Progressive alterations in amino acid and lipid metabolism correlate with peripheral neuropathy in PolgD257A mice

Esther W. Lim,Michal K. Handzlik,Elijah Trefts,Jivani M. Gengatharan,Carlos M Pondevida,R. Shaw,Christian M. Metallo

Published 2021 in Science Advances

ABSTRACT

Alanine accumulation in PolgD257A mice links mitochondrial defects to 1-deoxysphingolipids and peripheral neuropathy.

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