Transgenic mice over-expressing endothelial endothelin-1 show cognitive deficit with blood-brain barrier breakdown after transient ischemia with long-term reperfusion.

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Neurobiology of Learning and Memory

• Publication date

  2013-03-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/j.nlm.2013.01.002PMID 23313614
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Transgenic Mice Over-Expressing ET-1 in the Endothelial Cells Develop Systemic Hypertension with Altered Vascular Reactivity

  2011cited by this paper
• Endothelial endothelin-1 over-expression using receptor tyrosine kinase tie-1 promoter leads to more severe vascular permeability and blood brain barrier breakdown after transient middle cerebral artery occlusion.

  2009cited by this paper
• Peroxiredoxin 6 in human brain: molecular forms, cellular distribution and association with Alzheimer’s disease pathology

  2008cited by this paper
• Peroxiredoxins in the central nervous system.

  2007cited by this paper
• Sensorimotor and cognitive deficits after transient middle cerebral artery occlusion in the mouse.

  2007cited by this paper
• Characterization of neural cell types expressing peroxiredoxins in mouse brain.

  2005cited by this paper
• Post-stroke depression

  2005cited by this paper
• Anxious and hyperactive phenotype following brief ischemic episodes in mice.

  2005cited by this paper
• Progesterone Enhances Functional Recovery after Middle Cerebral Artery Occlusion in Male Mice

  2004cited by this paper
• Endothelial Cell-specific Over-expression of Endothelin- 1 Leads to More Severe Cerebral Damage following Transient Middle Cerebral Artery Occlusion

  2004cited by this paper
• The open field as a paradigm to measure the effects of drugs on anxiety-like behaviors: a review.

  2003cited by this paper
• Dysexecutive Syndrome After Mild Cerebral Ischemia?: Mice Learn Normally but Have Deficits in Strategy Switching

  2003cited by this paper
• Alzheimer Disease as a Vascular Disorder: Nosological Evidence

  2002cited by this paper
• The Relationship between Aβ and Memory in the Tg2576 Mouse Model of Alzheimer's Disease

  2002cited by this paper
• The relationship between Abeta and memory in the Tg2576 mouse model of Alzheimer's disease.

  2002cited by this paper
• Cognitive and behavioral assessment in experimental stroke research: will it prove useful?

  2001cited by this paper
• Poststroke dementia : clinical features and risk factors.

  2000cited by this paper
• Cognitive deficits after focal cerebral ischemia in mice.

  2000cited by this paper
• Transient focal cerebral ischemia induces sensorimotor deficits in mice.

  2000cited by this paper
• Behavioral phenotyping of transgenic and knockout mice: experimental design and evaluation of general health, sensory functions, motor abilities, and specific behavioral tests.

  1999cited by this paper
• Spatial Cognitive Performance after Chronic Focal Cerebral Ischemia in Rats

  1999cited by this paper
• Pathobiology of ischaemic stroke: an integrated view.

  1999cited by this paper
• Clinical determinants of poststroke dementia.

  1998cited by this paper
• Endothelin in cerebrospinal fluid and plasma of patients in the early stage of ischemic stroke.

  1997cited by this paper
• Why are stroke patients prone to develop dementia?

  1997cited by this paper
• Generalized anxiety and depression. Assessment over 2 years after stroke.

  1997cited by this paper
• Dementia after first stroke.

  1996cited by this paper
• Locomotor and passive avoidance deficits following occlusion of the middle cerebral artery.

  1995cited by this paper
• Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase.

  1994cited by this paper
• Endothelin-1 in cerebrospinal fluid in elderly patients with hypertension and dementia.

  1994cited by this paper
• Sensorimotor and cognitive consequences of middle cerebral artery occlusion in rats.

  1992cited by this paper
• Ischemia-induced slowly progressive neuronal damage in the rat brain.

  1990cited by this paper
• A novel potent vasoconstrictor peptide produced by vascular endothelial cells

  1988cited by this paper
• Behavioral changes after focal cerebral ischemia by left middle cerebral artery occlusion in rats.

  1988cited by this paper
• Temporal profile of neuronal damage in a model of transient forebrain ischemia

  1982cited by this paper
• Delayed neuronal death in the gerbil hippocampus following ischemia.

  1982cited by this paper

• Current updates on latest basic research of scientific relevance in hypertensive dementia

  2025cites this paper
• Vitamin D Prevents Spatial Learning and Memory Disturbance and Vascular Remodelling in the Hippocampus After Transient Global Cerebral Ischemia

  2025cites this paper
• Cellular Components of the Blood-Brain Barrier and Their Involvement in Aging-Associated Cognitive Impairment

  2024cites this paper
• DL-3-n-Butylphthalide Ameliorates Post-stroke Emotional Disorders by Suppressing Neuroinflammation and PANoptosis

  2024cites this paper
• Unveiling the Significance of Peroxiredoxin 6 in Central Nervous System Disorders

  2024cites this paper
• Astrocytic endothelin-1 overexpression impairs learning and memory ability in ischemic stroke via altered hippocampal neurogenesis and lipid metabolism

  2023cites this paper
• Protective Mechanism of Alisol A 24-Acetate on Brain Microvascular Endothelial Cells in Mice with Cerebral Ischemia-Reperfusion Injury by TRPM2/Akt/GSK3β Pathway

  2023cites this paper
• Transplantation of Bone Marrow Mesenchymal Stem Cells (BMSCs) Improves Nerve Cell Function in Rats with Cerebral Infarction and Injury

  2022cites this paper
• p38 MAPK Endogenous Inhibition Improves Neurological Deficits in Global Cerebral Ischemia/Reperfusion Mice

  2022cites this paper
• The Roles of Peroxiredoxin 6 in Brain Diseases

  2021cites this paper
• Blood-Brain Barrier Dysfunction in CNS Disorders and Putative Therapeutic Targets: An Overview

  2021cites this paper
• Endothelin-1 Induced Global Ischemia in adult Zebrafish: A Model With Novel Entity of Stroke Research.

  2021cites this paper
• The selective estrogen receptor modulator tamoxifen protects against subtle cognitive decline and early markers of injury 24 h after hippocampal silent infarct in male Sprague-Dawley rats.

  2021cites this paper
• Mediators of cerebral hypoperfusion and blood‐brain barrier leakiness in Alzheimer’s disease, vascular dementia and mixed dementia

  2021cites this paper
• Regulation of Prdx6 by Nrf2 Mediated Through aiPLA2 in White Matter Reperfusion Injury

  2020cites this paper
• Inhibition of p38 MAPK Mitigates Lung Ischemia Reperfusion Injury by Reducing Blood–Air Barrier Hyperpermeability

  2020cites this paper
• The selective estrogen receptor modulator tamoxifen protects against subtle cognitive decline and early markers of injury twenty-four hours after hippocampal silent infarct

  2020cites this paper
• Hippocampal silent infarct leads to subtle cognitive decline that is associated with inflammation and gliosis at twenty-four hours after injury in a rat model

  2020cites this paper
• Activation of CRHR1 contributes to cerebral endothelial barrier impairment via cPLA2 phosphorylation in experimental ischemic stroke.

  2019cites this paper
• Endothelins in inflammatory neurological diseases

  2019cites this paper
• Brain Vasculature and Cognition.

  2019cites this paper
• Animal Models of Hypertension: A Scientific Statement From the American Heart Association

  2019cites this paper
• CT perfusion imaging of cerebral microcirculatory changes following subarachnoid hemorrhage in rabbits: Specific role of endothelin-1 receptor antagonist.

  2018cites this paper
• Dysfunction of Cerebrovascular Endothelial Cells: Prelude to Vascular Dementia

  2018cites this paper
• Peroxiredoxin6, a Multitask Antioxidant Enzyme Involved in the Pathophysiology of Chronic Noncommunicable Diseases

  2018cites this paper
• Endothelin-1 inhibition improves the mBDNF/proBDNF ratio in endothelial cells and HT22 neurons under high glucose/palmitate growth conditions.

  2018cites this paper
• Neuroinflammation and Infection: Molecular Mechanisms Associated with Dysfunction of Neurovascular Unit

  2017cites this paper
• Blood-brain barrier dysfunction and recovery after ischemic stroke.

  2017cites this paper
• Protection of the Blood-Brain Barrier as a Therapeutic Strategy for Brain Damage.

  2017cites this paper
• Investigations into Hypoxia and Oxidative Stress at the Optic Nerve Head in a Rat Model of Glaucoma

  2017cites this paper
• Amygdalar Endothelin-1 Regulates Pyramidal Neuron Excitability and Affects Anxiety

  2017cites this paper
• A Single-Nucleotide Polymorphism in 3′-Untranslated Region of Endothelin-1 Reduces Risk of Dementia After Ischemic Stroke

  2016cites this paper
• Anxiety and depression with neurogenesis defects in exchange protein directly activated by cAMP 2-deficient mice are ameliorated by a selective serotonin reuptake inhibitor, Prozac

  2016cites this paper
• Sex Differences in Neural Regulation of Hypertension

  2016cites this paper
• Infralimbic Endothelin1 Is Critical for the Modulation of Anxiety-Like Behaviors

  2016cites this paper
• Relationship of endothelin-1 and NLRP3 inflammasome activation in HT22 hippocampal cells in diabetes.

  2016cites this paper
• Stroke, Cognitive Function, and Alzheimer’s Disease

  2016cites this paper
• Co-Morbidity Of Alzheimer’s Disease And Stroke: Cognitive Deficits And Cellular Pathologies In Two Co-Morbid Animal Models

  2015cites this paper
• Elevated Plasma C-Terminal Endothelin-1 Precursor Fragment Concentrations Are Associated with Less Anxiety in Patients with Cardiovascular Risk Factors. Results from the Observational DIAST-CHF Study

  2015cites this paper
• Beneficial Effects of Polygonum multiflorum on Hippocampal Neuronal Cells and Mouse Focal Cerebral Ischemia.

  2015cites this paper
• Damage effect of interleukin (IL)-23 on oxygen-glucose-deprived cells of the neurovascular unit via IL-23 receptor.

  2015cites this paper
• Selective Astrocytic Endothelin-1 Overexpression Contributes to Dementia Associated with Ischemic Stroke by Exaggerating Astrocyte-Derived Amyloid Secretion

  2015cites this paper
• Expression and distribution of peroxiredoxins in the retina and optic nerve

  2015cites this paper
• Neuroprotection and spatial memory enhancement of four herbal mixture extract in HT22 hippocampal cells and a mouse model of focal cerebral ischemia

  2015cites this paper
• Systemic Inflammation Impairs Tissue Reperfusion Through Endothelin-Dependent Mechanisms in Cerebral Ischemia

  2014cites this paper
• End o' the line revisited: moving on from nitric oxide to CGRP.

  2014cites this paper
• Ginsenoside Rd Attenuates Tau Protein Phosphorylation Via the PI3K/AKT/GSK-3β Pathway After Transient Forebrain Ischemia

  2014cites this paper
• Endothelin-1 overexpression exacerbate experimental allergic encephalomyelitis.

  2014cites this paper
• LRRK2 R1441G mice are more liable to dopamine depletion and locomotor inactivity

  2014cites this paper
• Endothelin-1 and its role in the pathogenesis of infectious diseases.

  2014cites this paper
• Controversies and evolving new mechanisms in subarachnoid hemorrhage.

  2014influential citation
• Cellular Components of the Blood-Brain Barrier and Their Regulation

  year unknowncites this paper