A model for spontaneous B-lineage lymphomas in IgHmu-HOX11 transgenic mice.

No abstract is available for this paper.

• Publication year

  1998

• Venue

  Proceedings of the National Academy of Sciences of the United States of America

• Publication date

  1998-11-10

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1073/PNAS.95.23.13853PMID 9811890PMCID PMC24927
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint

  1997cited by this paper
• Transforming function of the HOX11/TCL3 homeobox gene.

  1997cited by this paper
• Overexpression of HOXB3 in hematopoietic cells causes defective lymphoid development and progressive myeloproliferation.

  1997cited by this paper
• Genetic alterations in leukemias and lymphomas: impressive progress and continuing complexity.

  1997cited by this paper
• Reduction of early B lymphocyte precursors in transgenic mice overexpressing the murine heat-stable antigen.

  1996cited by this paper
• The Role of HOX Homeobox Genes in Normal and Leukemic Hematopoiesis

  1996cited by this paper
• The optimal binding sequence of the Hox11 protein contains a predicted recognition core motif.

  1995cited by this paper
• Dysregulation of HOX11 by chromosome translocations in T-cell acute lymphoblastic leukemia: a paradigm for homeobox gene involvement in human cancer.

  1995cited by this paper
• The Hox11 gene is essential for cell survival during spleen development.

  1995cited by this paper
• Localization of Pbx1 transcripts in developing rat embryos.

  1995cited by this paper
• Two forms of Hox11 a T cell leukemia oncogene, are expressed in fetal spleen but not in primary lymphocytes.

  1995cited by this paper
• HOX11 expression in pediatric acute lymphoblastic leukemia is associated with T-cell phenotype.

  1995cited by this paper
• Chromosomal translocations in human cancer

  1994cited by this paper
• Joining of recombination signals on the der 14q- chromosome in T-cell acute leukemia with t(10;14) chromosome translocation.

  1994cited by this paper
• The HOX11 homeobox-containing gene of human leukemia immortalizes murine hematopoietic precursors.

  1994cited by this paper
• Genetic mapping of two mouse homeobox genes Tlx-1 and Tlx-2 to murine chromosomes 19 and 6.

  1994cited by this paper
• Identification of homeobox genes expressed in human haemopoietic progenitor cells.

  1994cited by this paper
• Hox genes in vertebrate development.

  1994cited by this paper
• Hox11 controls the genesis of the spleen

  1994cited by this paper
• Characterization and developmental expression of Tlx-1, the murine homolog of HOX11.

  1993cited by this paper
• The HOX11 gene encodes a DNA-binding nuclear transcription factor belonging to a distinct family of homeobox genes.

  1993cited by this paper
• Molecular Characterisation of Three Murine HOX11‐Related Homeobox Genes, Tlx‐1, −2, and −3, and Restricted Expression of Tlx‐1 during Embryogenesis

  1993cited by this paper
• Chromosomal translocations in lymphoid malignancies reveal novel proto-oncogenes.

  1992cited by this paper
• Genomic organization of the putative human homeobox proto-oncogene HOX-11 (TCL-3) and its endogenous expression in T cells.

  1992cited by this paper
• Deregulation of a homeobox gene, HOX11, by the t(10;14) in T cell leukemia.

  1991cited by this paper
• HOX11, a homeobox-containing T-cell oncogene on human chromosome 10q24.

  1991cited by this paper
• A novel human homeobox gene lies at the chromosome 10 breakpoint in lymphoid neoplasias with chromosomal translocation t(10;14).

  1991cited by this paper
• Molecular characterization of the t(10;14) translocation breakpoints in T‐cell acute lymphoblastic leukemia: Further evidence for illegitimate physiological recombination

  1990cited by this paper
• The t(10;14)(q24;q11) of T-cell acute lymphoblastic leukemia juxtaposes the delta T-cell receptor with TCL3, a conserved and activated locus at 10q24.

  1990cited by this paper
• Molecular cloning : a laboratory manual. Cold Spring Harbor, NY

  1989cited by this paper
• Handicapped retroviral vectors efficiently transduce foreign genes into hematopoietic stem cells.

  1987cited by this paper
• A new translocation, t(10;14)(q24;q11), in T cell neoplasia.

  1986cited by this paper
• A tissue-specific transcription enhancer element is located in the major intron of a rearranged immunoglobulin heavy chain gene.

  1983cited by this paper
• An immunoglobulin promoter region is unaltered by DNA rearrangement and somatic mutation during B-cell development.

  1982cited by this paper

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  2014cites this paper
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  2012cites this paper
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  2011cites this paper
• Transient Responses to NOTCH and TLX1/HOX11 Inhibition in T-Cell Acute Lymphoblastic Leukemia/Lymphoma

  2011cites this paper
• Phosphorylation of HOX11/TLX1 on Threonine-247 during mitosis modulates expression of cyclin B1

  2010cites this paper
• MEIS proteins as partners of the TLX1/HOX11 oncoprotein.

  2010cites this paper
• The TLX1 oncogene drives aneuploidy in T-cell transformation

  2010cites this paper
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  2009cites this paper
• Molecular genetics of acute lymphoblastic leukemia.

  2009cites this paper
• A promoter with bidirectional activity is located between TLX1/HOX11 and a divergently transcribed novel human gene.

  2007cites this paper
• TLX1/HOX11 transcription factor inhibits differentiation and promotes a non‐haemopoietic phenotype in murine bone marrow cells

  2007cites this paper
• Loss of Ubr1 promotes aneuploidy and accelerates B-cell lymphomagenesis in TLX1/HOX11-transgenic mice

  2006cites this paper
• The nuclear oncoprotein TLX1/HOX11 associates with pericentromeric satellite 2 DNA in leukemic T-cells

  2006cites this paper
• Dysregulated expression of mitotic regulators is associated with B-cell lymphomagenesis in HOX11-transgenic mice

  2006cites this paper
• A Pbx1-dependent genetic and transcriptional network regulates spleen ontogeny

  2005cites this paper
• Erratum A Pbx 1-dependent genetic and transcriptional network regulates spleen ontogeny

  2005cites this paper
• Transgenic mice as an in vivo model of lymphomagenesis.

  2004cites this paper
• A microarray model system identifies potential new target genes of the proto‐oncogene HOX11

  2004cites this paper
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  2003cites this paper
• Role of Homeobox Genes in Normal Mammary Gland Development and Breast Tumorigenesis

  2003cites this paper
• Specific alternative HOX11 transcripts are expressed in paediatric neural tumours and T-cell acute lymphoblastic leukaemia.

  2003cites this paper
• The homeobox gene Hex induces T-cell-derived lymphomas when overexpressed in hematopoietic precursor cells

  2003cites this paper
• Enforced expression of HOX11 is associated with an immature phenotype in J2E erythroid cells

  2002cites this paper
• HOX and Non‐HOX Homeobox Genes in Leukemic Hematopoiesis

  2002cites this paper
• Expression and purification of the human homeodomain oncoprotein HOX11.

  2002cites this paper
• A new recurrent and specific cryptic translocation, t(5;14)(q35;q32), is associated with expression of the Hox11L2 gene in T acute lymphoblastic leukemia

  2001cites this paper
• Dendritic cell-based vaccines: from mouse models to clinical cancer immunotherapy.

  2000cites this paper
• Induction of tolerance to immunogenic tumor antigens associated with lymphomagenesis in HOX11 transgenic mice.

  2000cites this paper