeneration

  2014cites this paper
• Calcineurin overexpression regulates APP metabolism

  2013cites this paper
• Amyloid beta deregulates astroglial mGluR5‐mediated calcium signaling via calcineurin and Nf‐kB

  2013influential citation
• The synaptic maintenance problem: membrane recycling, Ca2+ homeostasis and late onset degeneration

  2013cites this paper
• Calpain cleaves methionine aminopeptidase-2 in a rat model of ischemia/reperfusion.

  2013cites this paper
• Protein phosphatases and Alzheimer's disease.

  2012cites this paper
• Targeting Astrocytes Ameliorates Neurologic Changes in a Mouse Model of Alzheimer's Disease

  2012influential citation
• Neural functions of calcineurin in synaptic plasticity and memory.

  2012cites this paper
• TargetingAstrocytesAmelioratesNeurologicChangesina MouseModelofAlzheimer'sDisease

  2012cites this paper
• The Alzheimer’s therapeutic PBT2 promotes amyloid‐β degradation and GSK3 phosphorylation via a metal chaperone activity

  2011cites this paper