Genetic Loss of Faah Compromises Male Fertility in Mice1

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Biology of Reproduction

• Publication date

  2009-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1095/biolreprod.108.072736PMID 18987328PMCID PMC2804815
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The Cannabinoid System and Male Reproductive Functions

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• New insights into the molecular mechanisms of sperm-egg interaction

  2007cited by this paper
• Mechanisms of sperm-egg interactions emerging from gene-manipulated animals

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• Follicle-stimulating hormone activates fatty acid amide hydrolase by protein kinase A and aromatase-dependent pathways in mouse primary Sertoli cells.

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• Inactivation of N-acyl phosphatidylethanolamine phospholipase D reveals multiple mechanisms for the biosynthesis of endocannabinoids.

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• A biosynthetic pathway for anandamide

  2006influential reference
• Endocannabinoid Biosynthesis Proceeding through Glycerophospho-N-acyl Ethanolamine and a Role for α/β-Hydrolase 4 in This Pathway*

  2006cited by this paper
• Jekyll and hyde: two faces of cannabinoid signaling in male and female fertility.

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• Moving to the beat: a review of mammalian sperm motility regulation.

  2006cited by this paper
• Human sperm express cannabinoid receptor Cb1, the activation of which inhibits motility, acrosome reaction, and mitochondrial function.

  2005cited by this paper
• Characterization of the endocannabinoid system in boar spermatozoa and implications for sperm capacitation and acrosome reaction

  2005cited by this paper
• The immunoglobulin superfamily protein Izumo is required for sperm to fuse with eggs

  2005cited by this paper
• Structure and function of fatty acid amide hydrolase.

  2005cited by this paper
• Aberrant cannabinoid signaling impairs oviductal transport of embryos

  2004cited by this paper
• Functional disassociation of the central and peripheral fatty acid amide signaling systems.

  2004cited by this paper
• Mice lacking fatty acid amide hydrolase exhibit a cannabinoid receptor‐mediated phenotypic hypoalgesia

  2004cited by this paper
• Molecular Characterization of a Phospholipase D Generating Anandamide and Its Congeners*

  2004cited by this paper
• Disruption of Mouse CD46 Causes an Accelerated Spontaneous Acrosome Reaction in Sperm

  2003cited by this paper
• Modulation of anxiety through blockade of anandamide hydrolysis

  2003cited by this paper
• The endocannabinoid system, anandamide and the regulation of mammalian cell apoptosis

  2003cited by this paper
• Cannabinoids: potential anticancer agents

  2003cited by this paper
• Anandamide activity and degradation are regulated by early postnatal aging and follicle-stimulating hormone in mouse Sertoli cells.

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• Pharmacokinetics of THC in brain and testis, male gametotoxicity and premature apoptosis of spermatozoa

  2002cited by this paper
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  2002cited by this paper
• Penetration, Adhesion, and Fusion in Mammalian Sperm-Egg Interaction

  2002cited by this paper
• Sperm from the calmegin-deficient mouse have normal abilities for binding and fusion to the egg plasma membrane.

  2002cited by this paper
• Evidence that anandamide‐signaling regulates human sperm functions required for fertilization

  2002cited by this paper
• The molecular basis of sperm-oocyte membrane interactions during mammalian fertilization.

  2002cited by this paper
• Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase

  2001cited by this paper
• Diversification of Cyclooxygenase-2-Derived Prostaglandins in Ovulation and Implantation1

  2001cited by this paper
• The central cannabinoid receptor inactivation suppresses endocrine reproductive functions.

  2001cited by this paper
• Increased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout mice.

  1999cited by this paper
• Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptors.

  1999cited by this paper
• Molecular characterization of human and mouse fatty acid amide hydrolases.

  1997cited by this paper
• Cannabinoids inhibit N- and P/Q-type calcium channels in cultured rat hippocampal neurons.

  1997influential reference
• Enzymatic synthesis of anandamide, an endogenous cannabinoid receptor ligand, through N-acylphosphatidylethanolamine pathway in testis: involvement of Ca(2+)-dependent transacylase and phosphodiesterase activities.

  1996cited by this paper
• Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides

  1996cited by this paper
• Coenzyme A-dependent cleavage of membrane phospholipids in several rat tissues: ATP-independent acyl-CoA synthesis and the generation of lysophospholipids.

  1995cited by this paper
• Acrobeads test: a new diagnostic test for assessment of the fertilizing capacity of human spermatozoa.

  1995cited by this paper
• Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors.

  1995cited by this paper
• Anandamide (arachidonylethanolamide), a brain cannabinoid receptor agonist, reduces sperm fertilizing capacity in sea urchins by inhibiting the acrosome reaction.

  1994cited by this paper
• Heparin-binding EGF-like growth factor gene is induced in the mouse uterus temporally by the blastocyst solely at the site of its apposition: a possible ligand for interaction with blastocyst EGF-receptor in implantation.

  1994cited by this paper
• Molecular characterization of a peripheral receptor for cannabinoids

  1993cited by this paper
• Isolation and structure of a brain constituent that binds to the cannabinoid receptor.

  1992cited by this paper
• Bicarbonate: carbon-dioxide regulation of sperm capacitation, hyperactivated motility, and acrosome reactions.

  1991cited by this paper
• Evidence for the function of hyperactivated motility in sperm.

  1991cited by this paper
• Structure of a cannabinoid receptor and functional expression of the cloned cDNA

  1990cited by this paper
• Determination and characterization of a cannabinoid receptor in rat brain.

  1988cited by this paper
• Changes in human spermatozoa associated with high dose marihuana smoking.

  1978cited by this paper
• Depression of plasma testosterone levels after chronic intensive marihuana use.

  1974cited by this paper
• Isolation, Structure, and Partial Synthesis of an Active Constituent of Hashish

  1964cited by this paper

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  2021cites this paper
• Decreasing sperm quality in mice subjected to chronic cannabidiol exposure: New insights of cannabidiol-mediated male reproductive toxicity.

  2021cites this paper
• Diverse role of endocannabinoid system in mammalian male reproduction.

  2021cites this paper
• Effects of BPA on zebrafish gonads: Focus on the endocannabinoid system.

  2020cites this paper
• The (endo)cannabinoid signaling in female reproduction: What are the latest advances?

  2019cites this paper
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  2019cites this paper
• The role of the endocannabinoid system in aetiopathogenesis of endometriosis: A potential therapeutic target.

  2019cites this paper
• Transcriptional abundance of type-1 endocannabinoid receptor (CB1) and fatty acid amide hydrolase (FAAH) in bull spermatozoa: Relationship with field fertility.

  2018cites this paper
• An interview with Dr Sudhansu K. Dey

  2017cites this paper
• Endocannabinoids modulate apoptosis in endometriosis and adenomyosis.

  2017cites this paper
• IZUMO1–JUNO Union Promotes Fertilization

  2016cites this paper
• Introductory Chapter: The Endocannabinoid System in Human Physiology

  2016cites this paper
• WORLD OF REPRODUCTIVE BIOLOGY: Progesterone and Endocannabinoid Interaction Alters Sperm Activation

  2016cites this paper
• Progesterone and Endocannabinoid Interaction Alters Sperm Activation

  2016cites this paper
• Genetic Manipulation of the Endocannabinoid System.

  2015cites this paper
• Interactions of the opioid and cannabinoid systems in reward: Insights from knockout studies

  2015cites this paper
• Endocannabinoids and Reproductive Events in Health and Disease.

  2015cites this paper
• Updates in Reproduction Coming from the Endocannabinoid System

  2014cites this paper
• Endocannabinoids as biomarkers of human reproduction.

  2014cites this paper
• Endocannabinoids are Involved in Male Vertebrate Reproduction: Regulatory Mechanisms at Central and Gonadal Level

  2014cites this paper
• The immunoexpression of androgen receptor, estrogen receptors alpha and beta, vanilloid type 1 receptor and cytochrome p450 aromatase in rats testis chronically treated with letrozole, an aromatase inhibitor.

  2014cites this paper
• Participación de la anandamida en la liberación de los espermatozoides del epitelio oviductal bovino

  2013cites this paper
• Anandamide modulates human sperm motility: implications for men with asthenozoospermia and oligoasthenoteratozoospermia.

  2013cites this paper
• Nuclear size as estrogen-responsive chromatin quality parameter of mouse spermatozoa.

  2013cites this paper
• Estrogens and Spermiogenesis: New Insights from Type 1 Cannabinoid Receptor Knockout Mice

  2013cites this paper
• Conditional deletion of Tsc1 in the female reproductive tract impedes normal oviductal and uterine function by enhancing mTORC1 signaling in mice.

  2013cites this paper
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  2013cites this paper
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  2013cites this paper
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  2012cites this paper
• Δ9‐Tetrahydrocannabinol (Δ9‐THC) attenuates mouse sperm motility and male fecundity

  2012influential citation
• Effects of chronic bhang (cannabis) administration on the reproductive system of male mice.

  2011cites this paper
• The contribution of lower vertebrate animal models in human reproduction research.

  2011cites this paper
• The manifold actions of endocannabinoids on female and male reproductive events.

  2011cites this paper
• Treatment with tetrahydrocannabinol (THC) prevents infertility in male cystic fibrosis mice

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• Anandamide Capacitates Bull Spermatozoa through CB1 and TRPV1 Activation

  2011cites this paper
• Fatty acid amide hydrolase inhibitors--progress and potential.

  2011cites this paper
• Cannabinoids for the control of experimental multiple sclerosis

  2010influential citation
• Is there a role for endocannabinoids in sperm-oviduct interaction?

  2010cites this paper
• Cannabinoids and Reproduction: A Lasting and Intriguing History

  2010influential citation
• Recent advances in the discovery and evaluation of fatty acid amide hydrolase inhibitors

  2010cites this paper
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  2010cites this paper
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  2010cites this paper
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  2010cites this paper
• Cannabinoid receptor 1 influences chromatin remodeling in mouse spermatids by affecting content of transition protein 2 mRNA and histone displacement.

  2010cites this paper
• Cannabis et fertilité masculine

  2010cites this paper
• Endocannabinoids and Human Sperm Cells

  2010cites this paper
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• The endocannabinoid system and pivotal role of the CB2 receptor in mouse spermatogenesis

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• Characterization of the endocannabinoid system in human spermatozoa and involvement of transient receptor potential vanilloid 1 receptor in their fertilizing ability.

  2009cites this paper
• Endocannabinoids: friends and foes of reproduction.

  2009cites this paper
• Fatty acid amide hydrolase as a potential therapeutic target for the treatment of pain and CNS disorders

  2009cites this paper