Identification of a New Ligand Binding Domain in the α1 Subunit of the Inhibitory Glycine Receptor

No abstract is available for this paper.

• Publication year

  1999

• Venue

  Journal of Neurochemistry

• Publication date

  1999-11-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1046/j.1471-4159.1999.02158.xPMID 10537076
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1998cited by this paper
• From muscle endplate to brain synapses: a short history of synapses and agonist-activated ion channels.

  1998cited by this paper
• The glycine receptor.

  1997cited by this paper
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  1997cited by this paper
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  1995cited by this paper
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  1995cited by this paper
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  1994cited by this paper
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  1994cited by this paper
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  1993cited by this paper
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  1993cited by this paper
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  1993cited by this paper
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  1993cited by this paper
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  1991cited by this paper
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  1990cited by this paper
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  1990cited by this paper
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  1990cited by this paper
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