S-oxidative cleavage of farnesylcysteine and farnesylcysteine methyl ester by the flavin-containing monooxygenase.

No abstract is available for this paper.

• Publication year

  1994

• Venue

  Chemical Research in Toxicology

• Publication date

  1994-03-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1021/TX00038A012PMID 8199308
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Stereo- and regioselective N- and S-oxidation of tertiary amines and sulfides in the presence of adult human liver microsomes.

  1993cited by this paper
• Protein isoprenylation and methylation at carboxyl-terminal cysteine residues.

  1992cited by this paper
• Flavin-containing monooxygenase-dependent stereoselective S-oxygenation and cytotoxicity of cysteine S-conjugates and mercapturates.

  1992cited by this paper
• Formation of glutathionyl-spironolactone disulfide by rat liver cytochromes P450 or hog liver flavin-containing monooxygenases: a functional probe of two-electron oxidations of the thiosteroid?

  1991cited by this paper
• Glutathione conjugate mediated toxicities.

  1990cited by this paper
• The gamma subunit of transducin is farnesylated.

  1990cited by this paper
• Mutants of Saccharomyces cerevisiae defective in the farnesylation of Ras proteins.

  1990cited by this paper
• Prenyl proteins in eukaryotic cells: a new type of membrane anchor.

  1990cited by this paper
• Farnesylated gamma-subunit of photoreceptor G protein indispensable for GTP-binding.

  1990cited by this paper
• The cellular functions of small GTP-binding proteins.

  1990cited by this paper
• Analysis of amine metabolites by high-performance liquid chromatography on silica gel with a non-aqueous ionic eluent.

  1990cited by this paper
• Inhibition of purified p21ras farnesyl:protein transferase by Cys-AAX tetrapeptides.

  1990cited by this paper
• Identification of a C-terminal protein carboxyl methyltransferase in rat liver membranes utilizing a synthetic farnesyl cysteine-containing peptide substrate.

  1990cited by this paper
• A polybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21ras to the plasma membrane.

  1990cited by this paper
• Cysteine conjugate S-oxidase. Characterization of a novel enzymatic activity in rat hepatic and renal microsomes.

  1990cited by this paper
• Flavin-containing monooxygenases: enzymes adapted for multisubstrate specificity.

  1990cited by this paper
• Post‐translational processing of p21ras is two‐step and involves carboxyl‐methylation and carboxy‐terminal proteolysis.

  1989cited by this paper
• p21ras is modified by a farnesyl isoprenoid.

  1989cited by this paper
• All ras proteins are polyisoprenylated but only some are palmitoylated.

  1989cited by this paper
• Human lamin B contains a farnesylated cysteine residue.

  1989cited by this paper
• Studies on substrate specificity of the hog liver flavin-containing monooxygenase. Anionic organic sulfur compounds.

  1987cited by this paper
• Dynamic fatty acylation of p21N‐ras.

  1987cited by this paper
• The p21 ras C-terminus is required for transformation and membrane association

  1984cited by this paper
• Ligand interactions with cytochrome P-450. I. Binding of primary amines.

  1969cited by this paper
• THE METABOLISM OF S-METHYL-L-CYSTEINE IN THE RAT.

  1964cited by this paper

• Biodegradability of polyisoprene rubber cross-linked with poly(l-cysteine) cross-linker

  2025cites this paper
• Oxyhalogen-sulfur chemistry: kinetics and mechanism of oxidation of chemoprotectant, sodium 2-mercaptoethanesulfonate, MESNA, by acidic bromate and aqueous bromine.

  2014cites this paper
• Flavin‐Containing Monooxygenase: The Role of Flavin‐Containing Monooxgenase in Lead Design and Selection

  2012cites this paper
• Lipid and sulfur substituted prenylcysteine analogs as human Icmt inhibitors.

  2011cites this paper
• Farnesylcysteine lyase is involved in negative regulation of abscisic acid signaling in Arabidopsis.

  2010cites this paper
• Organosulfur oxoacids. Part 2. A novel dimethylthiourea metabolite — Synthesis and characterization of the surprisingly stable and inert dimethylaminoiminomethane sulfonic acid

  2010cites this paper
• Proteomic analysis of human low‐density lipoprotein reveals the presence of prenylcysteine lyase, a hydrogen peroxide‐generating enzyme

  2009cites this paper
• Oxidative conversion of thiourea and N-substituted thioureas into formamidine disulfides with acidified chloramine-T: a kinetic and mechanistic approach

  2009cites this paper
• Flavin-containing monooxygenase 3 (FM03) : evolution, protein structure and causative mutations of Trimethylaminuria

  2008cites this paper
• Arabidopsis thaliana plants possess a specific farnesylcysteine lyase that is involved in detoxification and recycling of farnesylcysteine.

  2007cites this paper
• Quantification of farnesylmethylcysteine in lysates of peripheral blood mononuclear cells using liquid chromatography coupled with electrospray tandem mass spectrometry: pharmacodynamic assay for farnesyl transferase inhibitors.

  2006cites this paper
• S-oxygenation of thiocarbamides I: Oxidation of phenylthiourea by chlorite in acidic media.

  2005cites this paper
• Mammalian flavin-containing monooxygenases: structure/function, genetic polymorphisms and role in drug metabolism.

  2005influential citation
• Synthesis of desthio prenylcysteine analogs: sulfur is important for biological activity.

  2005cites this paper
• Protein Prenyltransferases: Anchor Size, Pseudogenes and Parasites

  2003cites this paper
• Stereospecificity and Kinetic Mechanism of Human Prenylcysteine Lyase, an Unusual Thioether Oxidase* 210

  2002cites this paper
• On the occurrence of multiple isoprenylated cysteine methyl ester hydrolase activities in bovine adrenal medulla.

  2001cites this paper
• Selenoxidation by flavin-containing monooxygenases as a novel pathway for beta-elimination of selenocysteine Se-conjugates.

  2001cites this paper
• Metabolism of [(14)C]omapatrilat, a sulfhydryl-containing vasopeptidase inhibitor in humans.

  2001cites this paper
• OMAPATRILAT , A SULFHYDRYL-CONTAINING VASOPEPTIDASE INHIBITOR IN HUMANS 1

  2000cites this paper
• In Vitro Metabolism: FMO and Related Oxygenations

  1999cites this paper
• Chemoprevention of mammary cancer with Se-allylselenocysteine and other selenoamino acids in the rat.

  1999cites this paper
• Identification and characterization of flavin-containing monooxygenase isoform 2 (FMO2) in Rhesus monkey and examination of a human FMO2 polymorphism

  1999cites this paper
• Geranylgeraniol Overcomes the Block of Cell Proliferation by Lovastatin in C6 Glioma Cells

  1998cites this paper
• Isolation and Characterization of a Prenylcysteine Lyase from Bovine Brain*

  1997cites this paper
• Geranylgeraniol promotes entry of UT-2 cells into the cell cycle in the absence of mevalonate.

  1997cites this paper
• Synthesis of prenylated peptides and peptide esters.

  1997cites this paper
• Detoxication of tyramine by the flavin-containing monooxygenase: stereoselective formation of the trans oxime.

  1997cites this paper
• Novel salvage pathway utilizing farnesol and geranylgeraniol for protein isoprenylation.

  1997cites this paper
• Microbiological transformations 36: Preparative scale synthesis of chiral thioacetal and thioketal sulfoxides using whole-cell biotransformations

  1997cites this paper
• Protein prenylation: molecular mechanisms and functional consequences.

  1996cites this paper
• Mass spectrometry.

  1996cites this paper
• The flavin-containing monooxygenase system.

  1996cites this paper
• Characterization of flavin-containing monooxygenase 5 (FMO5) cloned from human and guinea pig: evidence that the unique catalytic properties of FMO5 are not confined to the rabbit ortholog.

  1995cites this paper
• Potential role of the flavin-containing monooxygenases in the metabolism of endogenous compounds.

  1995cites this paper
• Fractionation and characterization of protein C-terminal prenyl-cysteine methylesterase activities from rabbit brain.

  1995cites this paper
• Enzymes and transport systems involved in the formation and disposition of glutathione S-conjugates. Role in bioactivation and detoxication mechanisms of xenobiotics.

  1995cites this paper
• Structural and catalytic properties of the mammalian flavin-containing monooxygenase.

  1995cites this paper