Structures of parasitic CDPK domains point to a common mechanism of activation

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Proteins: Structure, Function, and Bioinformatics

• Publication date

  2011-03-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1002/prot.22919PMID 21287613
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Molecular Basis of the Death-Associated Protein Kinase–Calcium/Calmodulin Regulator Complex

  2010cited by this paper
• Structure of the CaMKIIδ/Calmodulin Complex Reveals the Molecular Mechanism of CaMKII Kinase Activation

  2010cited by this paper
• Structures of apicomplexan calcium-dependent protein kinases reveal mechanism of activation by calcium

  2010cited by this paper
• Calcium-dependent signaling and kinases in apicomplexan parasites.

  2009cited by this paper
• Dissection of Mechanisms Involved in the Regulation of Plasmodium falciparum Calcium-dependent Protein Kinase 4*

  2009cited by this paper
• Gene expression signatures and small-molecule compounds link a protein kinase to Plasmodium falciparum motility.

  2008cited by this paper
• Inference of macromolecular assemblies from crystalline state.

  2007cited by this paper
• Structures and metal-ion-binding properties of the Ca2+-binding helix-loop-helix EF-hand motifs.

  2007cited by this paper
• The tumor suppressor DAPK is reciprocally regulated by tyrosine kinase Src and phosphatase LAR.

  2007cited by this paper
• Genome-scale protein expression and structural biology of Plasmodium falciparum and related Apicomplexan organisms.

  2007cited by this paper
• Structure of the regulatory apparatus of a calcium-dependent protein kinase (CDPK): a novel mode of calmodulin-target recognition.

  2006cited by this paper
• HKL-3000: the integration of data reduction and structure solution--from diffraction images to an initial model in minutes.

  2006cited by this paper
• A phyloproteomic characterization of in vitro autophosphorylation in calcium‐dependent protein kinases

  2006cited by this paper
• ConSurf 2005: the projection of evolutionary conservation scores of residues on protein structures

  2005cited by this paper
• Plants, symbiosis and parasites: a calcium signalling connection

  2005cited by this paper
• Coot: model-building tools for molecular graphics.

  2004cited by this paper
• Unexpected Structure of the Ca2+-regulatory Region from Soybean Calcium-dependent Protein Kinase-α*

  2004cited by this paper
• MOLPROBITY: structure validation and all-atom contact analysis for nucleic acids and their complexes

  2004cited by this paper
• The Mode of Action of Centrin

  2004cited by this paper
• Evidence for Differing Roles for Each Lobe of the Calmodulin-like Domain in a Calcium-dependent Protein Kinase*

  2004cited by this paper
• Proteomics of calcium-signaling components in plants.

  2004cited by this paper
• research papers Acta Crystallographica Section A Foundations of

  2003cited by this paper
• Calmodulin is a limiting factor in the cell.

  2002cited by this paper
• Calmodulin in action: diversity in target recognition and activation mechanisms.

  2002cited by this paper
• Intramolecular activation of a Ca(2+)-dependent protein kinase is disrupted by insertions in the tether that connects the calmodulin-like domain to the kinase.

  2000cited by this paper
• Intramolecular activation of a Ca(2+)-dependent protein kinase is disrupted by insertions in the tether that connects the calmodulin-like domain to the kinase

  2000cited by this paper
• Dynamics and thermodynamics of the regulatory domain of human cardiac troponin C in the apo- and calcium-saturated states.

  1998cited by this paper
• Ca2+-dependent protein kinases of Paramecium--cloning provides evidence of a multigene family.

  1998cited by this paper
• Calcium-binding properties of a calcium-dependent protein kinase from Plasmodium falciparum and the significance of individual calcium-binding sites for kinase activation.

  1994cited by this paper
• The CCP4 suite: programs for protein crystallography.

  1994cited by this paper
• Calcium and lipid regulation of an Arabidopsis protein kinase expressed in Escherichia coli.

  1993cited by this paper
• Automatic processing of rotation diffraction data from crystals of initially unknown symmetry and cell constants

  1993cited by this paper
• Differential recovery of Ca2+ binding activity in mutated EF-hands of cardiac troponin C.

  1993cited by this paper
• The amino acid sequence of bovine cardiac tamponin-C. Comparison with rabbit skeletal troponin-C.

  1975cited by this paper

• Computational Evaluation of Sea Buckthorn Phytochemicals as CDPK3 and CDPK4 Inhibitors against Plasmodium falciparum

  2026cites this paper
• Calcium-Dependent Protein Kinases in Plants: Structure, Signaling, and Multifaceted Regulatory Roles in Development and Stress Adaptation.

  2026cites this paper
• Calcium-dependent protein kinases 2A involved in the growth of both asexual and sexual stages of Cryptosporidium parvum

  2025cites this paper
• Two putative calcium-dependent protein kinases are involved in the regulation of sugarcane defense genes

  2024cites this paper
• Imaging of plant calcium-sensor kinase conformation monitors real time calcium-dependent decoding in planta.

  2023cites this paper
• Genome-wide identification of the CPK gene family in wheat (Triticum aestivum L.) and characterization of TaCPK40 associated with seed dormancy and germination.

  2023cites this paper
• Characterization of Calcium-Dependent Protein Kinase 2A, a Potential Drug Target Against Cryptosporidiosis

  2022cites this paper
• Managing activity and Ca2+ dependence through mutation in the Junction of the AtCPK1 coordinates the salt tolerance in transgenic tobacco plants.

  2021cites this paper
• Comparative analysis of the kinomes of Plasmodium falciparum, Plasmodium vivax and their host Homo sapiens

  2021influential citation
• CDPKs: The critical decoders of calcium signal at various stages of malaria parasite development

  2021cites this paper
• Phosphorylation of a Toxoplasma gondii tyrosine transporter by 3 calcium-dependent kinase 3 is important for parasite fitness . 4 5 Short Title : Phosphorylation of a tyrosine transporter in Toxoplasma gondii 6 7

  2021cites this paper
• Calcium-dependent Protein Kinases in Malaria Parasite Development and Infection

  2020cites this paper
• Phosphorylation-dependent subfunctionalization of the calcium-dependent protein kinase CPK28

  2020cites this paper
• Calcium Dependent Protein Kinases in Plants

  2020cites this paper
• Genome-wide investigation of calcium-dependent protein kinase gene family in pineapple: evolution and expression profiles during development and stress

  2020cites this paper
• In-silico analysis of Calcium Dependent Protein Kinase 6 of Cryptosporidium parvum through molecular modeling, docking, and dynamics simulation study

  2020influential citation
• Characterization of Calcium-Dependent Protein Kinases 3, a Protein Involved in Growth of Cryptosporidium parvum

  2020cites this paper
• Calcium and cyclic nucleotide signaling networks in Toxoplasma gondii

  2020cites this paper
• In silico analysis of plasmodium falciparum CDPK5 protein through molecular modeling, docking and dynamics.

  2019cites this paper
• Calcium Signaling: A Communication Network that Regulates Cellular Processes

  2019cites this paper
• Properties and functions of calcium-dependent protein kinases and their relatives in Arabidopsis thaliana.

  2019cites this paper
• Regulation of Plant Immune Signaling by Calcium-Dependent Protein Kinases.

  2019cites this paper
• Autophosphorylation of Ser-6 via an intermolecular mechanism is important for the rapid reduction of NtCDPK1 kinase activity for substrate RSG

  2018cites this paper
• Plasmodial Kinase Inhibitors: License to Cure?

  2018cites this paper
• The rice cold-responsive calcium-dependent protein kinase OsCPK17 is regulated by alternative splicing and post-translational modifications.

  2018cites this paper
• Revisiting paradigms of Ca2+ signaling protein kinase regulation in plants.

  2018cites this paper
• Toxoplasma Calcium-Dependent Protein Kinase 1 Inhibitors: Probing Activity and Resistance Using Cellular Thermal Shift Assays

  2018cites this paper
• Advances and current challenges in calcium signaling.

  2018cites this paper
• Analysis of noncanonical calciumdependent protein kinases in Toxoplasma gondii by targeted gene deletion using CRISPR / Cas 9

  2018influential citation
• Characterisation of the Toxoplasma gondii tyrosine transporter and its phosphorylation by the calcium‐dependent protein kinase 3

  2018cites this paper
• Phosphorylation of a Toxoplasma gondii tyrosine transporter by calcium-dependent kinase 3 is important for parasite fitness

  2018cites this paper
• miRNAs: The Game Changer in Producing Salinity Stress-Tolerant Crops

  2018cites this paper
• Vinay Kumar · Shabir Hussain Wani Penna Suprasanna · Lam-Son Phan Tran Editors

  2018cites this paper
• Phosphorylation Properties of Recombinant OsCPK11, a Calcium-dependent Protein Kinase from Rice

  2017cites this paper
• Biophysical characterization of the calmodulin-like domain of Plasmodium falciparum calcium dependent protein kinase 3

  2017cites this paper
• Discovery and structure activity relationship of the first potent cryptosporidium FIKK kinase inhibitor.

  2017cites this paper
• Functional Prioritization and Hydrogel Regulation Phenomena Created by a Combinatorial Pearl-Associated Two-Protein Biomineralization Model System.

  2017cites this paper
• Autophosphorylation Affects Substrate-Binding Affinity of Tobacco Ca2+-Dependent Protein Kinase11

  2017cites this paper
• The Evolution of Calcium-Based Signalling in Plants.

  2017cites this paper
• An Overview of Signaling Regulons During Cold Stress Tolerance in Plants

  2017cites this paper
• Autophosphorylation-based Calcium (Ca2+) Sensitivity Priming and Ca2+/Calmodulin Inhibition of Arabidopsis thaliana Ca2+-dependent Protein Kinase 28 (CPK28)

  2017cites this paper
• Genome wide identification and characterization of Calcium Dependent Protein Kinase gene family in Cajanus cajan

  2017cites this paper
• Calmodulin-like proteins localized to the conoid regulate motility and cell invasion by Toxoplasma gondii

  2017cites this paper
• Exploring structural requirements for the inhibition of Plasmodium falciparum calcium-dependent protein kinase-4 (PfCDPK-4) using multiple in silico approaches

  2016cites this paper
• Role of Calcium‐Dependent Protein Kinases during Abiotic Stress Tolerance

  2016cites this paper
• Structure of the STRA6 receptor for retinol uptake

  2016cites this paper
• Calcium-dependent Protein Kinases: Understanding Functional Diversification and Specificity of Plant Signalling Hubs Using the Most Conserved Members

  2016influential citation
• Analysis of Noncanonical Calcium-Dependent Protein Kinases in Toxoplasma gondii by Targeted Gene Deletion Using CRISPR/Cas9

  2016cites this paper
• Fast and Accurate Resonance Assignment of Small-to-Large Proteins by Combining Automated and Manual Approaches

  2015cites this paper
• Inhibition of Calcium-Dependent Protein Kinase 1 (CDPK1) In Vitro by Pyrazolopyrimidine Derivatives Does Not Correlate with Sensitivity of Cryptosporidium parvum Growth in Cell Culture

  2015cites this paper
• Increasing complexity and versatility: how the calcium signaling toolkit was shaped during plant land colonization.

  2015cites this paper
• ZmCPK1, a calcium-independent kinase member of the Zea mays CDPK gene family, functions as a negative regulator in cold stress signalling.

  2015cites this paper
• Genome-wide analysis of the calcium-dependent protein kinase gene family in Gossypium raimondii

  2015cites this paper
• The Toxoplasma gondii calcium‐dependent protein kinase 7 is involved in early steps of parasite division and is crucial for parasite survival

  2014cites this paper
• Calcium-dependent protein kinases in plants: evolution, expression and function.

  2014cites this paper
• Development of potent and selective Plasmodium falciparum calcium-dependent protein kinase 4 (PfCDPK4) inhibitors that block the transmission of malaria to mosquitoes.

  2014cites this paper
• CDPKs of Cryptosporidium parvum—stage-specific expression in vitro

  2014cites this paper
• From local to global: CDPKs in systemic defense signaling upon microbial and herbivore attack.

  2014cites this paper
• Scaffold Function of Ca 2 +-Dependent Protein Kinase : Tobacco Ca 2 +-DEPENDENT PROTEIN KINASE 1 Transfers 14-3-3 to the Substrate REPRESSION OF SHOOT GROWTH after Phosphorylation 1 [ C ] [ W ]

  2014influential citation
• Functions of Calcium-Dependent Protein Kinases in Plant Innate Immunity

  2014cites this paper
• Phosphorylation-independent binding of 14–3–3 to NtCDPK1 by a new mode

  2014cites this paper
• From crystal to compound: structure-based antimalarial drug discovery.

  2014cites this paper
• Protein Kinases and Phosphatases Involved in ABA Signaling

  2014cites this paper
• Scaffold Function of Ca2+-Dependent Protein Kinase: Tobacco Ca2+-DEPENDENT PROTEIN KINASE1 Transfers 14-3-3 to the Substrate REPRESSION OF SHOOT GROWTH after Phosphorylation1[C][W]

  2014influential citation
• Computational analysis of apicomplexan kinomes.

  2013cites this paper
• Investigating Potential Mechanisms of Cytocidal Drug Resistance in Plasmodium falciparum

  2013cites this paper
• Selective inhibition of parasite protein kinases.

  2013cites this paper
• Computational characterization of protein kinase adaptations in eukaryotic pathogens

  2013influential citation
• From compound to target: chemical proteomics and in silico screening for target identification in Plasmodium falciparum

  2013cites this paper
• Expression, purification and biochemical characterization of recombinant Ca-dependent protein kinase 2 of the malaria parasite Plasmodium falciparum.

  2013cites this paper
• Biochemical regulation of in vivo function of plant calcium-dependent protein kinases (CDPK).

  2013cites this paper
• Optimizing small molecule inhibitors of calcium-dependent protein kinase 1 to prevent infection by Toxoplasma gondii.

  2013cites this paper
• Function of calcium-dependent protein kinase CPK28 of Arabidopsis thaliana in plant stem elongation and vascular development.

  2013cites this paper
• Calcium-Dependent Protein Kinases: Hubs in Plant Stress Signaling and Development1

  2013cites this paper
• Calcium and Reactive Oxygen Species Rule the Waves of Signaling1

  2013cites this paper
• Calcium/Calmodulin-Dependent Protein Kinase Is Negatively and Positively Regulated by Calcium, Providing a Mechanism for Decoding Calcium Responses during Symbiosis Signaling[W][OPEN]

  2013cites this paper
• Impact of Ca2+ on structure of soybean CDPKβ and accessibility of the Tyr-24 autophosphorylation site

  2013cites this paper
• A Forward Genetic Screen Reveals that Calcium-dependent Protein Kinase 3 Regulates Egress in Toxoplasma

  2012cites this paper
• Plasmodium kinases as targets for new-generation antimalarials.

  2012cites this paper
• Genome-wide identification, classification, and expression analysis of CDPK and its closely related gene families in poplar (Populus trichocarpa)

  2012cites this paper
• Novel insights into the regulation of malarial calcium‐dependent protein kinase 1

  2012cites this paper
• Calcium-Dependent Protein Kinases from Arabidopsis Show Substrate Specificity Differences in an Analysis of 103 Substrates

  2011cites this paper
• The Cryptosporidium parvum Kinome

  2011influential citation
• Toxoplasma and Plasmodium protein kinases: roles in invasion and host cell remodelling.

  2011cites this paper
• Structure and Function of CDPK: A Sensor Responder of Calcium

  2011cites this paper
• Structural and evolutionary divergence of eukaryotic protein kinases in Apicomplexa

  2011influential citation