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Endophytes producing bioactive compounds from Piper spp.: a review on utilization, bottlenecks, and future perspectives

Shreyasi Mitra,P. Biswas,Anuradha Mukherjee,Potshanghbam Nongdam,D. Pandey,A. Dey

Published 2021 in Volatiles and Metabolites of Microbes

ABSTRACT

Abstract Endophyte is a broad term for microorganisms that colonize asymptomatically inside the healthy tissue of a host plant and maintain mutualistic association for the whole or part of their lifecycle. Many reports are found in the current literature on endophyte-mediated secondary metabolite production in diverse plant species. Piper is a genus belonging to family Piperaceae; it is commonly known as “Paan” and is cultivated extensively in Sri Lanka, India, Thailand, Taiwan, and other Southeast Asian countries. The parts of Piper utilized are leaves, roots, stems, stalks, and fruits. The plant has a large number of biomolecules that show diverse pharmacological activity. The leaves of Piper possess bioactivities with antitumor, antimutagenic, and antihelminthic properties. Piperine and piperidine are two such alkaloids found as the active compounds in the Piper. Few endophytes producing these compounds in Piper as secondary metabolites are reported and detailed in some existing literature. Further investigation needs to be undertaken for the identification of more such piperidine and piperine-producing fungi and survey on any bacterial endophytes. A survey of more such endophytes can assist in the commercial enrichment of these bioactive molecules and can limit the overuse of respective medicinal plant materials. The present review focuses on the utilization, extraction, and shortcomings of endophyte-mediated natural product biosynthesis in the major genera of Piper with a note on future perspectives.

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