The use of nitric oxide-donating nonsteroidal anti-inflammatory drugs in the chemoprevention of colorectal neoplasia

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Current Opinion in Gastroenterology

• Publication date

  2007-01-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1097/MOG.0b013e32801145b0PMID 17133086
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Nitric Oxide-Donating Aspirin Inhibits Colon Cancer Cell Growth via Mitogen-Activated Protein Kinase Activation

  2006cited by this paper
• NO-donating aspirin induces phase II enzymes in vitro and in vivo.

  2006cited by this paper
• Pilot study of nitric oxide-donating aspirin in patients with pancreatic cancer pain.

  2006cited by this paper
• Nitric oxide–releasing aspirin and indomethacin are potent inhibitors against colon cancer in azoxymethane-treated rats: effects on molecular targets

  2006influential reference
• NO-donating aspirin isomers downregulate peroxisome proliferator-activated receptor (PPAR)delta expression in APC(min/+) mice proportionally to their tumor inhibitory effect: Implications for the role of PPARdelta in carcinogenesis.

  2006cited by this paper
• In Vitro Metabolism of (Nitrooxy)butyl Ester Nitric Oxide-Releasing Compounds: Comparison with Glyceryl Trinitrate

  2006cited by this paper
• Nitric oxide-donating aspirin (NCX 4016): an overview of its pharmacological properties and clinical perspectives

  2006cited by this paper
• NO-donating aspirin inhibits both the expression and catalytic activity of inducible nitric oxide synthase in HT-29 human colon cancer cells.

  2005cited by this paper
• An introduction to NO-related therapeutic agents.

  2005cited by this paper
• In vitro and in vivo evaluation of NCX 4040 cytotoxic activity in human colon cancer cell lines

  2005cited by this paper
• In Vitro Metabolism of Nitric Oxide-Donating Aspirin: The Effect of Positional Isomerism

  2005cited by this paper
• Nitric oxide-donating aspirin induces apoptosis in human colon cancer cells through induction of oxidative stress.

  2005cited by this paper
• Direct and Irreversible Inhibition of Cyclooxygenase-1 by Nitroaspirin (NCX 4016)

  2005cited by this paper
• Molecular targets of nitric-oxide-donating aspirin in cancer.

  2005cited by this paper
• Novel nonsteroidal antiinflammatory drugs possessing a nitric oxide donor diazen-1-ium-1,2-diolate moiety: design, synthesis, biological evaluation, and nitric oxide release studies.

  2005cited by this paper
• Nitric oxide-releasing medications and colorectal cancer risk: the framingham study.

  2005cited by this paper
• Positional Isomerism Markedly Affects the Growth Inhibition of Colon Cancer Cells by Nitric Oxide-Donating Aspirin in Vitro and in Vivo

  2005influential reference
• Nitric oxide release and distribution following oral and intraperitoneal administration of nitroaspirin (NCX 4016) in the rat.

  2004cited by this paper
• Gastrointestinal safety of NO-aspirin (NCX-4016) in healthy human volunteers: a proof of concept endoscopic study.

  2003cited by this paper
• Growth inhibition of human colon cancer cells by nitric oxide (NO)-donating aspirin is associated with cyclooxygenase-2 induction and beta-catenin/T-cell factor signaling, nuclear factor-kappaB, and NO synthase 2 inhibition: implications for chemoprevention.

  2003cited by this paper
• Nitric oxide-releasing nonsteroidal anti-inflammatory drugs (NSAIDs) alter the kinetics of human colon cancer cell lines more effectively than traditional NSAIDs: implications for colon cancer chemoprevention.

  2001cited by this paper
• Cyclooxygenase-independent chemoprevention with an aspirin derivative in a rat model of colonic adenocarcinoma.

  1998cited by this paper
• Journal of Translational Medicine in Vitro and in Vivo Evaluation of Ncx 4040 Cytotoxic Activity in Human Colon Cancer Cell Lines

  year unknowninfluential reference

• Apoptotic Effect of Gallic Acid via Regulation of p-p38 and ER Stress in PANC-1 and MIA PaCa-2 Cells Pancreatic Cancer Cells

  2023cites this paper
• Mechanisms of the antiangiogenic effects of aspirin in cancer.

  2021cites this paper
• The Double-Faced Role of Nitric Oxide and Reactive Oxygen Species in Solid Tumors

  2020cites this paper
• Mechanisms of the Antiangiogenic Effects for Cancer by the Aspirin

  2020cites this paper
• Pyroptotic and apoptotic cell death in iNOS and nNOS overexpressing K562 cells: a mechanistic insight.

  2019cites this paper
• EVALUATE THE ANTI-INFLAMMATORY ACTIVITY AS WELL AS APOPTOTIC ACTIVITY OF ETHANOLIC EXTRACTS OF CROCUS SATIVUS

  2019cites this paper
• ESTIMATION OF ANTI-INFLAMMATORY ACTIVITY AS WELL AS APOPTOTIC ACTIVITY OF ETHANOLIC EXTRACTS OF CROCUS SATIVUS

  2019cites this paper
• The Chemoprevention of Ovarian Cancer: the Need and the Options

  2018cites this paper
• Anti-inflammatory activity and enhanced COX-2 selectivity of nitric oxide-donating zinc(ii)-NSAID complexes.

  2016cites this paper
• Mouse models of DNA mismatch repair in cancer research.

  2016cites this paper
• JPET #220806 1 The evolving role of NSAIDs in colon cancer prevention: A cause for optimism

  2015influential citation
• Phytochemicals for prostate cancer prevention: integrating redox signaling, epigenetics and genetics in vitro and in vivo

  2015cites this paper
• The Evolving Role of Nonsteroidal Anti-Inflammatory Drugs in Colon Cancer Prevention: A Cause for Optimism

  2015cites this paper
• Phospholipid remodeling and eicosanoid signaling in colon cancer cells.

  2014cites this paper
• In vitro evaluation of novel N-acetylalaninate prodrugs that selectively induce apoptosis in prostate cancer cells

  2014cites this paper
• Therapeutic Potential of Hydrazones as Anti-Inflammatory Agents

  2014cites this paper
• Activities of 2-phthalimidethanol and 2-phthalimidethyl nitrate, phthalimide analogs devoid of the glutarimide moiety, in experimental models of inflammatory pain and edema.

  2014cites this paper
• EXPLORING ANTIINFLAMMATORY POTENTIAL OF 1 , 3 , 4-OXADIAZOLE DERIVATIVES AS PROMISING

  2013cites this paper
• Comparative proteomic analysis of cysteine oxidation in colorectal cancer patients

  2013cites this paper
• The metabolism and pharmacokinetics of phospho‐sulindac (OXT‐328) and the effect of difluoromethylornithine

  2012cites this paper
• Synergistic Anti-Tumor Effects of Combination of Photodynamic Therapy and Arsenic Compound in Cervical Cancer Cells: In Vivo and In Vitro Studies

  2012cites this paper
• Synthesis and Antibacterial Activity of Acetoxybenzoyl Thioureas with Aryl and Amino Acid Side Chains

  2012cites this paper
• REVIEW EXPLORING ANTIINFLAMMATORY POTENTIAL OF 1,3,4-OXADIAZOLE DERIVATIVES AS PROMISING LEAD

  2012cites this paper
• Oxidative Stress Mediates through Apoptosis the Anticancer Effect of Phospho-Nonsteroidal Anti-Inflammatory Drugs: Implications for the Role of Oxidative Stress in the Action of Anticancer Agents

  2011cites this paper
• Aspirin and Low-Dose Nitric Oxide–Donating Aspirin Increase Life Span in a Lynch Syndrome Mouse Model

  2011cites this paper
• Pharmacodynamics of curcumin as DNA hypomethylation agent in restoring the expression of Nrf2 via promoter CpGs demethylation.

  2011cites this paper
• The novel phospho‐non‐steroidal anti‐inflammatory drugs, OXT‐328, MDC‐22 and MDC‐917, inhibit adjuvant‐induced arthritis in rats

  2011cites this paper
• Protein nitration and nitrosylation by NO-donating aspirin in colon cancer cells: Relevance to its mechanism of action.

  2011cites this paper
• Histone deacetylases and the immunological network: implications in cancer and inflammation

  2010cites this paper
• Wnt/β-catenin Signaling in Oral Tissue Development and Disease

  2010cites this paper
• Annexin 1 induced by anti-inflammatory drugs binds to NF-kappaB and inhibits its activation: anticancer effects in vitro and in vivo.

  2010cites this paper
• Phospho-sulindac (OXT-922) inhibits the growth of human colon cancer cell lines: a redox/polyamine-dependent effect.

  2010cites this paper
• Inhibitory effect of nitric oxide-donating aspirin against prostatic cancer angiogenesis in tumor-bearing mice: Inhibitory effect of nitric oxide-donating aspirin against prostatic cancer angiogenesis in tumor-bearing mice

  2010cites this paper
• Nitric Oxide Donors Are a New Class of Anti-cancer Therapeutics for the Reversal of Resistance and Inhibition of Metastasis

  2010cites this paper
• Novel Therapeutic Applications of Nitric Oxide in the Inhibition of Tumor Malignancy and Reversal of Resistance

  2010cites this paper
• REVIEWS IN BASIC AND CLINICAL GASTROENTEROLOGY

  2009cites this paper
• Suppression of Wnt/beta-catenin signaling inhibits prostate cancer cell proliferation.

  2009cites this paper
• Anti-tumor effects on the combination of photodynamic therapy with arsenic compound in TC-1 cells implanted C57BL/6 mice

  2009cites this paper
• The differential cell signaling effects of two positional isomers of the anticancer NO-donating aspirin.

  2009cites this paper
• Phosphoaspirin (MDC-43), a novel benzyl ester of aspirin, inhibits the growth of human cancer cell lines more potently than aspirin: a redox-dependent effect.

  2009cites this paper
• Targeting Cyclooxygenase and Nitric Oxide Pathway Cross-Talk: A New Signal Transduction Pathway for Developing More Effective Anti- Inflammatory Drugs

  2009cites this paper
• Nitric oxide-donating aspirin inhibits the growth of pancreatic cancer cells through redox-dependent signaling.

  2009influential citation
• Chemopreventive agents induce oxidative stress in cancer cells leading to COX-2 overexpression and COX-2-independent cell death.

  2009cites this paper
• Chemoprevention of colorectal neoplasia: the potential for personalized medicine.

  2008cites this paper
• Pharmacokinetic and pharmacodynamic study of NO-donating aspirin in F344 rats.

  2008cites this paper
• The thioredoxin system mediates redox-induced cell death in human colon cancer cells: implications for the mechanism of action of anticancer agents.

  2008cites this paper
• NSAIDs and apoptosis

  2008cites this paper
• The novel phenylester anticancer compounds: Study of a derivative of aspirin (phoshoaspirin).

  2008cites this paper
• Do ATP and NO interact in the CNS?

  2008cites this paper
• Histone deacetylase regulation of immune gene expression in tumor cells

  2008cites this paper
• trans-[Ru(NO)(NH3)4(py)](BF4)3.H2O encapsulated in PLGA microparticles for delivery of nitric oxide to B16-F10 cells: Cytotoxicity and phototoxicity.

  2008cites this paper
• NO-donating aspirin inhibits angiogenesis by suppressing VEGF expression in HT-29 human colon cancer mouse xenografts.

  2008cites this paper
• NO-donating NSAIDs and cancer: an overview with a note on whether NO is required for their action.

  2008cites this paper
• NO-Donating NSAIDs, PPARδ, and Cancer: Does PPARδ Contribute to Colon Carcinogenesis?

  2008cites this paper
• The mechanism of action of nitric oxide-donating aspirin.

  2007cites this paper
• Novel agents for cancer prevention based on nitric oxide.

  2007cites this paper
• A Potential Concept In The Management of Tumors With Modulation of Prostaglandin, Nitric Oxide and Antioxidants

  2007cites this paper