DNA methylation and blood pressure in Chinese adult twins

Abstract In this chapter, a total of 104 twins (43 pairs of monozygotic twins, 8 pairs of dizygotic twins, 4 singletons) from the Chinese National Twin Registry were recruited. Empirical Bayes paired moderated t-test was utilized to compare the methylation data within twin pairs. Four suspected significant methylation sites, cg00950476, cg08041400, cg26733338, and cg08580087 were identified. All of these four sites locate on known loci, which were LINC01252, BDP1, SYT1, and ODZ4, respectively. The main function includes transcriptional regulation, learning and cognitive, neurodevelopment. The significant sites were further replicated among two different replication populations. None of them, however, were significant. The methylation variation in the above sites may influence blood pressure, independent of genetic and early life environmental factors. More hypertension-discordant monozygotic twin pairs are needed to replicate these findings in the future to explore the stability of the results.

• Publication year

  2021

• Venue

  Twin and Family Studies of Epigenetics

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/b978-0-12-820951-6.00013-2
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• An epigenome‐wide DNA methylation study of workers with an occupational exposure to lead

  2019cited by this paper
• Association of angiotensinogen gene SNPs and haplotypes with risk of hypertension in eastern Indian population

  2017cited by this paper
• Essential tremor linked TENM4 mutation found in healthy Chinese individuals.

  2016cited by this paper
• Identification of polymorphic and off-target probe binding sites on the Illumina Infinium MethylationEPIC BeadChip

  2016cited by this paper
• Twin methodology in epigenetic studies

  2015cited by this paper
• Determination of Zygosity in Adult Chinese Twins Using the 450K Methylation Array versus Questionnaire Data

  2015cited by this paper
• Missense mutations in TENM4, a regulator of axon guidance and central myelination, cause essential tremor.

  2015cited by this paper
• Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation

  2015cited by this paper
• Genetic Contribution to the Variance of Blood Pressure and Heart Rate: A Systematic Review and Meta-Regression of Twin Studies

  2015cited by this paper
• A systematic study of normalization methods for Infinium 450K methylation data using whole-genome bisulfite sequencing data

  2015cited by this paper
• Accounting for Population Stratification in DNA Methylation Studies

  2014cited by this paper
• Minfi: a flexible and comprehensive Bioconductor package for the analysis of Infinium DNA methylation microarrays

  2014cited by this paper
• Identification of potential biomarkers for artificial cold exposure-induced hypertensive stroke by proteomic analysis.

  2014cited by this paper
• Linkage Study and Exome Sequencing Identify a BDP1 Mutation Associated with Hereditary Hearing Loss

  2013cited by this paper
• Association Between Promoter Methylation of Serotonin Transporter Gene and Depressive Symptoms: A Monozygotic Twin Study

  2013cited by this paper
• Epigenome-Wide Scans Identify Differentially Methylated Regions for Age and Age-Related Phenotypes in a Healthy Ageing Population

  2012cited by this paper
• Analysing and interpreting DNA methylation data

  2012cited by this paper
• Modulation of the BP response to diet by genes in the renin-angiotensin system and the adrenergic nervous system.

  2011cited by this paper
• Genetic Variants in Novel Pathways Influence Blood Pressure and Cardiovascular Disease Risk

  2011cited by this paper
• A twin approach to unraveling epigenetics

  2011cited by this paper
• Variation, patterns, and temporal stability of DNA methylation: considerations for epigenetic epidemiology

  2010cited by this paper
• Promoter hypomethylation upregulates Na+-K+-2Cl- cotransporter 1 in spontaneously hypertensive rats.

  2010cited by this paper
• How does multiple testing correction work?

  2009cited by this paper
• BMC Bioinformatics BioMed Central

  2008cited by this paper
• Epigenetics of Personality Traits: An Illustrative Study of Identical Twins Discordant for Risk-Taking Behavior

  2008cited by this paper
• Capturing Heterogeneity in Gene Expression Studies by “ Surrogate Variable Analysis ”

  2007cited by this paper
• Epigenetic Modification of the Renin-Angiotensin System in the Fetal Programming of Hypertension

  2007cited by this paper
• Linear Models and Empirical Bayes Methods for Assessing Differential Expression in Microarray Experiments

  2004cited by this paper
• Twin zygosity. Automated determination with microsatellites.

  1997cited by this paper
• Controlling the false discovery rate: a practical and powerful approach to multiple testing

  1995cited by this paper
• Nature Publishing Group Original Contributions Expression of Na + -k + -2cl − Cotransporter 1 Is Epigenetically Regulated during Postnatal Development of Hypertension

  year unknowncited by this paper
• Bioinformatics Applications Note Gene Expression the Sva Package for Removing Batch Effects and Other Unwanted Variation in High-throughput Experiments

  year unknowncited by this paper

• Association Between DNA Methylation and Blood Pressure: A 5-Year Longitudinal Twin Study

  2022cites this paper