Ongoing diversification of the rearranged immunoglobulin light-chain gene in a bursal lymphoma cell line

No abstract is available for this paper.

• Publication year

  1990

• Venue

  Molecular and Cellular Biology

• Publication date

  1990-06-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/mcb.10.6.3224-3231.1990PMID 2111450PMCID PMC360687
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1990cited by this paper
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  1989cited by this paper
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  1989cited by this paper
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  1989cited by this paper
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  1989cited by this paper
• Might gene conversion be the mechanism of somatic hypermutation of mammalian immunoglobulin genes?

  1989cited by this paper
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  1989cited by this paper
• Expression of v-rel induces mature B-cell lines that reflect the diversity of avian immunoglobulin heavy- and light-chain rearrangements

  1988cited by this paper
• Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase.

  1988cited by this paper
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  1988cited by this paper
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  1987cited by this paper
• Somatic diversification of the chicken immunoglobulin light chain gene is limited to the rearranged variable gene segment.

  1987cited by this paper
• The effect of alterations in myc gene expression on B cell development in the bursa of Fabricius.

  1987cited by this paper
• Analyses of chicken immunoglobulin light chain cDNA clones indicate a few germline V lambda genes and allotypes of the C lambda locus.

  1987cited by this paper
• A hyperconversion mechanism generates the chicken light chain preimmune repertoire.

  1987influential reference
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  1986cited by this paper
• Frameshift mutations produced by proflavin in bacteriophage T4: specificity within a hotspot.

  1986cited by this paper
• Rearrangement of chicken immunoglobulin genes is not an ongoing process in the embryonic bursa of Fabricius.

  1986cited by this paper
• Spectrum of spontaneous frameshift mutations. Sequences of bacteriophage T4 rII gene frameshifts.

  1986cited by this paper
• A single rearrangement event generates most of the chicken immunoglobulin light chain diversity.

  1985cited by this paper
• Cell lines derived from avian lymphomas exhibit two distinct phenotypes.

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• The molecular evolution of the immune response.

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• Formation of a transformed follicle is necessary but not sufficient for development of an avian leukosis virus-induced lymphoma.

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• Alteration of c-myc chromatin structure by avian leukosis virus integration

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• Gene conversion and the generation of antibody diversity

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• Multiple immunoglobulin heavy-chain gene transcripts in Abelson murine leukemia virus-transformed lymphoid cell lines

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• Apoptosis induction-related cytosolic calcium responses revealed by the dual FRET imaging of calcium signals and caspase-3 activation in a single cell.

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• MSH6- or PMS2-deficiency causes re-replication in DT40 B cells, but it has little effect on immunoglobulin gene conversion or on repair of AID-generated uracils

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• Harnessing Gene Conversion in Chicken B Cells to Create a Human Antibody Sequence Repertoire

  2013cites this paper
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  2012cites this paper
• Measurement of diversification in the immunoglobulin light chain gene of DT40 cells.

  2012cites this paper
• Functional dissection of the Smc5/6 complex: roles of the SUMO ligase Nse2/Mms21 in the maintenance of genome stability

  2011cites this paper
• Uracil residues dependent on the deaminase AID in immunoglobulin gene variable and switch regions

  2011cites this paper
• Immunology and Developmental Biology of the Chicken

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• Conditional transformation of immunoglobulin mutation pattern from gene conversion into point mutation by controlling XRCC3 expression in the DT40 B cell line.

  2010cites this paper
• Efficient affinity maturation of antibodies in an engineered chicken B cell line DT40-SW by increasing point mutation.

  2010cites this paper
• Enhancement of hypermutation frequency in the chicken B cell line DT40 for efficient diversification of the antibody repertoire.

  2010cites this paper
• Transcription factors PU.1 and IRF4 regulate activation induced cytidine deaminase in chicken B cells.

  2010cites this paper
• Bursa of Fabricius

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• Enhancement of antibody production from a chicken B cell line DT40 by reducing Pax5 expression.

  2009cites this paper
• [Creation of valuable antibodies by an in vitro antibody generation system using a hypermutating B cell line].

  2009cites this paper
• E2A Acts in cis in G1 Phase of Cell Cycle to Promote Ig Gene Diversification1

  2009cites this paper
• Activation-induced cytidine deaminase-mediated hypermutation in the DT40 cell line

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• The regulation of AID function by transcription factors PU.1 and IRF4 in chicken B cells

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• NF-kappaB family of transcription factor facilitates gene conversion in chicken B cells.

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  2007cites this paper
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  2006cites this paper
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  2006cites this paper
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  2006cites this paper
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  2004cites this paper
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  2003cites this paper
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• Notch Signaling Suppresses IgH Gene Expression in Chicken B Cells: Implication in Spatially Restricted Expression of Serrate2/Notch1 in the Bursa of Fabricius1

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• Efficient antibody diversification by gene conversion in vivo in the absence of selection for V(D)J‐encoded determinants

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• B cells in the bursa of Fabricius express a novel C-type lectin gene.

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• CTCF, a conserved nuclear factor required for optimal transcriptional activity of the chicken c-myc gene, is an 11-Zn-finger protein differentially expressed in multiple forms

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• Surface epitope variation via mosaic gene formation is potential key to long-term survival of Trypanosoma brucei.

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  1991cites this paper
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