Acyl‐coenzyme A:cholesterol acyltransferase 1 – significance of single‐nucleotide polymorphism at residue 526 and the role of Pro347 near the fifth transmembrane domain

No abstract is available for this paper.

• Publication year

  2014

• Venue

  The FEBS Journal

• Publication date

  2014-04-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1111/febs.12739PMID 24517390PMCID PMC4060832
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Acat1 knockdown gene therapy decreases amyloid-β in a mouse model of Alzheimer's disease.

  2013cited by this paper
• Acat1 Gene Ablation in Mice Increases Hematopoietic Progenitor Cell Proliferation in Bone Marrow and Causes Leukocytosis

  2013cited by this paper
• A novel mouse model of Niemann-Pick type C disease carrying a D1005G-Npc1 mutation comparable to commonly observed human mutations.

  2012cited by this paper
• Membrane-bound O-acyltransferases (MBOATs)

  2011cited by this paper
• ACAT1 gene ablation increases 24(S)-hydroxycholesterol content in the brain and ameliorates amyloid pathology in mice with AD

  2010cited by this paper
• The Acyl-Coenzyme A: Cholesterol Acyltransferase Inhibitor CI-1011 Reverses Diffuse Brain Amyloid Pathology in Aged Amyloid Precursor Protein Transgenic Mice

  2010cited by this paper
• Acyl-coenzyme A:cholesterol acyltransferases.

  2009cited by this paper
• Identification of membrane O-acyltransferase family motifs.

  2009cited by this paper
• Oxysterols: Sources, cellular storage and metabolism, and new insights into their roles in cholesterol homeostasis.

  2009cited by this paper
• RNA secondary structures located in the interchromosomal region of human ACAT1 chimeric mRNA are required to produce the 56-kDa isoform

  2008cited by this paper
• Hhat Is a Palmitoylacyltransferase with Specificity for N-Palmitoylation of Sonic Hedgehog*♦

  2008cited by this paper
• Functionality of the seventh and eighth transmembrane domains of acyl-coenzyme A:cholesterol acyltransferase 1.

  2007cited by this paper
• Cis–trans isomerization at a proline opens the pore of a neurotransmitter-gated ion channel

  2005cited by this paper
• The disulfide linkage and the free sulfhydryl accessibility of acyl-coenzyme A:cholesterol acyltransferase 1 as studied by using mPEG5000-maleimide.

  2005cited by this paper
• Sphingosine-1-Phosphate Prevents Tumor Necrosis Factor-&agr;–Mediated Monocyte Adhesion to Aortic Endothelium in Mice

  2005cited by this paper
• The Active Site His-460 of Human Acyl-coenzyme A:Cholesterol Acyltransferase 1 Resides in a Hitherto Undisclosed Transmembrane Domain*

  2005cited by this paper
• The influence of the acyl-CoA:cholesterol acyltransferase-1 gene (-77G-->A) polymorphisms on plasma lipid and apolipoprotein levels in normolipidemic and hyperlipidemic subjects.

  2004cited by this paper
• Human acyl-coenzyme A:cholesterol acyltransferase expressed in chinese hamster ovary cells: membrane topology and active site location.

  2003cited by this paper
• The critical role of transmembrane prolines in human prostacyclin receptor activation.

  2002cited by this paper
• Consequences of cellular cholesterol accumulation: basic concepts and physiological implications.

  2002cited by this paper
• Role of the N-terminal hydrophilic domain of acyl-coenzyme A:cholesterol acyltransferase 1 on the enzyme's quaternary structure and catalytic efficiency.

  2002cited by this paper
• Mammalian acyl-CoA:cholesterol acyltransferases.

  2000cited by this paper
• Human Acyl-CoA:Cholesterol Acyltransferase-1 Is a Homotetrameric Enzyme in Intact Cells and in Vitro *

  1999cited by this paper
• Identification of a Form of Acyl-CoA:Cholesterol Acyltransferase Specific to Liver and Intestine in Nonhuman Primates*

  1998cited by this paper
• Characterization of Two Human Genes Encoding Acyl Coenzyme A:Cholesterol Acyltransferase-related Enzymes*

  1998cited by this paper
• Recombinant Acyl-CoA:cholesterol Acyltransferase-1 (ACAT-1) Purified to Essential Homogeneity Utilizes Cholesterol in Mixed Micelles or in Vesicles in a Highly Cooperative Manner*

  1998cited by this paper
• Functional rafts in cell membranes

  1997cited by this paper
• Acyl-coenzyme A:cholesterol acyltransferase.

  1997cited by this paper
• Regulation and Immunolocalization of Acyl-Coenzyme A:Cholesterol Acyltransferase in Mammalian Cells as Studied with Specific Antibodies (*)

  1995cited by this paper
• Cell Toxicity Induced by Inhibition of Acyl Coenzyme A:Cholesterol Acyltransferase and Accumulation of Unesterified Cholesterol *

  1995cited by this paper
• Molecular cloning and functional expression of human acyl-coenzyme A:cholesterol acyltransferase cDNA in mutant Chinese hamster ovary cells.

  1993cited by this paper
• A simple method for reconstitution of CHO cell and human fibroblast acyl coenzyme A: cholesterol acyltransferase activity into liposomes.

  1988cited by this paper
• Cycloheximide sensitivity in regulation of acyl coenzyme A:cholesterol acyltransferase activity in Chinese hamster ovary cells. 1. Effect of exogenous sterols.

  1986cited by this paper
• Evidence indicating that inactivation of 3-hydroxy-3-methylglutaryl coenzyme A reductase by low density lipoprotein or by 25-hydroxycholesterol requires mediator protein(s) with rapid turnover rate.

  1981cited by this paper
• A method for the chemical synthesis of 14C-labeled fatty acyl coenzyme A's of high specific activity.

  1980cited by this paper
• The active site

  1977cited by this paper

• Oxysterol-binding protein ORP6 regulates lipid metabolism and brain Aβ production

  2025cites this paper
• Effects of impaired steryl ester biosynthesis on tomato growth and developmental processes

  2022cites this paper
• Acyl-Coenzyme A: Cholesterol Acyltransferase (ACAT) in Cholesterol Metabolism: From Its Discovery to Clinical Trials and the Genomics Era

  2021cites this paper
• Inhibition mechanism of human sterol O-acyltransferase 1 by competitive inhibitor

  2020cites this paper
• Structural insights into the inhibition mechanism of human sterol O-acyltransferase 1 by a competitive inhibitor

  2020cites this paper
• Identification and Characterization of Sterol Acyltransferases Responsible for Steryl Ester Biosynthesis in Tomato

  2018influential citation
• mTORC1 Activates SREBP-2 through Maintenance of Endosomal Cycling and Suppression of Autophagy

  2017cites this paper