A Baculovirus Dual Expression System-Based Malaria Vaccine Induces Strong Protection against Plasmodium berghei Sporozoite Challenge in Mice

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Infection and Immunity

• Publication date

  2009-02-17

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/IAI.01226-08PMID 19223476PMCID PMC2681746
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Phase 2a trial of 0, 1, and 3 month and 0, 7, and 28 day immunization schedules of malaria vaccine RTS,S/AS02 in malaria-naïve adults at the Walter Reed Army Institute of Research.

  2008cited by this paper
• Efficacy of RTS,S/AS01E vaccine against malaria in children 5 to 17 months of age.

  2008cited by this paper
• Construction and immunogenicity of recombinant pseudotype baculovirus expressing the capsid protein of porcine circovirus type 2 in mice.

  2008cited by this paper
• The skin stage of malaria infection: biology and relevance to the malaria vaccine effort.

  2008cited by this paper
• Memory CD8 T cell responses exceeding a large but definable threshold provide long-term immunity to malaria

  2008cited by this paper
• Insect Baculoviruses Strongly Potentiate Adaptive Immune Responses by Inducing Type I IFN1

  2007cited by this paper
• Direct Microscopic Quantification of Dynamics of Plasmodium berghei Sporozoite Transmission from Mosquitoes to Mice

  2007cited by this paper
• A phase I/IIa safety, immunogenicity, and efficacy bridging randomized study of a two-dose regimen of liquid and lyophilized formulations of the candidate malaria vaccine RTS,S/AS02A in malaria-naïve adults.

  2007cited by this paper
• Safety of the RTS,S/AS02D candidate malaria vaccine in infants living in a highly endemic area of Mozambique: a double blind randomised controlled phase I/IIb trial.

  2007cited by this paper
• CD8+ T lymphocytes protective against malaria liver stages are primed in skin-draining lymph nodes

  2007cited by this paper
• Insect baculoviruses strongly potentiate adaptive immune responses by inducing type I IFN

  2007cited by this paper
• Baculovirus-based vaccination vectors allow for efficient induction of immune responses against plasmodium falciparum circumsporozoite protein.

  2007cited by this paper
• Quantitative imaging of Plasmodium transmission from mosquito to mammal

  2006cited by this paper
• A DNA Prime-Modified Vaccinia Virus Ankara Boost Vaccine Encoding Thrombospondin-Related Adhesion Protein but Not Circumsporozoite Protein Partially Protects Healthy Malaria-Naive Adults against Plasmodium falciparum Sporozoite Challenge

  2006cited by this paper
• Viral vectors for malaria vaccine development

  2006cited by this paper
• Involvement of the Toll-Like Receptor 9 Signaling Pathway in the Induction of Innate Immunity by Baculovirus

  2005cited by this paper
• Targeting the innate immune response with improved vaccine adjuvants

  2005cited by this paper
• Role of K-ras and Pten in the development of mouse models of endometriosis and endometrioid ovarian cancer

  2005cited by this paper
• Quantitative Dynamics of Plasmodium yoelii Sporozoite Transmission by Infected Anopheline Mosquitoes

  2005cited by this paper
• Enhanced T cell-mediated protection against malaria in human challenges by using the recombinant poxviruses FP9 and modified vaccinia virus Ankara.

  2005cited by this paper
• Quantitative Plasmodium sporozoite neutralization assay (TSNA).

  2004cited by this paper
• Efficacy of the RTS,S/AS02A vaccine against Plasmodium falciparum infection and disease in young African children: randomised controlled trial.

  2004cited by this paper
• Intravital microscopy demonstrating antibody-mediated immobilisation of Plasmodium berghei sporozoites injected into skin by mosquitoes.

  2004cited by this paper
• Early Self-Regulatory Mechanisms Control the Magnitude of CD8+ T Cell Responses Against Liver Stages of Murine Malaria1

  2003cited by this paper
• Baculovirus Induces an Innate Immune Response and Confers Protection from Lethal Influenza Virus Infection in Mice1

  2003cited by this paper
• In Vitro and In Vivo Gene Delivery by Recombinant Baculoviruses

  2003cited by this paper
• Baculovirus virions displaying Plasmodium berghei circumsporozoite protein protect mice against malaria sporozoite infection.

  2003cited by this paper
• Short-term antigen presentation and single clonal burst limit the magnitude of the CD8+ T cell responses to malaria liver stages

  2002cited by this paper
• Efficacy of recombinant circumsporozoite protein vaccine regimens against experimental Plasmodium falciparum malaria.

  2001cited by this paper
• In Vivo Gene Transfer in Mouse Skeletal Muscle Mediated by Baculovirus Vectors

  2001cited by this paper
• DNA Immunization by Plasmodium falciparum Liver-Stage Antigen 3 Induces Protection againstPlasmodium yoelii Sporozoite Challenge

  2001cited by this paper
• Detection of malaria liver-stages in mice infected through the bite of a single Anopheles mosquito using a highly sensitive real-time PCR.

  2001cited by this paper
• Efficacy of RTS,S/AS02 malaria vaccine against Plasmodium falciparum infection in semi-immune adult men in The Gambia: a randomised trial.

  2001cited by this paper
• ELISPOT assay to measure antigen-specific murine CD8(+) T cell responses.

  2001cited by this paper
• Baculovirus-mediated periadventitial gene transfer to rabbit carotid artery

  2000cited by this paper
• Direct immunization of malaria DNA vaccine into the liver by gene gun protects against lethal challenge of Plasmodium berghei sporozoite.

  2000cited by this paper
• Transient and stable gene expression in mammalian cells transduced with a recombinant baculovirus vector.

  1999cited by this paper
• A single-chain antibody fragment specific for the Plasmodium berghei ookinete protein Pbs21 confers transmission blockade in the mosquito midgut.

  1999cited by this paper
• Infectivity of Plasmodium bergheiSporozoites Delivered by Intravenous Inoculation versus Mosquito Bite: Implications for Sporozoite Vaccine Trials

  1999cited by this paper
• Enhanced immunogenicity for CD8+ T cell induction and complete protective efficacy of malaria DNA vaccination by boosting with modified vaccinia virus Ankara

  1998cited by this paper
• Efficient induction of protective anti-malaria immunity by recombinant adenovirus.

  1998cited by this paper
• Boosting with recombinant vaccinia increases immunogenicity and protective efficacy of malaria DNA vaccine.

  1998cited by this paper
• Phase I/IIa safety, immunogenicity, and efficacy trial of NYVAC-Pf7, a pox-vectored, multiantigen, multistage vaccine candidate for Plasmodium falciparum malaria.

  1998cited by this paper
• Efficient gene transfer into various mammalian cells, including non-hepatic cells, by baculovirus vectors.

  1997cited by this paper
• Efficient Transduction of Mammalian Cells by a Recombinant Baculovirus Having the Vesicular Stomatitis Virus G Glycoprotein

  1997cited by this paper
• Delayed migration of Plasmodium sporozoites from the mosquito bite site to the blood.

  1997cited by this paper
• Baculoviral display of the green fluorescent protein and rubella virus envelope proteins.

  1997cited by this paper
• Plasmodium yoelii sporozoite infectivity varies as a function of sporozoite loads in Anopheles stephensi mosquitoes.

  1997cited by this paper
• Clinical manifestations of Plasmodium falciparum malaria experimentally induced by mosquito challenge.

  1997cited by this paper
• Expression of foreign proteins on the surface of Autographa californica nuclear polyhedrosis virus.

  1997cited by this paper
• Baculovirus-mediated gene transfer into mammalian cells.

  1996cited by this paper
• Gene Transfer into Hepatocytes and Human Liver Tissue by Baculovirus Vectors

  1996cited by this paper
• Efficient gene transfer into human hepatocytes by baculovirus vectors.

  1995influential reference
• “Baculophage:” A new tool for protein display

  1995cited by this paper
• Influenza and vaccinia viruses expressing malaria CD8+ T and B cell epitopes. Comparison of their immunogenicity and capacity to induce protective immunity.

  1994cited by this paper
• Protection against malaria by immunization with a Plasmodium yoelii circumsporozoite protein nucleic acid vaccine.

  1994cited by this paper
• Differences in susceptibility among mouse strains to infection with Plasmodium berghei (ANKA clone) sporozoites and its relationship to protection by gamma-irradiated sporozoites.

  1990cited by this paper
• Signals important for high-level expression of foreign genes in Autographa californica nuclear polyhedrosis virus expression vectors.

  1988cited by this paper
• Characterization of Plasmodium yoelii monoclonal antibodies directed against stage-specific sporozoite antigens

  1987cited by this paper
• Baculovirus expression vectors: the requirements for high level expression of proteins, including glycoproteins.

  1987cited by this paper
• Direct infection of hepatocytes by sporozoites of Plasmodium berghei.

  1982cited by this paper
• Monovalent fragments (Fab) of monoclonal antibodies to a sporozoite surface antigen (Pb44) protect mice against malarial infection

  1980cited by this paper
• The Walter Reed Army Institute of Research.

  1961cited by this paper

• Development of a Vaccine Candidate Based on Surface-Displayed Particles of Mycobacterium tuberculosis from the MTB39A Protein

  2025cites this paper
• A Head-to-Head Comparative Study of the Replication-Competent Vaccinia Virus and AAV1-Based Malaria Vaccine versus RTS,S/AS01 in Murine Models

  2024cites this paper
• Baculovirus Display of Peptides and Proteins for Medical Applications

  2023cites this paper
• TLR9 activation is required for cytotoxic response elicited by baculovirus capsid display

  2022cites this paper
• How can we develop an effective subunit vaccine to achieve successful malaria eradication?

  2021cites this paper
• Baculoviruses in Gene Therapy and Personalized Medicine

  2021cites this paper
• Induction of mucosal immunity against pathogens by using recombinant baculoviral vectors: Mechanisms, advantages, and limitations

  2020cites this paper
• Anopheline antiplatelet protein from mosquito saliva regulates blood feeding behavior

  2019cites this paper
• Down‐selecting circumsporozoite protein‐based malaria vaccine: A comparison of malaria sporozoite challenge model

  2019cites this paper
• Hybrid baculovirus-mediated prolonged hemagglutinin expression and secretion in vivo enhances the vaccine efficacy

  2018cites this paper
• Adenovirus-prime and baculovirus-boost heterologous immunization achieves sterile protection against malaria sporozoite challenge in a murine model

  2018cites this paper
• Baculovirus-inducing fast-acting innate immunity kills Plasmodium liver stages

  2018cites this paper
• Baculovirus Surface Display of Immunogenic Proteins for Vaccine Development

  2018cites this paper
• Baculovirus-Induced Fast-Acting Innate Immunity Kills Liver-Stage Plasmodium

  2018cites this paper
• Baculovirus capsid display in vaccination schemes: effect of a previous immunity against the vector on the cytotoxic response to delivered antigens

  2018cites this paper
• Transduction of a Neospora caninum antigen gene into mammalian cells using a modified Bombyx mori nucleopolyhedrovirus for antibody production.

  2017cites this paper
• Protective efficacy of an IL‐12‐expressing baculoviral malaria vaccine

  2017cites this paper
• DAF-shielded baculovirus-vectored vaccine enhances protection against malaria sporozoite challenge in mice

  2017cites this paper
• Development of a Plasmodium berghei transgenic parasite expressing the full-length Plasmodium vivax circumsporozoite VK247 protein for testing vaccine efficacy in a murine model

  2016cites this paper
• The Plasmodium berghei sexual stage antigen PSOP12 induces anti-malarial transmission blocking immunity both in vivo and in vitro.

  2015cites this paper
• Protection against Amoebic Liver Abscess in Hamster by Intramuscular Immunization with an Autographa californica Baculovirus Driving the Expression of the Gal-Lectin LC3 Fragment

  2015cites this paper
• Update on baculovirus as an expression and/or delivery vehicle for vaccine antigens

  2014cites this paper
• Baculovirus-Vectored Multistage Plasmodium vivax Vaccine Induces Both Protective and Transmission-Blocking Immunities against Transgenic Rodent Malaria Parasites

  2014cites this paper
• Bioengineered baculoviruses as new class of therapeutics using micro and nanotechnologies: principles, prospects and challenges.

  2014cites this paper
• Protective and Transmission-blocking Immunities against Transgenic Rodent 2

  2014cites this paper
• Plasmodium berghei sexual stage antigen PSOP 12 induces nti-malarial transmission blocking immunity both in vivo and n vitro

  2014cites this paper
• Cross-protective efficacy of bivalent recombinant baculoviral vaccine against heterologous influenza H5N1 challenge.

  2013cites this paper
• Protective Efficacy of Baculovirus Dual Expression System Vaccine Expressing Plasmodium falciparum Circumsporozoite Protein

  2013cites this paper
• Immunological effects of Anticarsia gemmatalis multiple nucleopolyhedrovirus (AgMNPV) by stimulation of mice in vivo and in vitro.

  2013cites this paper
• Baculovirus vector as an avian influenza vaccine: hemagglutinin expression and presentation augment the vaccine immunogenicity.

  2013cites this paper
• Baculovirus Display: A Novel Tool for Vaccination

  2013influential citation
• Induction of antisporozoite antibodies by biting of transgenic Anopheles stephensi delivering malarial antigen via blood feeding

  2012cites this paper
• Baculovirus as a vaccine vector

  2012cites this paper
• Baculovirus vectors in experimental gene- and vaccine therapy

  2011cites this paper
• Rapid baculovirus titration based on regulatable green fluorescent protein expression in mammalian cells.

  2011cites this paper
• Baculovirus as a gene delivery vector: Recent understandings of molecular alterations in transduced cells and latest applications

  2011influential citation
• Recent patents on the baculovirus systems.

  2011cites this paper
• Insect cell technology is a versatile and robust vaccine manufacturing platform

  2011cites this paper
• Mucosal Delivery of ACNPV Baculovirus Driving Expression of the Gal-Lectin LC3 Fragment Confers Protection against Amoebic Liver Abscess in Hamster

  2011cites this paper
• A baculovirus dual expression system-based vaccine confers complete protection against lethal challenge with H9N2 avian influenza virus in mice

  2011cites this paper
• Baculovirus Capsid Display Potentiates OVA Cytotoxic and Innate Immune Responses

  2011cites this paper
• Functional immunogenicity of baculovirus expressing Pfs25, a human malaria transmission-blocking vaccine candidate antigen.

  2010cites this paper
• Hemagglutinin displayed baculovirus protects against highly pathogenic influenza.

  2010cites this paper
• Baculovirus Protects Against Highly athogenic Influenza

  2010cites this paper
• A novel mitogen fusion protein against CD40+ cells with potent vaccine adjuvant properties.

  2010cites this paper
• Human glutathione S-transferase polymorphisms and plasmodium falciparum ATP-binding cassette transport proteins in malaria.

  2010cites this paper
• Baculovirus as an avian influenza vaccine vector: differential immune responses elicited by different vector forms.

  2010cites this paper
• Baculovirus as vaccine vectors.

  2010cites this paper
• Intranasal and intramuscular immunization with Baculovirus Dual Expression System-based Pvs25 vaccine substantially blocks Plasmodium vivax transmission.

  2010cites this paper
• Baculovirus-Based Nasal Drop Vaccine Confers Complete Protection against Malaria by Natural Boosting of Vaccine-Induced Antibodies in Mice

  2009cites this paper
• Novel vectors for simultaneous high-level dual protein expression in vertebrate and insect cells by recombinant baculoviruses.

  2009cites this paper