Reactivity of penicillin-binding proteins with peptidoglycan-mimetic beta-lactams: what's wrong with these enzymes?

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Biochemistry

• Publication date

  2006-12-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1021/BI061804FPMID 17176110
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Interaction between two murein (peptidoglycan) synthases, PBP3 and PBP1B, in Escherichia coli

  2006cited by this paper
• Crystal structure of penicillin binding protein 4 (dacB) from Escherichia coli, both in the native form and covalently linked to various antibiotics.

  2006cited by this paper
• Transpeptidation reactions of a specific substrate catalyzed by the Streptomyces R61 DD-peptidase: the structural basis of acyl acceptor specificity.

  2005cited by this paper
• In Vitro Murein (Peptidoglycan) Synthesis by Dimers of the Bifunctional Transglycosylase-Transpeptidase PBP1B from Escherichia coli*

  2005cited by this paper
• Activation for catalysis of penicillin-binding protein 2a from methicillin-resistant Staphylococcus aureus by bacterial cell wall.

  2005cited by this paper
• 2P017 Crystal structure of penicillin binding protein 4 from Escherichia coli, both in the native form and covalently linked to antibiotics

  2005cited by this paper
• Penicillin-binding protein 2x of Streptococcus pneumoniae: enzymic activities and interactions with fI-lactams

  2005cited by this paper
• Crystal structures of complexes between the R61 DD-peptidase and peptidoglycan-mimetic beta-lactams: a non-covalent complex with a "perfect penicillin".

  2005cited by this paper
• Crystal Structure of a Peptidoglycan Synthesis Regulatory Factor (PBP3) from Streptococcus pneumoniae*

  2005cited by this paper
• Active site restructuring regulates ligand recognition in class A penicillin-binding proteins.

  2005cited by this paper
• Crystal Structure of the Actinomadura R39 DD-peptidase Reveals New Domains in Penicillin-binding Proteins*

  2005cited by this paper
• The perfect penicillin? Inhibition of a bacterial DD-peptidase by peptidoglycan-mimetic beta-lactams.

  2004cited by this paper
• Synthesis and evaluation of new substrate analogues of streptomyces R61 DD-peptidase: dissection of a specific ligand.

  2004cited by this paper
• Synthetic peptidoglycan substrates for penicillin-binding protein 5 of Gram-negative bacteria.

  2004cited by this paper
• Substrate recognition strategy for botulinum neurotoxin serotype A

  2004cited by this paper
• Neisseria gonorrhoeae penicillin-binding protein 3 exhibits exceptionally high carboxypeptidase and beta-lactam binding activities.

  2003cited by this paper
• Crystal Structure of Wild-type Penicillin-binding Protein 5 from Escherichia coli

  2003cited by this paper
• Functional Characterization of Penicillin-Binding Protein 1b from Streptococcus pneumoniae

  2003cited by this paper
• Role of penicillin-binding proteins in bacterial cell morphogenesis.

  2003cited by this paper
• Structure-based design approaches to cell wall biosynthesis inhibitors.

  2003cited by this paper
• On the substrate specificity of bacterial DD-peptidases: evidence from two series of peptidoglycan-mimetic peptides.

  2003cited by this paper
• Structural aspects for evolution of beta-lactamases from penicillin-binding proteins.

  2003cited by this paper
• Bifunctional penicillin-binding proteins: focus on the glycosyltransferase domain and its specific inhibitor moenomycin.

  2002cited by this paper
• Structural basis for the β lactam resistance of PBP2a from methicillin-resistant Staphylococcus aureus

  2002cited by this paper
• Functional evolution of the serine β-lactamase active site

  2002cited by this paper
• Development of a Whole-Cell Assay for Peptidoglycan Biosynthesis Inhibitors

  2002cited by this paper
• Structures of two kinetic intermediates reveal species specificity of penicillin-binding proteins.

  2002cited by this paper
• The 2.4-Å crystal structure of the penicillin-resistant penicillin-binding protein PBP5fm from Enterococcus faecium in complex with benzylpenicillin

  2002cited by this paper
• pH, inhibitor, and substrate specificity studies on Escherichia coli penicillin-binding protein 5.

  2002cited by this paper
• Biochemistry and Comparative Genomics of SxxK Superfamily Acyltransferases Offer a Clue to the Mycobacterial Paradox: Presence of Penicillin-Susceptible Target Proteins versus Lack of Efficiency of Penicillin as Therapeutic Agent

  2002cited by this paper
• Structural basis for the beta lactam resistance of PBP2a from methicillin-resistant Staphylococcus aureus.

  2002cited by this paper
• Lipid II: total synthesis of the bacterial cell wall precursor and utilization as a substrate for glycosyltransfer and transpeptidation by penicillin binding protein (PBP) 1b of Escherichia coli.

  2001cited by this paper
• Crystal Structure of PBP2x from a Highly Penicillin-resistant Streptococcus pneumoniae Clinical Isolate

  2001cited by this paper
• Antimicrobial effects of novel siderophores linked to β-lactam antibiotics

  2000cited by this paper
• Antimicrobial effects of novel siderophores linked to beta-lactam antibiotics.

  2000cited by this paper
• Dipeptide binding to the extended active site of the Streptomyces R61 D-alanyl-D-alanine-peptidase: the path to a specific substrate.

  2000cited by this paper
• The crystal structure of the penicillin-binding protein 2x from Streptococcus pneumoniae and its acyl-enzyme form: implication in drug resistance.

  2000cited by this paper
• The catalytic, glycosyl transferase and acyl transferase modules of the cell wall peptidoglycan‐polymerizing penicillin‐binding protein 1b of Escherichia coli

  1999cited by this paper
• Demonstration of Molecular Interactions between the Murein Polymerase PBP1B, the Lytic Transglycosylase MltA, and the Scaffolding Protein MipA of Escherichia coli *

  1999cited by this paper
• Growth of the Stress-Bearing and Shape-Maintaining Murein Sacculus of Escherichia coli

  1998cited by this paper
• Identification of a structural determinant for resistance to beta-lactam antibiotics in Gram-positive bacteria.

  1998cited by this paper
• Acquisition of Five High-MrPenicillin-Binding Protein Variants during Transfer of High-Level β-Lactam Resistance from Streptococcus mitis toStreptococcus pneumoniae

  1998cited by this paper
• Biochemical characterization of penicillin-resistant and -sensitive penicillin-binding protein 2x transpeptidase activities of Streptococcus pneumoniae and mechanistic implications in bacterial resistance to beta-lactam antibiotics

  1997cited by this paper
• Program DYNAFIT for the analysis of enzyme kinetic data: application to HIV proteinase.

  1996cited by this paper
• The refined crystallographic structure of a DD-peptidase penicillin-target enzyme at 1.6 A resolution.

  1995cited by this paper
• Biochemistry of the penicilloyl serine transferases

  1994cited by this paper
• Relative specificities of a series of beta-lactam-recognizing enzymes towards the side-chains of penicillins and of acyclic thioldepsipeptides.

  1994cited by this paper
• Crystal structures of thrombin and thrombin complexes as a framework for antithrombotic drug design

  1994cited by this paper
• Chapter 4 Utilization of lipid-linked precursors and the formation of peptidoglycan in the process of cell growth and division: membrane enzymes involved in the final steps of peptidoglycan synthesis and the mechanism of their regulation

  1994cited by this paper
• Penicillin-binding protein 1B from Escherichia coli contains a membrane association site in addition to its transmembrane anchor.

  1993cited by this paper
• Penicillin-binding protein 2x of Streptococcus pneumoniae: enzymic activities and interactions with beta-lactams.

  1993cited by this paper
• Probing the binding site of the penicillin side-chain based on the tipper-Strominger hypothesis

  1993cited by this paper
• Mode of action: interaction with the penicillin binding proteins

  1992cited by this paper
• Cytosolic Enzymes in Peptidoglycan Biosynthesis as Potential Antibacterial Targets

  1992cited by this paper
• Primary and predicted secondary structures of the Actinomadura R39 extracellular DD-peptidase, a penicillin-binding protein (PBP) related to the Escherichia coli PBP4.

  1992cited by this paper
• Serine beta-lactamases and penicillin-binding proteins.

  1991cited by this paper
• Penicillin‐binding protein 4 of Escherichia coli: molecular cloning of the dacB gene, controlled overexpression, and alterations in murein composition

  1991cited by this paper
• Nucleotide sequence of the rodA gene, responsible for the rod shape of Escherichia coli: rodA and the pbpA gene, encoding penicillin-binding protein 2, constitute the rodA operon

  1989cited by this paper
• Relations between beta-lactamases and penicillin-binding proteins: beta-lactamase activity of penicillin-binding protein 5 from Escherichia coli.

  1988cited by this paper
• Relations Between β-Lactamases and Penicillin-Binding Proteins: β-Lactamase Activity of Penicillin-Binding Protein 5 from Escherichia coli

  1988cited by this paper
• Radiolabelling of penicillin-binding proteins (PBPs) in intact Pseudomonas aeruginosa cells: consequences of beta-lactamase activity by PBP-5.

  1987cited by this paper
• Peptidoglycan synthetic activities in membranes of Escherichia coli caused by overproduction of penicillin-binding protein 2 and rodA protein.

  1986cited by this paper
• Penicillin-sensitive enzymes in peptidoglycan biosynthesis.

  1985cited by this paper
• METHOTREXATE ANALOGS. 20. REPLACEMENT OF GLUTAMATE BY LONGER-CHAIN AMINO DIACIDS: EFFECTS ON DIHYDROFOLATE REDUCTASE INHIBITION, CYTOTOXICITY, AND IN VIVO ANTITUMOR ACTIVITY

  1984cited by this paper
• Methotrexate analogues. 20. Replacement of glutamate by longer-chain amino diacids: effects on dihydrofolate reductase inhibition, cytotoxicity, and in vivo antitumor activity.

  1983cited by this paper
• SYNTHESIS AND BIOLOGICAL ACTIVITY OF SOME FUSED β-LACTAM PEPTIDOGLYCAN ANALOGS

  1983cited by this paper
• Penicillin-binding proteins and the mechanism of action of beta-lactam antibiotics.

  1983cited by this paper
• Synthesis and biological activity of some fused β-lactam peptidoglycan analogues

  1983cited by this paper
• Microbial cell walls and membranes

  1980cited by this paper
• Purification and properties of penicillin-binding proteins 5 and 6 from Escherichia coli membranes.

  1980cited by this paper
• The chemistry of penicillanic acids. Part III. A route to 1,2-secopenicillins.

  1975cited by this paper
• Penicillin-binding proteins and cell shape in E. coli

  1975cited by this paper
• Conformation of penicillin as a transition-state analog of the substrate of peptidoglycan transpeptidase.

  1971cited by this paper
• Mechanism of action of penicillins: a proposal based on their structural similarity to acyl-D-alanyl-D-alanine.

  1965cited by this paper

• Unveiling the therapeutic significance of shikimate pathway-derived phenolic acids against penicillin-binding protein 3 of Pseudomonas aeruginosa

  2024cites this paper
• Unveiling the Potential of Bergenia Phenolics: Vitexin's Role in Allosteric Modulation of PBP2a as a Strategy against MRSA Resistance.

  2024cites this paper
• Cheminformatics identification of phenolics as modulators of penicillin-binding protein-3 of Pseudomonas aeruginosa towards interventive antibacterial therapy

  2023cites this paper
• Mechanistic Insights into the Activities of Major Families of Enzymes in Bacterial Peptidoglycan Assembly and Breakdown

  2023cites this paper
• Cheminformatics Identification of Phenolics as Modulators of Penicillin-Binding Protein 2a of Staphylococcus aureus: A Structure–Activity-Relationship-Based Study

  2022cites this paper
• Medicinal Chemistry of β‐Lactam Antibiotics

  2021cites this paper
• β-Lactams against the Fortress of the Gram-Positive Staphylococcus aureus Bacterium.

  2020cites this paper
• Substrate and stereochemical control of peptidoglycan crosslinking by transpeptidation by Escherichia coli PBP1B.

  2020cites this paper
• Kinetic Evidence for a Second Ligand Binding Site on Streptococcus pneumoniae Penicillin-Binding Protein 2x.

  2018cites this paper
• Synthesis and Kinetic Analysis of Two Conformationally Restricted Peptide Substrates of Escherichia coli Penicillin-Binding Protein 5.

  2016cites this paper
• A New Covalent Inhibitor of Class C β-Lactamases Reveals Extended Active Site Specificity.

  2015cites this paper
• Bacterial Cell Wall

  2015cites this paper
• Antibióticos cefalosporánicos: Actualidades y perspectivas

  2015cites this paper
• Novel Penicillin-Type Analogues Bearing a Variable Substituted 2-Azetidinone Ring at Position 6: Synthesis and Biological Evaluation

  2015cites this paper
• Substrate Specificity of Bacterial DD-Peptidases

  2014influential citation
• Resistance to β-Lactam Antibiotics Conferred by Point Mutations in Penicillin-Binding Proteins PBP3, PBP4 and PBP6 in Salmonella enterica

  2014cites this paper
• Continuous fluorescence anisotropy-based assay of BOCILLIN FL penicillin reaction with penicillin binding protein 3.

  2013cites this paper
• Dual substrate specificity of Bacillus subtilis PBP4a.

  2013cites this paper
• Inhibition of DD-peptidases by a specific trifluoroketone: crystal structure of a complex with the Actinomadura R39 DD-peptidase.

  2013cites this paper
• Dual Substrate Speci fi city of Bacillus subtilis PBP 4 a

  2013cites this paper
• Inhibition of bacterial DD-peptidases (penicillin-binding proteins) in membranes and in vivo by peptidoglycan-mimetic boronic acids.

  2012cites this paper
• High-Throughput Screening for Novel Inhibitors of Neisseria gonorrhoeae Penicillin-Binding Protein 2

  2012cites this paper
• Crystal structures of penicillin-binding protein 3 (PBP3) from methicillin-resistant Staphylococcus aureus in the apo and cefotaxime-bound forms.

  2012cites this paper
• Peptidoglycan Degrading and Sensing Systems of Mycobacterium tuberculosis

  2012cites this paper
• Asymmetric Synthesis of New β-Lactam Lipopeptides as Bacterial Signal Peptidase I Inhibitors

  2011cites this paper
• A computational evaluation of the mechanism of penicillin-binding protein-catalyzed cross-linking of the bacterial cell wall.

  2011cites this paper
• Crystal structures of covalent complexes of β -lactam antibiotics with E. coli penicillin-binding protein 5: toward an understanding of antibiotic specificity

  2011cites this paper
• Substrate specificity of low-molecular mass bacterial DD-peptidases.

  2011cites this paper
• β-Lactam Antibiotics

  2010cites this paper
• Crystal structures of covalent complexes of β-lactam antibiotics with Escherichia coli penicillin-binding protein 5: toward an understanding of antibiotic specificity.

  2010cites this paper
• Crystal structure of a complex between the Actinomadura R39 DD-peptidase and a peptidoglycan-mimetic boronate inhibitor: interpretation of a transition state analogue in terms of catalytic mechanism.

  2010cites this paper
• Mutational analysis of the substrate specificity of Escherichia coli penicillin binding protein 4.

  2009cites this paper
• Discovery of new inhibitors of resistant Streptococcus pneumoniae penicillin binding protein (PBP) 2x by structure-based virtual screening.

  2009cites this paper
• 13 Bacterial Cell Wall Morphology and Biochemistry

  2009cites this paper
• Neisseria gonorrhoeae penicillin-binding protein 3 demonstrates a pronounced preference for N(epsilon)-acylated substrates.

  2009cites this paper
• Crystal structures of complexes of bacterial DD-peptidases with peptidoglycan-mimetic ligands: the substrate specificity puzzle.

  2008cites this paper
• Substrate specificity of bacterial DD-peptidases (penicillin-binding proteins)

  2008cites this paper
• Crystal Structures of Biapenem and Tebipenem Complexed with Penicillin-Binding Proteins 2X and 1A from Streptococcus pneumoniae

  2008cites this paper
• Physiological functions of D-alanine carboxypeptidases in Escherichia coli.

  2008cites this paper
• Evolution of peptidoglycan biosynthesis under the selective pressure of antibiotics in Gram-positive bacteria.

  2008cites this paper
• Investigation of the mechanism of the cell wall DD-carboxypeptidase reaction of penicillin-binding protein 5 of Escherichia coli by quantum mechanics/molecular mechanics calculations.

  2008cites this paper
• Comparative Study of the Susceptibilities of Major Epidemic Clones of Methicillin-Resistant Staphylococcus aureus to Oxacillin and to the New Broad-Spectrum Cephalosporin Ceftobiprole

  2008cites this paper
• Cutting and stitching: the cross-linking of peptidoglycan in the assembly of the bacterial cell wall.

  2007cites this paper
• Direct diazo-transfer reaction on beta-lactam: synthesis and preliminary biological activities of 6-triazolylpenicillanic acids.

  2007cites this paper
• Reactions of peptidoglycan-mimetic beta-lactams with penicillin-binding proteins in vivo and in membranes.

  2007cites this paper
• Design, Synthesis and Evaluation of Specific Substrates for E. coli Penicillin-Binding Protein 2

  2007cites this paper