Exploring the therapeutic promise of targeting Rho kinase in rheumatoid arthritis

No abstract is available for this paper.

• Publication year

  2021

• Venue

  InflammoPharmacology

• Publication date

  2021-10-26

• Fields of study

  Medicine

• Identifiers
  DOI 10.1007/s10787-021-00884-xPMID 34704172
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The Role of the RhoA/ROCK Signaling Pathway in Mechanical Strain-Induced Scleral Myofibroblast Differentiation.

  2018cited by this paper
• Verbesserte Frühdiagnostik rheumatischer Erkrankungen

  2018cited by this paper
• Use of Rho kinase Inhibitors in Ophthalmology: A Review of the Literature

  2018cited by this paper
• Atherosclerosis in Rheumatoid Arthritis: Promoters and Opponents

  2018cited by this paper
• Alzheimer’s Disease and Rheumatoid Arthritis: A Mendelian Randomization Study

  2018cited by this paper
• Rho Kinase Inhibitors as a Novel Treatment for Glaucoma and Ocular Hypertension.

  2018cited by this paper
• Role of the Rho GTPase/Rho kinase signaling pathway in pathogenesis and treatment of glaucoma: Bench to bedside research

  2017cited by this paper
• AMA0428, A Potent Rock Inhibitor, Attenuates Early and Late Experimental Diabetic Retinopathy

  2017cited by this paper
• ROCK-1 mediates diabetes-induced retinal pigment epithelial and endothelial cell blebbing: Contribution to diabetic retinopathy

  2017cited by this paper
• Rho Kinases in Autoimmune Diseases.

  2016cited by this paper
• Nasal NSAIDs for Alzheimer's Disease

  2014cited by this paper
• Rho GTPases as regulators of mitosis and cytokinesis in mammalian cells

  2014cited by this paper
• Ripasudil: First Global Approval

  2014cited by this paper
• Involvement of RhoA/ROCK1 signaling pathway in hyperglycemia-induced microvascular endothelial dysfunction in diabetic retinopathy.

  2014cited by this paper
• A key role for ROCK in TNF-α-mediated diabetic microvascular damage.

  2013cited by this paper
• Rho-associated coiled-coil kinase (ROCK) signaling and disease

  2013cited by this paper
• Inhibition of the Rho signaling pathway improves neurite outgrowth and neuronal differentiation of mouse neural stem cells.

  2013cited by this paper
• Republished research: Non-steroidal anti-inflammatory drugs (NSAIDs)

  2013cited by this paper
• Mechanosensitivity and compositional dynamics of cell–matrix adhesions

  2013cited by this paper
• Rho-associated kinase inhibitors: a novel glaucoma therapy.

  2013cited by this paper
• Rho/Rho-associated kinase pathway in glaucoma (Review).

  2013cited by this paper
• Husbandry and healthcare of pet and smallholder pigs

  2013cited by this paper
• Rho-associated protein kinase modulates neurite extension by regulating microtubule remodeling and vinculin distribution

  2013cited by this paper
• Rho kinase: A new target for treatment of cerebral ischemia/reperfusion injury

  2013cited by this paper
• Rap1 potentiates endothelial cell junctions by spatially controlling myosin II activity and actin organization

  2013cited by this paper
• Faculty Opinions recommendation of Rap1 potentiates endothelial cell junctions by spatially controlling myosin II activity and actin organization.

  2013cited by this paper
• Rho/ROCK pathway is essential to the expansion, differentiation, and morphological rearrangements of human neural stem/progenitor cells induced by lysophosphatidic acid[S]

  2013cited by this paper
• NSAIDs Inhibit Tumorigenesis, but How?

  2013cited by this paper
• Distinct roles for ROCK1 and ROCK2 in the regulation of cell detachment

  2013cited by this paper
• Gene pathway analysis of the mechanism by which the Rho-associated kinase inhibitor Y-27632 inhibits apoptosis in isolated thawed human embryonic stem cells.

  2012cited by this paper
• Repulsive guidance molecule B (RGMB) plays negative roles in breast cancer by coordinating BMP signaling

  2012cited by this paper
• Vasodilator effects of cromakalim and HA 1077 in diabetic rat aorta.

  2012cited by this paper
• Comparative evaluation for the use of oral ibuprofen and intravenous indomethacin in Korean infants with patent ductus

  2012cited by this paper
• A Collapsin Response Mediator Protein 2 Isoform Controls Myosin II-Mediated Cell Migration and Matrix Assembly by Trapping ROCK II

  2012cited by this paper
• Rock1 & 2 Perform Overlapping and Unique Roles in Angiogenesis and Angiosarcoma Tumor Progression

  2012cited by this paper
• The development of a rat in vitro model of spinal cord injury demonstrating the additive effects of rho and ROCK inhibitors on neurite outgrowth and myelination

  2012cited by this paper
• Fastigial Nucleus Electrostimulation Reduces the Expression of Repulsive Guidance Molecule, Improves Axonal Growth Following Focal Cerebral Ischemia

  2012cited by this paper
• Novel Mechanism for Negatively Regulating Rho-Kinase (ROCK) Signaling through Coronin1B Protein in Neuregulin 1 (NRG-1)-induced Tumor Cell Motility*

  2012cited by this paper
• Rho-associated coiled kinase inhibitor Y-27632 promotes neuronal-like differentiation of adult human adipose tissue-derived stem cells.

  2012cited by this paper
• Rho‐associated kinases in tumorigenesis: re‐considering ROCK inhibition for cancer therapy

  2012cited by this paper
• Inhibition of the Rho/ROCK pathway prevents neuronal degeneration in vitro and in vivo following methylmercury exposure.

  2011cited by this paper
• The structural determinations of the leucine zipper coiled-coil domains of the cGMP-dependent protein kinase Iα and its interaction with the myosin binding subunit of the myosin light chains phosphase.

  2011cited by this paper
• The p75 receptor mediates axon growth inhibition through an association with PIR-B

  2011cited by this paper
• Rho-Kinase in Development and Heart Failure: Insights From Genetic Models

  2011cited by this paper
• Rho kinase as a therapeutic target in cardiovascular disease.

  2011cited by this paper
• Plant actin controls membrane permeability.

  2011cited by this paper
• Accelerated neurite growth from spiral ganglion neurons exposed to the Rho kinase inhibitor H-1152.

  2010cited by this paper
• Rho-Kinase/ROCK: A Key Regulator of the Cytoskeleton and Cell Polarity

  2010cited by this paper
• Receptors for myelin inhibitors: Structures and therapeutic opportunities.

  2010cited by this paper
• Rheumatoid arthritis

  2010cited by this paper
• Rho kinase inhibition protects CA1 cells in organotypic hippocampal slices during in vitro ischemia.

  2010cited by this paper
• Expression of a dominant-negative Rho-kinase promotes neurite outgrowth in a microenvironment mimicking injured central nervous system

  2010cited by this paper
• Induction of RhoA gene expression by interleukin-4 in cultured human bronchial smooth muscle cells.

  2010cited by this paper
• ADF/cofilin: a functional node in cell biology.

  2010cited by this paper
• The protective effect of Rho-associated kinase inhibitor on aluminum-induced neurotoxicity in rat cortical neurons.

  2010cited by this paper
• Network meta-analysis of indomethacin versus ibuprofen versus placebo for PDA in preterm infants

  2010cited by this paper
• Multiple roles for RhoA during T cell transendothelial migration

  2010cited by this paper
• Rho family GTPases and their regulators in lymphocytes

  2009cited by this paper
• Collapsin response mediator protein-2 regulates neurite formation by modulating tubulin GTPase activity.

  2009cited by this paper
• Rho-kinase inhibitors as therapeutics: from pan inhibition to isoform selectivity

  2009cited by this paper
• Rho/ROCK and MAPK signaling pathways are involved in glioblastoma cell migration and proliferation.

  2009cited by this paper
• Targeted Disruption of ROCK1 Causes Insulin Resistance in Vivo*

  2009cited by this paper
• PDK1 regulates cancer cell motility by antagonising inhibition of ROCK1 by RhoE

  2008cited by this paper
• Effects of K-115, a Rho-Kinase Inhibitor, on Aqueous Humor Dynamics in Rabbits

  2008cited by this paper
• PirB, a second receptor for the myelin inhibitors of axonal regeneration Nogo66, MAG, and OMgp: implications for regeneration in vivo.

  2008cited by this paper
• ROCK inhibition and CNTF interact on intrinsic signalling pathways and differentially regulate survival and regeneration in retinal ganglion cells.

  2008cited by this paper
• Neogenin-RGMa signaling at the growth cone is bone morphogenetic protein-independent and involves RhoA, ROCK, and PKC.

  2007cited by this paper
• Neogenin-RGMa Signaling at the Growth Cone Is Bone Morphogenetic Protein-independent and Involves RhoA, ROCK, and PKC*

  2007cited by this paper
• The Nogo-66 Receptor NgR1 Is Required Only for the Acute Growth Cone-Collapsing But Not the Chronic Growth-Inhibitory Actions of Myelin Inhibitors

  2007cited by this paper
• Actin cytoskeleton dynamics linked to synovial fibroblast activation as a novel pathogenic principle in TNF-driven arthritis

  2007cited by this paper
• Inhibition of Rho kinase (ROCK) increases neurite outgrowth on chondroitin sulphate proteoglycan in vitro and axonal regeneration in the adult optic nerve in vivo

  2007cited by this paper
• Phosphorylation of Rho-associated kinase (Rho-kinase/ROCK/ROK) substrates by protein kinases A and C.

  2007cited by this paper
• Molecular mechanism for the regulation of rho-kinase by dimerization and its inhibition by fasudil.

  2006cited by this paper
• Targeted deletion of ROCK1 protects the heart against pressure overload by inhibiting reactive fibrosis

  2006cited by this paper
• Apoptosis of rheumatoid synovial cells by statins through the blocking of protein geranylgeranylation: a potential therapeutic approach to rheumatoid arthritis.

  2006cited by this paper
• Fibronectin matrix assembly requires distinct contributions from Rho kinases I and -II.

  2006cited by this paper
• RhoA-mediated, tumor necrosis factor alpha-induced activation of NF-kappaB in rheumatoid synoviocytes: inhibitory effect of simvastatin.

  2006cited by this paper
• RhoA‐mediated, tumor necrosis factor α–induced activation of NF‐κB in rheumatoid synoviocytes: Inhibitory effect of simvastatin

  2006cited by this paper
• RhoE function is regulated by ROCK I‐mediated phosphorylation

  2005cited by this paper
• ROCK-I regulates closure of the eyelids and ventral body wall by inducing assembly of actomyosin bundles

  2005cited by this paper
• ROCK‐I and ROCK‐II cooperatively regulate closure of eyelid and ventral body wall in mouse embryo

  2005cited by this paper
• Small GTP-binding protein Rho-mediated signaling promotes proliferation of rheumatoid synovial fibroblasts

  2005cited by this paper
• Rho kinase, a promising drug target for neurological disorders

  2005cited by this paper
• The Rho kinases I and II regulate different aspects of myosin II activity

  2005cited by this paper
• Targeted Disruption of the Mouse Rho-Associated Kinase 2 Gene Results in Intrauterine Growth Retardation and Fetal Death

  2003cited by this paper
• RhoE Binds to ROCK I and Inhibits Downstream Signaling

  2003cited by this paper
• IL-1 Receptor-Associated Kinase and Low Molecular Weight GTPase RhoA Signal Molecules Are Required for Bacterial Lipopolysaccharide-Induced Cytokine Gene Transcription1

  2002cited by this paper
• Rho kinases play an obligatory role in vertebrate embryonic organogenesis.

  2001cited by this paper
• Regulation of Myosin Phosphatase by Rho and Rho-Associated Kinase (Rho-Kinase)

  1996cited by this paper

• Design, Synthesis, and Evaluation of a Potent and Selective ROCK2 Inhibitor for Atopic Dermatitis Treatment.

  2026cites this paper
• Exploring the mechanism of triptolide inhibiting the motility of fibroblast-like synoviocytes in rheumatoid arthritis via RhoA/Rho-associated kinase axis, based on network pharmacology, molecular docking and molecular dynamics simulations

  2025cites this paper
• Mesenchymal Stem Cell-Derived Exosomes: A Paradigm Shift in Clinical Therapeutics.

  2025cites this paper
• Proteomic profiling of extracellular vesicles in synovial fluid and plasma from Oligoarticular Juvenile Idiopathic Arthritis patients reveals novel immunopathogenic biomarkers

  2023cites this paper
• RND3 Transcriptionally Regulated by FOXM1 Inhibits the Migration and Inflammation of Synovial Fibroblasts in Rheumatoid Arthritis Through the Rho/ROCK Pathway

  2022cites this paper
• In-depth bibliometric analysis and current scientific mapping research in the context of rheumatoid arthritis pharmacotherapy.

  2022cites this paper