MMSET is dynamically regulated during cell-cycle progression and promotes normal DNA replication

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Cell Cycle

• Publication date

  2016-01-02

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1080/15384101.2015.1121323PMID 26771714PMCID PMC4825781
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Point mutation E1099K in MMSET/NSD2 enhances its methyltranferase activity and leads to altered global chromatin methylation in lymphoid malignancies

  2014cited by this paper
• Dedicator of Cytokinesis 8 Interacts with Talin and Wiskott-Aldrich Syndrome Protein To Regulate NK Cell Cytotoxicity

  2013cited by this paper
• Meier-Gorlin syndrome and Wolf-Hirschhorn syndrome: two developmental disorders highlighting the importance of efficient DNA replication for normal development and neurogenesis.

  2013cited by this paper
• Global chromatin profiling reveals NSD2 mutations in pediatric acute lymphoblastic leukemia

  2013cited by this paper
• The Histone Methyltransferase MMSET/WHSC1 Activates TWIST1 to Promote an Epithelial-Mesenchymal Transition and Invasive Properties of Prostate Cancer

  2012cited by this paper
• ORC1 BAH domain links H4K20me2 to DNA replication licensing and Meier-Gorlin syndrome

  2012cited by this paper
• CRL4CDT2 Targets CHK1 for PCNA-Independent Destruction

  2012influential reference
• Characterizing the functional consequences of haploinsufficiency of NELF-A (WHSC2) and SLBP identifies novel cellular phenotypes in Wolf-Hirschhorn syndrome.

  2012cited by this paper
• Translational homeostasis via the mRNA cap-binding protein, eIF4E.

  2012cited by this paper
• The Histone Methyltransferase and Putative Oncoprotein MMSET Is Overexpressed in a Large Variety of Human Tumors

  2011cited by this paper
• Histone lysine methyltransferase Wolf-Hirschhorn syndrome candidate 1 is involved in human carcinogenesis through regulation of the Wnt pathway.

  2011cited by this paper
• NSD2 links dimethylation of histone H3 at lysine 36 to oncogenic programming.

  2011cited by this paper
• MMSET is highly expressed and associated with aggressiveness in neuroblastoma.

  2011cited by this paper
• Chromatin Remodeler Sucrose Nonfermenting 2 Homolog (SNF2H) Is Recruited onto DNA Replication Origins through Interaction with Cdc10 Protein-dependent Transcript 1 (Cdt1) and Promotes Pre-replication Complex Formation*

  2011cited by this paper
• The Stability of Histone Acetyltransferase General Control Non-derepressible (Gcn) 5 Is Regulated by Cullin4-RING E3 Ubiquitin Ligase*

  2011influential reference
• The MMSET histone methyl transferase switches global histone methylation and alters gene expression in t(4;14) multiple myeloma cells.

  2011cited by this paper
• Mechanism of CRL4(Cdt2), a PCNA-dependent E3 ubiquitin ligase.

  2011influential reference
• CRL4(Cdt2)-mediated destruction of the histone methyltransferase Set8 prevents premature chromatin compaction in S phase.

  2010influential reference
• HBO1 histone acetylase activity is essential for DNA replication licensing and inhibited by Geminin.

  2010cited by this paper
• The histone H4 Lys 20 methyltransferase PR-Set7 regulates replication origins in mammalian cells

  2010influential reference
• Activation of the MCM2-7 helicase by association with Cdc45 and GINS proteins.

  2010cited by this paper
• MMSET is overexpressed in cancers: link with tumor aggressiveness.

  2009cited by this paper
• A histone H3 lysine 36 trimethyltransferase links Nkx2-5 to Wolf–Hirschhorn syndrome

  2009cited by this paper
• MMSET deregulation affects cell cycle progression and adhesion regulons in t(4;14) myeloma plasma cells

  2009cited by this paper
• Identification and Functional Analysis of a Novel Cyclin E/Cdk2 Substrate Ankrd17*

  2009cited by this paper
• The MMSET protein is a histone methyltransferase with characteristics of a transcriptional corepressor.

  2008cited by this paper
• PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex.

  2008cited by this paper
• Replication licensing and cancer — a fatal entanglement?

  2008cited by this paper
• The CRL4 Cdt2 ubiquitin ligase targets the degradation of p21 Cip1 to control replication licensing

  2008cited by this paper
• CDK Inhibitor p21 Is Degraded by a Proliferating Cell Nuclear Antigen-coupled Cul4-DDB1Cdt2 Pathway during S Phase and after UV Irradiation*

  2008cited by this paper
• The CRL4Cdt2 ubiquitin ligase targets the degradation of p21Cip1 to control replication licensing.

  2008cited by this paper
• DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase.

  2007cited by this paper
• The histone methyltransferase SET8 is required for S-phase progression

  2007cited by this paper
• Ubiquitin proteasome system (UPS): what can chromatin do for you?

  2007cited by this paper
• PR-Set7–dependent lysine methylation ensures genome replication and stability through S phase

  2007cited by this paper
• PCNA, the maestro of the replication fork.

  2007cited by this paper
• Strength in numbers: preventing rereplication via multiple mechanisms in eukaryotic cells.

  2007cited by this paper
• Ten years and counting: so what do we know about t(4;14)(p16;q32) multiple myeloma

  2006cited by this paper
• DDB1 Maintains Genome Integrity through Regulation of Cdt1

  2006cited by this paper
• Distinct Action of the Retinoblastoma Pathway on the DNA Replication Machinery Defines Specific Roles for Cyclin-Dependent Kinase Complexes in Prereplication Complex Assembly and S-Phase Progression

  2006cited by this paper
• Isolation of the Cdc45/Mcm2–7/GINS (CMG) complex, a candidate for the eukaryotic DNA replication fork helicase

  2006cited by this paper
• DTL/CDT2 is essential for both CDT1 regulation and the early G2/M checkpoint.

  2006cited by this paper
• PCNA functions as a molecular platform to trigger Cdt1 destruction and prevent re-replication

  2006influential reference
• A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1.

  2006cited by this paper
• Overexpression of transcripts originating from the MMSET locus characterizes all t(4;14)(p16;q32)-positive multiple myeloma patients.

  2005cited by this paper
• The etiology of Wolf-Hirschhorn syndrome.

  2005cited by this paper
• Preventing re-replication of chromosomal DNA

  2005cited by this paper
• Human Orc2 localizes to centrosomes, centromeres and heterochromatin during chromosome inheritance

  2005cited by this paper
• Deletion of short arms of chromosome 4–5 in a child with defects of midline fusion

  2004cited by this paper
• Proteolysis of DNA Replication Licensing Factor Cdt1 in S-phase Is Performed Independently of Geminin through Its N-terminal Region*

  2004cited by this paper
• CUL-4 ubiquitin ligase maintains genome stability by restraining DNA-replication licensing

  2003cited by this paper
• A subset of multiple myeloma harboring the t(4;14)(p16;q32) translocation lacks FGFR3 expression but maintains an IGH/MMSET fusion transcript.

  2003cited by this paper
• The SCFSkp2 Ubiquitin Ligase Complex Interacts with the Human Replication Licensing Factor Cdt1 and Regulates Cdt1 Degradation*

  2003cited by this paper
• In multiple myeloma, t(4;14)(p16;q32) is an adverse prognostic factor irrespective of FGFR3 expression.

  2003cited by this paper
• Perpetuating the double helix: molecular machines at eukaryotic DNA replication origins.

  2003cited by this paper
• Mitotic-specific methylation of histone H4 Lys 20 follows increased PR-Set7 expression and its localization to mitotic chromosomes.

  2002cited by this paper
• Orc6 Involved in DNA Replication, Chromosome Segregation, and Cytokinesis

  2002cited by this paper
• Repression of origin assembly in metaphase depends on inhibition of RLF-B/Cdt1 by geminin

  2001cited by this paper
• A novel PCNA-binding motif identified by the panning of a random peptide display library.

  2001cited by this paper
• Inhibition of eukaryotic DNA replication by geminin binding to Cdt1.

  2000cited by this paper
• Wolf-Hirschhorn and Pitt-Rogers-Danks syndromes caused by overlapping 4p deletions.

  1998cited by this paper
• The t(4;14) translocation in myeloma dysregulates both FGFR3 and a novel gene, MMSET, resulting in IgH/MMSET hybrid transcripts.

  1998cited by this paper
• WHSC1, a 90 kb SET domain-containing gene, expressed in early development and homologous to a Drosophila dysmorphy gene maps in the Wolf-Hirschhorn syndrome critical region and is fused to IgH in t(4;14) multiple myeloma.

  1998cited by this paper
• The t(4;14) Translocation in Myeloma Dysregulates Both FGFR3 and a Novel Gene, MMSET, Resulting in IgH/MMSET Hybrid Transcripts

  1998cited by this paper
• A transcript map of the newly defined 165 kb Wolf-Hirschhorn syndrome critical region.

  1997cited by this paper
• Human cyclin E, a nuclear protein essential for the G1-to-S phase transition

  1995cited by this paper

• Multi-population Genome-Wide Association Study Identifies Multiple Novel Loci Associated with Asymptomatic Intracranial Large Artery Stenosis.

  2025cites this paper
• NSD proteins in anti-tumor immunity and their therapeutic targeting by protein degraders

  2025cites this paper
• Multi-population Genome-Wide Association Study Identifies Multiple Novel Loci associated with Asymptomatic Intracranial Large Artery Stenosis

  2025cites this paper
• Conditional knockout of the NSD2 gene in mouse intestinal epithelial cells inhibits colorectal cancer progression

  2024cites this paper
• Drug Discovery Targeting Nuclear Receptor Binding SET Domain Protein 2 (NSD2).

  2023cites this paper
• Role of DTL in Hepatocellular Carcinoma and Its Impact on the Tumor Microenvironment

  2022cites this paper
• Deciphering cervical cancer-associated biomarkers by integrated multi-omics approach.

  2022cites this paper
• Genome Instability in Multiple Myeloma: Facts and Factors

  2021cites this paper
• The Role of Methyltransferase NSD2 as a Potential Oncogene in Human Solid Tumors

  2020cites this paper
• The NSD2/WHSC1/MMSET methyltransferase prevents cellular senescence‐associated epigenomic remodeling

  2020cites this paper
• Regulation of cell cycle drivers by Cullin-RING ubiquitin ligases

  2020cites this paper
• OTT_A_259873 6837..6846

  2020cites this paper
• The emerging role for Cullin 4 family of E3 ligases in tumorigenesis.

  2019cites this paper
• The DNA Replication Machinery as Therapeutic Targets

  2019cites this paper
• The histone methyltransferase WHSC1 is regulated by EZH2 and is important for ovarian clear cell carcinoma cell proliferation

  2019cites this paper
• Chromatin-Bound Cullin-Ring Ligases: Regulatory Roles in DNA Replication and Potential Targeting for Cancer Therapy

  2018cites this paper
• Wolf-Hirschhorn Syndrome Candidate 1 Is Necessary for Correct Hematopoietic and B Cell Development.

  2017influential citation
• MB4-2/MB4-3 transcripts of IGH-MMSET fusion gene in t(4;14)pos multiple myeloma indicate poor prognosis.

  2017cites this paper
• AKT-mediated stabilization of histone methyltransferase WHSC1 promotes prostate cancer metastasis

  2017cites this paper
• Necessary for Correct Hematopoietic and B Cell Development Graphical Abstract Highlights

  2017influential citation
• The Roles of Cullin RING Ligases and the Anaphase Promoting Complex/Cyclosome in the Regulation of DNA Double Strand Break Repair

  2017cites this paper
• MB4-2/MB4-3 transcripts of IGH-MMSET fusion gene in t(4;14)pos multiple myeloma indicate poor prognosis

  2017cites this paper
• The Journal of Clinical Investigation

  2016cites this paper