A randomized, controlled exploratory study of clonidine in diarrhea-predominant irritable bowel syndrome.

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Clinical Gastroenterology and Hepatology

• Publication date

  2003-03-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1053/CGH.2003.50019PMID 15017503
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2001cited by this paper
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  2001cited by this paper
• V. Stress and irritable bowel syndrome.

  2001cited by this paper
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  2000cited by this paper
• The neurobiology of stress and gastrointestinal disease

  2000cited by this paper
• Colonic motility abnormality in patients with irritable bowel syndrome exhibiting abdominal pain and diarrhea

  2000cited by this paper
• Recombinant human neurotrophic factors accelerate colonic transit and relieve constipation in humans.

  2000cited by this paper
• Efficacy and safety of alosetron in women with irritable bowel syndrome: a randomised, placebo-controlled trial.

  2000cited by this paper
• Colonic motility abnormality in patients with irritable bowel syndrome exhibiting abdominal pain and diarrhea

  2000cited by this paper
• Irritable bowel syndrome: definition, diagnosis and epidemiology.

  1999cited by this paper
• Modulation of gastric sensory and motor functions by nitrergic and alpha2-adrenergic agents in humans.

  1999cited by this paper
• Functional bowel disorders and functional abdominal pain

  1999cited by this paper
• Development of a test to measure gastric accommodation in humans.

  1999cited by this paper
• A national survey of practice patterns of gastroenterologists with comparison to the past two decades.

  1999cited by this paper
• Impact of Irritable Bowel Syndrome on Quality of Life and Resource Use in the United States and United Kingdom

  1999cited by this paper
• Effects of an irritable bowel syndrome educational class on health-promoting behaviors and symptoms

  1998cited by this paper
• Adequate Relief as an Endpoint in Clinical Trials in Irritable Bowel Syndrome

  1998cited by this paper
• Quality of Life in Persons with Irritable Bowel Syndrome (Development and Validation of a New Measure)

  1998cited by this paper
• Adequate relief as an endpoint in clinical trials in irritable bowel syndrome.

  1998cited by this paper
• Review article: colonic sensorimotor physiology in health, and its alteration in constipation and diarrhoeal disorders

  1998cited by this paper
• Differences between individuals with self-reported irritable bowel syndrome (IBS) and IBS-like symptoms.

  1997cited by this paper
• Adrenergic modulation of human colonic motor and sensory function.

  1997cited by this paper
• Acute colonic pseudoobstruction (Ogilvie's syndrome) in two patients receiving high dose clonidine for delirium tremens

  1997cited by this paper
• Rapid gastric emptying in patients with functional diarrhea.

  1997cited by this paper
• A pilot study of motility and tone of the left colon in patients with diarrhea due to functional disorders and dysautonomia.

  1997cited by this paper
• Adrenergic modulation of human colonic motor and sensory function.

  1997cited by this paper
• Differences Between Individuals with Self-Reported Irritable Bowel Syndrome (IBS) and IBS-Like Symptoms

  1997cited by this paper
• Clinical economics review: irritable bowel syndrome

  1997cited by this paper
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  1997cited by this paper
• Irritable bowel syndrome: a technical review for practice guideline development.

  1997cited by this paper
• Pharmacological modulation of rectal tone alters perception of distention in humans.

  1997cited by this paper
• Impact of irritable bowel syndrome on quality of life

  1996cited by this paper
• Gastrointestinal sensation. Mechanisms and relation to functional gastrointestinal disorders.

  1996cited by this paper
• Treatment of diabetic gastroparesis with oral clonidine

  1995cited by this paper
• Irritable bowel syndrome and dyspepsia in the general population: overlap and lack of stability over time.

  1995cited by this paper
• Altered rectal perception is a biological marker of patients with irritable bowel syndrome.

  1995cited by this paper
• Predominant symptoms in irritable bowel syndrome correlate with specific autonomic nervous system abnormalities.

  1994cited by this paper
• Autonomic Nervous System Function

  1993cited by this paper
• Transit through the proximal colon influences stool weight in the irritable bowel syndrome.

  1992cited by this paper
• Defecation frequency and timing, and stool form in the general population: a prospective study.

  1992cited by this paper
• Actions of noradrenaline on myenteric neurons in the guinea pig gastric antrum.

  1992cited by this paper
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  1992cited by this paper
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  1992cited by this paper
• Towards a relatively inexpensive, noninvasive, accurate test for colonic motility disorders.

  1992cited by this paper
• Nuclear imaging of the stomach of healthy dogs.

  1991cited by this paper
• Alpha 2-adrenergic model of gastroparesis: validation with renzapride, a stimulator of motility.

  1991cited by this paper
• Towards a less costly but accurate test of gastric emptying and small bowel transit

  1991cited by this paper
• Irritable bowel syndrome in office-based practice in the United States.

  1991cited by this paper
• Transit of solids through the human colon: regional quantification in the unprepared bowel.

  1990cited by this paper
• Human gastric emptying and colonic filling of solids characterized by a new method.

  1989cited by this paper
• Experimental diabetic diarrhea in rats

  1986cited by this paper
• Experimental diabetic diarrhea in rats. Intestinal mucosal denervation hypersensitivity and treatment with clonidine.

  1986cited by this paper
• Treatment of diabetic diarrhea with clonidine.

  1985cited by this paper
• The relationship between technetium 99m pertechnetate gastric scanning and gastric contents.

  1983cited by this paper
• The Hospital Anxiety and Depression Scale

  1983cited by this paper
• A secretory epithelium of the small intestine with increased sensitivity to bile acids in irritable bowel syndrome associated with diarrhoea.

  1978cited by this paper
• Pain from distension of the pelvic colon by inflating a balloon in the irritable colon syndrome 1

  1973cited by this paper

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  2024cites this paper
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  2024cites this paper
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  2023cites this paper
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  2023cites this paper
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  2021cites this paper
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  2018cites this paper
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  2017cites this paper
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  2017cites this paper
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  2016cites this paper
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  2016cites this paper
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  2015cites this paper
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  2015cites this paper
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  2012influential citation
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  2012cites this paper
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  2011cites this paper
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  2011cites this paper
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  2011cites this paper
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  2007cites this paper
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  2005cites this paper
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  2005cites this paper
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  2005cites this paper
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  2005cites this paper
• Irritable bowel syndrome

  2005cites this paper
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  2005cites this paper
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  2004cites this paper
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  2004cites this paper
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  2004cites this paper
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  2004cites this paper
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  2004cites this paper
• Functional abdominal pain syndrome.

  2004cites this paper
• Advances in Pharmacological Treatments of IBS

  2004cites this paper
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