Metabolomics for early detection of drug-induced kidney injury: review of the current status.

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Bioanalysis

• Publication date

  2009-12-07

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.4155/bio.09.142PMID 21083109
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Cardiovascular , Pulmonary and Renal Pathology Alterations in Fatty Acid Utilization and an Impaired Antioxidant Defense Mechanism Are Early Events in Podocyte Injury A Proteomic Analysis

  2010cited by this paper
• Comparative analysis of novel noninvasive renal biomarkers and metabonomic changes in a rat model of gentamicin nephrotoxicity.

  2009cited by this paper
• Alterations in fatty acid utilization and an impaired antioxidant defense mechanism are early events in podocyte injury: a proteomic analysis.

  2009cited by this paper
• Renal toxicity of therapeutic drugs

  2009cited by this paper
• Measurement of dietary exposure: a challenging problem which may be overcome thanks to metabolomics?

  2009cited by this paper
• Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites

  2009cited by this paper
• A Metabonomic Study on the Biochemical Effects of Doxorubicin in Rats Using 1H-NMR Spectroscopy

  2009cited by this paper
• Assay Validation for KIM-1: human urinary renal dysfunction biomarker

  2009cited by this paper
• Integrated, nontargeted ultrahigh performance liquid chromatography/electrospray ionization tandem mass spectrometry platform for the identification and relative quantification of the small-molecule complement of biological systems.

  2009cited by this paper
• Measurement of internal body time by blood metabolomics

  2009cited by this paper
• Discovery of Metabolomics Biomarkers for Early Detection of Nephrotoxicity

  2009cited by this paper
• Omic profiling for drug safety assessment: current trends and public-private partnerships.

  2009cited by this paper
• Normalization strategies for metabonomic analysis of urine samples.

  2009cited by this paper
• Urine metabolites reflect time-dependent effects of cyclosporine and sirolimus on rat kidney function.

  2009cited by this paper
• Biomarkers of nephrotoxic acute kidney injury.

  2008cited by this paper
• Urinary Biomarkers for Sensitive and Specific Detection of Acute Kidney Injury in Humans

  2008cited by this paper
• Time dependent effects of gentamicin on the enzymes of carbohydrate metabolism, brush border membrane and oxidative stress in rat kidney tissues.

  2008cited by this paper
• Biomarkers of acute kidney injury.

  2008cited by this paper
• Biomarkers of acute kidney injury.

  2008cited by this paper
• Integrated pathway analysis of rat urine metabolic profiles and kidney transcriptomic profiles to elucidate the systems toxicology of model nephrotoxicants.

  2008cited by this paper
• The utility of a rodent model in detecting pediatric drug-induced nephrotoxicity.

  2007cited by this paper
• Preclinical Predictors of Clinical Safety: Opportunities for Improvement

  2007cited by this paper
• Biomarker qualification pilot process at the US Food and Drug Administration

  2007cited by this paper
• Biochemical mechanisms of nephrotoxicity: application for metabolomics.

  2007cited by this paper
• Biochemical mechanisms of nephrotoxicity: application for metabolomics

  2007cited by this paper
• The Predictive Safety Testing Consortium: A synthesis of the goals, challenges and accomplishments of the Critical Path.

  2007cited by this paper
• Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury

  2007cited by this paper
• Metabolic profiling using combined GC–MS and LC–MS provides a systems understanding of aristolochic acid‐induced nephrotoxicity in rat

  2007cited by this paper
• Biochemical Mechanisms of Renal Toxicity

  2007cited by this paper
• Polyamine analogues – an update

  2007cited by this paper
• Prediction and classification of drug toxicity using probabilistic modeling of temporal metabolic data: the consortium on metabonomic toxicology screening approach.

  2007cited by this paper
• Metabolomics in monitoring kidney transplants

  2006cited by this paper
• Declining mortality in patients with acute renal failure, 1988 to 2002.

  2006cited by this paper
• Renal nucleoside transporters: physiological and clinical implications.

  2006cited by this paper
• Drug-associated renal dysfunction and injury

  2006cited by this paper
• Estimating the cost of new drug development: is it really 802 million dollars?

  2006cited by this paper
• Exploration of the direct metabolic effects of mercury II chloride on the kidney of Sprague-Dawley rats using high-resolution magic angle spinning 1H NMR spectroscopy of intact tissue and pattern recognition.

  2006cited by this paper
• Metabolomic study of cisplatin-induced nephrotoxicity.

  2006cited by this paper
• Prediction of Nephrotoxicant Action and Identification of Candidate Toxicity-Related Biomarkers

  2005cited by this paper
• Acute renal failure in critically ill patients: a multinational, multicenter study.

  2005cited by this paper
• Cholesterol Emboli-induced Renal Failure and Gastric Ulcer After Thrombolytic Therapy

  2005cited by this paper
• The Consortium for Metabonomic Toxicology (COMET): aims, activities and achievements.

  2005cited by this paper
• Metabonomics with 1H-NMR spectroscopy and liquid chromatography-mass spectrometry applied to the investigation of metabolic changes caused by gentamicin-induced nephrotoxicity in the rat

  2005cited by this paper
• Polyamines and apoptosis

  2005cited by this paper
• Metabonomic identification of two distinct phenotypes in Sprague-Dawley (Crl:CD(SD)) rats.

  2005cited by this paper
• Drug-induced nephropathy: an update

  2005cited by this paper
• Drug-induced renal failure: a focus on tubulointerstitial disease.

  2005cited by this paper
• Measurement of kidney function.

  2005cited by this paper
• Metabonomics in toxicology: a review.

  2005cited by this paper
• Metabonomic deconvolution of embedded toxicity: application to thioacetamide hepato- and nephrotoxicity.

  2005cited by this paper
• Trying to Catch Troublemakers With a Metabolic Profile

  2005cited by this paper
• Using Serum Creatinine To Estimate Glomerular Filtration Rate: Accuracy in Good Health and in Chronic Kidney Disease

  2004cited by this paper
• Can the pharmaceutical industry reduce attrition rates?

  2004cited by this paper
• A metabonomic investigation of the biochemical effects of mercuric chloride in the rat using 1H NMR and HPLC-TOF/MS: time dependent changes in the urinary profile of endogenous metabolites as a result of nephrotoxicity.

  2004cited by this paper
• Renal metabolism of amino acids: its role in interorgan amino acid exchange.

  2004cited by this paper
• The price of innovation: new estimates of drug development costs.

  2003cited by this paper
• 1H NMR pattern recognition and 31P NMR studies with d-Serine in rat urine and kidney, time- and dose-related metabolic effects.

  2003cited by this paper
• NMR spectroscopic-based metabonomic studies of urinary metabolite variation in acclimatizing germ-free rats.

  2003cited by this paper
• Diseases of the Kidney and Urinary Tract

  2001cited by this paper
• Metabolic profiling of chronic cadmium exposure in the rat.

  2001cited by this paper
• Metabonomics: evaluation of nuclear magnetic resonance (NMR) and pattern recognition technology for rapid in vivo screening of liver and kidney toxicants.

  2000cited by this paper
• Chemometric models for toxicity classification based on NMR spectra of biofluids.

  2000cited by this paper
• Treatment of acute renal failure.

  1998cited by this paper
• The Measurement of Renal Injury

  1998cited by this paper
• The identification of novel biomarkers of renal toxicity using automatic data reduction techniques and PCA of proton NMR spectra of urine

  1998cited by this paper
• Nephrotoxicity of xenobiotics.

  1995cited by this paper
• Classification of toxin-induced changes in 1H NMR spectra of urine using an artificial neural network.

  1995cited by this paper
• Introduction to Biochemical Toxicology

  1994cited by this paper
• Assessment of renal function--glomerular and tubular.

  1993cited by this paper
• Nuclear magnetic resonance spectroscopy and pattern recognition analysis of the biochemical processes associated with the progression of and recovery from nephrotoxic lesions in the rat induced by mercury(II) chloride and 2-bromoethanamine.

  1992cited by this paper

• A pilot study on hemodynamically stable isolated chest trauma patients reveals dysregulation of oxidative metabolism

  2025cites this paper
• Renal toxicity of ifosfamide in children with cancer: an exploratory study integrating aldehyde dehydrogenase enzymatic activity data and a wide-array urinary metabolomics approach

  2024cites this paper
• The identification of key metabolites and mechanisms during isoniazid/rifampicin-induced neurotoxicity and hepatotoxicity in a mouse model by HPLC-TOF/MS-based untargeted urine metabolomics.

  2023cites this paper
• Protective effect of Clinacanthus nutans in cisplatin-induced nephrotoxicity on human kidney cell (PCS-400-010) elucidated by an LCMS-based metabolomics approach.

  2023cites this paper
• Maternal Plasma Metabolic Profile Demarcates a Role for Neuroinflammation in Non-Typical Development of Children

  2021cites this paper
• Identification of key metabolites during cisplatin-induced acute kidney injury using an HPLC-TOF/MS-based non-targeted urine and kidney metabolomics approach in rats.

  2020cites this paper
• PEDF, a pleiotropic WTC-LI biomarker: Machine learning biomarker identification and validation

  2020cites this paper
• Metabolome and microbiome in kidney diseases

  2020cites this paper
• Toxicity and Its Mechanism Study of Arecae semen Aqueous Extract in Wistar Rats by UPLC-HDMS-Based Serum Metabolomics

  2020cites this paper
• Biomarkers of Acute and Chronic Kidney Disease.

  2019cites this paper
• Assessing the Protective Metabolome Using Machine Learning in World Trade Center Particulate Exposed Firefighters at Risk for Lung Injury

  2019cites this paper
• Genome-scale model-based identification of metabolite indicators for early detection of kidney toxicity.

  2019cites this paper
• Targeting human urinary metabolome by LC-MS/MS: a review.

  2018cites this paper
• Metabolomics of World Trade Center-Lung Injury: a machine learning approach

  2018cites this paper
• Urinary metabolites predict prolonged duration of delayed graft function in DCD kidney transplant recipients

  2018cites this paper
• ^1H NMR-based nontargeted metabonomics study of plasma and urinary biochemical changes in Kudouzi treated rats

  2018cites this paper
• Nephrotoxicity of Herbal Products

  2017cites this paper
• Targeted Metabolomics: The Next Generation of Clinical Chemistry!

  2016cites this paper
• Metabolomics as a tool to evaluate the toxicity of formulations containing amphotericin B, an antileishmanial drug.

  2016cites this paper
• Plasma Biomarkers for Monitoring Brain Pathophysiology in FMR1 Premutation Carriers

  2016cites this paper
• Application of Clinical Bioinformatics

  2016cites this paper
• Plasma metabolic profile delineates roles for neurodegeneration, pro-inflammatory damage and mitochondrial dysfunction in the FMR1 premutation.

  2016cites this paper
• Assessing physiological .response to toxic industrial chemical exposure in megacities

  2016cites this paper
• Transgenic mice and metabolomics for study of hepatic xenobiotic metabolism and toxicity

  2015cites this paper
• Activation of the calcium-sensing receptor before renal ischemia/reperfusion exacerbates kidney injury.

  2015cites this paper
• Toxic Markers of Matrine Determined Using 1H-NMR-Based Metabolomics in Cultured Cells In Vitro and Rats In Vivo

  2015cites this paper
• Metabolomics in nephrotoxicity.

  2014cites this paper
• Identification of metabolomic biomarkers for drug‐induced acute kidney injury in rats

  2014cites this paper
• Academic College of Emergency Experts in India's INDO-US Joint Working Group and OPUS12 Foundation Consensus Statement on Creating A Coordinated, Multi-Disciplinary, Patient-Centered, Global Point-of-Care Biomarker Discovery Network

  2014cites this paper
• Normalization to specific gravity prior to analysis improves information recovery from high resolution mass spectrometry metabolomic profiles of human urine.

  2014cites this paper
• Safety pharmacology — Current and emerging concepts D P R O O F

  2013cites this paper
• Future Directions and New Technology in Peritoneal Dialysis

  2013cites this paper
• Urinary metabonomic study of the surface layer of Poria cocos as an effective treatment for chronic renal injury in rats.

  2013cites this paper
• Safety pharmacology--current and emerging concepts.

  2013cites this paper
• Diagnosis of acute kidney injury using functional and injury biomarkers: workgroup statements from the tenth Acute Dialysis Quality Initiative Consensus Conference.

  2013cites this paper
• Implementation of novel biomarkers in the diagnosis, prognosis, and management of acute kidney injury: executive summary from the tenth consensus conference of the Acute Dialysis Quality Initiative (ADQI).

  2013cites this paper
• Functional assessments in repeat-dose toxicity studies: the art of the possible

  2013cites this paper
• A Metabolomics Approach for Evaluation of Target-organ Toxicity

  2013cites this paper
• Toxicometabolomics: Technology and Applications

  2013cites this paper
• Chapter 33 – Toxicometabolomics: Technology and Applications

  2013cites this paper
• The Use of Metabolomics In Vivo for the Development of Agrochemical Products

  2013cites this paper
• Urinary metabolomics in newborns and infants.

  2012cites this paper
• Biomarkers in Acute and Chronic Kidney Diseases

  2012cites this paper
• 1H NMR-based metabolomic analysis of triptolide-induced toxicity in liver-specific cytochrome P450 reductase knockout mice

  2012cites this paper
• Marking renal injury: can we move beyond serum creatinine?

  2012cites this paper
• Urinary metabonomics study on biochemical changes in an experimental model of chronic renal failure by adenine based on UPLC Q-TOF/MS.

  2012cites this paper
• Application of systems biology to the study of chronic kidney disease.

  2012cites this paper
• Metabolic Profiling of the Protozoan Parasite Entamoeba invadens Revealed Activation of Unpredicted Pathway during Encystation

  2012cites this paper
• Pharma-metabolomics in neonatology: is it a dream or a fact?

  2012cites this paper
• Animal Models of Alzheimer's Disease

  2011cites this paper
• Toxicogenomics and metabolomics of pentamethylchromanol (PMCol)-induced hepatotoxicity.

  2011cites this paper
• Analytical metabolomics: nutritional opportunities for personalized health.

  2011cites this paper
• Identification of urinary metabolites that distinguish membranous lupus nephritis from proliferative lupus nephritis and focal segmental glomerulosclerosis

  2011cites this paper
• The role of metabonomics at the interface between drug metabolism and safety assessment.

  2010cites this paper
• Bioanalysis: the best of 2009.

  2010cites this paper
• Metabolomic Profiling Reveals Biochemical Pathways and Biomarkers Associated with Pathogenesis in Cystic Fibrosis Cells

  2010cites this paper
• Ablation of the Locus Coeruleus Increases Oxidative Stress in Tg-2576 Transgenic but Not Wild-Type Mice

  2010cites this paper
• Early Prediction of Lupus Nephritis Using Advanced Proteomics

  2008cites this paper