Regulation of vascular endothelial growth factor, VEGF, gene promoter by the tumor suppressor, WT1.

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Frontiers in Bioscience

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.2741/2230PMID 17127464PMCID PMC2562899
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Hormone treatment enhances WT1 activation of Renilla luciferase constructs in LNCaP cells.

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• Vascular endothelial growth factor expression in untreated and androgen-deprived patients with prostate cancer.

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• Angioblast-mesenchyme induction of early kidney development is mediated by Wt1 and Vegfa

  2005cited by this paper
• WT1 induces apoptosis through transcriptional regulation of the proapoptotic Bcl-2 family member Bak.

  2005cited by this paper
• Suppression of prostate tumor cell growth in vivo by WT1, the Wilms' tumor suppressor gene.

  2004cited by this paper
• Activator protein 2alpha inhibits tumorigenicity and represses vascular endothelial growth factor transcription in prostate cancer cells.

  2004cited by this paper
• Estrogen regulation of vascular endothelial growth factor gene expression in ZR-75 breast cancer cells through interaction of estrogen receptor α and SP proteins

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• Expression and function of androgen receptor coactivators in prostate cancer.

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• Estrogen regulation of vascular endothelial growth factor gene expression in ZR-75 breast cancer cells through interaction of estrogen receptor alpha and SP proteins.

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• Par-4 Transcriptionally Regulates Bcl-2 through a WT1-binding Site on the bcl-2 Promoter*

  2003cited by this paper
• Normalization of luciferase reporter assays under conditions that alter internal controls.

  2003cited by this paper
• WT1-p53 Interactions in Insulin-like Growth Factor-I Receptor Gene Regulation*

  2003cited by this paper
• Oxidative Stress Regulates Vascular Endothelial Growth Factor-A Gene Transcription through Sp1- and Sp3-dependent Activation of Two Proximal GC-rich Promoter Elements*

  2003cited by this paper
• Role of Wilms Tumor 1 (WT1) in the Transcriptional Regulation of the Mullerian-Inhibiting Substance Promoter1

  2003cited by this paper
• A Review of the Wilms' Tumor 1 Gene (WT1) and Its Role in Hematopoiesis and Leukemia

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• Antibody to vascular endothelial growth factor slows growth of an androgen-independent xenograft model of prostate cancer.

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• Changes in WT1 splicing are associated with a specific gene expression profile in Wilms' tumour

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• The Role of WT1 in Oncogenesis: Tumor Suppressor or Oncogene?

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• Transcriptional regulation of the androgen signaling pathway by the Wilms' tumor suppressor gene WT1.

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• Two splice variants of the Wilms' tumor 1 gene have distinct functions during sex determination and nephron formation.

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• Constitutive Sp1 activity is essential for differential constitutive expression of vascular endothelial growth factor in human pancreatic adenocarcinoma.

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• A Functional Interaction with CBP Contributes to Transcriptional Activation by the Wilms Tumor Suppressor WT1*

  2001cited by this paper
• Vascular endothelial growth factor expression and tumor angiogenesis are regulated by androgens in hormone responsive human prostate carcinoma: evidence for androgen dependent destabilization of vascular endothelial growth factor transcripts.

  2001cited by this paper
• Par4 is a coactivator for a splice isoform-specific transcriptional activation domain in WT1.

  2001cited by this paper
• Functions of the VEGF/VEGF Receptor System in the Vascular System

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• Vascular endothelial growth factor expression and capillary architecture in high‐grade PIN and prostate cancer in untreated and androgen‐ablated patients

  2000cited by this paper
• Coexpression of hypoxia-inducible factor 1-alpha and vascular endothelial growth factor in Wilms' tumor.

  2000cited by this paper
• Regulation of vascular endothelial growth factor (VEGF) gene transcription by estrogen receptors alpha and beta.

  2000cited by this paper
• Regulation of vascular endothelial growth factor ( VEGF ) gene transcription by estrogen receptors a and b

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• Detection of a Novel Truncated WT1 Transcript in Human Neoplasia

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• Wilms' tumor suppressor gene WT1: from structure to renal pathophysiologic features.

  2000influential reference
• Mice homozygous for a truncated form of CREB-binding protein exhibit defects in hematopoiesis and vasculo-angiogenesis.

  1999cited by this paper
• Wilms' tumor 1 and Dax-1 modulate the orphan nuclear receptor SF-1 in sex-specific gene expression.

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• Androgens regulate vascular endothelial growth factor content in normal and malignant prostatic tissue.

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• The WT1 Protein Is a Negative Regulator of the Normalbcl-2 Allele in t(14;18) Lymphomas*

  1997cited by this paper
• The Wilms' tumor gene WT1 can regulate genes involved in sex determination and differentiation: SRY, Müllerian-inhibiting substance, and the androgen receptor.

  1997influential reference
• Differential splicing of exon 5 of the Wilms tumour (WT1) gene

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• A novel repressor, par-4, modulates transcription and growth suppression functions of the Wilms' tumor suppressor WT1

  1996cited by this paper
• The WT1 Wilms' tumor suppressor gene: how much do we really know?

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• Expression of the tumor suppressor gene WT1 in both human and mouse bone marrow.

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• Regulation of the proto-oncogenes bcl-2 and c-myc by the Wilms' tumor suppressor gene WT1.

  1995cited by this paper
• WT1 suppresses synthesis of the epidermal growth factor receptor and induces apoptosis.

  1995cited by this paper
• MatInd and MatInspector: new fast and versatile tools for detection of consensus matches in nucleotide sequence data.

  1995cited by this paper
• Transcriptional repression of the insulin-like growth factor I receptor (IGF-I-R) gene by the tumor suppressor WT1 involves binding to sequences both upstream and downstream of the IGF-I-R gene transcription start site.

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• Repression of the transforming growth factor-beta 1 gene by the Wilms' tumor suppressor WT1 gene product.

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• WT-1 is required for early kidney development.

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• The expression of the Wilms' tumour gene, WT1, in the developing mammalian embryo.

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• Angiogenesis

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• The Wilms' tumor gene product, WT1, represses transcription of the platelet-derived growth factor A-chain gene.

  1992cited by this paper
• Human platelet-derived growth factor A chain is transcriptionally repressed by the Wilms tumor suppressor WT1.

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• Repression of the insulin-like growth factor II gene by the Wilms tumor suppressor WT1.

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• Transcriptional repression mediated by the WT1 Wilms tumor gene product.

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• Germline mutations in the Wilms' tumor suppressor gene are associated with abnormal urogenital development in Denys-Drash syndrome.

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• Binding of the Wilms' tumor locus zinc finger protein to the EGR-1 consensus sequence.

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• Comparison of methyltrienolone and dihydrotestosterone binding and metabolism in human genital skin fibroblasts.

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• Journal of Clinical Endocrinology and Metabolism Printed in U.S.A. Copyright © 1997 by The Endocrine Society Decreased Expression of Wilms ’ Tumor Gene WT-1 and Elevated Expression of Insulin Growth Factor-II (IGF-II) and Type 1 IGF Receptor Genes in Pros

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