Investigation of The Antiproliferative Effect of Camelia Sinensis on Liver Cancer (Hepg2) Cell Line

Liver cancer is the second leading cause of death among other cancer types in the world. The use of preclinical models to develop new diagnostic technologies and new therapies for the prevention of liver metastasis is inevitable. Tea is a beverage that attracts the attention of many researchers because of the bioactive substances in its composition. In recent years, intensive researches have been conducted to examine the effects of green tea on health. The study aimed was to investigate the antiproliferative effect of green tea ( Camelia sinensis ) extract on liver cell lines. XTT test was performed to investigate the cytotoxicity of HepG2 and WI-38 cell lines. In the study, IC 50 was found to be 150 µg / mL in the WI-38 cell line of Green tea and 72 µg / mL in the HepG2 cell line. Green tea has an effect on HepG2 cell lines. And more work is needed in this area. .

• Publication year

  2019

• Venue

  International Journal of Academic Medicine and Pharmacy

• Publication date

  Unknown publication date

• Fields of study

  Not labeled

• Identifiers
  DOI 10.29228/jamp.40233
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Tea and human health: biomedical functions of tea active components and current issues

  2015cited by this paper
• Polyphenols in disease: from diet to supplements.

  2014cited by this paper
• Mechanistic issues concerning cancer prevention by tea catechins.

  2011cited by this paper
• Mutation Research/Reviews in Mutation Research

  2009cited by this paper
• Tea and health.

  2009cited by this paper
• Molecular Mechanisms of Green Tea Polyphenols

  2009cited by this paper
• Green tea polyphenols and cancer: biologic mechanisms and practical implications.

  2009cited by this paper
• Tea and Tea Products : Chemistry and Health-Promoting Properties

  2008cited by this paper
• Catechin as an antioxidant in liver mitochondrial toxicity: Inhibition of tamoxifen‐Induced protein oxidation and lipid peroxidation

  2007cited by this paper
• Combined Inhibitory Effects of Green Tea Polyphenols and Selective Cyclooxygenase-2 Inhibitors on the Growth of Human Prostate Cancer Cells Both In vitro and In vivo

  2007cited by this paper
• Effects of green tea on serum paraoxonase/arylesterase activities in streptozotocin-induced diabetic rats

  2005cited by this paper
• Anti‐proliferative and proapoptotic effects of (−)‐epigallocatechin‐3‐gallate on human melanoma: Possible implications for the chemoprevention of melanoma

  2005cited by this paper
• Effects of green tea polyphenols on murine transplant-reactive T cell immunity.

  2004cited by this paper
• Neurological mechanisms of green tea polyphenols in Alzheimer's and Parkinson's diseases.

  2004cited by this paper
• Recycling the Cell Cycle Cyclins Revisited

  2004cited by this paper
• Pharmacological effects of green tea on the gastrointestinal system.

  2004cited by this paper
• Evolution of dietary antioxidants.

  2003cited by this paper
• Dietary antioxidants—past, present and future?

  2003cited by this paper
• Molecular Biology of the Cell (4th Ed)

  2002cited by this paper
• Green tea constituent epigallocatechin-3-gallate inhibits angiogenic differentiation of human endothelial cells.

  2002cited by this paper
• Tea flavonoids: their functions, utilisation and analysis

  2000cited by this paper
• Antimutagenic and anticarcinogenic activity of tea polyphenols.

  1999cited by this paper
• Mechanistic findings of green tea as cancer preventive for humans.

  1999cited by this paper
• Inhibition of cyclin‐dependent kinases 2 and 4 activities as well as induction of cdk inhibitors p21 and p27 during growth arrest of human breast carcinoma cells by (−)‐epigallocatechin‐3‐gallate

  1999cited by this paper
• Cyclin‐dependent protein kinases: Key regulators of the eukaryotic cell cycle

  1995cited by this paper
• Do cells cycle?

  1973cited by this paper

• No citing papers are available for this paper.