Vascular injury during elevated glucose can be mitigated by erythropoietin and Wnt signaling.

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Current Neurovascular Research

• Publication date

  2007-07-31

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.2174/156720207781387150PMID 17691973PMCID PMC2678063
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Cellular demise and inflammatory microglial activation during beta-amyloid toxicity are governed by Wnt1 and canonical signaling pathways.

  2007cited by this paper
• Erythropoietin involves the phosphatidylinositol 3‐kinase pathway, 14‐3‐3 protein and FOXO3a nuclear trafficking to preserve endothelial cell integrity

  2007cited by this paper
• Oxidative stress biology and cell injury during type 1 and type 2 diabetes mellitus.

  2007cited by this paper
• INHIBITION OF GLYCOGEN SYNTHASE KINASE (GSK) 3 PROMOTES REPLICATION AND SURVIVAL OF PANCREATIC BETA CELLS

  2007cited by this paper
• Mechanistic insights into diabetes mellitus and oxidative stress.

  2007cited by this paper
• Metabotropic glutamate receptor 3 protects neurons from glucose‐induced oxidative injury by increasing intracellular glutathione concentration

  2007cited by this paper
• Inhibition of GSK3 Promotes Replication and Survival of Pancreatic Beta Cells*

  2007cited by this paper
• Faculty Opinions recommendation of NMDA-receptor activation induces calpain-mediated beta-catenin cleavages for triggering gene expression.

  2007cited by this paper
• The pro-survival pathways of mTOR and protein kinase B target glycogen synthase kinase-3beta and nuclear factor-kappaB to foster endogenous microglial cell protection.

  2007cited by this paper
• NMDA-receptor activation induces calpain-mediated beta-catenin cleavages for triggering gene expression.

  2007cited by this paper
• Effects of a Single Dose of Erythropoietin on Subsequent Seizure Susceptibility in Rats Exposed to Acute Hypoxia at P10

  2007cited by this paper
• Upregulation of the WNT pathway in tuberous sclerosis-associated subependymal giant cell astrocytomas.

  2007cited by this paper
• A "classical" homodimeric erythropoietin receptor is essential for the antiapoptotic effects of erythropoietin on differentiated neuroblastoma SH-SY5Y and pheochromocytoma PC-12 cells.

  2007cited by this paper
• Erythropoietin-Mobilized Endothelial Progenitors Enhance Reendothelialization via Akt–Endothelial Nitric Oxide Synthase Activation and Prevent Neointimal Hyperplasia

  2006cited by this paper
• Detection of Erythropoietin in Exhaled Breath Condensate of Nonhypoxic Subjects Using a Multiplex Bead Array

  2006cited by this paper
• Streptozotocin-induced diabetes progressively increases blood-brain barrier permeability in specific brain regions in rats.

  2006cited by this paper
• Genome-wide sequence and functional analysis of early replicating DNA in normal human fibroblasts

  2006cited by this paper
• Anemia, chronic renal disease and congestive heart failure—the cardio renal anemia syndrome: the need for cooperation between cardiologists and nephrologists

  2006cited by this paper
• These include: Supplemental material

  2006cited by this paper
• Erythropoietin Concentrations and Neurodevelopmental Outcome in Preterm Infants

  2006cited by this paper
• Erythropoietin and cerebral vascular protection: role of nitric oxide

  2006cited by this paper
• Prevalence and associations of low plasma erythropoietin in patients with Type 2 diabetes mellitus

  2006cited by this paper
• Erythropoietin, Modified to Not Stimulate Red Blood Cell Production, Retains Its Cardioprotective Properties

  2006cited by this paper
• Winding through the WNT pathway during cellular development and demise.

  2006cited by this paper
• Inappropriately low erythropoietin response for the degree of anemia in patients with noninsulin-dependent diabetes mellitus

  2006cited by this paper
• Glycogen synthase kinase 3β and Alzheimer’s disease: pathophysiological and therapeutic significance

  2006cited by this paper
• Wnt/beta-catenin signaling modulates survival of high glucose-stressed mesangial cells.

  2006cited by this paper
• Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes

  2006cited by this paper
• Insulin-stimulated insulin receptor substrate-2-associated phosphatidylinositol 3-kinase activity is enhanced in human skeletal muscle after exercise.

  2006cited by this paper
• Susceptibility of brain microvascular endothelial cells to advanced glycation end products-induced tissue factor upregulation is associated with intracellular reactive oxygen species.

  2006cited by this paper
• Cell Life versus cell longevity: the mysteries surrounding the NAD+ precursor nicotinamide.

  2006cited by this paper
• Microglial integrity is maintained by erythropoietin through integration of Akt and its substrates of glycogen synthase kinase-3beta, beta-catenin, and nuclear factor-kappaB.

  2006cited by this paper
• Antioxidant pyrrolidine dithiocarbamate activates Akt-GSK signaling and is neuroprotective in neonatal hypoxia-ischemia.

  2006cited by this paper
• Signals for stress erythropoiesis are integrated via an erythropoietin receptor-phosphotyrosine-343-Stat5 axis.

  2006cited by this paper
• Insulin Restores Metabolic Function in Cultured Cortical Neurons Subjected to Oxidative Stress

  2006cited by this paper
• Type 1 diabetes.

  2006cited by this paper
• Recombinant erythropoietin down-regulates IL-6 and CXCR4 genes in TNF-alpha-treated primary cultures of human microvascular endothelial cells: implications for multiple sclerosis.

  2005cited by this paper
• Stress in the brain: novel cellular mechanisms of injury linked to Alzheimer's disease.

  2005cited by this paper
• Overexpressed beta-catenin blocks nitric oxide-induced apoptosis in colonic cancer cells.

  2005cited by this paper
• Driving cellular plasticity and survival through the signal transduction pathways of metabotropic glutamate receptors.

  2005cited by this paper
• New avenues of exploration for erythropoietin.

  2005cited by this paper
• GSK-3β regulates phosphorylation of CRMP-2 and neuronal polarity

  2005cited by this paper
• Oxidative stress in the brain: novel cellular targets that govern survival during neurodegenerative disease.

  2005cited by this paper
• Anemia with impaired erythropoietin response in diabetic patients.

  2005cited by this paper
• Vital elements of the Wnt-Frizzled signaling pathway in the nervous system.

  2005cited by this paper
• Rosiglitazone treatment in Zucker diabetic Fatty rats is associated with ameliorated cardiac insulin resistance and protection from ischemia/reperfusion-induced myocardial injury.

  2005cited by this paper
• Erythropoietin requires NF-kappaB and its nuclear translocation to prevent early and late apoptotic neuronal injury during beta-amyloid toxicity.

  2005cited by this paper
• Blockade of Wnt-1 signaling induces apoptosis in human colorectal cancer cells containing downstream mutations

  2005cited by this paper
• Employing new cellular therapeutic targets for Alzheimer's disease: a change for the better?

  2005cited by this paper
• High serum erythropoietin level is associated with smaller infarct size in patients with acute myocardial infarction who undergo successful primary percutaneous coronary intervention.

  2005cited by this paper
• Erythropoietin in the brain: can the promise to protect be fulfilled?

  2004cited by this paper
• Diabetes mellitus in midlife and the risk of dementia three decades later

  2004cited by this paper
• Short-term intensive insulin therapy in newly diagnosed type 2 diabetes.

  2004cited by this paper
• Low-Dose Therapy With the Long-Acting Erythropoietin Analogue Darbepoetin Alpha Persistently Activates Endothelial Akt and Attenuates Progressive Organ Failure

  2004cited by this paper
• Poor control of risk factors for vascular disease among adults with previously diagnosed diabetes.

  2004cited by this paper
• Epoetin alfa. Clinical evolution of a pleiotropic cytokine.

  2004cited by this paper
• Erythropoietin on a Tightrope: Balancing Neuronal and Vascular Protection between Intrinsic and Extrinsic Pathways

  2004cited by this paper
• High amniotic fluid erythropoietin levels are associated with an increased frequency of fetal and neonatal morbidity in Type 1 diabetic pregnancies

  2004cited by this paper
• Prognostic value of plasma erythropoietin on mortality in patients with chronic heart failure.

  2004cited by this paper
• Targeting WNT, protein kinase B, and mitochondrial membrane integrity to foster cellular survival in the nervous system.

  2004cited by this paper
• Association of the gene encoding wingless-type mammary tumor virus integration-site family member 5B (WNT5B) with type 2 diabetes.

  2004cited by this paper
• Inhibition of Wnt-1 Signaling Induces Apoptosis in β-Catenin-Deficient Mesothelioma Cells

  2004cited by this paper
• Short-Term Intensive Insulin Therapy in Newly Diagnosed Type 2 Diabetes

  2004cited by this paper
• The effect of correction of anaemia in diabetics and non-diabetics with severe resistant congestive heart failure and chronic renal failure by subcutaneous erythropoietin and intravenous iron.

  2003cited by this paper
• Apaf-1, Bcl-xL, Cytochrome c, and Caspase-9 Form the Critical Elements for Cerebral Vascular Protection by Erythropoietin

  2003cited by this paper
• Erythropoietin fosters both intrinsic and extrinsic neuronal protection through modulation of microglia, Akt1, Bad, and caspase‐mediated pathways

  2003cited by this paper
• Combined aerobic and resistance exercise improves glycemic control and fitness in type 2 diabetes.

  2002cited by this paper
• Erythropoietin Is a Novel Vascular Protectant Through Activation of Akt1 and Mitochondrial Modulation of Cysteine Proteases

  2002cited by this paper
• Wnt and frizzled receptors as potential targets for immunotherapy in head and neck squamous cell carcinomas

  2002cited by this paper
• Type 2 diabetes: epidemiology, pathophysiology, and diagnosis.

  2001cited by this paper
• Cardiovascular disease in type 2 diabetes: challenge for treatment and prevention

  2001cited by this paper
• Diurnal variation in fasting plasma glucose: implications for diagnosis of diabetes in patients examined in the afternoon.

  2000cited by this paper
• Wnt-1 dependent activation of the survival factor NF-kappaB in PC12 cells.

  2000cited by this paper
• Therapeutic use of continuous subcutaneous infusion of recombinant human erythropoietin in malnourished predialysis anemic patients with diabetic nephropathy.

  1998cited by this paper
• Expression and characterization of glycogen synthase kinase-3 mutants and their effect on glycogen synthase activity in intact cells.

  1996cited by this paper
• Prevalence and Clinical Features of Known Type 2 Diabetes in the Elderly: A Population‐based Study

  1994cited by this paper
• [Erythropoietin and cancer].

  1992cited by this paper
• Development and characterisation of a rat brain capillary endothelial culture: towards an in vitro blood-brain barrier.

  1992cited by this paper
• Development of a new radioimmunoassay for erythropoietin using recombinant erythropoietin.

  1990cited by this paper

• Exosomes, Circadian Rhythms, and Cancer Precision Medicine: New Frontiers.

  2024cites this paper
• Cornerstone Cellular Pathways for Metabolic Disorders and Diabetes Mellitus: Non-Coding RNAs, Wnt Signaling, and AMPK

  2023cites this paper
• Fluorescence probe for real-time malonaldehyde detection in epilepsy model.

  2023cites this paper
• The impact of aging and oxidative stress in metabolic and nervous system disorders: programmed cell death and molecular signal transduction crosstalk

  2023cites this paper
• Sirtuins in metabolic disease: innovative therapeutic strategies with SIRT1, AMPK, mTOR, and nicotinamide

  2021cites this paper
• Novel treatment strategies for neurodegenerative disease with sirtuins

  2021cites this paper
• Diabetic Neuropathy: Review on Molecular Mechanisms.

  2021cites this paper
• Effects of Erythropoietin in White Adipose Tissue and Bone Microenvironment

  2020cites this paper
• Nicotinamide: Oversight of Metabolic Dysfunction through SIRT1, mTOR, and Clock Genes.

  2020cites this paper
• Ghrelin combined with sodium tanshinone IIA sulfonate pretreatment reduces apoptosis and fractalkine expression induced by high-dose glucose in human umbilical vein endothelial cells.

  2020cites this paper
• New Insights for nicotinamide: Metabolic disease, autophagy, and mTOR.

  2020cites this paper
• Cognitive impairment with diabetes mellitus and metabolic disease: innovative insights with the mechanistic target of rapamycin and circadian clock gene pathways

  2019cites this paper
• MEPO promotes neurogenesis and angiogenesis but suppresses gliogenesis in mice with acute ischemic stroke

  2019cites this paper
• Asiaticoside nitric oxide gel accelerates diabetic cutaneous ulcers healing by activating Wnt/β-catenin signaling pathway.

  2019cites this paper
• Intramyocardial angiogenetic stem cells and epicardial erythropoietin save the acute ischemic heart

  2018cites this paper
• Regulatory Mechanisms of the Wnt/β-Catenin Pathway in Diabetic Cutaneous Ulcers

  2018cites this paper
• Streptozotocin induced hyperglycemia stimulates molecular signaling that promotes cell cycle reentry in mouse hippocampus

  2018cites this paper
• Harnessing the Power of SIRT1 and Non-coding RNAs in Vascular Disease.

  2017cites this paper
• Moving to the Rhythm with Clock (Circadian) Genes, Autophagy, mTOR, and SIRT1 in Degenerative Disease and Cancer.

  2017cites this paper
• Activation of Wnt3α/β-catenin signal pathway attenuates apoptosis of the cerebral microvascular endothelial cells induced by oxygen-glucose deprivation.

  2017cites this paper
• Warming Up to New Possibilities with the Capsaicin Receptor TRPV1: mTOR, AMPK, and Erythropoietin.

  2017cites this paper
• Novel nervous and multi-system regenerative therapeutic strategies for diabetes mellitus with mTOR

  2016cites this paper
• Erythropoietin and mTOR: A "One-Two Punch" for Aging-Related Disorders Accompanied by Enhanced Life Expectancy.

  2016cites this paper
• Knockdown of GSK3β increases basal autophagy and AMPK signalling in nutrient-laden human aortic endothelial cells

  2016cites this paper
• Regeneration in the nervous system with erythropoietin.

  2016cites this paper
• Regeneration in the nervous system with erythropoietin.

  2016cites this paper
• Novel Stem Cell Strategies with mTOR

  2016cites this paper
• Novel applications of trophic factors, Wnt and WISP for neuronal repair and regeneration in metabolic disease

  2015influential citation
• The Effects of Chinese Medicine on Activation of Wnt/β-Catenin Signal Pathway under High Glucose Condition

  2015cites this paper
• Programming apoptosis and autophagy with novel approaches for diabetes mellitus.

  2015cites this paper
• Correlation between erythropoietin serum levels and erythrocyte susceptibility to lipid peroxidation in elderly with type 2 diabetes.

  2015cites this paper
• mTOR: Driving apoptosis and autophagy for neurocardiac complications of diabetes mellitus.

  2015cites this paper
• The effects of sodium tanshinone IIa sulfonate pretreatment on high glucose-induced expression of fractalkine and apoptosis in human umbilical vein endothelial cells.

  2015cites this paper
• FoxO Transcription Factors and Regenerative Pathways in Diabetes Mellitus.

  2015influential citation
• High-Fat Diet/Low-Dose Streptozotocin-Induced Type 2 Diabetes in Rats Impacts Osteogenesis and Wnt Signaling in Bone Marrow Stromal Cells

  2015cites this paper
• New Insights for Oxidative Stress and Diabetes Mellitus

  2015influential citation
• Glycogen synthase kinase 3 inhibitor protects against microvascular hyperpermeability following hemorrhagic shock

  2015cites this paper
• Erythropoietin and diabetes mellitus.

  2015cites this paper
• Stem cell guidance through the mechanistic target of rapamycin.

  2015cites this paper
• From neurogenesis to neuroprotection in the epilepsy: signalling by erythropoietin.

  2014cites this paper
• WISP1: Clinical insights for a proliferative and restorative member of the CCN family.

  2014cites this paper
• Therapeutic potential of umbilical cord mesenchymal stem cells with Wnt/β-catenin signaling pathway pre-activated for the treatment of diabetic wounds.

  2014cites this paper
• Targeting erythropoietin for chronic neurodegenerative diseases

  2013cites this paper
• Novel directions for diabetes mellitus drug discovery

  2013cites this paper
• Prevention of β-amyloid degeneration of microglia by erythropoietin depends on Wnt1, the PI 3-K/mTOR pathway, Bad, and Bcl-xL

  2012cites this paper
• Mammalian target of rapamycin signaling in diabetic cardiovascular disease

  2012cites this paper
• The Vasculome of the Mouse Brain The Harvard community has made this article openly available. Please share how this access benefits you. Your story matters

  2012cites this paper
• The Vasculome of the Mouse Brain

  2012cites this paper
• Therapeutic Potential of a Monoclonal Antibody Blocking the Wnt Pathway in Diabetic Retinopathy

  2012cites this paper
• Erythropoietin: New Directions for the Nervous System

  2012influential citation
• Wnt1 inducible signaling pathway protein 1 (WISP1) blocks neurodegeneration through phosphoinositide 3 kinase/Akt1 and apoptotic mitochondrial signaling involving Bad, Bax, Bim, and Bcl-xL.

  2012cites this paper
• Targeting disease through novel pathways of apoptosis and autophagy

  2012cites this paper
• EPO relies upon novel signaling of Wnt1 that requires Akt1, FoxO3a, GSK-3β, and β-catenin to foster vascular integrity during experimental diabetes.

  2011influential citation
• Translating cell survival and cell longevity into treatment strategies with SIRT1.

  2011cites this paper
• Erythropoietin and Wnt1 govern pathways of mTOR, Apaf-1, and XIAP in inflammatory microglia.

  2011cites this paper
• Non-erythropoietic erythropoietin derivatives protect from light-induced and genetic photoreceptor degeneration

  2011cites this paper
• Erythropoietin employs cell longevity pathways of SIRT1 to foster endothelial vascular integrity during oxidant stress.

  2011cites this paper
• Novel Avenues of Drug Discovery and Biomarkers for Diabetes Mellitus

  2011cites this paper
• Wnt1 neuroprotection translates into improved neurological function during oxidant stress and cerebral ischemia through AKT1 and mitochondrial apoptotic pathways.

  2010influential citation
• Oxidative stress: Biomarkers and novel therapeutic pathways

  2010influential citation
• Erythropoietin-induced neuroprotection requires cystine glutamate exchanger activity.

  2010cites this paper
• Novel Strategies for Neurovascular Longevity During Aging

  2010cites this paper
• FOXO3a governs early and late apoptotic endothelial programs during elevated glucose through mitochondrial and caspase signaling.

  2010cites this paper
• Diabetes mellitus: channeling care through cellular discovery.

  2010cites this paper
• Wnt1, FoxO3a, and NF-kappaB oversee microglial integrity and activation during oxidant stress.

  2010cites this paper
• Early apoptotic vascular signaling is determined by Sirt1 through nuclear shuttling, forkhead trafficking, bad, and mitochondrial caspase activation.

  2010cites this paper
• Wnt signalling and cancer stem cells

  2009cites this paper
• New strategies for Alzheimer disease and cognitive impairment

  2009cites this paper
• Erythropoietin treatment leads to reduced blood glucose levels and body mass: insights from murine models.

  2009cites this paper
• The Vitamin Nicotinamide: Translating Nutrition into Clinical Care

  2009cites this paper
• The "O" class: crafting clinical care with FoxO transcription factors.

  2009cites this paper
• A fork in the path

  2009cites this paper
• FoxO proteins: cunning concepts and considerations for the cardiovascular system.

  2009cites this paper
• Erythropoietin, Forkhead Proteins, and Oxidative Injury: Biomarkers and Biology

  2009cites this paper
• A “FOXO” in sight: Targeting Foxo proteins from conception to cancer

  2009cites this paper
• Rogue proliferation versus restorative protection: Where do we draw the line for Wnt and Forkhead signaling?

  2008cites this paper
• Tissue sites of EPO and its biological functions EPO production and expression sites Biological function Kidney Erythropoiesis Liver Protection and erythropoiesis Kupfer cells Hepatocytes Uterus Proliferation Brain Neurons

  2008cites this paper
• Erythropoietin and oxidative stress.

  2008cites this paper
• Neuroprotective effect of herpes simplex virus-mediated gene transfer of erythropoietin in hyperglycemic dorsal root ganglion neurons.

  2008cites this paper
• The Wnt signaling pathway: aging gracefully as a protectionist?

  2008cites this paper
• Therapeutic promise and principles

  2008cites this paper
• Raves and risks for erythropoietin.

  2008cites this paper
• Therapeutic promise and principles Metabotropic glutamate receptors

  2008cites this paper
• Diabetic stress: new triumphs and challenges to maintain vascular longevity

  2008cites this paper
• OutFOXOing disease and disability: the therapeutic potential of targeting FoxO proteins.

  2008cites this paper
• Triple play: promoting neurovascular longevity with nicotinamide, WNT, and erythropoietin in diabetes mellitus.

  2008influential citation
• Erythropoietin: elucidating new cellular targets that broaden therapeutic strategies.

  2008cites this paper
• Clever cancer strategies with FoxO transcription factors

  2008cites this paper
• "Sly as a FOXO": new paths with Forkhead signaling in the brain.

  2007cites this paper
• A fork in the path Developing therapeutic inroads with FoxO proteins

  year unknowncites this paper