Clonal heterogeneity of thymic B cells from early-onset myasthenia gravis patients with antibodies against the acetylcholine receptor.

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Journal of Autoimmunity

• Publication date

  2014-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.jaut.2013.12.008PMID 24439114
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Central role of interferon-beta in thymic events leading to myasthenia gravis.

  2014cited by this paper
• Implication of double‐stranded RNA signaling in the etiology of autoimmune myasthenia gravis

  2013cited by this paper
• Autoantigen induced clonal expansion in immortalized B cells from the peripheral blood of multiple sclerosis patients.

  2013cited by this paper
• Lack of evidence for epstein‐barr virus infection in myasthenia gravis thymus

  2011cited by this paper
• Reduced thymic expression of ErbB receptors without auto-antibodies against synaptic ErbB in myasthenia gravis.

  2011cited by this paper
• The auto-antigen repertoire in myasthenia gravis

  2010cited by this paper
• A novel method for making human monoclonal antibodies

  2010cited by this paper
• Thymoma and paraneoplastic myasthenia gravis

  2010cited by this paper
• Ectopic GC in the thymus of myasthenia gravis patients show characteristics of normal GC

  2010cited by this paper
• A Human Recombinant Autoantibody-Based Immunotoxin Specific for the Fetal Acetylcholine Receptor Inhibits Rhabdomyosarcoma Growth In Vitro and in a Murine Transplantation Model

  2010cited by this paper
• Epstein‐Barr virus persistence and reactivation in myasthenia gravis thymus

  2009cited by this paper
• ENDPLATE DESTRUCTION DUE TO MATERNAL ANTIBODIES IN ARTHROGRYPOSIS MULTIPLEX CONGENITA

  2009cited by this paper
• Bosque: integrated phylogenetic analysis software

  2008cited by this paper
• Thymus and Myasthenia Gravis: what can we learn from DNA microarrays?

  2008cited by this paper
• The myasthenia gravis thymus: a rare source of human autoantibody-secreting plasma cells for testing potential therapeutics.

  2008cited by this paper
• Autoreactive IgG memory antibodies in patients with systemic lupus erythematosus arise from nonreactive and polyreactive precursors

  2008cited by this paper
• Treatment of Myasthenia Gravis by Preventing Acetylcholine Receptor Modulation

  2008cited by this paper
• Anti-Inflammatory Activity of Human IgG4 Antibodies by Dynamic Fab Arm Exchange

  2007cited by this paper
• B cells in autoimmune diseases: insights from analyses of immunoglobulin variable (Ig V) gene usage.

  2007cited by this paper
• Autoreactivity in human IgG+ memory B cells.

  2007cited by this paper
• Isolation and functional characterization of anti-acetylcholine receptor subunit-specific autoantibodies from myasthenic patients: Receptor loss in cell culture

  2007cited by this paper
• Immunopathology and Infectious Disease Myasthenia Gravis Thymus Complement Vulnerability of Epithelial and Myoid Cells , Complement Attack on Them , and Correlations with Autoantibody Status

  2007cited by this paper
• Expression and characterization of soluble forms of the extracellular domains of the β, γ and ε subunits of the human muscle acetylcholine receptor

  2006cited by this paper
• Expression and characterization of soluble forms of the extracellular domains of the beta, gamma and epsilon subunits of the human muscle acetylcholine receptor.

  2006cited by this paper
• The thymus is a source of B-cell-survival factors-APRIL and BAFF-in myasthenia gravis.

  2006cited by this paper
• Microarrays Reveal Distinct Gene Signatures in the Thymus of Seropositive and Seronegative Myasthenia Gravis Patients and the Role of CC Chemokine Ligand 21 in Thymic Hyperplasia1

  2006cited by this paper
• Isolation of potent human Fab fragments against a novel highly immunogenic region on human muscle acetylcholine receptor which protect the receptor from myasthenic autoantibodies

  2005cited by this paper
• Increased expression of rapsyn in muscles prevents acetylcholine receptor loss in experimental autoimmune myasthenia gravis.

  2005cited by this paper
• An efficient method to make human monoclonal antibodies from memory B cells: potent neutralization of SARS coronavirus

  2004cited by this paper
• Characterization of the Human Ig Heavy Chain Antigen Binding Complementarity Determining Region 3 Using a Newly Developed Software Algorithm, JOINSOLVER

  2004cited by this paper
• Thymic myoid cells express high levels of muscle genes.

  2004cited by this paper
• Antibodies to Acetylcholine Receptor in Parous Women with Myasthenia: Evidence for Immunization by Fetal Antigen

  2002cited by this paper
• B cells in epithelial and perivascular compartments of human adult thymus.

  2001cited by this paper
• Somatic Hypermutation and Selection of B Cells in Thymic Germinal Centers Responding to Acetylcholine Receptor in Myasthenia Gravis1

  2001cited by this paper
• Practice parameter: Thymectomy for autoimmune myasthenia gravis (an evidence-based review)

  2000cited by this paper
• Teratogen update: maternal myasthenia gravis as a cause of congenital arthrogryposis.

  2000cited by this paper
• Molecular targets for autoimmune and genetic disorders of neuromuscular transmission.

  2000cited by this paper
• Presence Of B Cell Progenitors In the Thymus

  1997cited by this paper
• Acetylcholine receptor autoantibody secretion by thymocytes: Relationship to myasthenia gravis

  1997cited by this paper
• Presence of B cell progenitors in the thymus.

  1997cited by this paper
• Diverse Fab specific for acetylcholine receptor epitopes from a myasthenia gravis thymus combinatorial library.

  1997cited by this paper
• Human anti-nicotinic acetylcholine receptor recombinant Fab fragments isolated from thymus-derived phage display libraries from myasthenia gravis patients reflect predominant specificities in serum and block the action of pathogenic serum antibodies.

  1997cited by this paper
• Expression of acetylcholine receptor genes in human thymic epithelial cells: implications for myasthenia gravis.

  1996cited by this paper
• A transfected human muscle cell line expressing the adult subtype of the human muscle acetylcholine receptor for diagnostic assays in myasthenia gravis

  1996cited by this paper
• The thymus and the pathogenesis of myasthenia gravis.

  1996cited by this paper
• Location and sequence of rearranged immunoglobulin genes in human thymus

  1995cited by this paper
• Arthrogryposis multiplex congenita with maternal autoantibodies specific for a fetal antigen.

  1995cited by this paper
• Functional analysis of thymic B cells.

  1994cited by this paper
• Properties of human thymic B cells.

  1992cited by this paper
• Anti-acetylcholine receptor antibodies decrease after thymectomy in patients with myasthenia gravis. Clinical correlations.

  1991cited by this paper
• Individual germinal centres of myasthenia gravis human thymuses contain polyclonal activated B cells that express all the VH and VK families

  1991cited by this paper
• Distinct mechanisms of neonatal tolerance induced by dendritic cells and thymic B cells

  1991cited by this paper
• Thymic B cells from myasthenia gravis patients are activated B cells. Phenotypic and functional analysis.

  1990cited by this paper
• Self-nonself discrimination by T cells.

  1990cited by this paper
• Intrathymic presentation of nominal antigen by B cells.

  1990cited by this paper
• In vitro synthesis of antibodies to acetylcholine receptor by Epstein-Barr virus-stimulated B-lymphocytes derived from patients with myasthenia gravis.

  1989cited by this paper
• Thymus in myasthenia gravis. Isolation of T-lymphocyte lines specific for the nicotinic acetylcholine receptor from thymuses of myasthenic patients.

  1988cited by this paper
• The human thymus contains a novel population of B lymphocytes.

  1987cited by this paper
• Thymic B lymphocyte clones from patients with myasthenia gravis secrete monoclonal striational autoantibodies reacting with myosin, alpha actinin, or actin

  1986cited by this paper
• Antibodies to acetylcholine receptor and tetanus toxoid: in vitro synthesis by thymic lymphocytes.

  1986cited by this paper
• Thymic B‐cell activation in myasthenia gravis

  1984cited by this paper
• Immunohistological studies of the thymus in myasthenia gravis. Correlation with clinical state and thymocyte culture responses.

  1982cited by this paper
• Acetylcholine receptor antibody synthesis by thymic lymphocytes

  1981cited by this paper
• Thymus cells in myasthenia gravis selectively enhance production of anti-acetylcholine-receptor antibody by autologous blood lymphocytes.

  1981cited by this paper
• In-vitro synthesis of anti-acetylcholine-receptor antibody by thymic lymphocytes in myasthenia gravis.

  1978cited by this paper
• Myasthenic antibodies cross-link acetylcholine receptors to accelerate degradation.

  1978cited by this paper
• Modulation of acetylcholine receptor by antibody against the receptor.

  1977cited by this paper
• Antibody to acetylcholine receptor in myasthenia gravis

  1976cited by this paper
• Lymphocyte subpopulation in neoplastic and non-neoplastic thymus and in blood of patients with Myasthenia gravis.

  1976cited by this paper
• The thymus in myasthenia gravis. Evidence for altered cell populations.

  1974cited by this paper
• Detection of formiminoglutamic acid in urine without histidine loading.

  1962cited by this paper
• pathogenesis of myast henia gravis: transient expression of acetylcholine receptors on thymus-derived myogenic cells

  year unknowncited by this paper

• Hock immunization: a refined alternative for developing Experimental Autoimmune Myasthenia Gravis (EAMG) in mice

  2025cites this paper
• Therapeutic IgG- and IgM-specific proteases disarm the acetylcholine receptor autoantibodies that drive myasthenia gravis pathology

  2025cites this paper
• Hock immunization, a refined alternative for developing experimental autoimmune myasthenia gravis (EAMG) in mice

  2025cites this paper
• Thymic physiology and pathophysiology in Myasthenia Gravis.

  2025cites this paper
• Thymic hyperplasia in myasthenia gravis: a narrative review

  2025cites this paper
• Structure-based inhibition of acetylcholinesterase and butyrylcholinesterase with 2-Aryl-6-carboxamide benzoxazole derivatives: synthesis, enzymatic assay, and in silico studies

  2024cites this paper
• Immune repertoire profiling in myasthenia gravis

  2024cites this paper
• Antigen presentation for central tolerance induction

  2024cites this paper
• Targeting autoimmune mechanisms by precision medicine in Myasthenia Gravis

  2024cites this paper
• Establishment of novel cell lines that maintain the features of B cells derived from patients with neuromyelitis optica spectrum disorder

  2024cites this paper
• Individual myasthenia gravis autoantibody clones can efficiently mediate multiple mechanisms of pathology

  2023cites this paper
• MicroRNA‑155‑5p affects regulatory T cell activation and immunosuppressive function by targeting BCL10 in myasthenia gravis

  2023cites this paper
• Identification of Rare Membrane Antigen Specific Human B Cells

  2023cites this paper
• Astragaloside IV ameliorates experimental autoimmune myasthenia gravis by regulating CD4 + T cells and altering gut microbiota

  2023cites this paper
• Myastenia gravis: features of epidemiology, pathogenesis, treatment and relation to thymomas

  2023cites this paper
• Novel pathophysiological insights in autoimmune myasthenia gravis

  2022cites this paper
• miRNAs as the important regulators of myasthenia gravis: involvement of major cytokines and immune cells

  2022cites this paper
• Overview of biomarkers in myasthenia gravis

  2022cites this paper
• Inhibitory potential of nitrogen, oxygen and sulfur containing heterocyclic scaffolds against acetylcholinesterase and butyrylcholinesterase

  2022cites this paper
• Short- and Long-Lived Autoantibody-Secreting Cells in Autoimmune Neurological Disorders

  2021cites this paper
• Myasthenia Gravis: Epidemiology, Pathophysiology and Clinical Manifestations

  2021cites this paper
• Autoantibody Specificities in Myasthenia Gravis; Implications for Improved Diagnostics and Therapeutics

  2020cites this paper
• Současný pohled na imunopatogenezi myasthenia gravis

  2020cites this paper
• Autoimmune Pathology in Myasthenia Gravis Disease Subtypes Is Governed by Divergent Mechanisms of Immunopathology

  2020cites this paper
• MicroRNA-146a Is a Wide-Reaching Neuroinflammatory Regulator and Potential Treatment Target in Neurological Diseases

  2020cites this paper
• Thymus-derived B cell clones persist in the circulation after thymectomy in myasthenia gravis

  2020cites this paper
• Myasthenia Gravis: Autoantibody Specificities and Their Role in MG Management

  2020cites this paper
• Současný pohled na imunopatogenezi myasthenia gravis The Cur rent View of Im munopathogenesis of Myasthenia Gravis

  2019cites this paper
• Myasthenia Gravis: Pathogenic Effects of Autoantibodies on Neuromuscular Architecture

  2019cites this paper
• Isolation and characterization of rare circulating autoantibody-producing cells from patients with muscle-specific kinase myasthenia gravis

  2018cites this paper
• Thymus involvement in early‐onset myasthenia gravis

  2018cites this paper
• The overexpression of Fra1 disorders the inflammatory cytokine secretion by mTEC of myasthenia gravis thymus

  2018cites this paper
• B cells in the pathophysiology of myasthenia gravis

  2018cites this paper
• Flavonoids as acetylcholinesterase inhibitors: Current therapeutic standing and future prospects.

  2018cites this paper
• Hinge-deleted IgG4 blocker therapy for acetylcholine receptor myasthenia gravis in rhesus monkeys

  2017cites this paper
• IgG 4 blocker therapy for acetylcholine receptor myasthenia gravis in rhesus monkeys

  2017cites this paper
• [Thymic B cells: not simple bystanders of T cell lymphopoiesis].

  2017cites this paper
• Regulatory T cells in multiple sclerosis and myasthenia gravis

  2017cites this paper
• Analysis of peripheral B cells and autoantibodies against the anti-nicotinic acetylcholine receptor derived from patients with myasthenia gravis using single-cell manipulation tools

  2017cites this paper
• This information is current as Revealed through Deep Sequencing Formation in Myasthenia Gravis Patients Dysregulation of B Cell Repertoire

  2017cites this paper
• Dysregulation of B Cell Repertoire Formation in Myasthenia Gravis Patients Revealed through Deep Sequencing

  2017cites this paper
• Development of humanized scFv antibody fragment(s) that targets and blocks specific HLA alleles linked to myasthenia gravis

  2017cites this paper
• Characterization of an anti-fetal AChR monoclonal antibody isolated from a myasthenia gravis patient

  2017cites this paper
• Use of Toll-Like Receptor Agonists to Induce Ectopic Lymphoid Structures in Myasthenia Gravis Mouse Models

  2017cites this paper
• B cells and antibodies in progressive multiple sclerosis: Contribution to neurodegeneration and progression.

  2016cites this paper
• Myasthenia gravis: a pathologic approach

  2016cites this paper
• The critical role of toll-like receptors--From microbial recognition to autoimmunity: A comprehensive review.

  2016cites this paper
• Role of the thymus in autoimmune myasthenia gravis

  2016cites this paper
• Thymic B cells promote thymus-derived regulatory T cell development and proliferation.

  2015cites this paper
• Intrathymic B cells as Mediators of Autoimmune Type 1 Diabetes

  2015cites this paper
• Generation of Recombinant Human IgG Monoclonal Antibodies from Immortalized Sorted B Cells.

  2015cites this paper
• Guidelines for pre-clinical assessment of the acetylcholine receptor--specific passive transfer myasthenia gravis model-Recommendations for methods and experimental designs.

  2015cites this paper
• Thymic B Cells and Central T Cell Tolerance

  2015cites this paper
• Two-year outcome of thymectomy with or without immunosuppressive treatment in nonthymomatous myasthenia gravis and its effect on regulatory T cells.

  2015cites this paper
• Clinical and scientific aspects of acetylcholine receptor myasthenia gravis.

  2014cites this paper
• Myasthenia Gravis: paradox versus paradigm in autoimmunity.

  2014cites this paper