Quercetin ameliorates methotrexate-induced renal damage, apoptosis and oxidative stress in rats

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Renal Failure

• Publication date

  2015-08-31

• Fields of study

  Medicine

• Identifiers
  DOI 10.3109/0886022X.2015.1074521PMID 26338102
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Methods Of Enzymatic Analysis

  2016cited by this paper
• Carvacrol prevents methotrexate-induced renal oxidative injury and renal damage in rats.

  2014cited by this paper
• Erratum to: Nephroprotective activities of quercetin with potential relevance to oxidative stress induced by valproic acid

  2014cited by this paper
• Nephroprotective activities of quercetin with potential relevance to oxidative stress induced by valproic acid

  2014cited by this paper
• Quercetin protects radiation-induced DNA damage and apoptosis in kidney and bladder tissues of rats

  2014cited by this paper
• Effect of quercetin against dichlorvos induced nephrotoxicity in rats.

  2014cited by this paper
• Ultrastructural evaluation of the effect of N-acetylcysteine on methotrexate nephrotoxicity in rats.

  2013cited by this paper
• The Protective Effect of Hesperidin on Methotrexate-Induced Intestinal Epithelial Damage in Rats: An Experimental Study

  2013cited by this paper
• Renoprotective effects of montelukast, a cysteinyl leukotriene receptor antagonist, against methotrexate-induced kidney damage in rats

  2013influential reference
• Methotrexate for inflammatory bowel disease.

  2013cited by this paper
• Curcumin Ameliorates Methotrexate-Induced Nephrotoxicity in Rats

  2013cited by this paper
• Tekrarlayan Dozlarda Metotreksat Uygulamasının Sıçan Böbrek Dokusu Üzerine Etkileri

  2013cited by this paper
• Protective Effect of Quercetin Against Renal Toxicity Induced by Cadmium in Rats

  2012cited by this paper
• The protective effects of Prunus armeniaca L (apricot) against methotrexate-induced oxidative damage and apoptosis in rat kidney

  2012influential reference
• Caffeic acid phenethyl ester (CAPE) prevents methotrexate‐induced hepatorenal oxidative injury in rats

  2011cited by this paper
• Metotreksat’ın Neden Olduğu Akut Böbrek Hasarına Karşı Montelukast’ın Etkileri

  2011cited by this paper
• Protective effect of pentoxyfilline in renal toxicity after methotrexate administration.

  2010influential reference
• Melatonin attenuates methotrexate‐induced oxidative stress and renal damage in rats

  2010cited by this paper
• Quercetin protects the rat kidney against oxidative stress-mediated DNA damage and apoptosis induced by lead.

  2010cited by this paper
• Decrease of adenosine deaminase activity and increase of the lipid peroxidation after acute methotrexate treatment in young rats: protective effects of grape seed extract

  2010cited by this paper
• Protective effect of quercetin against gentamicin-induced nephrotoxicity in rats.

  2009cited by this paper
• Neutrophil Infiltration and Oxidative Stress May Play a Critical Role in Methotrexate-Induced Renal Damage

  2009cited by this paper
• Role of Ursodeoxycholic Acid in Prevention of Methotrexate-induced Liver Toxicity

  2008cited by this paper
• Mirisetin ve Kuersetin Bileşiklerinin Antioksidan Etkinliklerinin Dft Yöntemiyle İncelenmesi

  2007cited by this paper
• Methotrexate and Hepatic Toxicity in Rheumatoid Arthritis and Psoriatic Arthritis

  2006cited by this paper
• L-Carnitine ameliorates methotrexate-induced oxidative organ injury and inhibits leukocyte death

  2006cited by this paper
• N-acetylcysteine ameliorates methotrexate-induced oxidative liver damage in rats.

  2006cited by this paper
• Methotrexate-induced renal oxidative stress in rats: the role of a novel antioxidant caffeic acid phenethyl ester

  2006cited by this paper
• Histological and Histochemical Studies on the Effects of Methotrexate on the Liver of Adult Male Albino Rat

  2006cited by this paper
• The activity of adenosine deaminase and the level of nitric oxide in spinal cord of methotrexate administered rats: protective effect of caffeic acid phenethyl ester.

  2006cited by this paper
• Taurine protects against methotrexate-induced toxicity and inhibits leukocyte death.

  2005cited by this paper
• Methotrexate in inflammatory bowel disease.

  2004cited by this paper
• The antioxidative and antihistaminic properties of quercetin in ethanol-induced gastric lesions.

  2003cited by this paper
• Melatonin prevents methotrexate‐induced hepatorenal oxidative injury in rats

  2003influential reference
• The protective mechanism of magnolol, a Chinese herb drug, against warm ischemia-reperfusion injury of rat liver.

  2003cited by this paper
• Akut Metotreksat Toksisitesinin Erken Belirtisi;Deri Ülserleri

  2002cited by this paper
• The role of caspases in methotrexate-induced gastrointestinal toxicity.

  2001cited by this paper
• Bioflavonoid quercetin inhibits mitosis and apoptosis of glomerular cells in vitro and in vivo.

  2000cited by this paper
• A simple method for clinical assay of superoxide dismutase.

  1988cited by this paper
• The role of 7-hydroxymethotrexate during methotrexate anti-cancer therapy.

  1980cited by this paper
• Microsomal lipid peroxidation.

  1978cited by this paper
• Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase.

  1967cited by this paper
• Protein measurement with the Folin phenol reagent.

  1951cited by this paper

• Quercetin alleviates vancomycin-induced renal damage by modulating the TLR4/MyD88/NF-κB, Bax/Bcl-2/Caspase-3, Nrf2/Keap1/HO1, and PPARγ pathways.

  2026cites this paper
• Natural Compounds as Nephroprotective Agents: Therapeutic Potential Against Drug‐Induced Kidney Injury

  2025cites this paper
• Apremilast ameliorates methotrexate-induced renal injury in rats: role of TLR4/NF-κB/P38 MAPK/caspase-3 and Nrf2/HO-1 signaling pathways.

  2025cites this paper
• Phytoconstituents as therapeutic agents in combating methotrexate-induced hepatotoxicity and nephrotoxicity

  2025cites this paper
• Protective effects of roselle (Hibiscus sabdariffa) aqueous extract against aristolochic acid-induced developmental nephrotoxicity in zebrafish

  2025cites this paper
• Hesperidin loaded bilosomes mitigate the nephrotoxicity induced by methotrexate; biochemical and molecular in vivo investigations

  2025cites this paper
• Oxidative Stress and Nutritional Antioxidants in Renal Diseases: A Narrative Review

  2025cites this paper
• Quercetin mitigates sepsis-induced renal injury via inhibiting inflammatory and oxidative pathways in mice

  2025cites this paper
• Investigation of the Preventive Effect of Quercetin on 5-Fluorouracil Toxicity.

  2025cites this paper
• Role of Vitamin C on methotrexate-induced nephrotoxicity in psoriasis context: A preclinical assessment

  2024cites this paper
• Empagliflozin mitigates methotrexate-induced nephrotoxicity in male albino rats: insights on the crosstalk of AMPK/Nrf2 signaling pathway

  2024cites this paper
• Nephroprotective Effect of Fennel (Foeniculum vulgare) Seeds and Their Sprouts on CCl4-Induced Nephrotoxicity and Oxidative Stress in Rats

  2023cites this paper
• Preclinical evidence of reno-protective effect of quercetin on acute kidney injury: a meta-analysis of animal studies

  2023cites this paper
• Protective effects of sitagliptin on methotrexate-induced nephrotoxicity in rats

  2023cites this paper
• Apocynin abrogates methotrexate-induced nephrotoxicity: role of TLR4/NF-κB-p65/p38-MAPK, IL-6/STAT-3, PPAR-γ, and SIRT1/FOXO3 signaling pathways

  2023cites this paper
• Elecampane rhizome extract alleviates methotrexate-induced hepatotoxicity and nephrotoxicity in male rats

  2023cites this paper
• Flavonoids-mediated TLR4 inhibition as a promising therapy for renal diseases.

  2023cites this paper
• Influence of exposure to microbial ligands, immunosuppressive drugs and chronic kidney disease on endogenous immunomodulatory gene expression in feline adipose-derived mesenchymal stem cells

  2022cites this paper
• Quercetin-loaded chitosan nanoparticles ameliorate adjuvant-induced arthritis in rats by regulating anti-oxidant enzymes and downregulating pro- and inflammatory cytokines

  2022cites this paper
• Methotrexate-Induced Alteration of Renal Aquaporins 1 and 2, Oxidative Stress and Tubular Apoptosis Can Be Attenuated by Omega-3 Fatty Acids Supplementation

  2022cites this paper
• The Protective Effects of Nutraceutical Components in Methotrexate-Induced Toxicity Models—An Overview

  2022cites this paper
• Protective effect of quercetin on kidney diseases: From chemistry to herbal medicines

  2022cites this paper
• Protective effect of luteolin against chemical and natural toxicants by targeting NF‐κB pathway

  2022cites this paper
• Melatonin Attenuates Methotrexate-Induced Reduction of Antioxidant Activity Related to Decreases of Neurogenesis in Adult Rat Hippocampus and Prefrontal Cortex

  2022cites this paper
• Reno-protective effect of mangiferin against methotrexate-induced kidney damage in male rats: PPARγ-mediated antioxidant activity

  2022cites this paper
• Anisi Stellati Fructus, a Significant Traditional Chinese Medicine (TCM) Herb and Its Bioactivity against Gastric Cancer

  2022cites this paper
• The Protective Impact of Salsola imbricata Leaf Extract From Taif Against Acrylamide-Induced Hepatic Inflammation and Oxidative Damage: The Role of Antioxidants, Cytokines, and Apoptosis-Associated Genes

  2022cites this paper
• Phytochemical add-on therapy to DMARDs therapy in rheumatoid arthritis: In vitro and in vivo bases, clinical evidence and future trends.

  2021cites this paper
• A Micellar Formulation of Quercetin Prevents Cisplatin Nephrotoxicity

  2021cites this paper
• Herbal antioxidants in dialysis patients: a review of potential mechanisms and medical implications

  2021cites this paper
• CP-25 ameliorates methotrexate induced nephrotoxicity via improving renal apoptosis and methotrexate excretion.

  2021cites this paper
• Punicalagin Reverses Methotrexate-Induced Nephrotoxicity by Attenuating Oxidative Stress, Inflammation and Apoptosis

  2021cites this paper
• Anticorrosive and antioxidant effect of the aqueous extract of the leaves, flowers, and stems of Cistus monspeliensis L: Experimental and computational study

  2021cites this paper
• Toxicity of thioacetamide and protective effects of quercetin in zebrafish (Danio rerio) larvae

  2021cites this paper
• Antioxidant-rich fraction of Amomum subulatum fruits mitigates experimental methotrexate-induced oxidative stress by regulating TNF-α, IL-1β, and IL-6 proinflammatory cytokines.

  2021cites this paper
• Protective effects of hesperidin against MTX-induced hepatotoxicity in male albino rats

  2020cites this paper
• Protective Effects of Origanum onites Essential Oil in the Methotrexate-Induced Rat Model: Role on Apoptosis and Hepatoxicity

  2020cites this paper
• Assessment of the Anti-apoptotic Effects of Peganum harmala Leaf Extract on Type 2 Diabetes in the Kidney of Male Wistar Rats

  2020cites this paper
• Mechanistic Aspects and Therapeutic Potential of Quercetin against COVID-19-Associated Acute Kidney Injury

  2020cites this paper
• Gossypin attenuates methotrexate-induced nephrotoxicity: Role of COX II/MMP-9 and fas ligand.

  2020cites this paper
• Protective activity of phalaris canariensis against methotrexate-induced nephrotoxicity via BCL2 pathway

  2020cites this paper
• Tumour initiation, store-operated calcium entry (SOCE) and apoptosis: cyclic nucleotide dependence.

  2020cites this paper
• The ameliorative impacts of Moringa oleifera leaf extract against oxidative stress and methotrexate-induced hepato-renal dysfunction.

  2020cites this paper
• In Silico and In Vivo Studies on Quercetin as Potential Anti-Parkinson Agent.

  2020cites this paper
• Eugenia uniflora (pitanga) leaf extract prevents the progression of experimental acute kidney injury

  2020cites this paper
• Using glycyrrhizic acid to target sumoylation processes during Epstein-Barr virus latency

  2019cites this paper
• The impact of Keap1/Nrf2, P38MAPK/NF-κB and Bax/Bcl2/caspase-3 signaling pathways in the protective effects of berberine against methotrexate-induced nephrotoxicity.

  2019cites this paper
• Hepatic and renal protective effects of quercetin in ferrous sulfateinduced toxicity.

  2019cites this paper
• Ginkgo Biloba Extract Alleviates Methotrexate-Induced Renal Injury: New Impact on PI3K/Akt/mTOR Signaling and MALAT1 Expression

  2019cites this paper
• Moringa oleifera seed oil modulates redox imbalance and iNOS/NF-κB/caspase-3 signaling pathway to exert antioxidant, anti-inflammatory and antiapoptotic mechanisms against anticancer drug 5-fluorouracil-induced nephrotoxicity in rats

  2019cites this paper
• Crocin ameliorates methotrexate-induced liver injury via inhibition of oxidative stress and inflammation in rats

  2019cites this paper
• Protective effects of a natural herbal compound quercetin against snake venom-induced hepatic and renal toxicities in rats.

  2018cites this paper
• Flavonoids in Kidney Health and Disease

  2018cites this paper
• Vanillin mitigates the adverse impact of cisplatin and methotrexate on rat kidneys

  2018cites this paper
• Beneficial role of virgin coconut oil supplementation against acute methotrexate chemotherapy-induced oxidative toxicity and inflammation in rats

  2018cites this paper
• Side effects of methotrexate therapy for rheumatoid arthritis: A systematic review.

  2018cites this paper
• Quercetin is able to alleviate TGF-β-induced fibrosis in renal tubular epithelial cells by suppressing miR-21

  2018cites this paper
• Commiphora molmol protects against methotrexate-induced nephrotoxicity by up-regulating Nrf2/ARE/HO-1 signaling.

  2018cites this paper
• Therapeutic effect of quercetin on renal function and tissue damage in the obesity induced rats.

  2017cites this paper
• Therapeutic effects of silymarin and naringin on methotrexate‐induced nephrotoxicity in rats: Biochemical evaluation of anti‐inflammatory, antiapoptotic, and antiautophagic properties

  2017cites this paper
• Ratlarda Methotrexate Kaynaklı Karaciğer Toksisitesine Karşı Silymarin ve Naringin’in Yararlı Etkileri

  2017cites this paper
• Protective effect of Chlorogenic acid against methotrexate induced oxidative stress, inflammation and apoptosis in rat liver: An experimental approach.

  2017cites this paper
• Antioxidant and anti-inflammatory effects of virgin coconut oil supplementation abrogate acute chemotherapy oxidative nephrotoxicity induced by anticancer drug methotrexate in rats.

  2017influential citation
• Quercetin alters uterine fluid volume and aquaporin (AQP) subunits (AQP-1, 2, 5 & 7) expression in the uterus in the presence of sex-steroids in rats.

  2017cites this paper
• Effects of oregano essential oil or quercetin supplementation on body weight loss, carcass characteristics, meat quality and antioxidant status in finishing pigs under transport stress

  2016cites this paper
• Anti-Cancer Effect of Quercetin in Xenograft Models with EBV-Associated Human Gastric Carcinoma

  2016cites this paper
• Mitochondria: a new therapeutic target in chronic kidney disease

  2015cites this paper