Uso de estrogênio e progesterona na terapia hormonal pós-menopausa: revisão sistemática de sua influência no domínio cognitivo

O objetivo deste artigo foi identificar possível padrão de resposta cognitiva associada a suplementação de estrogênio e/ou progesterona em mulheres após a menopausa. Foi realizada uma revisão sistemática da literatura utilizando o protocolo PRISMA, de corte transversal e análise quanti-qualitativa nas bases de dados PubMed e Scientific Electronic Library Online (SCIELO) utilizando os seguintes Descritores em Ciências da Saúde (DeCS) “Cognição” e “Terapia de reposição hormonal” em inglês e seus sinônimos. Foram identificados 349 artigos que após a aplicação dos filtros resultaram 82 publicações. Não houve duplicidade entre as bases pesquisadas. Após a exclusão de estudos com animais, revisões de literatura e aqueles que a Terapia de Reposição Hormonal foi utilizada com outras finalidades que não o tratamento dos sintomas da menopausa restaram 09 artigos a serem analisados. A terapia hormonal influenciou negativamente a orientação, raciocínio abstrato, volume cerebral e perguntas, além de exacerbar efeitos negativos do Diabetes Mellitus sobre a cognição. Porém, nos domínios atenção, velocidade de processamento, memória operacional e verbal houve uma influência positiva mostrando que as mulheres que utilizaram terapia hormonal obtiveram desempenho melhor que as que nunca utilizaram. Diante dos resultados conflitantes, faz-se necessários mais estudos que avaliem a influência das diferentes formulações, além disso, os fatores de risco para declínio cognitivo devem ser levados em consideração no momento da indicação de terapia hormonal, pois ainda que o tratamento não seja indicado para fins cognitivos, o declínio deste pode causar grande impacto na qualidade de vida das mulheres.

• Publication year

  2021

• Venue

  Research, Society and Development

• Publication date

  2021-09-13

• Fields of study

  Not labeled

• Identifiers
  DOI 10.33448/rsd-v10i12.20075
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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