[Pharmacokinetics and biotransformation of the analgesic flupirtine in humans].

No abstract is available for this paper.

• Publication year

  1985

• Venue

  Arzneimittel-Forschung

• Publication date

  Unknown publication date

• Fields of study

  Medicine, Chemistry

• Identifiers
  PMID 4039154
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• [The pharmacologic effect of flupirtine, a structurally new analgesic].

  1985cited by this paper
• [General pharmacologic studies on the analgesic flupirtine].

  1985cited by this paper
• [Pharmacokinetics and biotransformation of the analgesic flupirtine in the rat and dog].

  1985cited by this paper
• [Synthesis of C14-flupirtine maleate].

  1985cited by this paper

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• Simultaneous quantification of acidic and basic flupirtine metabolites by supercritical fluid chromatography according to European Medicines Agency validation.

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• Disease Modification in Multiple Sclerosis by Flupirtine—Results of a Randomized Placebo Controlled Phase II Trial

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• Brain Distribution and Metabolism of Flupirtine, a Nonopioid Analgesic Drug with Antiseizure Effects, in Neonatal Rats

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• Pharmacokinetics and disposition of flupirtine in the horse.

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• Evaluation of neuroprotective effect of flupirtine in brain of albino rats

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• Oxidation Potentials of N‐Modified Derivatives of the Analgesic Flupirtine Linked to Potassium KV7 Channel Opening Activity But Not Hepatocyte Toxicity

  2015cites this paper
• Pharmacokinetic profiles of the analgesic flupirtine in dogs after the administration of four pharmaceutical formulations.

  2015cites this paper
• Effects of advanced age and renal dysfunction on the single- and repeated-dose pharmacokinetics of modified-release flupirtine.

  2015cites this paper
• Metabolic activation and analgesic effect of flupirtine in healthy subjects, influence of the polymorphic NAT2, UGT1A1 and GSTP1.

  2015cites this paper
• Risk Factors for Development of Cholestatic Drug-Induced Liver Injury: Inhibition of Hepatic Basolateral Bile Acid Transporters Multidrug Resistance-Associated Proteins 3 and 4

  2014cites this paper
• Pharmacokinetic profiles of the analgesic drug flupirtine in cats.

  2014influential citation
• Activation of axonal Kv7 channels in human peripheral nerve by flupirtine but not placebo - therapeutic potential for peripheral neuropathies: results of a randomised controlled trial

  2013cites this paper
• Effect of flupirtine on the growth and viability of U373 malignant glioma cells

  2013cites this paper
• Role of flupirtine in the treatment of pain - chemistry and its effects.

  2012cites this paper
• Flupirtine: A Human Drug with Potential for Use in the Veterinary Field

  2012cites this paper
• Pathology of flupirtine-induced liver injury:

  2011cites this paper
• ON THE MECHANISM OF ACTION OF THE NON-OPIOID ANALGESIC FLUPIRTINE

  2011influential citation
• Correlation versus Causation? Pharmacovigilance of the Analgesic Flupirtine Exemplifies the Need for Refined Spontaneous ADR Reporting

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• Qualitative structure-metabolism relationships in the hydrolysis of carbamates

  2010cites this paper
• Enhancement of axonal potassium conductance reduces nerve hyperexcitability in an in vitro model of oxaliplatin-induced acute neuropathy.

  2010cites this paper
• The Kv7 potassium channel activator flupirtine affects clinical excitability parameters of myelinated axons in isolated rat sural nerve

  2010influential citation
• Green urine following exposure to flupirtine.

  2010cites this paper
• Flupirtine in Pain Management

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• Flupirtine: pharmacology and clinical applications of a nonopioid analgesic and potentially neuroprotective compound

  2009cites this paper
• Investigation of the in Vitro Metabolism of the Analgesic Flupirtine

  2009influential citation
• Tumor-necrosis-factor-related apoptosis-inducing-ligand (TRAIL)-mediated death of neurons in living human brain tissue is inhibited by flupirtine-maleate.

  2005cites this paper
• Effect of functional NMDA-antagonist flupirtine on automatic postural responses in Parkinson's disease

  2002cites this paper
• Simultaneous determination of flupirtine and its major active metabolite in human plasma by liquid chromatography-tandem mass spectrometry.

  2001cites this paper
• [E-Z ratio and stability of halogenated benzylidene derivatives formed during the detection of glycine conjugates].

  2000cites this paper
• Flupirtine shows functional NMDA receptor antagonism by enhancing Mg2+ block via activation of voltage independent potassium channels

  1999cites this paper
• [Neuronal potassium channel opening with flupirtine].

  1999cites this paper
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• Flupirtine: A Review of Its Neuroprotective and Behavioral Properties

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• Effect of the triaminopyridine flupirtine on calcium uptake, membrane potential and ATP synthesis in rat heart mitochondria

  1998cites this paper
• Pharmacological intervention in age-associated brain disorders by Flupirtine: Alzheimer's and prion diseases.

  1998cites this paper
• In vitro glucuronidation of D-23129, a new anticonvulsant, by human liver microsomes and liver slices.

  1997cites this paper
• Effect of flupirtine on Bcl-2 and glutathione level in neuronal cells treated in vitro with the prion protein fragment (PrP106-126).

  1997cites this paper
• Zentrale Schmerzmittel vom Typ Nichtopioid

  1996cites this paper
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  1993cites this paper
• Dose-proportional plasma levels of the analgesic flupirtine maleate in man. Application of a new HPLC assay.

  1992cites this paper
• Dose-related analgesic effects of flupirtine.

  1991cites this paper
• Mode of antinociceptive action of flupirtine in the rat

  1989cites this paper
• Pharmacokinetics of flupirtine in elderly volunteers and in patients with moderate renal impairment.

  1988cites this paper
• On the adverse reactions and efficacy of long-term treatment with flupirtine: preliminary results of an ongoing twelve-month study with 200 patients suffering from chronic pain states in arthrosis or arthritis.

  1987cites this paper
• Clinical experience with flupirtine in the U.S.

  1987cites this paper
• [Synthesis of C14-flupirtine maleate].

  1985cites this paper
• Trial of oral flupirtine maleate in the treatment of pain after orthopaedic surgery.

  1985cites this paper
• [Pharmacokinetics and biotransformation of the analgesic flupirtine in the rat and dog].

  1985cites this paper