Prostanoid EP1‐ and TP‐receptors involved in the contraction of human pulmonary veins

No abstract is available for this paper.

• Publication year

  2001

• Venue

  British Journal of Pharmacology

• Publication date

  2001-12-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1038/sj.bjp.0704423PMID 11739243PMCID PMC1572903
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Prostanoid receptors of the EP3 subtype mediate the inhibitory effect of prostaglandin E2 on noradrenaline release in the mouse brain cortex

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• Biphasic actions of prostaglandin E(2) on the renal afferent arteriole : role of EP(3) and EP(4) receptors.

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• Prostanoid receptors involved in the relaxation of human pulmonary vessels

  1999cited by this paper
• Responses of intraocular pressure and the pupil of feline eyes to prostaglandin EP1 and FP receptor agonists.

  1999cited by this paper
• Prostaglandin E 2 inhibits renal collecting duct Na + absorption by activating the EP 1 receptor

  1998influential reference
• Pharmacological characterization of thromboxane and prostanoid receptors in human isolated urinary bladder

  1998cited by this paper
• Characterization of a prostanoid EP3‐receptor in guinea‐pig aorta: partial agonist action of the non‐prostanoid ONO‐AP‐324

  1998cited by this paper
• Pharmacology of [3H]prostaglandin E1/[3H]prostaglandin E2 and [3H]prostaglandin F2alpha binding to EP3 and FP prostaglandin receptor binding sites in bovine corpus luteum: characterization and correlation with functional data.

  1998cited by this paper
• Prostaglandin E2 inhibits renal collecting duct Na+ absorption by activating the EP1 receptor.

  1998influential reference
• Thromboxanes: synthase and receptors.

  1998cited by this paper
• Prostanoid-induced contraction of the rabbit isolated uterus is mediated by FP receptors.

  1998cited by this paper
• Prostanoid receptor heterogeneity through alternative mRNA splicing.

  1998cited by this paper
• SOME QUANTITATIVE USES OF DRUG ANTAGONISTS

  1997cited by this paper
• Prostaglandin effects on the contractility of bovine trabecular meshwork and ciliary muscle.

  1997cited by this paper
• Molecular cloning and characterization of the four rat prostaglandin E2 prostanoid receptor subtypes.

  1997influential reference
• Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells

  1997influential reference
• Inhibition of vagally mediated gastric acid secretion by activation of central prostanoid EP3 receptors in urethane‐anaesthetized rats

  1996cited by this paper
• Pharmacological nature of TP receptor mediated contraction in human intrapulmonary artery.

  1996cited by this paper
• [Critical pulmonary edema following cesarean section].

  1995cited by this paper
• Receptor subtypes involved in dual effects induced by prostaglandin E2 in circular smooth muscle from dog colon.

  1995cited by this paper
• Pharmacological characterization in vitro of prostanoid receptors in the myometrium of nonpregnant ewes.

  1995cited by this paper
• Characterization of the prostanoid receptors mediating constriction and relaxation of human isolated uterine artery

  1995influential reference
• Pulmonary edema in association with an intravenous infusion of sulprostone

  1995cited by this paper
• 6-Isopropoxy-9-oxoxanthene-2-carboxylic acid (AH 6809), a human EP2 receptor antagonist.

  1995cited by this paper
• Molecular mechanisms of diverse actions of prostanoid receptors.

  1995cited by this paper
• Reduced responses of retinal vessels of the newborn pig to prostaglandins but not to thromboxane.

  1994cited by this paper
• Studies on the Ocular Hypotensive Effects of Prostaglandin F2α Ester Prodrugs and Receptor Selective Prostaglandin Analogs

  1994cited by this paper
• Cardiogenic pulmonary oedema: presentation of pre‐eclampsia exacerbated by prostaglandin abortifacients

  1994cited by this paper
• International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes.

  1994cited by this paper
• Potent contractile actions of prostanoid EP3‐receptor agonists on human isolated pulmonary artery

  1994influential reference
• Studies on the ocular hypotensive effects of prostaglandin F2 alpha ester prodrugs and receptor selective prostaglandin analogs.

  1994cited by this paper
• VIII. International union of pharmacology classification of prostanoid receptors: Properties, distribution, and structure of the receptors and their subtypes

  1994cited by this paper
• Intraocular pressure effects of selective prostanoid receptor agonists involve different receptor subtypes according to radioligand binding studies.

  1993cited by this paper
• Cloning and expression of a cDNA for the human prostaglandin E receptor EP1 subtype.

  1993cited by this paper
• Stimulatory (EP1 and EP3) and inhibitory (EP2) prostaglandin E2 receptors in isolated ileal smooth muscle cells.

  1993cited by this paper
• In vitro characterization of prostanoid receptors on human myometrium at term pregnancy

  1993cited by this paper
• Cloning and expression of cDNA for a mouse EP1 subtype of prostaglandin E receptor.

  1993influential reference
• In vitro characterization of prostanoid FP‐, DP‐, IP‐ and TP‐receptors on the non‐pregnant human myometrium

  1992cited by this paper
• Characterization of receptors involved in the direct and indirect actions of prostaglandins E and I on the guinea‐pig ileum

  1992influential reference
• Inhibition of noradrenaline release in the rat vena cava via prostanoid receptors of the EP3‐subtype

  1992cited by this paper
• Heterogeneity of thromboxane A2 (TP‐) receptors: evidence from antagonist but not agonist potency measurements

  1991cited by this paper
• Endothelium-dependent relaxation and effects of prostacyclin, endothelin and platelet-activating factor in human hand veins and arteries.

  1991cited by this paper
• Inhibitory effects of BAY u3405 on prostanoid‐induced contractions in human isolated bronchial and pulmonary arterial muscle preparations

  1991cited by this paper
• Heterogeneity of prostaglandin H2/thromboxane A2 receptors: distinct subtypes mediate vascular smooth muscle contraction and platelet aggregation.

  1991cited by this paper
• BAY u3405, a potent and selective thromboxane A2 receptor antagonist on airway smooth muscle in vitro

  1991cited by this paper
• Characterization of contraction-mediating prostanoid receptors in human hand veins: effects of the thromboxane receptor antagonists BM13,505 and AH23848.

  1991cited by this paper
• Maintenance of functional activity of human pulmonary arteries after cryopreservation

  1991cited by this paper
• The role of endogenous thromboxane in contractions to U46619, oxygen, 5‐HT and 5‐CT in the human isolated umbilical artery

  1991influential reference
• EP3, but not EP2, FP, or TP prostanoid-receptor stimulation may reduce intraocular pressure.

  1990cited by this paper
• Prostanoid‐induced contraction of human bronchial smooth muscle is mediated by TP‐receptors

  1989cited by this paper
• GR32191, a highly potent and specific thromboxane A2 receptor blocking drug on platelets and vascular and airways smooth muscle in vitro

  1989influential reference
• Prostaglandin F2 alpha effects on intraocular pressure negatively correlate with FP-receptor stimulation.

  1989cited by this paper
• The strong contractile effect of the thromboxane receptor agonist U-46619 in isolated human pulmonary arteries and its competitive antagonism by BM-13.505.

  1989cited by this paper
• Characterisation of receptors mediating the contractile effects of prostanoids in guinea-pig and human airways.

  1988cited by this paper
• Amino acid pharmacology in neocortical slices: evidence for bimolecular actions from an extension of the Hill and Gaddum‐Schild equations

  1988cited by this paper
• AH6809, a prostaglandin DP‐receptor blocking drug on human platelets

  1988cited by this paper
• The action of prostanoid receptor agonists and antagonists on smooth muscle and platelets

  1988influential reference
• Effects of the thromboxane receptor antagonist SK&F 88046 in the canine, monkey and human coronary vasculature.

  1988cited by this paper
• Prostaglandin E receptor subtypes in smooth muscle: agonist activities of stable prostacyclin analogues

  1986cited by this paper
• CHARACTERIZATION OF THROMBOXANE A2 RECEPTORS IN THE HUMAN FETAL PLACENTAL VESSELS AND UMBILICAL VEIN

  1986cited by this paper
• Pharmacologic characterization of human and canine thromboxane A2/prostaglandin H2 receptors in platelets and blood vessels: evidence for different receptors.

  1985cited by this paper
• A Comparison of the Contractile Responses of Rodent and Human Pulmonary Vascular Segments to Eicosanoids

  1985cited by this paper
• Characterisation of the prostanoid receptors mediating contraction of guinea-pig isolated trachea.

  1985cited by this paper
• Characterization of the prostanoid receptors and of the contractile effects of prostaglandin F2 alpha in human pial arteries.

  1984cited by this paper
• Studies on the characterisation of prostanoid receptors: a proposed classification.

  1982cited by this paper
• EFFECTS OF PROSTAGLANDINS AND THROMBOXANE ANALOGUES ON BULLOCK AND DOG IRIS SPHINCTER PREPARATIONS

  1982cited by this paper
• The antiplatelet and cardiovascular actions of a new carbacyclin derivative (ZK 36 374) — Equipotent to PGI2 in vitro

  1981cited by this paper
• CONTRACTILE AND RELAXANT ACTIONS OF PROSTAGLANDINS ON GUINEA‐PIG ISOLATED TRACHEA

  1980cited by this paper
• The effects of some natural prostaglandins on isolated human circular bronchial muscle.

  1975cited by this paper
• Antagonism of prostaglandin E2 by 1-acetyl-2-(8-chloro-10,11-dihydrodibenz (b,f) (1,4) oxazepine-10-carbonyl) hydrazine (SC-19220).

  1969cited by this paper
• Antagonism of prostaglandin E2 by 1-acetyl-2-(8-chloro-10,11-dihydrodibenz (b,f) (1,4) oxazepine-10-carbonyl) hydrazine (SC-19220).

  1969cited by this paper

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  2020cites this paper
• International Union of Basic and Clinical Pharmacology. CIX. Differences and Similarities between Human and Rodent Prostaglandin E2 Receptors (EP1–4) and Prostacyclin Receptor (IP): Specific Roles in Pathophysiologic Conditions

  2020cites this paper
• Molecular Mechanism of Congenital Heart Disease and Pulmonary Hypertension

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• Diverse Pharmacology of Prostacyclin Mimetics: Implications for Pulmonary Hypertension

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  2019cites this paper
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  2018cites this paper
• Selectively targeting prostanoid E (EP) receptor-mediated cell signalling pathways: Implications for lung health and disease.

  2018cites this paper
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