EP2 and EP4 receptors differentially mediate MAPK pathways underlying anabolic actions of prostaglandin E2 on bone formation in rat calvaria cell cultures.

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Bone

• Publication date

  2009-06-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.bone.2009.02.010PMID 19233324
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Effect of deletion of the prostaglandin EP2 receptor on the anabolic response to prostaglandin E2 and a selective EP2 receptor agonist.

  2008influential reference
• Canine prostaglandin E2 synthase (PGES) and its receptors (EP2 and EP4): expression in the corpus luteum during dioestrus.

  2008cited by this paper
• p38 mitogen-activated protein kinase regulates osteoblast differentiation through osterix.

  2007cited by this paper
• Prostaglandin E2 Increases Transforming Growth Factor-β Type III Receptor Expression through CCAAT Enhancer-Binding Protein δ in Osteoblasts

  2007cited by this paper
• Cyclooxygenase-2 gene disruption promotes proliferation of murine calvarial osteoblasts in vitro.

  2007cited by this paper
• Prostaglandin E2 increases transforming growth factor-beta type III receptor expression through CCAAT enhancer-binding protein delta in osteoblasts.

  2007cited by this paper
• Lack of interaction between prostaglandin E2 receptor subtypes in regulating adenylyl cyclase activity in cultured rat dorsal root ganglion cells.

  2006cited by this paper
• Prostaglandin E2 (PGE2) increases the number of rat bone marrow osteogenic stromal cells (BMSC) via binding the EP4 receptor, activating sphingosine kinase and inhibiting caspase activity.

  2006cited by this paper
• Bone formation : maturation and functional activities of osteoblast lineage cells

  2006cited by this paper
• Downregulation of cAMP-dependent protein kinase inhibitor gamma is required for BMP-2-induced osteoblastic differentiation.

  2006cited by this paper
• Effects of selective prostaglandins E2 receptor agonists on cultured calvarial murine osteoblastic cells.

  2006influential reference
• Human mast cells express multiple EP receptors for prostaglandin E2 that differentially modulate activation responses.

  2006cited by this paper
• Parathyroid hormone regulates osterix and Runx2 mRNA expression predominantly through protein kinase A signaling in osteoblast-like cells

  2006cited by this paper
• Prostaglandin-dependent activation of ERK mediates cell proliferation induced by transforming growth factor beta in mouse osteoblastic cells.

  2005influential reference
• Prostaglandin E2 strongly inhibits human osteoclast formation.

  2005cited by this paper
• Growth inhibition and apoptosis in liver myofibroblasts promoted by hepatocyte growth factor leads to resolution from liver cirrhosis.

  2005cited by this paper
• A Nonprostanoid EP4 Receptor Selective Prostaglandin E2 Agonist Restores Bone Mass and Strength in Aged, Ovariectomized Rats

  2005cited by this paper
• Prostaglandin E2 Promotes Colon Cancer Cell Growth Through a Gs-Axin-ß-Catenin Signaling Axis

  2005cited by this paper
• Osthole-Mediated Cell Differentiation through Bone Morphogenetic Protein-2/p38 and Extracellular Signal-Regulated Kinase 1/2 Pathway in Human Osteoblast Cells

  2005cited by this paper
• BMP-2 and Insulin-like Growth Factor-I Mediate Osterix (Osx) Expression in Human Mesenchymal Stem Cells via the MAPK and Protein Kinase D Signaling Pathways*

  2005cited by this paper
• Prostaglandin E2 Stimulates Fibronectin Expression through EP1 Receptor, Phospholipase C, Protein Kinase Cα, and c-Src Pathway in Primary Cultured Rat Osteoblasts*

  2005cited by this paper
• Osteopenia and impaired fracture healing in aged EP4 receptor knockout mice.

  2005cited by this paper
• Prostaglandins: Mechanisms of action and regulation of production in bone

  2005cited by this paper
• PGE2 Signal Through EP2 Promotes the Growth of Articular Chondrocytes

  2004cited by this paper
• A selective EP4 receptor antagonist abrogates the stimulation of osteoblast recruitment from bone marrow stromal cells by prostaglandin E2 in vivo and in vitro.

  2004cited by this paper
• Stimulation of cAMP production and cyclooxygenase-2 by prostaglandin E(2) and selective prostaglandin receptor agonists in murine osteoblastic cells.

  2004cited by this paper
• Downregulation of Osteoblast Markers and Induction of the Glial Fibrillary Acidic Protein by Oncostatin M in Osteosarcoma Cells Require PKCδ and STAT3

  2004cited by this paper
• E-Prostanoid (EP)2/EP4 Receptor-Dependent Maturation of Human Monocyte-Derived Dendritic Cells and Induction of Helper T2 Polarization

  2004cited by this paper
• Regulation of the osteoblast‐specific transcription factor, Runx2: Responsiveness to multiple signal transduction pathways

  2003cited by this paper
• The Protein Kinase C Pathway Plays a Central Role in the Fibroblast Growth Factor-stimulated Expression and Transactivation Activity of Runx2*

  2003cited by this paper
• An EP2 receptor-selective prostaglandin E2 agonist induces bone healing

  2003cited by this paper
• A Novel, Non‐Prostanoid EP2 Receptor‐Selective Prostaglandin E2 Agonist Stimulates Local Bone Formation and Enhances Fracture Healing

  2003cited by this paper
• Prostaglandin E2 Induced Functional Expression of Early Growth Response Factor-1 by EP4, but Not EP2, Prostanoid Receptors via the Phosphatidylinositol 3-Kinase and Extracellular Signal-regulated Kinases*

  2003cited by this paper
• Stanniocalcin 1 stimulates osteoblast differentiation in rat calvaria cell cultures.

  2003cited by this paper
• Prostaglandin E2 Stimulates Bone Sialoprotein (BSP) Expression through cAMP and Fibroblast Growth Factor 2 Response Elements in the Proximal Promoter of the Rat BSP Gene*

  2003cited by this paper
• Effects of selective prostaglandin EP2 and EP4 receptor agonists on bone resorption and formation in fetal rat organ cultures.

  2003cited by this paper
• Multiple Signaling Pathways Converge on the Cbfa1/Runx2 Transcription Factor to Regulate Osteoblast Differentiation

  2003cited by this paper
• Paracrine regulation of fat cell formation in bone marrow cultures via adiponectin and prostaglandins.

  2002cited by this paper
• A phosphodiesterase inhibitor, pentoxifylline, enhances the bone morphogenetic protein-4 (BMP-4)-dependent differentiation of osteoprogenitor cells.

  2002cited by this paper
• Stimulation of bone formation and prevention of bone loss by prostaglandin E EP4 receptor activation

  2002influential reference
• Expression of the prostaglandin E(2) (PGE(2)) receptor subtype EP(4) and its regulation by PGE(2) in osteoblastic cell lines and adult rat bone tissue.

  2001cited by this paper
• Prostaglandin receptor EP(4) mediates the bone anabolic effects of PGE(2).

  2001cited by this paper
• Expression of the prostaglandin E2 (PGE2) receptor subtype EP4 and its regulation by PGE2 in osteoblastic cell lines and adult rat bone tissue1

  2001cited by this paper
• Prostanoid receptors: subtypes and signaling.

  2001cited by this paper
• Involvement of prostaglandin E(2) in interleukin-1alpha-induced parathyroid hormone-related peptide production in synovial fibroblasts of patients with rheumatoid arthritis.

  2001cited by this paper
• Minireview: transcriptional control of osteoblast differentiation.

  2001cited by this paper
• Bone biomechanical properties in prostaglandin EP1 and EP2 knockout mice.

  2001cited by this paper
• Genetic and pharmacological analysis of prostanoid receptor function.

  2001influential reference
• Prostaglandin E receptors and the kidney.

  2000cited by this paper
• Runt Domain Factor (Runx)-dependent Effects on CCAAT/ Enhancer-binding Protein δ Expression and Activity in Osteoblasts*

  2000cited by this paper
• The role of prostaglandin E receptor subtypes (EP1, EP2, EP3, and EP4) in bone resorption: an analysis using specific agonists for the respective EPs.

  2000influential reference
• Prostaglandin E2-induced up-regulation of c-fos messenger ribonucleic acid is primarily mediated by 3',5'-cyclic adenosine monophosphate in MC3T3-E1 osteoblasts.

  2000cited by this paper
• Prostaglandin E2-Induced Up-Regulation of c-fos Messenger Ribonucleic Acid Is Primarily Mediated by 3',5'-Cyclic Adenosine Monophosphate in MC3T3-E1 Osteoblasts1.

  2000influential reference
• Parathyroid Hormone Regulation of the Rat Collagenase-3 Promoter by Protein Kinase A-dependent Transactivation of Core Binding Factor α1*

  2000cited by this paper
• The anabolic effect of PGE2in rat bone marrow cultures is mediated via the EP4 receptor subtype.

  1999cited by this paper
• The anabolic effect of PGE2 in rat bone marrow cultures is mediated via the EP4 receptor subtype.

  1999cited by this paper
• Systemic administration of an anabolic dose of prostaglandin E2 induces early-response genes in rat bones.

  1997cited by this paper
• The in vivo anabolic actions of prostaglandins in bone.

  1997cited by this paper
• Prostaglandin E receptor subtypes in mouse osteoblastic cell line.

  1996influential reference
• Functional characterization of prostaglandin E2 inducible osteogenic colony forming units in cultures of cells isolated from the neonatal rat calvarium

  1996cited by this paper
• Expression of prostaglandin E receptor subtypes in bone: expression of EP2 in bone development.

  1995cited by this paper
• Effect of prostaglandin E2 on mineralization of bone nodules formed by fetal rat calvarial cells

  1994cited by this paper
• Phenotypic differences in subclones and long‐term cultures of clonally derived rat bone cell lines

  1986cited by this paper

• Mechanosignaling in Osteoporosis: When Cells Feel the Force

  2025cites this paper
• Shangke Jiegu tablet enhances callus formation during fracture repair by promoting angiogenesis-osteogenesis coupling via PTGS2-PGE2/EP4 axis.

  2025cites this paper
• Prostaglandin E2-Transporting Pathway and Its Roles via EP2/EP4 in Cultured Human Dental Pulp.

  2023cites this paper
• Metformin attenuates high-fat diet induced metabolic syndrome related osteoarthritis through inhibition of prostaglandins

  2023cites this paper
• Examining Mechanisms for Voltage-Sensitive Calcium Channel-Mediated Secretion Events in Bone Cells

  2023influential citation
• In Vivo Measurement of Voltage and Resistance in Fractured Human Bone: A Pilot Study

  2023cites this paper
• Prostate cancer expressing membrane-bound TGF-α induces bone formation mediated by the autocrine effect of prostaglandin E2 in osteoblasts.

  2022cites this paper
• Stem cells and regenerative medicine for musculoskeletal tissue

  2022cites this paper
• Prostaglandin EP4 Selective Agonist AKDS001 Enhances New Bone Formation by Minimodeling in a Rat Heterotopic Xenograft Model of Human Bone

  2022cites this paper
• Skeletal Functions of Voltage Sensitive Calcium Channels

  2021cites this paper
• The Potential Role of Exercise Training and Mechanical Loading on Bone-Associated Skeletal Nerves

  2021cites this paper
• G Protein-Coupled Estrogen Receptor Mediates Cell Proliferation through the cAMP/PKA/CREB Pathway in Murine Bone Marrow Mesenchymal Stem Cells

  2020cites this paper
• Sensory nerves regulate mesenchymal stromal cell lineage commitment by tuning sympathetic tones.

  2020cites this paper
• The Role of Prostaglandin E2 on Osteoblast Proliferation Induced by Hydroxyapatite

  2020cites this paper
• Active sites of human MEPE-ASARM regulating bone matrix mineralization.

  2020cites this paper
• A Synthetic Peptide, CK2.3, Inhibits RANKL-Induced Osteoclastogenesis through BMPRIa and ERK Signaling Pathway

  2020cites this paper
• The Effect of Non-Steroidal Anti-inflammatory Drugs (NSAIDs) on Bone Healing around Osseointegrated Dental Implants - A Systematic Review

  2020cites this paper
• Mechanisms of Bone Remodeling Disorder in Hemophilia

  2020cites this paper
• Crosstalk between the COX2‐PGE2‐EP4 signaling pathway and primary cilia in osteoblasts after mechanical stimulation

  2020cites this paper
• International Union of Basic and Clinical Pharmacology. CIX. Differences and Similarities between Human and Rodent Prostaglandin E2 Receptors (EP1–4) and Prostacyclin Receptor (IP): Specific Roles in Pathophysiologic Conditions

  2020cites this paper
• Dose-dependent roles of aspirin and other non-steroidal anti-inflammatory drugs in abnormal bone remodeling and skeletal regeneration

  2019cites this paper
• Prostaglandin E2 mediates sensory nerve regulation of bone homeostasis

  2019cites this paper
• Genetic Causes of Inflammatory Bone Disease

  2019cites this paper
• A study on effects of non-steroidal anti-inflammatory drugs (NSAIDs) on differentiation capacity of canine osteogenic cells

  2019cites this paper
• Therapeutic potentials and modulatory mechanisms of fatty acids in bone

  2019cites this paper
• Lights and shadows of NSAIDs in bone healing: the role of prostaglandins in bone metabolism

  2018cites this paper
• Lights and shadows of NSAiDs in bone healing: the role of prostaglandins in bone metabolism

  2018cites this paper
• Soluble Klotho causes hypomineralization in Klotho-deficient mice.

  2018cites this paper
• Effect of Prostaglandin E 2 on Human Dental Follicle Cells during Osteogenic Differentiation

  2018cites this paper
• Functional Adaptation of Bone: The Mechanostat and Beyond

  2018cites this paper
• Changes in PGE2 signaling after submandibulectomy alter post–tooth extraction socket healing

  2018cites this paper
• Signalling transduction events involved in agonist‐induced PGE2/EP4 receptor externalization in cultured rat dorsal root ganglion neurons

  2018cites this paper
• Effect of rumen protected vitamin B complex on metabolic parameters, milk production and day 14 conceptus and endometrial gene expression in Holstein dairy cows

  2017cites this paper
• THU0364 Immunogenicity of anti-tnf drugs and clinical response in patients with spondyloarthritis

  2017cites this paper
• Effects of pulpotomy using mineral trioxide aggregate on prostaglandin transporter and receptors in rat molars

  2017cites this paper
• TGF-β1 stimulates cyclooxygenase-2 expression and PGE2 production of human dental pulp cells: Role of ALK5/Smad2 and MEK/ERK signal transduction pathways.

  2017cites this paper
• Mechanisms of Bone Remodelling in Psoriatic Arthritis

  2016cites this paper
• p38 MAPK Signaling in Osteoblast Differentiation

  2016cites this paper
• Effect of low-intensity pulsed ultrasound on orthodontically induced root resorption caused by torque: A prospective, double-blind, controlled clinical trial.

  2016cites this paper
• Cellular and Molecular Aspects of Bone Remodeling.

  2016cites this paper
• The role of microRNA in periodontal tissue: A review of the literature.

  2016cites this paper
• Effect of low intensity pulsed ultrasound on orthodontically induced root resorption caused by torque: A prospective double blinded controlled clinical trial

  2015cites this paper
• Prostaglandin Dependent Control of an Endogenous Estrogen Receptor Agonist by Osteoblasts

  2015cites this paper
• COX2 Inhibition Reduces Aortic Valve Calcification In Vivo

  2015cites this paper
• Complications rachidiennes de la spondyloarthrite ankylosante

  2015cites this paper
• Compensatory Cellular Reactions to Nonsteroidal Anti-Inflammatory Drugs on Osteogenic Differentiation in Canine Bone Marrow-Derived Mesenchymal Stem Cells

  2014cites this paper
• In vivo imaging reveals PKA regulation of ERK activity during neutrophil recruitment to inflamed intestines

  2014cites this paper
• Bone formation in axial spondyloarthritis.

  2014cites this paper
• Prostaglandin E2 inhibits in-vitro mineral deposition by human periodontal ligament cells via modulating the expression of TWIST1 and RUNX2.

  2014cites this paper
• Developmental Pathways in CAVD

  2013cites this paper
• Prostaglandin receptor EP2 in the crosshairs of anti-inflammation, anti-cancer, and neuroprotection.

  2013cites this paper
• Pregnancy recognition signaling mechanisms in ruminants and pigs

  2013cites this paper
• Targeting Drugs to Cancer: A Tough Journey to the Tumor Cell

  2013cites this paper
• Calcium-mediated increased expression of fibroblast growth factor-2 acts through NF-κB and PGE2/EP4 receptor signaling pathways in cementoblasts.

  2013cites this paper
• PGE₂ and BMP-2 in bone and cartilage metabolism: 2 intertwining pathways.

  2012cites this paper
• The EP4-ERK-dependent pathway stimulates osteo-adipogenic progenitor proliferation resulting in increased adipogenesis in fetal rat calvaria cell cultures.

  2012influential citation
• Targeting polymer therapeutics to bone.

  2012influential citation
• Oral administration of prostaglandin E(2)-specific receptor 4 antagonist inhibits lipopolysaccharide-induced osteoclastogenesis in rat periodontal tissue.

  2012cites this paper
• Prostaglandin E2 Signals Through PTGER2 to Regulate Sclerostin Expression

  2011cites this paper
• Effect of PGE₂ induced by compressive and tensile stresses on cementoblast differentiation in vitro.

  2011cites this paper
• Sost down-regulation by mechanical strain in human osteoblastic cells involves PGE2 signaling via EP4

  2011cites this paper
• Novel pathways for implantation and establishment and maintenance of pregnancy in mammals.

  2010cites this paper
• Serotonergic 5-HT2B Receptor Controls Tissue-nonspecific Alkaline Phosphatase Activity in Osteoblasts via Eicosanoids and Phosphatidylinositol-specific Phospholipase C*

  2010cites this paper
• Long-chain polyunsaturated fatty acids: selected mechanisms of action on bone.

  2010cites this paper
• Prostaglandins in bone: bad cop, good cop?

  2010cites this paper
• Replicating Human B Cells Cytosine Deaminase Expression within Pathway Augments Activation-Induced 2 A Cyclooxygenase-2/Prostaglandin E

  2010cites this paper
• A Cyclooxygenase-2/Prostaglandin E2 Pathway Augments Activation-Induced Cytosine Deaminase Expression within Replicating Human B Cells

  2010cites this paper
• Ultrasound stimulation induces PGE(2) synthesis promoting cementoblastic differentiation through EP2/EP4 receptor pathway.

  2010cites this paper
• Effects of cyclic hydraulic pressure on osteocytes.

  2010cites this paper