Molecular dissection of Meis1 reveals 2 domains required for leukemia induction and a key role for Hoxa gene activation.

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Blood

• Publication date

  2006-07-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1182/BLOOD-2005-06-2244PMID 16469876
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• MEIS C Termini Harbor Transcriptional Activation Domains That Respond to Cell Signaling*

  2005cited by this paper
• HOXB6 overexpression in murine bone marrow immortalizes a myelomonocytic precursor in vitro and causes hematopoietic stem cell expansion and acute myeloid leukemia in vivo.

  2005cited by this paper
• Identification of cooperative genes for NUP98-HOXA9 in myeloid leukemogenesis using a mouse model.

  2005cited by this paper
• High incidence of proviral integrations in the Hoxa locus in a new model of E2a-PBX1-induced B-cell leukemia.

  2005cited by this paper
• Meis1 programs transcription of FLT3 and cancer stem cell character, using a mechanism that requires interaction with Pbx and a novel function of the Meis1 C-terminus.

  2005cited by this paper
• The EMBL Nucleotide Sequence Database

  2004cited by this paper
• Differential and Common Leukemogenic Potentials of Multiple NUP98-Hox Fusion Proteins Alone or with Meis1

  2004cited by this paper
• Global down-regulation of HOX gene expression in PML-RARalpha + acute promyelocytic leukemia identified by small-array real-time PCR.

  2003cited by this paper
• Nonmuscle Myosin Promotes Cytoplasmic Localization of PBX

  2003cited by this paper
• Structure of HoxA9 and Pbx1 bound to DNA: Hox hexapeptide and DNA recognition anterior to posterior.

  2003cited by this paper
• Induction of acute myeloid leukemia in mice by the human leukemia-specific fusion gene NUP98-HOXD13 in concert with Meis1.

  2003cited by this paper
• Transformation of myeloid progenitors by MLL oncoproteins is dependent on Hoxa7 and Hoxa9.

  2003cited by this paper
• Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells

  2003cited by this paper
• Frequent co‐expression of HoxA9 and Meis1 genes in infant acute lymphoblastic leukaemia with MLL rearrangement

  2002cited by this paper
• Quantitative HOX expression in chromosomally defined subsets of acute myelogenous leukemia

  2002cited by this paper
• MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia

  2002cited by this paper
• Oncogenic interaction between BCR-ABL and NUP98-HOXA9 demonstrated by the use of an in vitro purging culture system.

  2002cited by this paper
• Novel NUP98-HOXC11 fusion gene resulted from a chromosomal break within exon 1 of HOXC11 in acute myeloid leukemia with t(11;12)(p15;q13).

  2002cited by this paper
• A murine model of CML blast crisis induced by cooperation between BCR/ABL and NUP98/HOXA9

  2002cited by this paper
• Single-translocation and double-chimeric transcripts: detection of NUP98-HOXA9 in myeloid leukemias with HOXA11 or HOXA13 breaks of the chromosomal translocation t(7;11)(p15;p15).

  2002cited by this paper
• Defining Roles for HOX and MEIS1 Genes in Induction of Acute Myeloid Leukemia

  2001cited by this paper
• Meis3 synergizes with Pbx4 and Hoxb1b in promoting hindbrain fates in the zebrafish.

  2001cited by this paper
• NUP98–HOXA9 expression in hemopoietic stem cells induces chronic and acute myeloid leukemias in mice

  2001cited by this paper
• XMeis3 protein activity is required for proper hindbrain patterning in Xenopus laevis embryos.

  2001cited by this paper
• Genetic evidence for the transcriptional-activating function of Homothorax during adult fly development.

  2001cited by this paper
• A conformational change in PBX1A is necessary for its nuclear localization.

  2000cited by this paper
• AP-1 complex is effector of Hox-induced cellular proliferation and transformation

  2000cited by this paper
• MEIS1 and HOXA7 genes in human acute myeloid leukemia.

  2000cited by this paper
• The subcellular localization of PBX1 and EXD proteins depends on nuclear import and export signals and is modulated by association with PREP1 and HTH.

  1999cited by this paper
• HOXA9 Forms Triple Complexes with PBX2 and MEIS1 in Myeloid Cells

  1999cited by this paper
• Molecular classification of cancer: class discovery and class prediction by gene expression monitoring.

  1999cited by this paper
• Regulation of Hox target genes by a DNA bound Homothorax/Hox/Extradenticle complex.

  1999cited by this paper
• Trimeric Association of Hox and TALE Homeodomain Proteins Mediates Hoxb2 Hindbrain Enhancer Activity

  1999cited by this paper
• Control of the nuclear localization of Extradenticle by competing nuclear import and export signals.

  1999cited by this paper
• PBX and MEIS as Non-DNA-Binding Partners in Trimeric Complexes with HOX Proteins

  1999cited by this paper
• The Oncoprotein E2A-Pbx1a Collaborates with Hoxa9 To Acutely Transform Primary Bone Marrow Cells

  1999cited by this paper
• Hoxa9 transforms primary bone marrow cells through specific collaboration with Meis1a but not Pbx1b

  1998cited by this paper
• A Conserved C-terminal Domain in PBX Increases DNA Binding by the PBX Homeodomain and Is Not a Primary Site of Contact for the YPWM Motif of HOXA1*

  1998cited by this paper
• NUP98-HOXD13 gene fusion in therapy-related acute myelogenous leukemia.

  1998cited by this paper
• Functional and regulatory interactions between Hox and extradenticle genes.

  1998cited by this paper
• Overexpression of HOXA10 in murine hematopoietic cells perturbs both myeloid and lymphoid differentiation and leads to acute myeloid leukemia

  1997cited by this paper
• Oncogenic transcription factors in the human acute leukemias.

  1997cited by this paper
• Fusion of the nucleoporin gene NUP98 to HOXA9 by the chromosome translocation t(7;11)(p15;p15) in human myeloid leukaemia

  1996cited by this paper
• The t(7;11)(p15;p15) translocation in acute myeloid leukaemia fuses the genes for nucleoporin NUP96 and class I homeoprotein HOXA9

  1996cited by this paper
• Cooperative activation of Hoxa and Pbx1-related genes in murine myeloid leukaemias

  1996cited by this paper
• Segmental expression of Hoxb-1 is controlled by a highly conserved autoregulatory loop dependent upon exd/pbx.

  1995cited by this paper
• The specificity of homeotic gene function

  1995cited by this paper
• Meis1, a PBX1-related homeobox gene involved in myeloid leukemia in BXH-2 mice

  1995cited by this paper
• PCR amplification of up to 35-kb DNA with high fidelity and high yield from lambda bacteriophage templates.

  1994cited by this paper
• The gadd and MyD genes define a novel set of mammalian genes encoding acidic proteins that synergistically suppress cell growth

  1994cited by this paper
• Differential expression of homeobox genes in functionally distinct CD34+ subpopulations of human bone marrow cells.

  1994cited by this paper
• Conditional immortalization of mouse myelomonocytic, megakaryocytic and mast cell progenitors by the Hox‐2.4 homeobox gene.

  1993cited by this paper
• Multiple cytokines induce the tyrosine phosphorylation of Shc and its association with Grb2 in hemopoietic cells.

  1993cited by this paper
• The oncogenic potential of deregulated homeobox genes.

  1993cited by this paper
• The human t(1;19) translocation in pre-B ALL produces multiple nuclear E2A-Pbx1 fusion proteins with differing transforming potentials.

  1991cited by this paper
• Chromosomal translocation t(1;19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factor.

  1990cited by this paper

• Cooperative reading of DECA-CCAAT composite element by the TALE/NF-Y/Sp2 transcription factors

  2026cites this paper
• Ubiquitous MEIS transcription factors actuate lineage-specific transcription to establish cell fate

  2025cites this paper
• Normal and Aberrant TALE-Class Homeobox Gene Activities in Pro-B-Cells and B-Cell Precursor Acute Lymphoblastic Leukemia

  2022cites this paper
• MEIS1 and its potential as a cancer therapeutic target (Review)

  2021cites this paper
• MEIS1 in Hematopoiesis and Cancer. How MEIS1-PBX Interaction Can Be Used in Therapy

  2021cites this paper
• Mapping the native interaction surfaces of PREP1 with PBX1 by cross-linking mass-spectrometry and mutagenesis

  2020cites this paper
• P2X7 promotes the progression of MLL-AF9-induced acute myeloid leukemia by upregulation of Pbx3

  2020cites this paper
• Epigenetic Dysregulation in Pediatric Leukemia

  2018cites this paper
• Arginine Methylation Regulates MEIS2 Nuclear Localization to Promote Neuronal Differentiation of Adult SVZ Progenitors

  2018cites this paper
• Meis2 as a critical player in MN1-induced leukemia

  2017cites this paper
• The IRX1/HOXA connection: insights into a novel t(4;11)- specific cancer mechanism

  2016cites this paper
• The miR-17∼92 cluster contributes to MLL leukemia through the repression of MEIS1 competitor PKNOX1.

  2016cites this paper
• The MIR-17-92 Cluster Contributes to MLL Leukemia Development Through the Repression of the Meis1 Competitor Pknox1

  2015cites this paper
• Caractérisation du rôle et des mécanismes d’action des gènes Hoxa dans l’hématopoïèse adulte

  2015cites this paper
• Pbx3 and Meis1 cooperate through multiple mechanisms to support Hox-induced murine leukemia

  2015cites this paper
• Validation of two novel mouse models of conditional Meis1 deletion to study roles in adult mouse hematopoiesis

  2014influential citation
• Prep1 and Meis1 competition for Pbx1 binding regulates protein stability and tumorigenesis

  2014cites this paper
• Characterization of the putative CALM/AF10 collaborator Meis1 in leukemia development

  2013cites this paper
• Contrôle de l'expression du gène HOXA9 dans les cellules souches/progénitrices hématopoïétiques : rôle des enzymes épigénétiques MOZ et MLL, et du facteur de polyadénylation Symplekin

  2013cites this paper
• Zebrafish hoxd4a Acts Upstream of meis1.1 to Direct Vasculogenesis, Angiogenesis and Hematopoiesis

  2013cites this paper
• Dynamic expression of MEIS1 homeoprotein in E14.5 forebrain and differentiated forebrain-derived neural stem cells.

  2013cites this paper
• Biochemistry of the tale transcription factors PREP, MEIS, and PBX in vertebrates

  2013cites this paper
• Elucidation of the physical and functional interactions between the MEIS1A and the CREB and CRTC transcription factors

  2012influential citation
• Dual actions of Meis1 inhibit erythroid progenitor development and sustain general hematopoietic cell proliferation.

  2012cites this paper
• The Role of Meis1 in Hematopoietic Development

  2012cites this paper
• The homeodomain region controls the phenotype of HOX-induced murine leukemia.

  2012cites this paper
• C-terminal domain of MEIS1 converts PKNOX1 (PREP1) into a HOXA9-collaborating oncoprotein.

  2011cites this paper
• Selectively weakened binding of methotrexate by human dihydrofolate reductase allows rapid ex vivo selection of mammalian cells

  2011cites this paper
• C-terminal domain of MEIS 1 converts PKNOX 1 ( PREP 1 ) into a HOXA 9-collaborating oncoprotein

  2011cites this paper
• Identification of Gene Regulatory Elements Associated With the Meis Family of Homeobox Genes

  2011cites this paper
• RNA-seq analysis of 2 closely related leukemia clones that differ in their self-renewal capacity.

  2011cites this paper
• The t(4;11) fusion protein MLL/AF4 regulates telomerase reverse transcriptase (TERT) expression

  2011cites this paper
• HoxA cluster is haploinsufficient for activity of hematopoietic stem and progenitor cells.

  2010cites this paper
• Leukemogenic transformation by HOXA cluster genes.

  2010cites this paper
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  2010cites this paper
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  2009cites this paper
• Transcriptional Activation by MEIS1A in Response to Protein Kinase A Signaling Requires the Transducers of Regulated CREB Family of CREB Co-activators

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• Hoxa6 potentiates short-term hemopoietic cell proliferation and extended self-renewal.

  2009cites this paper
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  2009cites this paper
• Chromosomal binding sites of the homeotic cofactor Homothorax

  2008cites this paper
• Grappling with the HOX network in hematopoiesis and leukemia.

  2008cites this paper
• Linkage of Meis1 leukemogenic activity to multiple downstream effectors including Trib2 and Ccl3.

  2008cites this paper
• MN1 affects expression of genes involved in hematopoiesis and can enhance as well as inhibit RAR/RXR-induced gene expression.

  2008cites this paper
• HOX proteins and leukemia.

  2008cites this paper
• Unraveling the crucial roles of Meis1 in leukemogenesis and normal hematopoiesis.

  2007cites this paper
• Hox genes in hematopoiesis and leukemogenesis

  2007cites this paper
• Transcriptional Profiling of Initial Atherogenesis in LDL Receptor Deficient Mice Identifies Diet Induced Upregulation of FOXO1 controlled Genes

  2007cites this paper
• Development and Cancer: The HOX Gene Connection

  2007cites this paper
• Trib1 and Evi1 cooperate with Hoxa and Meis1 in myeloid leukemogenesis.

  2007cites this paper
• Satoshi in myeloid leukemogenesis Meis 1 and Hoxa cooperate with Evi 1 and Trib

  2007cites this paper
• ホメオボックス遺伝子と白血病 : HOX-MEIS相互作用の役割

  2006cites this paper
• [The réseau de recherche sur le cancer: favoring a multi-disciplinary approach].

  2006cites this paper
• Cdx4 dysregulates Hox gene expression and generates acute myeloid leukemia alone and in cooperation with Meis1a in a murine model

  2006cites this paper
• Hox homeobox transcription factors drive leukemogenesis efficiently only in the presence of Meis or Pbx proteins

  year unknowncites this paper