Beta2-adrenergic receptor activation delays wound healing.

No abstract is available for this paper.

• Publication year

  2006

• Venue

  The FASEB Journal

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  PMID 16394270
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• RACK1-mediated Integration of Adhesion and Insulin-like Growth Factor I (IGF-I) Signaling and Cell Migration Are Defective in Cells Expressing an IGF-I Receptor Mutated at Tyrosines 1250 and 1251*

  2005cited by this paper
• Protein Phosphatase 2A Negatively Regulates Insulin's Metabolic Signaling Pathway by Inhibiting Akt (Protein Kinase B) Activity in 3T3-L1 Adipocytes

  2004cited by this paper
• Social facilitation of wound healing.

  2004cited by this paper
• Beta-blocker use is associated with improved outcomes in adult burn patients.

  2004cited by this paper
• PAI‐1 expression is required for epithelial cell migration in two distinct phases of in vitro wound repair

  2004cited by this paper
• ERK activation propagates in epithelial cell sheets and regulates their migration during wound healing.

  2004cited by this paper
• Laminin 5 deposition regulates keratinocyte polarization and persistent migration

  2004cited by this paper
• Increased in vitro expression of beta2-adrenoceptors in differentiating lesional keratinocytes of vitiligo patients

  2004cited by this paper
• Autocrine catecholamine biosynthesis and the beta-adrenoceptor signal promote pigmentation in human epidermal melanocytes.

  2004cited by this paper
• Estrogen modulates cutaneous wound healing by downregulating macrophage migration inhibitory factor.

  2003cited by this paper
• PP2A activation by beta2-adrenergic receptor agonists: novel regulatory mechanism of keratinocyte migration.

  2003cited by this paper
• p38 and ERK1/2 Coordinate Cellular Migration and Proliferation in Epithelial Wound Healing

  2003cited by this paper
• Cell Migration: Integrating Signals from Front to Back

  2003cited by this paper
• Beta2-adrenergic receptor antagonist accelerates skin barrier recovery and reduces epidermal hyperplasia induced by barrier disruption.

  2003cited by this paper
• Mechanisms in LPA-induced tumor cell migration: critical role of phosphorylated ERK

  2003cited by this paper
• Gene therapy, electroporation, and the future of wound-healing therapies.

  2002cited by this paper
• Hepatocyte Growth Factor Induces ERK-dependent Paxillin Phosphorylation and Regulates Paxillin-Focal Adhesion Kinase Association*

  2002cited by this paper
• Dynamic characterization of the molecular events during in vitro epidermal wound healing.

  2002cited by this paper
• E2F-1 Is Essential for Normal Epidermal Wound Repair*

  2002cited by this paper
• Beta-adrenergic receptor activation inhibits keratinocyte migration via a cyclic adenosine monophosphate-independent mechanism.

  2002cited by this paper
• Direct integrin alphavbeta6-ERK binding: implications for tumour growth.

  2002cited by this paper
• Nascent Focal Adhesions Are Responsible for the Generation of Strong Propulsive Forces in Migrating Fibroblasts

  2001cited by this paper
• Mechanism of Actin-Based Motility

  2001cited by this paper
• Isoproterenol Activates Extracellular Signal–Regulated Protein Kinases in Cardiomyocytes Through Calcineurin

  2001cited by this paper
• Phosphorylation of the beta1 integrin cytoplasmic domain: toward an understanding of function and mechanism.

  2000cited by this paper
• The beta(2)-adrenergic receptor mediates extracellular signal-regulated kinase activation via assembly of a multi-receptor complex with the epidermal growth factor receptor.

  2000cited by this paper
• β2-Adrenergic Receptor Activates Extracellular Signal-regulated Kinases (ERKs) via the Small G Protein Rap1 and the Serine/Threonine Kinase B-Raf*

  2000cited by this paper
• Stress alters cutaneous permeability barrier homeostasis.

  2000cited by this paper
• Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics.

  2000cited by this paper
• Role of ERK and JNK pathways in regulating cell motility and matrix metalloproteinase 9 production in growth factor‐stimulated human epidermal keratinocytes

  1999cited by this paper
• Cutaneous wound healing.

  1999cited by this paper
• Src-mediated Tyrosine Phosphorylation of Dynamin Is Required for β2-Adrenergic Receptor Internalization and Mitogen-activated Protein Kinase Signaling*

  1999cited by this paper
• Cytostatin, an inhibitor of cell adhesion to extracellular matrix, selectively inhibits protein phosphatase 2A.

  1999cited by this paper
• Multiple signalling pathways exist in the stress-triggered regulation of gene expression for catecholamine biosynthetic enzymes and several neuropeptides in the rat adrenal medulla.

  1999cited by this paper
• Regulation of protein kinase cascades by protein phosphatase 2A.

  1999cited by this paper
• Modeling of wound healing processes in human skin using tissue culture

  1998cited by this paper
• Regulation of Cell Motility by Mitogen-activated Protein Kinase

  1997cited by this paper
• Wound Healing--Aiming for Perfect Skin Regeneration

  1997cited by this paper
• Epidermal adrenergic signal transduction as part of the neuronal network in the human epidermis.

  1997cited by this paper
• Corneal epithelial deficiency induced by the use of beta-blocker eye drops.

  1997cited by this paper
• Adrenergic receptor stimulation of the mitogen-activated protein kinase cascade and cardiac hypertrophy.

  1996cited by this paper
• Autoradiographic mapping of beta-adrenoceptors in human skin

  1996cited by this paper
• Molecular mechanisms for focal adhesion assembly through regulation of protein-protein interactions.

  1996cited by this paper
• Catecholamines in human keratinocyte differentiation.

  1995cited by this paper
• Dual effect of beta-adrenergic receptors on mitogen-activated protein kinase. Evidence for a beta gamma-dependent activation and a G alpha s-cAMP-mediated inhibition.

  1995cited by this paper
• Effect of topical beta blockers on corneal epithelial wound healing in the rabbit.

  1994cited by this paper
• Changes in the distribution of actin-associated proteins during epidermal wound healing.

  1993cited by this paper
• Expression of integrins and basement membrane components by wound keratinocytes.

  1993cited by this paper
• Binding of beta-adrenergic receptors in human skin.

  1992cited by this paper
• Low-energy helium-neon laser irradiation increases the motility of cultured human keratinocytes.

  1990cited by this paper
• Beta Adrenoceptors and Regenerating Corneal Epithelium

  1990cited by this paper
• Beta‐adrenergic stimulation of cyclic AMP is defective in cultured dermal fibroblasts of psoriatic subjects

  1990cited by this paper
• Focal contacts: Transmembrane links between the extracellular matrix and the cytoskeleton

  1989cited by this paper
• Influence of catecholamines on epidermal cell migration during wound closure in adult newts.

  1984cited by this paper
• Down syndrome fibroblasts are hyperresponsive to beta-adrenergic stimulation.

  1981cited by this paper
• Cytoplasmic filaments and gap junctions in epithelial cells and myofibroblasts during wound healing

  1978cited by this paper
• Serial cultivation of strains of human epidermal keratinocytes: the formation of keratinizing colonies from single cells.

  1975cited by this paper
• [Adrenergic innervation of normal human skin].

  1972cited by this paper

• Type 2 Diabetes‐Associated Phenylacetylglutamine Induces Deleterious Inflammation Cycle in Myeloid Cells through β2 Adrenergic Receptors and Impedes Wound Healing

  2025cites this paper
• Topical Salbutamol Cutaneous Gel Is Safe in a Double-Blind, Placebo-Controlled, Randomized Trial of Scarring from Sutured Wound Margins on the Arms of Healthy Human Volunteers

  2025cites this paper
• Single-Cell Proteomics Uncovers Dual Traits of Dermal Sheath Cells in Wound Repair

  2025cites this paper
• Recent advances in the role of neuroregulation in skin wound healing

  2025cites this paper
• G Protein-Coupled Receptors in Skin Aging.

  2024cites this paper
• Recent advances in the adjunctive management of diabetic foot ulcer: Focus on noninvasive technologies

  2024cites this paper
• β2-Adrenoceptor Activation Favor Acquisition of Tumorigenic Properties in Non-Tumorigenic MCF-10A Breast Epithelial Cells

  2024cites this paper
• Postbiotic lactobacilli induce cutaneous antimicrobial response and restore the barrier to inhibit the intracellular invasion of Staphylococcus aureus in vitro and ex vivo

  2024cites this paper
• Neural and Inflammatory Interactions in Wound Healing

  2024cites this paper
• Sympathetic System in Wound Healing: Multistage Control in Normal and Diabetic Skin

  2023cites this paper
• Mechanism and application of β‐adrenoceptor blockers in soft tissue wound healing

  2023cites this paper
• Adrenergic receptor signaling induced by Klf15, a regulator of regeneration enhancer, promotes kidney reconstruction

  2022cites this paper
• Effects of topical timolol for the prevention of radiation-induced dermatitis in breast cancer: a pilot triple-blind, placebo-controlled trial

  2022cites this paper
• The role of topical timolol in wound healing and the treatment of vascular lesions: A narrative review

  2021cites this paper
• Regulation of hyaluronan production by β2 adrenergic receptor signaling.

  2021cites this paper
• Propranolol-loaded electrospun nanofibrous wound dressing: From fabrication and characterization to preliminary wound healing evaluation

  2021cites this paper
• Evaluation of timolol maleate gel for management of hard-to-heal chronic venous leg ulcers. Phase II randomised-controlled study.

  2021cites this paper
• The Adrenergic System in Plastic and Reconstructive Surgery

  2021cites this paper
• Alpha and beta adrenergic receptors modulate keratinocyte migration

  2021cites this paper
• Inhibitory designer receptors aggravate memory loss in a mouse model of down syndrome.

  2020cites this paper
• [Mechanisms of adrenergic β-antagonist for wounds and its application prospect in diabetic foot ulcers].

  2020cites this paper
• Beta-adrenergic antagonist for the healing of chronic diabetic foot ulcers: study protocol for a prospective, randomized, double-blinded, controlled and parallel-group study

  2020cites this paper
• Trace amines produced by skin bacteria accelerate wound healing in mice

  2020cites this paper
• Trace amines produced by skin bacteria accelerate wound healing in mice

  2020cites this paper
• Absorption and Safety of Topically Applied Timolol for Treatment of Chronic Cutaneous Wounds

  2019cites this paper
• Side Effects of Frequently Used Antihypertensive Drugs on Wound Healing in vitro

  2019cites this paper
• Accelerated skin wound healing by selective 11β-Hydroxylase (CYP11B1) inhibitors.

  2018cites this paper
• Extended live‐tracking and quantitative characterization of wound healing and cell migration with SiR‐Hoechst

  2018cites this paper
• Antihypertensives in dermatology Part I - Uses of antihypertensives in dermatology

  2018cites this paper
• Lead optimization of highly potent and selective CYP11B1 inhibitors for the treatment of Cushing’s syndrome and chronic wounds

  2017cites this paper
• Optical coherence tomography for assessment of epithelialization in a human ex vivo wound model

  2017cites this paper
• Topical timolol promotes healing of chronic leg ulcer.

  2017cites this paper
• Topical 1% propranolol cream promotes cutaneous wound healing in spontaneously diabetic mice

  2017cites this paper
• Stress and Skin Disorders

  2017cites this paper
• CFTR Involvement in Cell Migration and Epithelial Restitution

  2017cites this paper
• Topical Agents for Melasma: A Perspective on Therapeutic Approaches and their Molecular Bases

  2015cites this paper
• Activation of β2-adrenergic receptor by (R,R')-4'-methoxy-1-naphthylfenoterol inhibits proliferation and motility of melanoma cells.

  2015cites this paper
• Agonist binding to β-adrenergic receptors on human airway epithelial cells inhibits migration and wound repair.

  2015cites this paper
• Propranolol impairs the closure of pressure ulcers in mice.

  2014cites this paper
• Melasma in Men

  2014cites this paper
• Epithelialization in Wound Healing: A Comprehensive Review

  2014cites this paper
• Crosstalk Between Adrenergic and Toll‐Like Receptors in Human Mesenchymal Stem Cells and Keratinocytes: A Recipe for Impaired Wound Healing

  2014cites this paper
• Topical timolol for a chronic ulcer — a case with its own control

  2014cites this paper
• The stimulatory effects of alpha1-adrenergic receptors on TGF-beta1, IGF-1 and hyaluronan production in human skin fibroblasts

  2014cites this paper
• Acute wounding alters the beta2-adrenergic signaling and catecholamine synthetic pathways in keratinocytes.

  2014cites this paper
• β2-Adrenoceptor Activation Modulates Skin Wound Healing Processes to Reduce Scarring

  2014cites this paper
• The effect of psychological stress and social isolation on neuroimmunoendocrine communication.

  2014cites this paper
• Keratinocytes : A Recipe for Impaired Wound Healing Crosstalk Between Adrenergic and Toll-Like Receptors in Human Mesenchymal

  2014cites this paper
• Collagenase ointment and topical timolol gel for treating idiopathic pyoderma gangrenosum.

  2014cites this paper
• Beta-adrenoceptor modulation of dermal endothelial cell function and angiogenesis

  2013influential citation
• Successful treatment of a chronic venous leg ulcer using a topical beta-blocker.

  2013cites this paper
• Exchange Protein Directly Activated by cAMP (epac): A Multidomain cAMP Mediator in the Regulation of Diverse Biological Functions

  2013cites this paper
• Human ex vivo wound healing model.

  2013cites this paper
• Topical Timolol for a Refractory Wound

  2012influential citation
• Dopamine Agonists Upregulate IL-6 and IL-8 Production in Human Keratinocytes

  2012cites this paper
• Galectin-3 regulates intracellular trafficking of epidermal growth factor receptor through Alix and promotes keratinocyte migration

  2012cites this paper
• P2Y2 receptor inhibits EGF-induced MAPK pathway to stabilise keratinocyte hemidesmosomes

  2012cites this paper
• Impact of substrate elasticity on human hematopoietic stem and progenitor cell adhesion and motility

  2012cites this paper
• The wound‐healing response and upregulated embryonic mechanisms: brothers‐in‐arms forever

  2012cites this paper
• Stress-Induced Hormones Cortisol and Epinephrine Impair Wound Epithelization

  2012cites this paper
• β2AR Antagonists and β2AR Gene Deletion Both Promote Skin Wound Repair Processes

  2012cites this paper
• A Biphasic and Brain-Region Selective Down-Regulation of Cyclic Adenosine Monophosphate Concentrations Supports Object Recognition in the Rat

  2012cites this paper
• Multiple Facets of cAMP Signalling and Physiological Impact: cAMP Compartmentalization in the Lung

  2012cites this paper
• INSTITUTO POLITÉCNICO NACIONAL ESCUELA SUPERIOR DE MEDICINA SECCIÓN DE ESTUDIOS DE POSGRADO E INVESTIGACIÓN

  2011cites this paper
• Cortisol Synthesis in Epidermis Is Induced by IL-1 and Tissue Injury*

  2011cites this paper
• The melanogenesis and mechanisms of skin‐lightening agents – existing and new approaches

  2011influential citation
• Adrenergic Signaling in Human Oral Keratinocytes and Wound Repair

  2011influential citation
• Somatostatin Inhibits Cell Migration and Reduces Cell Counts of Human Keratinocytes and Delays Epidermal Wound Healing in an Ex Vivo Wound Model

  2011cites this paper
• Attenuation of the Transforming Growth Factor β-Signaling Pathway in Chronic Venous Ulcers

  2010cites this paper
• Single cell mechanics of keratinocyte cells.

  2010cites this paper
• The effect of stress on the defense systems

  2010cites this paper
• A vHTS approach for the identification of beta-adrenoceptor ligands.

  2010cites this paper
• ERK2 dependent signaling contributes to wound healing after a partial-thickness burn.

  2009cites this paper
• Stress-Mediated Increases in Systemic and Local Epinephrine Impair Skin Wound Healing: Potential New Indication for Beta Blockers

  2009cites this paper
• β‐1 and β‐2, but not α‐1 and α‐2, adrenoceptor blockade delays rat cutaneous wound healing

  2009cites this paper
• Acute propranolol infusion stimulates protein synthesis in rabbit skin wound.

  2009cites this paper
• Interaction of monocarboxylate transporter 4 with beta1-integrin and its role in cell migration.

  2009cites this paper
• FSH-induced phosphoprotein phosphatase 2A-mediated deactivation of particulate phosphodiesterase-4 activities is abolished after alteration in proteoglycan synthesis in immature rat Sertoli cells.

  2008cites this paper
• Beta2-adrenergic receptor signaling mediates corneal epithelial wound repair.

  2008cites this paper
• Dickkopf 1 (DKK1) regulates skin pigmentation and thickness by affecting Wnt/ β‐catenin signaling in keratinocytes

  2008cites this paper
• beta-Adrenergic receptor modulation of wound repair.

  2008cites this paper
• Microgravity and the implications for wound healing

  2008cites this paper
• Gab2 requires membrane targeting and the met binding motif to promote lamellipodia, cell scatter, and epithelial morphogenesis downstream from the met receptor

  2008cites this paper
• Association between the use of beta-adrenergic receptor agents and the development of venous leg ulcers.

  2007cites this paper
• Beta adrenergic receptors in keratinocytes.

  2007cites this paper
• G alpha(q/11)-coupled P2Y2 nucleotide receptor inhibits human keratinocyte spreading and migration.

  2007cites this paper
• Wound re-epithelialization: modulating keratinocyte migration in wound healing.

  2007cites this paper
• Recombinant human platelet-derived growth factor enhanced dermal wound healing by a pathway involving ERK and c-fos in diabetic rats.

  2007cites this paper
• ß‐adrenergic receptor agonists delay while antagonists accelerate epithelial wound healing: Evidence of an endogenous adrenergic network within the corneal epithelium

  2007cites this paper
• Stress, Social Support, and Delayed Skin Barrier Recovery

  2007cites this paper
• Depressive Symptoms Predict Mucosal Wound Healing

  2007cites this paper
• Sheet migration by wounded monolayers as an emergent property of single-cell dynamics

  2007cites this paper
• Neuronal control of skin function: the skin as a neuroimmunoendocrine organ.

  2006cites this paper
• beta4 integrin and epidermal growth factor coordinately regulate electric field-mediated directional migration via Rac1.

  2006cites this paper
• beta-Adrenergic receptor antagonists accelerate skin wound healing: evidence for a catecholamine synthesis network in the epidermis.

  2006cites this paper
• The β2-adrenergic receptor activates pro-migratory and pro-proliferative pathways in dermal fibroblasts via divergent mechanisms

  2006cites this paper
• Interaction of Monocarboxylate Transporter 4 with ␤ 1 -integrin and Its Role in Cell Migration

  year unknowncites this paper
• G␣(q/11)-coupled P2y 2 Nucleotide Receptor Inhibits Human Keratinocyte Spreading and Migration

  year unknowncites this paper